Gsdma2 (gasdermin A2) - Rat Genome Database

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Gene: Gsdma2 (gasdermin A2) Mus musculus
Analyze
No known orthologs.
Symbol: Gsdma2
Name: gasdermin A2
RGD ID: 1623898
MGI Page MGI
Description: Predicted to enable phospholipid binding activity and wide pore channel activity. Predicted to be involved in defense response to bacterium and pyroptosis. Predicted to act upstream of or within programmed cell death. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in membrane. Is expressed in esophagus epithelium; skin; and stomach. Orthologous to human GSDMA (gasdermin A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2200001G21Rik; 2210006M16Rik; 2210009F20Rik; 2210411P14Rik; gasdermin 2; gasdermin-2; gasdermin-A2; gasderminA-2; Gsdm; Gsdm2; GsdmA-2; Gsdml2; MGC130173; MGC130174
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,537,569 - 98,548,791 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,537,585 - 98,548,790 (+)EnsemblGRCm39 Ensembl
GRCm381198,646,743 - 98,657,964 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,646,759 - 98,657,964 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,508,073 - 98,519,271 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,462,853 - 98,474,043 (+)NCBIMGSCv36mm8
Celera11108,301,135 - 108,312,333 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.28NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15010812   PMID:15475261   PMID:16141072   PMID:16141073   PMID:17350798   PMID:18799693  
PMID:21677750   PMID:21873635  


Genomics

Variants

.
Variants in Gsdma2
295 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:953
Count of miRNA genes:484
Interacting mature miRNAs:584
Transcripts:ENSMUST00000017355, ENSMUST00000093938, ENSMUST00000127692, ENSMUST00000129186, ENSMUST00000131549, ENSMUST00000136111, ENSMUST00000138686
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
1301491Abbp4_mA/J and C57BL/6 blood pressure 4 (mouse)Not determined118869958899081597Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1301153Estq3_mestradiol regulated response QTL 3 (mouse)Not determined119689769399327028Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse

Markers in Region
D11Mit264  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,645,606 - 98,645,724UniSTSGRCm38
MGSCv371198,506,920 - 98,507,038UniSTSGRCm37
Celera11108,299,982 - 108,300,100UniSTS
Cytogenetic Map11DUniSTS
cM Map1159.0UniSTS
Whitehead Genetic1161.2UniSTS
Whitehead/MRC_RH111304.47UniSTS
Whitehead_YAC11 UniSTS
Gsdma1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11DUniSTS
cM Map11 UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000017355   ⟹   ENSMUSP00000017355
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,537,589 - 98,548,779 (+)Ensembl
GRCm38.p6 Ensembl1198,646,763 - 98,657,953 (+)Ensembl
RefSeq Acc Id: ENSMUST00000093938   ⟹   ENSMUSP00000091470
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,537,585 - 98,548,790 (+)Ensembl
GRCm38.p6 Ensembl1198,646,759 - 98,657,964 (+)Ensembl
RefSeq Acc Id: ENSMUST00000127692
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,537,589 - 98,540,949 (+)Ensembl
GRCm38.p6 Ensembl1198,646,763 - 98,650,123 (+)Ensembl
RefSeq Acc Id: ENSMUST00000129186
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,542,347 - 98,545,770 (+)Ensembl
GRCm38.p6 Ensembl1198,651,521 - 98,654,944 (+)Ensembl
RefSeq Acc Id: ENSMUST00000131549
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,537,595 - 98,539,910 (+)Ensembl
GRCm38.p6 Ensembl1198,646,769 - 98,649,084 (+)Ensembl
RefSeq Acc Id: ENSMUST00000136111
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,541,485 - 98,542,886 (+)Ensembl
GRCm38.p6 Ensembl1198,650,659 - 98,652,060 (+)Ensembl
RefSeq Acc Id: ENSMUST00000138686
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,537,601 - 98,540,521 (+)Ensembl
GRCm38.p6 Ensembl1198,646,775 - 98,649,695 (+)Ensembl
RefSeq Acc Id: NM_001363220   ⟹   NP_001350149
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391198,537,585 - 98,548,790 (+)NCBI
GRCm381198,646,759 - 98,657,964 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001363221   ⟹   NP_001350150
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391198,537,585 - 98,548,790 (+)NCBI
GRCm381198,646,759 - 98,657,964 (+)NCBI
Sequence:
RefSeq Acc Id: NM_029727   ⟹   NP_084003
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391198,537,585 - 98,548,790 (+)NCBI
GRCm381198,646,759 - 98,657,964 (+)NCBI
MGSCv371198,508,073 - 98,519,271 (+)RGD
Celera11108,301,135 - 108,312,333 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006534455   ⟹   XP_006534518
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391198,537,569 - 98,548,774 (+)NCBI
GRCm381198,646,743 - 98,657,948 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036157079   ⟹   XP_036012972
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391198,537,569 - 98,548,791 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_084003   ⟸   NM_029727
- Peptide Label: isoform 1
- UniProtKB: Q8CF01 (UniProtKB/Swiss-Prot),   Q9D810 (UniProtKB/Swiss-Prot),   Q32M21 (UniProtKB/Swiss-Prot),   A0A679B178 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006534518   ⟸   XM_006534455
- Peptide Label: isoform X1
- UniProtKB: A0A679B178 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001350150   ⟸   NM_001363221
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001350149   ⟸   NM_001363220
- Peptide Label: isoform 1
- UniProtKB: Q8CF01 (UniProtKB/Swiss-Prot),   Q32M21 (UniProtKB/Swiss-Prot),   Q9D810 (UniProtKB/Swiss-Prot),   A0A679B178 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000091470   ⟸   ENSMUST00000093938
RefSeq Acc Id: ENSMUSP00000017355   ⟸   ENSMUST00000017355
RefSeq Acc Id: XP_036012972   ⟸   XM_036157079
- Peptide Label: isoform X1
- UniProtKB: A0A679B178 (UniProtKB/TrEMBL)
Protein Domains
Gasdermin pore forming   Gasdermin PUB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q32M21-F1-model_v2 AlphaFold Q32M21 1-443 view protein structure

Promoters
RGD ID:8676504
Promoter ID:EPDNEW_M16283
Type:multiple initiation site
Name:Gsdma2_1
Description:Mus musculus gasdermin A2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381198,646,767 - 98,646,827EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921490 AgrOrtholog
Ensembl Genes ENSMUSG00000017211 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000017355 ENTREZGENE
  ENSMUST00000017355.12 UniProtKB/Swiss-Prot
  ENSMUST00000093938 ENTREZGENE
  ENSMUST00000093938.10 UniProtKB/Swiss-Prot
InterPro Gasdermin_pore UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gasdermin_PUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:76758 UniProtKB/Swiss-Prot
MGD MGI:1921490 ENTREZGENE
NCBI Gene 76758 ENTREZGENE
PANTHER GASDERMIN-A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR16399 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Gasdermin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gasdermin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gsdma2 PhenoGen
UniProt A0A679B178 ENTREZGENE, UniProtKB/TrEMBL
  GSDA2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8CF01 ENTREZGENE
  Q9D810 ENTREZGENE
UniProt Secondary Q8CF01 UniProtKB/Swiss-Prot
  Q9D810 UniProtKB/Swiss-Prot