Tcta (T cell leukemia translocation altered gene) - Rat Genome Database
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Gene: Tcta (T cell leukemia translocation altered gene) Mus musculus
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Symbol: Tcta
Name: T cell leukemia translocation altered gene
RGD ID: 1623864
MGI Page MGI
Description: Predicted to be involved in negative regulation of osteoclast differentiation and osteoclast fusion. Predicted to localize to integral component of membrane. Is expressed in cranial ganglion; dorsal root ganglion; sensory organ; and trigeminal nerve. Orthologous to human TCTA (T cell leukemia translocation altered); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9130410M22Rik; AW553637; C85065; T-cell leukemia translocation altered; T-cell leukemia translocation-altered gene protein homolog; Tct; Tctal
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,180,154 - 108,183,358 (-)NCBIGRCm39mm39
GRCm389108,302,955 - 108,306,159 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,302,958 - 108,306,160 (-)EnsemblGRCm38mm10GRCm38
MGSCv379108,205,289 - 108,208,282 (-)NCBIGRCm37mm9NCBIm37
MGSCv369108,161,051 - 108,164,044 (-)NCBImm8
Celera9107,912,001 - 107,914,995 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7728759   PMID:8889548   PMID:10349636   PMID:10508511   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273  
PMID:16110338   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635  


Genomics

Comparative Map Data
Tcta
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,180,154 - 108,183,358 (-)NCBIGRCm39mm39
GRCm389108,302,955 - 108,306,159 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,302,958 - 108,306,160 (-)EnsemblGRCm38mm10GRCm38
MGSCv379108,205,289 - 108,208,282 (-)NCBIGRCm37mm9NCBIm37
MGSCv369108,161,051 - 108,164,044 (-)NCBImm8
Celera9107,912,001 - 107,914,995 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.2NCBI
TCTA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl349,412,206 - 49,416,475 (+)EnsemblGRCh38hg38GRCh38
GRCh38349,412,206 - 49,416,476 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37349,449,639 - 49,453,909 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,424,643 - 49,428,913 (+)NCBINCBI36hg18NCBI36
Build 34349,424,642 - 49,428,912NCBI
Celera349,414,426 - 49,418,696 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef349,509,361 - 49,513,631 (+)NCBIHuRef
CHM1_1349,402,406 - 49,406,676 (+)NCBICHM1_1
Tcta
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08117,079,094 - 117,082,338 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,079,095 - 117,082,162 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,427,898 - 116,431,164 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,291,610 - 108,294,678 (-)NCBICelera
Cytogenetic Map8q32NCBI
Tcta
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,347,639 - 1,349,864 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,347,639 - 1,349,864 (+)NCBIChiLan1.0ChiLan1.0
TCTA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1350,584,614 - 50,588,891 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0349,340,010 - 49,344,288 (+)NCBIMhudiblu_PPA_v0panPan3
TCTA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2039,822,211 - 39,824,200 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12039,820,845 - 39,824,526 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Tcta
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365291,045,735 - 1,047,922 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TCTA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,991,567 - 31,998,168 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,991,408 - 31,995,274 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TCTA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,809,342 - 10,813,655 (+)NCBI
ChlSab1.1 Ensembl2210,809,595 - 10,812,029 (+)Ensembl
Tcta
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247303,362,037 - 3,365,621 (+)NCBI

Position Markers
RH127115  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389108,303,019 - 108,303,268UniSTSGRCm38
MGSCv379108,205,350 - 108,205,599UniSTSGRCm37
Celera9107,912,062 - 107,912,311UniSTS
Cytogenetic Map9F2UniSTS
cM Map960.0UniSTS
Whitehead/MRC_RH91109.33UniSTS
AW553637  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389108,303,312 - 108,303,461UniSTSGRCm38
MGSCv379108,205,643 - 108,205,792UniSTSGRCm37
Celera9107,912,355 - 107,912,504UniSTS
Cytogenetic Map9F2UniSTS
cM Map960.0UniSTS
Whitehead/MRC_RH91110.29UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:427
Count of miRNA genes:327
Interacting mature miRNAs:358
Transcripts:ENSMUST00000044725
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000044725   ⟹   ENSMUSP00000045063
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,302,958 - 108,305,990 (-)Ensembl
RefSeq Acc Id: ENSMUST00000192886   ⟹   ENSMUSP00000142002
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,303,654 - 108,306,160 (-)Ensembl
RefSeq Acc Id: ENSMUST00000195615   ⟹   ENSMUSP00000141592
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,303,890 - 108,305,948 (-)Ensembl
RefSeq Acc Id: NM_001311156   ⟹   NP_001298085
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,180,154 - 108,183,358 (-)NCBI
GRCm389108,302,955 - 108,306,159 (-)NCBI
Sequence:
RefSeq Acc Id: NM_133986   ⟹   NP_598747
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,180,154 - 108,183,358 (-)NCBI
GRCm389108,302,955 - 108,306,159 (-)NCBI
MGSCv379108,205,289 - 108,208,282 (-)RGD
Celera9107,912,001 - 107,914,995 (-)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_598747   ⟸   NM_133986
- Peptide Label: isoform 1
- UniProtKB: Q8VEA7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001298085   ⟸   NM_001311156
- Peptide Label: isoform 2
- UniProtKB: A0A0A6YXI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000142002   ⟸   ENSMUST00000192886
RefSeq Acc Id: ENSMUSP00000045063   ⟸   ENSMUST00000044725
RefSeq Acc Id: ENSMUSP00000141592   ⟸   ENSMUST00000195615

Promoters
RGD ID:6845039
Promoter ID:MM_KWN:58785
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_016802,   NM_133986
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369108,207,666 - 108,209,322 (+)MPROMDB
RGD ID:8670874
Promoter ID:EPDNEW_M13468
Type:initiation region
Name:Tcta_2
Description:Mus musculus T cell leukemia translocation altered gene , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13469  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389108,305,948 - 108,306,008EPDNEW
RGD ID:8670876
Promoter ID:EPDNEW_M13469
Type:single initiation site
Name:Tcta_1
Description:Mus musculus T cell leukemia translocation altered gene , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13468  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389108,306,160 - 108,306,220EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1918829 AgrOrtholog
Ensembl Genes ENSMUSG00000039461 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000045063 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000141592 UniProtKB/TrEMBL
  ENSMUSP00000142002 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000044725 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000192886 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000195615 UniProtKB/TrEMBL
InterPro TCTA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:102791 UniProtKB/Swiss-Prot
MGD MGI:1918829 ENTREZGENE
NCBI Gene 102791 ENTREZGENE
PANTHER PTHR32267 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam T_cell_tran_alt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tcta PhenoGen
PIRSF TCTA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.24670 ENTREZGENE
UniProt A0A0A6YWL1_MOUSE UniProtKB/TrEMBL
  A0A0A6YXI4 ENTREZGENE, UniProtKB/TrEMBL
  Q8VEA7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-02-07 Tcta  T cell leukemia translocation altered gene  Tcta  T-cell leukemia translocation altered gene  Symbol and/or name change 5135510 APPROVED