Spag11b (sperm associated antigen 11B) - Rat Genome Database

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Gene: Spag11b (sperm associated antigen 11B) Mus musculus
Analyze
Symbol: Spag11b
Name: sperm associated antigen 11B
RGD ID: 1623534
MGI Page MGI
Description: Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide and cytolysis by host of symbiont cells. Predicted to act upstream of or within defense response to bacterium. Predicted to be located in extracellular region. Orthologous to human SPAG11B (sperm associated antigen 11B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-defensin-like peptide; Bin1b; EG546038; Ep2c/h; Ep2e; Spag11; Spag11c/h; Sperm-associated antigen 11; sperm-associated antigen 11B; sperm-associated antigen 11c/h
RGD Orthologs
Human
Rat
Dog
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39819,190,775 - 19,193,026 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl819,190,775 - 19,193,026 (+)EnsemblGRCm39 Ensembl
GRCm38819,140,759 - 19,143,010 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl819,140,759 - 19,143,010 (+)EnsemblGRCm38mm10GRCm38
MGSCv37819,140,759 - 19,143,010 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36819,140,736 - 19,142,987 (+)NCBIMGSCv36mm8
Celera819,271,045 - 19,273,297 (+)NCBICelera
Cytogenetic Map8A1.3NCBI
cM Map810.35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16033865   PMID:16141072   PMID:16141073   PMID:20003482   PMID:21677750  


Genomics

Comparative Map Data
Spag11b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39819,190,775 - 19,193,026 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl819,190,775 - 19,193,026 (+)EnsemblGRCm39 Ensembl
GRCm38819,140,759 - 19,143,010 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl819,140,759 - 19,143,010 (+)EnsemblGRCm38mm10GRCm38
MGSCv37819,140,759 - 19,143,010 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36819,140,736 - 19,142,987 (+)NCBIMGSCv36mm8
Celera819,271,045 - 19,273,297 (+)NCBICelera
Cytogenetic Map8A1.3NCBI
cM Map810.35NCBI
SPAG11B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3887,447,754 - 7,463,542 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl87,442,684 - 7,463,674 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl87,847,876 - 7,868,867 (+)EnsemblGRCh38hg38GRCh38
GRCh3787,305,276 - 7,321,064 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3687,292,686 - 7,308,602 (-)NCBINCBI36Build 36hg18NCBI36
Build 3487,295,495 - 7,297,297NCBI
Cytogenetic Map8p23.1NCBI
CHM1_187,306,597 - 7,322,529 (+)NCBICHM1_1
T2T-CHM13v2.087,176,751 - 7,192,550 (-)NCBIT2T-CHM13v2.0
Spag11b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2 Ensembl1670,698,127 - 70,700,110 (-)EnsemblmRatBN7.2 Ensembl
RGSC_v3.41675,491,074 - 75,493,021 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1668,565,073 - 68,567,020 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
SPAG11B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11659,006,365 - 59,011,878 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1659,006,110 - 59,012,037 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1654,528,769 - 54,534,282 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01657,036,119 - 57,041,636 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1657,036,000 - 57,041,891 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11659,165,032 - 59,170,582 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01655,047,906 - 55,053,476 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01655,422,556 - 55,428,126 (+)NCBIUU_Cfam_GSD_1.0

Variants

.
Variants in Spag11b
90 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:507
Count of miRNA genes:367
Interacting mature miRNAs:400
Transcripts:ENSMUST00000039075, ENSMUST00000110767
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124751082Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130447432Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8495000035067154Mouse
1357525Pnhdlc3_mplasma non-HDL cholesterol 3 (mouse)Not determined8721249923753815Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8721249935110107Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse
11532713Sluc42_msusceptibility to lung cancer 42 (mouse)81344721035321225Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81550657249506729Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81550657249506729Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81656937350569697Mouse
4142199Poats1_mpost-ovarectomy adrenal tumor susceptibility 1 (mouse)Not determined1708262628849467Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81832109752321225Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000039075   ⟹   ENSMUSP00000048125
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl819,190,814 - 19,192,765 (+)Ensembl
GRCm38.p6 Ensembl819,140,798 - 19,142,749 (+)Ensembl
RefSeq Acc Id: ENSMUST00000110767   ⟹   ENSMUSP00000106395
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl819,190,775 - 19,193,026 (+)Ensembl
GRCm38.p6 Ensembl819,140,759 - 19,143,010 (+)Ensembl
RefSeq Acc Id: NM_001034905   ⟹   NP_001030077
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39819,190,775 - 19,193,026 (+)NCBI
GRCm38819,140,759 - 19,143,010 (+)ENTREZGENE
MGSCv37819,140,759 - 19,143,010 (+)RGD
Celera819,271,045 - 19,273,297 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001039563   ⟹   NP_001034652
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39819,190,775 - 19,193,026 (+)NCBI
GRCm38819,140,759 - 19,143,010 (+)ENTREZGENE
MGSCv37819,140,759 - 19,143,010 (+)RGD
Celera819,271,045 - 19,273,297 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001286493   ⟹   NP_001273422
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39819,190,775 - 19,193,026 (+)NCBI
GRCm38819,140,759 - 19,143,010 (+)NCBI
Celera819,271,045 - 19,273,297 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001030077   ⟸   NM_001034905
- Peptide Label: isoform 3 precursor
- UniProtKB: Q3UW43 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001034652   ⟸   NM_001039563
- Peptide Label: isoform c precursor
- UniProtKB: Q2HPE2 (UniProtKB/Swiss-Prot),   Q3UW43 (UniProtKB/TrEMBL),   Q2HPE3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273422   ⟸   NM_001286493
- Peptide Label: isoform 1 precursor
- UniProtKB: B7ZNZ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000106395   ⟸   ENSMUST00000110767
RefSeq Acc Id: ENSMUSP00000048125   ⟸   ENSMUST00000039075

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K4N2-F1-model_v2 AlphaFold Q8K4N2 1-71 view protein structure

Promoters
RGD ID:8666571
Promoter ID:EPDNEW_M11317
Type:multiple initiation site
Name:Spag11b_1
Description:Mus musculus sperm associated antigen 11B , transcript variant3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38819,140,759 - 19,140,819EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3647173 AgrOrtholog
Ensembl Genes ENSMUSG00000059463 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000039075 ENTREZGENE
  ENSMUST00000039075.8 UniProtKB/Swiss-Prot
  ENSMUST00000110767 ENTREZGENE
  ENSMUST00000110767.2 UniProtKB/Swiss-Prot
InterPro Defensin_beta-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sperm_Ag_11A_B UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
KEGG Report mmu:546038 UniProtKB/Swiss-Prot
MGD MGI:3647173 ENTREZGENE
NCBI Gene 546038 ENTREZGENE
PANTHER PTHR14081 UniProtKB/Swiss-Prot
  SPERM-ASSOCIATED ANTIGEN 11A-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPERM-ASSOCIATED ANTIGEN 11A-RELATED-RELATED UniProtKB/TrEMBL
Pfam Defensin_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sperm_Ag_HE2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Spag11b PhenoGen
UniProt B7ZNZ8 ENTREZGENE, UniProtKB/TrEMBL
  Q2HPE2 ENTREZGENE
  Q2HPE3 ENTREZGENE, UniProtKB/TrEMBL
  Q3UW43 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q2HPE2 UniProtKB/Swiss-Prot