Tug1 (taurine upregulated gene 1) - Rat Genome Database

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Gene: Tug1 (taurine upregulated gene 1) Mus musculus
Analyze
Symbol: Tug1
Name: taurine upregulated gene 1
RGD ID: 1623542
MGI Page MGI
Description: Enables cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including mitochondrion organization; photoreceptor cell development; and spermatogenesis. Located in cytoplasm. Is active in nucleus. Is expressed in several structures, including central nervous system; olfactory epithelium; retina; spleen; and testis. Orthologous to human TUG1 (taurine up-regulated 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI316828; taurine up-regulated 1
RGD Orthologs
Human
Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,589,313 - 3,599,021 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl113,589,785 - 3,599,673 (-)EnsemblGRCm39 Ensembl
GRCm38113,639,785 - 3,648,814 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,639,785 - 3,649,673 (-)EnsemblGRCm38mm10GRCm38
MGSCv37113,539,797 - 3,548,811 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36113,539,797 - 3,548,811 (-)NCBIMGSCv36mm8
Celera114,130,991 - 4,140,005 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.56NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA)
nucleus  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Zhenbao Pill reduces Treg cell proportion in acute spinal cord injury rats by regulating TUG1/miR-214/HSP27 axis. He Y, etal., Biosci Rep. 2018 Nov 7;38(6). pii: BSR20180895. doi: 10.1042/BSR20180895. Print 2018 Dec 21.
2. Long non-coding RNAs in Huntington's disease neurodegeneration. Johnson R Neurobiol Dis. 2012 May;46(2):245-54. doi: 10.1016/j.nbd.2011.12.006. Epub 2011 Dec 14.
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. LncRNA TUG1 Promotes Apoptosis, Invasion, and Angiogenesis of Retinal Endothelial Cells in Retinopathy of Prematurity via MiR-145-5p. Wang Y, etal., Front Med (Lausanne). 2022 Apr 4;9:803214. doi: 10.3389/fmed.2022.803214. eCollection 2022.
Additional References at PubMed
PMID:8631027   PMID:8889548   PMID:10349636   PMID:10725249   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15797018   PMID:16141072  
PMID:16141073   PMID:18799693   PMID:19191220   PMID:22487937   PMID:24381249   PMID:24393600   PMID:25871529   PMID:25909911   PMID:26034286   PMID:26048247   PMID:26785829   PMID:27760046  
PMID:27760051   PMID:29268138   PMID:30066872   PMID:30468486   PMID:31115515   PMID:31145943   PMID:31183682   PMID:31539141   PMID:31679623   PMID:31697952   PMID:31709761   PMID:31787746  
PMID:31858814   PMID:31907757   PMID:31930775   PMID:32057178   PMID:32467232   PMID:32597038   PMID:32841583   PMID:32869325   PMID:32888158   PMID:32894169   PMID:33047284   PMID:33059750  
PMID:33125086   PMID:33135476   PMID:33164260   PMID:33640857   PMID:33660806   PMID:33853366   PMID:33971184   PMID:34062006   PMID:34153134   PMID:34380028   PMID:34547172   PMID:34743197  
PMID:34851489   PMID:35084431   PMID:35298636   PMID:35850762   PMID:35989413   PMID:36166514   PMID:36450139   PMID:36653890   PMID:36653891   PMID:36658478   PMID:36952210   PMID:37582412  
PMID:37610146   PMID:37642238   PMID:37721623  


Genomics

Comparative Map Data
Tug1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,589,313 - 3,599,021 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl113,589,785 - 3,599,673 (-)EnsemblGRCm39 Ensembl
GRCm38113,639,785 - 3,648,814 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,639,785 - 3,649,673 (-)EnsemblGRCm38mm10GRCm38
MGSCv37113,539,797 - 3,548,811 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36113,539,797 - 3,548,811 (-)NCBIMGSCv36mm8
Celera114,130,991 - 4,140,005 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.56NCBI
TUG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382230,969,265 - 30,979,395 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2230,969,245 - 30,979,395 (+)EnsemblGRCh38hg38GRCh38
GRCh372231,365,251 - 31,375,381 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,695,634 - 29,705,381 (+)NCBINCBI36Build 36hg18NCBI36
Celera2215,165,777 - 15,175,526 (+)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2214,327,854 - 14,337,603 (+)NCBIHuRef
CHM1_12231,325,458 - 31,335,205 (+)NCBICHM1_1
T2T-CHM13v2.02231,432,823 - 31,442,955 (+)NCBIT2T-CHM13v2.0
Tug1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81482,743,501 - 82,750,534 (-)NCBIGRCr8
mRatBN7.21478,519,894 - 78,526,927 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1478,522,506 - 78,526,927 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1482,961,035 - 82,968,068 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01484,201,125 - 84,208,158 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01480,646,916 - 80,653,949 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01483,878,757 - 83,885,791 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1483,878,295 - 83,887,584 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01484,563,854 - 84,570,784 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1477,432,155 - 77,439,189 (-)NCBICelera
Cytogenetic Map14q21NCBI

Variants

.
Variants in Tug1
308 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:239
Count of miRNA genes:162
Interacting mature miRNAs:172
Transcripts:ENSMUST00000132077, ENSMUST00000144852, ENSMUST00000153313, ENSMUST00000182330
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11125976374Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
27095914Pglq16_mpelvic girdle length QTL 16, 16 week (mouse)11325000018150000Mouse
27095919Pglq10_mpelvic girdle length QTL 10, 10 week (mouse)11325000018450000Mouse
27095925Pglq5_mpelvic girdle length QTL 5, 5 week (mouse)11325000019750000Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse

