Tcaf3 (TRPM8 channel-associated factor 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Tcaf3 (TRPM8 channel-associated factor 3) Mus musculus
Analyze
No known orthologs.
Symbol: Tcaf3
Name: TRPM8 channel-associated factor 3
RGD ID: 1623651
MGI Page MGI
Description: Predicted to enable transmembrane transporter binding activity. Predicted to be involved in positive regulation of protein targeting to membrane. Predicted to be located in cell junction. Predicted to be active in plasma membrane. Orthologous to human TCAF2 (TRPM8 channel associated factor 2) and TCAF2C (TRPM8 channel associated factor 2C).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ea; Eapa2; experimental autoimmune prostatitis antigen 2; Fam115; Fam115e; family with sequence similarity 115, member E
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39642,564,147 - 42,574,306 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl642,561,800 - 42,574,626 (-)EnsemblGRCm39 Ensembl
GRCm38642,587,213 - 42,597,372 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl642,584,866 - 42,597,692 (-)EnsemblGRCm38mm10GRCm38
MGSCv37642,537,212 - 42,547,371 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36642,516,820 - 42,526,979 (-)NCBIMGSCv36mm8
Celera642,532,114 - 42,543,562 (-)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map620.8NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell junction  (ISO)
plasma membrane  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16223778   PMID:21677750   PMID:21873635   PMID:25559186   PMID:28709804  


Genomics

Variants

.
Variants in Tcaf3
369 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:400
Count of miRNA genes:303
Interacting mature miRNAs:356
Transcripts:ENSMUST00000069023, ENSMUST00000134707, ENSMUST00000151898
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707443297168Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797146118069Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122146751333Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122146751333Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61769999953476985Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61771159851711719Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61771159851711719Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1771159851711719Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61961634653616346Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61961634653616346Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61961634653616346Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62004983054049830Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62377693457776934Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2829099362291115Mouse
4141454Obrq4_mobesity resistance QTL 4 (mouse)Not determined3170349965703611Mouse
12880425V25Dq5_mvitamin D inactive form serum level QTL 5 (mouse)63267698066676980Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3282758578215957Mouse
1300959Lxw2_mlupus BXSB x NZW 2 (mouse)Not determined63387226167872400Mouse
11252142Mom12_mModifier of Min 12 (mouse)63387226167872400Mouse
1300767Aliq4_macute lung injury QTL 4 (mouse)Not determined63627333270273435Mouse
1357539Bsbob3_mBSB obesity 3 (mouse)Not determined63644845670448576Mouse
4141094Hrtr1_mheart rate 1 (mouse)Not determined3674146370741463Mouse
14746995Manh60_mmandible shape 60 (mouse)63720266271202662Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
1301326Trbv4c2_mT cell receptor beta variable 4 (mouse)Not determined64086823071356155Mouse
12880424V25Dq4_mvitamin D inactive form serum level QTL 4 (mouse)64157698575576985Mouse
11040600Lmr4c_mleishmaniasis resistance 4c (mouse)64209335876093500Mouse
11040601Lmr4a_mleishmaniasis resistance 4a (mouse)64209335876093500Mouse
11533915Mts4_mmammary tumor susceptibility 4 (mouse)64209335876093500Mouse
1301266Lmr4_mleishmaniasis resistance 4 (mouse)Not determined64209335876093500Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000069023   ⟹   ENSMUSP00000064060
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl642,564,147 - 42,574,306 (-)Ensembl
GRCm38.p6 Ensembl642,587,213 - 42,597,372 (-)Ensembl
RefSeq Acc Id: ENSMUST00000134707   ⟹   ENSMUSP00000123321
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl642,571,084 - 42,574,626 (-)Ensembl
GRCm38.p6 Ensembl642,594,150 - 42,597,692 (-)Ensembl
RefSeq Acc Id: ENSMUST00000151898
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl642,561,800 - 42,564,563 (-)Ensembl
GRCm38.p6 Ensembl642,584,866 - 42,587,629 (-)Ensembl
RefSeq Acc Id: NM_203396   ⟹   NP_981933
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39642,564,147 - 42,574,306 (-)NCBI
GRCm38642,587,213 - 42,597,372 (-)NCBI
MGSCv37642,537,212 - 42,547,371 (-)RGD
Celera642,532,114 - 42,543,562 (-)RGD
cM Map6 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_981933 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAS18676 (Get FASTA)   NCBI Sequence Viewer  
  EDL13474 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000064060
  ENSMUSP00000064060.4
  ENSMUSP00000123321.2
GenBank Protein Q6QR59 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_981933   ⟸   NM_203396
- UniProtKB: Q6QR59 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000123321   ⟸   ENSMUST00000134707
RefSeq Acc Id: ENSMUSP00000064060   ⟸   ENSMUST00000069023
Protein Domains
Peptidase M60

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6QR59-F1-model_v2 AlphaFold Q6QR59 1-914 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3042585 AgrOrtholog
Ensembl Genes ENSMUSG00000018656 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000069023 ENTREZGENE
  ENSMUST00000069023.4 UniProtKB/Swiss-Prot
  ENSMUST00000134707.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.390.30 UniProtKB/Swiss-Prot
  Peptidase M60, enhancin-like domain 1 UniProtKB/Swiss-Prot
  Peptidase M60, enhancin-like domain 2 UniProtKB/Swiss-Prot
InterPro Class_I_gatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M60-like_N UniProtKB/Swiss-Prot
  pep_M60_3 UniProtKB/Swiss-Prot
  Peptidase_M60_dom UniProtKB/Swiss-Prot
KEGG Report mmu:403088 UniProtKB/Swiss-Prot
MGD MGI:3042585 ENTREZGENE
NCBI Gene 403088 ENTREZGENE
PANTHER EXPERIMENTAL AUTOIMMUNE PROSTATITIS ANTIGEN 2-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPM8 CHANNEL-ASSOCIATED FACTOR 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam M60-like_N UniProtKB/Swiss-Prot
  Peptidase_M60 UniProtKB/Swiss-Prot
PhenoGen Tcaf3 PhenoGen
PROSITE PEPTIDASE_M60 UniProtKB/Swiss-Prot
SMART M60-like UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52317 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3Z045_MOUSE UniProtKB/TrEMBL
  Q6QR59 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-01-27 Tcaf3  TRPM8 channel-associated factor 3  Fam115e  family with sequence similarity 115, member E  Symbol and/or name change 5135510 APPROVED
2011-07-27 Fam115e  family with sequence similarity 115, member E  Eapa2  experimental autoimmune prostatitis antigen 2  Symbol and/or name change 5135510 APPROVED