Prss58 (serine protease 58) - Rat Genome Database

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Gene: Prss58 (serine protease 58) Mus musculus
Analyze
Symbol: Prss58
Name: serine protease 58
RGD ID: 1623780
MGI Page MGI
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Predicted to be located in extracellular region. Predicted to be active in extracellular space and secretory granule. Orthologous to human PRSS58 (serine protease 58).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1700020H15; protease, serine 58; putative inactive serine protease 58; putative trypsin-X3; trypsin-X3; Tryx3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39640,872,196 - 40,877,321 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl640,872,204 - 40,877,321 (-)EnsemblGRCm39 Ensembl
GRCm38640,895,262 - 40,900,387 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl640,895,270 - 40,900,387 (-)EnsemblGRCm38mm10GRCm38
MGSCv37640,845,261 - 40,850,386 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36640,824,869 - 40,829,994 (-)NCBIMGSCv36mm8
Celera640,881,514 - 40,886,641 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map618.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:20562862   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:32561905  


Genomics

Comparative Map Data
Prss58
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39640,872,196 - 40,877,321 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl640,872,204 - 40,877,321 (-)EnsemblGRCm39 Ensembl
GRCm38640,895,262 - 40,900,387 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl640,895,270 - 40,900,387 (-)EnsemblGRCm38mm10GRCm38
MGSCv37640,845,261 - 40,850,386 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36640,824,869 - 40,829,994 (-)NCBIMGSCv36mm8
Celera640,881,514 - 40,886,641 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map618.94NCBI
PRSS58
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387142,252,143 - 142,258,058 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7142,252,143 - 142,258,058 (-)EnsemblGRCh38hg38GRCh38
GRCh377141,951,963 - 141,957,878 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367141,598,441 - 141,604,347 (-)NCBINCBI36Build 36hg18NCBI36
Celera7136,729,455 - 136,735,370 (-)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7136,246,697 - 136,252,617 (-)NCBIHuRef
CHM1_17141,886,110 - 141,892,030 (-)NCBICHM1_1
T2T-CHM13v2.07143,567,197 - 143,573,112 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27141,290,166 - 141,296,085 (-)NCBI
Prss58
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8470,719,326 - 70,731,158 (-)NCBIGRCr8
mRatBN7.2469,752,646 - 69,757,306 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl469,752,573 - 69,756,962 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx474,676,103 - 74,680,032 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0470,597,244 - 70,601,173 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0469,010,706 - 69,014,647 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0469,145,435 - 69,152,111 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl469,145,397 - 69,149,520 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04133,935,374 - 133,939,671 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4468,534,119 - 68,538,075 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1468,810,248 - 68,814,205 (-)NCBI
Celera464,743,249 - 64,747,205 (-)NCBICelera
Cytogenetic Map4q23NCBI
Prss58
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554941,277,297 - 1,283,748 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554941,277,333 - 1,283,610 (+)NCBIChiLan1.0ChiLan1.0
PRSS58
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26179,035,095 - 179,042,947 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1731,045,350 - 31,053,202 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07134,179,697 - 134,185,609 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17146,649,838 - 146,655,755 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7146,649,838 - 146,655,728 (-)Ensemblpanpan1.1panPan2
LOC475522
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1167,001,061 - 7,005,198 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl167,001,408 - 7,005,186 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha167,859,857 - 7,863,994 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0166,922,105 - 6,926,242 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl166,922,452 - 6,926,230 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1166,875,606 - 6,879,743 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0166,716,965 - 6,721,091 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0166,785,611 - 6,789,748 (+)NCBIUU_Cfam_GSD_1.0
Prss58
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511813,166,133 - 13,170,467 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936971193,268 - 195,843 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936971193,268 - 195,843 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRSS58
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl187,715,879 - 7,723,937 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1187,715,969 - 7,725,465 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2187,984,174 - 7,992,282 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRSS58
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121110,988,537 - 110,994,720 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21110,988,631 - 110,994,088 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660727,694,375 - 7,702,860 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prss58
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248219,612,653 - 9,618,461 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prss58
291 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:126
Count of miRNA genes:117
Interacting mature miRNAs:120
Transcripts:ENSMUST00000063523
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1771159851711719Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797146118069Mouse
11252142Mom12_mModifier of Min 12 (mouse)63387226167872400Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61771159851711719Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122146751333Mouse
1300959Lxw2_mlupus BXSB x NZW 2 (mouse)Not determined63387226167872400Mouse
1300767Aliq4_macute lung injury QTL 4 (mouse)Not determined63627333270273435Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61771159851711719Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
14746995Manh60_mmandible shape 60 (mouse)63720266271202662Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62004983054049830Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
4141094Hrtr1_mheart rate 1 (mouse)Not determined3674146370741463Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2829099362291115Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1301326Trbv4c2_mT cell receptor beta variable 4 (mouse)Not determined64086823071356155Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61961634653616346Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3282758578215957Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61961634653616346Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
12880425V25Dq5_mvitamin D inactive form serum level QTL 5 (mouse)63267698066676980Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707443297168Mouse
4141454Obrq4_mobesity resistance QTL 4 (mouse)Not determined3170349965703611Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62377693457776934Mouse
1357539Bsbob3_mBSB obesity 3 (mouse)Not determined63644845670448576Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61769999953476985Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61961634653616346Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122146751333Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000063523   ⟹   ENSMUSP00000069833
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl640,872,204 - 40,877,321 (-)Ensembl
GRCm38.p6 Ensembl640,895,270 - 40,900,387 (-)Ensembl
RefSeq Acc Id: NM_175020   ⟹   NP_778185
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39640,872,196 - 40,877,321 (-)NCBI
GRCm38640,895,262 - 40,900,387 (-)ENTREZGENE
MGSCv37640,845,261 - 40,850,386 (-)RGD
Celera640,881,514 - 40,886,641 (-)RGD
cM Map6 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_778185 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB69042 (Get FASTA)   NCBI Sequence Viewer  
  AAH48599 (Get FASTA)   NCBI Sequence Viewer  
  BAC35932 (Get FASTA)   NCBI Sequence Viewer  
  EDL13564 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000069833
  ENSMUSP00000069833.4
GenBank Protein Q8BW11 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_778185   ⟸   NM_175020
- Peptide Label: precursor
- UniProtKB: Q8BW11 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000069833   ⟸   ENSMUST00000063523
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BW11-F1-model_v2 AlphaFold Q8BW11 1-241 view protein structure

Promoters
RGD ID:6889434
Promoter ID:EPDNEW_M8168
Type:multiple initiation site
Name:Prss58_1
Description:Mus musculus protease, serine 58 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38640,900,379 - 40,900,439EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3608323 AgrOrtholog
Ensembl Genes ENSMUSG00000051936 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000063523 ENTREZGENE
  ENSMUST00000063523.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
KEGG Report mmu:232717 UniProtKB/Swiss-Prot
MGD MGI:3608323 ENTREZGENE
NCBI Gene 232717 ENTREZGENE
PANTHER KALLIKREIN-RELATED UniProtKB/Swiss-Prot
  SERINE PROTEASE 58 UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot
PhenoGen Prss58 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
UniProt PRS58_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-08-29 Prss58  serine protease 58  Prss58  protease, serine 58  Symbol and/or name change 5135510 APPROVED
2011-07-27 Prss58  protease, serine 58  BC048599  cDNA sequence BC048599  Symbol and/or name change 5135510 APPROVED