Markers in Region
RH136128  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381654,619,688 - 54,619,887UniSTSGRCm38
GRCm38113,640,184 - 3,640,383UniSTSGRCm38
MGSCv371654,619,801 - 54,620,000UniSTSGRCm37
MGSCv37113,540,187 - 3,540,386UniSTSGRCm37
Celera1654,944,989 - 54,945,188UniSTS
Celera114,131,381 - 4,131,580UniSTS
Cytogenetic Map11A1UniSTS
UniSTS:236495  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38113,645,032 - 3,645,240UniSTSGRCm38
MGSCv37113,545,035 - 3,545,243UniSTSGRCm37
Celera114,136,229 - 4,136,437UniSTS
Cytogenetic Map11A1UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001396521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_002321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK033381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL691413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY723779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D50523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ517434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ517435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000132077
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl113,589,785 - 3,597,536 (-)Ensembl
GRCm38.p6 Ensembl113,639,785 - 3,647,536 (-)Ensembl
RefSeq Acc Id: ENSMUST00000144852
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl113,589,794 - 3,598,812 (-)Ensembl
GRCm38.p6 Ensembl113,639,794 - 3,648,812 (-)Ensembl
RefSeq Acc Id: ENSMUST00000153313
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl113,589,794 - 3,597,530 (-)Ensembl
GRCm38.p6 Ensembl113,639,794 - 3,647,530 (-)Ensembl
RefSeq Acc Id: ENSMUST00000182330
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl113,596,840 - 3,599,042 (-)Ensembl
GRCm38.p6 Ensembl113,646,840 - 3,649,042 (-)Ensembl
RefSeq Acc Id: ENSMUST00000193809   ⟹   ENSMUSP00000159371
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl113,598,062 - 3,599,673 (-)Ensembl
GRCm38.p6 Ensembl113,648,062 - 3,649,673 (-)Ensembl
RefSeq Acc Id: ENSMUST00000226545
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl113,594,935 - 3,597,282 (-)Ensembl
GRCm38.p6 Ensembl113,644,935 - 3,647,282 (-)Ensembl
RefSeq Acc Id: ENSMUST00000226724
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl113,592,462 - 3,597,906 (-)Ensembl
GRCm38.p6 Ensembl113,642,462 - 3,647,906 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227137
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl113,594,999 - 3,597,132 (-)Ensembl
GRCm38.p6 Ensembl113,644,999 - 3,647,132 (-)Ensembl
RefSeq Acc Id: NM_001396521   ⟹   NP_001383450
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39113,589,313 - 3,599,021 (-)NCBI
RefSeq Acc Id: NR_002321
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39113,589,313 - 3,599,021 (-)NCBI
GRCm38113,639,785 - 3,648,814 (-)NCBI
MGSCv37113,539,797 - 3,548,811 (-)RGD
Celera114,130,982 - 4,140,011 (-)NCBI
cM Map11 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001383450 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000159371
  ENSMUSP00000159371.2
RefSeq Acc Id: ENSMUSP00000159371   ⟸   ENSMUST00000193809
RefSeq Acc Id: NP_001383450   ⟸   NM_001396521
- UniProtKB: A0A6I8MX38 (UniProtKB/Swiss-Prot),   A0A8Q0QWN6 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A6I8MX38-F1-model_v2 AlphaFold A0A6I8MX38 1-142 view protein structure

Promoters
RGD ID:6822401
Promoter ID:MM_KWN:6183
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   MEF_B6
Transcripts:NR_002322,   UC007HTJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36113,546,591 - 3,548,287 (-)MPROMDB
RGD ID:6820954
Promoter ID:MM_KWN:6184
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK133410_GM10216,   OTTMUST00000011197
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36113,548,341 - 3,549,332 (-)MPROMDB
RGD ID:8673744
Promoter ID:EPDNEW_M14902
Type:multiple initiation site
Name:AK033381_1
Description:n/a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38113,647,505 - 3,647,565EPDNEW
RGD ID:8673820
Promoter ID:EPDNEW_M14903
Type:multiple initiation site
Name:Tug1_1
Description:Mus musculus taurine upregulated gene 1 , transcript varianta, long non-coding RNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38113,648,796 - 3,648,856EPDNEW
RGD ID:15093879
Promoter ID:EPDNEWNC_M1786
Type:multiple initiation site
Name:Tug1_1
Description:taurine upregulated gene 1 [Source:MGISymbol;Acc:MGI:2144114]
SO ACC ID:SO:0000170
Source:EPDNEWNC (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38113,649,021 - 3,649,081EPDNEWNC

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2144114 AgrOrtholog
Ensembl Genes ENSMUSG00000056579 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000144852 ENTREZGENE
  ENSMUST00000193809 ENTREZGENE
  ENSMUST00000193809.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.270 UniProtKB/TrEMBL
InterPro DNA/RNA_pol_sf UniProtKB/TrEMBL
  Rev_trsase/Diguanyl_cyclase UniProtKB/TrEMBL
MGD MGI:2144114 ENTREZGENE
NCBI Gene 544752 ENTREZGENE
PhenoGen Tug1 PhenoGen
Superfamily-SCOP SSF56672 UniProtKB/TrEMBL
UniProt A0A6I8MX38 ENTREZGENE
  A0A8Q0QWN6 ENTREZGENE, UniProtKB/TrEMBL
  Q3TNP2_MOUSE UniProtKB/TrEMBL
  Q8CI88_MOUSE UniProtKB/TrEMBL
  TUG1_MOUSE UniProtKB/Swiss-Prot