Spin2c (spindlin family, member 2C) - Rat Genome Database

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Gene: Spin2c (spindlin family, member 2C) Mus musculus
Analyze
Symbol: Spin2c
Name: spindlin family, member 2C
RGD ID: 1623717
MGI Page MGI
Description: Predicted to enable methylated histone binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be active in cytosol and nucleoplasm. Is expressed in embryo. Orthologous to human SPIN2A (spindlin family member 2A) and SPIN2B (spindlin family member 2B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BC068162; MGC93001; S; SPIN-2; SPIN-2C; Spin2; spindlin family, member 2; spindlin-2; spindlin-2C; spindlin-like protein 2; spindlin-like protein 2C
RGD Orthologs
Human
Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm14332   Gm14334   Gm14349   Gm14350   Gm2837   Gm6019   Gm9427  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X152,615,246 - 152,617,239 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX152,615,221 - 152,617,239 (+)EnsemblGRCm39 Ensembl
GRCm38X153,832,004 - 153,834,243 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX153,832,225 - 153,834,243 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X150,266,836 - 150,268,783 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X149,173,009 - 149,174,956 (+)NCBIMGSCv36mm8
CeleraX135,410,353 - 135,412,498 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX72.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,ISO)
nucleoplasm  (IBA,ISO)
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10922068   PMID:12145692   PMID:12477932   PMID:15489334   PMID:21873635   PMID:24194600  


Genomics

Comparative Map Data
Spin2c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X152,615,246 - 152,617,239 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX152,615,221 - 152,617,239 (+)EnsemblGRCm39 Ensembl
GRCm38X153,832,004 - 153,834,243 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX153,832,225 - 153,834,243 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X150,266,836 - 150,268,783 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X149,173,009 - 149,174,956 (+)NCBIMGSCv36mm8
CeleraX135,410,353 - 135,412,498 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX72.38NCBI
SPIN2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X57,134,265 - 57,147,180 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX57,134,530 - 57,137,523 (-)EnsemblGRCh38hg38GRCh38
GRCh37X57,162,083 - 57,163,830 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X57,178,808 - 57,180,783 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X57,045,104 - 57,047,079NCBI
CeleraX61,016,469 - 61,018,444 (-)NCBICelera
Cytogenetic MapXp11.21NCBI
HuRefX54,225,452 - 54,227,427 (-)NCBIHuRef
CHM1_1X57,152,222 - 57,154,197 (-)NCBICHM1_1
T2T-CHM13v2.0X56,433,139 - 56,446,055 (-)NCBIT2T-CHM13v2.0
Spin2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X20,847,871 - 20,849,854 (-)NCBIGRCr8
mRatBN7.2X17,511,018 - 17,513,001 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX17,511,022 - 17,513,001 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX14,858,054 - 14,860,037 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X25,264,893 - 25,266,876 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X17,918,561 - 17,920,544 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X17,962,905 - 17,964,888 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX17,962,909 - 17,964,888 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX18,340,688 - 18,341,467 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X18,730,378 - 18,732,361 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X37,609,279 - 37,610,330 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX17,758,434 - 17,760,417 (-)NCBICelera
Cytogenetic MapXq12NCBI

Variants

.
Variants in Spin2c
36 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:346
Count of miRNA genes:222
Interacting mature miRNAs:232
Transcripts:ENSMUST00000049999, ENSMUST00000123264, ENSMUST00000148708
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357823Spha3_msperm head anomaly 3 (mouse)Not determinedX102055848162758941Mouse
1301209Cia19_mcollagen induced arthritis 19 (mouse)Not determinedX120993165160213038Mouse
10412164Cmv2_mcytomegalovirus resistance 2 (mouse)Not determinedX125685149159685269Mouse
13824981Svwq2_mseminal vesicle weight QTL 2 (mouse)X128900749153782996Mouse
1558900Bw3_mbody weight QTL 3 (mouse)Not determinedX133540040165298595Mouse
10401118Pgia39_mproteoglycan induced arthritis 39 (mouse)Not determinedX144474380169476592Mouse
1302000Pgia25_mproteoglycan induced arthritis 2 (mouse)Not determinedX144474380169476592Mouse
12738421Lfibq17_mliver fibrosis QTL 17 (mouse)X148148453164945064Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000049999   ⟹   ENSMUSP00000059499
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX152,615,289 - 152,617,239 (+)Ensembl
GRCm38.p6 EnsemblX153,832,293 - 153,834,243 (+)Ensembl
RefSeq Acc Id: ENSMUST00000123264   ⟹   ENSMUSP00000115368
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX152,615,237 - 152,616,519 (+)Ensembl
GRCm38.p6 EnsemblX153,832,241 - 153,833,523 (+)Ensembl
RefSeq Acc Id: ENSMUST00000148708   ⟹   ENSMUSP00000120680
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX152,615,221 - 152,616,506 (+)Ensembl
GRCm38.p6 EnsemblX153,832,225 - 153,833,510 (+)Ensembl
RefSeq Acc Id: NM_001005370   ⟹   NP_001005370
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X152,615,246 - 152,617,239 (+)NCBI
GRCm38X153,832,293 - 153,834,240 (+)NCBI
MGSCv37X150,266,836 - 150,268,783 (+)RGD
CeleraX135,410,353 - 135,412,498 (-)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001418374   ⟹   NP_001405303
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X152,615,246 - 152,617,239 (+)NCBI
RefSeq Acc Id: NM_001418375   ⟹   NP_001405304
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X152,615,246 - 152,617,239 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001005370   ⟸   NM_001005370
- UniProtKB: Q6NVE3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000120680   ⟸   ENSMUST00000148708
RefSeq Acc Id: ENSMUSP00000059499   ⟸   ENSMUST00000049999
RefSeq Acc Id: ENSMUSP00000115368   ⟸   ENSMUST00000123264
RefSeq Acc Id: NP_001405303   ⟸   NM_001418374
- UniProtKB: Q6NVE3 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001405304   ⟸   NM_001418375
- UniProtKB: Q6NVE3 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6NVE3-F1-model_v2 AlphaFold Q6NVE3 1-257 view protein structure

Promoters
RGD ID:6846398
Promoter ID:MM_KWN:62438
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell,   MEF_B6
Transcripts:OTTMUST00000046239,   OTTMUST00000046240,   OTTMUST00000046241
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X150,266,591 - 150,267,091 (+)MPROMDB
RGD ID:13681688
Promoter ID:EPDNEW_M24993
Type:multiple initiation site
Name:Spin2c_1
Description:Mus musculus spindlin family, member 2C , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X153,832,253 - 153,832,313EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3605548 AgrOrtholog
Ensembl Genes ENSMUSG00000046550 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000049999 ENTREZGENE
  ENSMUST00000049999.9 UniProtKB/Swiss-Prot
  ENSMUST00000123264.2 UniProtKB/TrEMBL
  ENSMUST00000148708.2 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro SPIN/Ssty UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPIN/Ssty_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:278240 UniProtKB/Swiss-Prot
MGD MGI:3605548 ENTREZGENE
NCBI Gene 278240 ENTREZGENE
PANTHER PTHR10405 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10405:SF32 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Spin-Ssty UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Spin2c PhenoGen
UniProt B1AXT4_MOUSE UniProtKB/TrEMBL
  B1AXT5_MOUSE UniProtKB/TrEMBL
  Q6NVE3 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-09-03 Spin2c  spindlin family, member 2C  Spin2  spindlin family, member 2  Symbol and/or name change 5135510 APPROVED