Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-nicotine | decreases expression | ISO | SUPT4H1 (Homo sapiens) | 6480464 | Nicotine results in decreased expression of SUPT4H1 mRNA | CTD | PMID:18247414 | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of SUPT4A mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of SUPT4H1 mRNA | CTD | PMID:17555576 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | SUPT4H1 (Homo sapiens) | 6480464 | Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SUPT4H1 mRNA] | CTD | PMID:11007951 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Supt4h1 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SUPT4H1 mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SUPT4H1 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Supt4h1 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SUPT4H1 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the reaction [AHR protein binds to SUPT4H1 promoter] | CTD | PMID:19654925 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | SUPT4H1 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SUPT4H1 mRNA | CTD | PMID:11007951 | 2-hydroxypropanoic acid | decreases expression | ISO | SUPT4H1 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of SUPT4H1 mRNA | CTD | PMID:30851411 | 2-naphthylamine | increases expression | ISO | SUPT4H1 (Homo sapiens) | 6480464 | 2-Naphthylamine results in increased expression of SUPT4H1 mRNA | CTD | PMID:18247414 | 4,4'-diaminodiphenylmethane | increases expression | EXP | | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of SUPT4H1 mRNA | CTD | PMID:18648102 | 5-aza-2'-deoxycytidine | affects expression | ISO | SUPT4H1 (Homo sapiens) | 6480464 | Decitabine affects the expression of SUPT4H1 mRNA | CTD | PMID:23300844 | all-trans-retinoic acid | increases expression | ISO | SUPT4H1 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of SUPT4H1 mRNA | CTD | PMID:33167477 | amphetamine | increases expression | ISO | Supt4h1 (Rattus norvegicus) | 6480464 | Amphetamine results in increased expression of SUPT4H1 mRNA | CTD | PMID:30779732 | Aroclor 1254 | increases expression | EXP | | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased expression of SUPT4H1 mRNA | CTD | PMID:23650126 | arsenite(3-) | multiple interactions | ISO | SUPT4H1 (Homo sapiens) | 6480464 | arsenite promotes the reaction [G3BP1 protein binds to SUPT4H1 mRNA] | CTD | PMID:32406909 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | Benzo(a)pyrene affects the reaction [AHR protein binds to SUPT4H1 promoter] | CTD | PMID:19654925 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of SUPT4H1 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases expression | ISO | SUPT4H1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of SUPT4H1 mRNA | CTD | PMID:18247414 | bisphenol A | increases expression | ISO | Supt4h1 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of SUPT4H1 mRNA | CTD | PMID:25181051 and PMID:32145629 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SUPT4A mRNA | CTD | PMID:33221593 | cisplatin | affects expression | ISO | SUPT4H1 (Homo sapiens) | 6480464 | Cisplatin affects the expression of SUPT4H1 mRNA | CTD | PMID:23300844 | copper atom | multiple interactions | ISO | SUPT4H1 (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in decreased expression of SUPT4H1 mRNA | CTD | PMID:24690739 | copper(0) | multiple interactions | ISO | SUPT4H1 (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in decreased expression of SUPT4H1 mRNA | CTD | PMID:24690739 | CU-O LINKAGE | increases expression | ISO | SUPT4H1 (Homo sapiens) | 6480464 | cupric oxide results in increased expression of SUPT4H1 mRNA | CTD | PMID:22077320 | cycloheximide | multiple interactions | ISO | SUPT4H1 (Homo sapiens) | 6480464 | Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SUPT4H1 mRNA] | CTD | PMID:11007951 | disulfiram | multiple interactions | ISO | SUPT4H1 (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in decreased expression of SUPT4H1 mRNA | CTD | PMID:24690739 | N-methyl-4-phenylpyridinium | increases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of SUPT4A protein | CTD | PMID:26558463 | nicotine | decreases expression | ISO | SUPT4H1 (Homo sapiens) | 6480464 | Nicotine results in decreased expression of SUPT4H1 mRNA | CTD | PMID:18247414 | perfluorooctane-1-sulfonic acid | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of SUPT4A mRNA | CTD | PMID:36331819 | rac-lactic acid | decreases expression | ISO | SUPT4H1 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of SUPT4H1 mRNA | CTD | PMID:30851411 | tamoxifen | affects expression | EXP | | 6480464 | Tamoxifen affects the expression of SUPT4H1 mRNA | CTD | PMID:17555576 | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of SUPT4A mRNA | CTD | PMID:33045310 | trovafloxacin | increases expression | EXP | | 6480464 | trovafloxacin results in increased expression of SUPT4A mRNA | CTD | PMID:35537566 | vitamin E | increases expression | ISO | SUPT4H1 (Homo sapiens) | 6480464 | Vitamin E results in increased expression of SUPT4H1 mRNA | CTD | PMID:19244175 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
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Gene-Chemical Interaction Annotations
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Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Control of transcriptional elongation. | Kwak H and Lis JT, Annu Rev Genet. 2013;47:483-508. doi: 10.1146/annurev-genet-110711-155440. Epub 2013 Sep 11. |
| 2. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 3. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 4. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 5. | RNA polymerase I activity is regulated at multiple steps in the transcription cycle: recent insights into factors that influence transcription elongation. | Schneider DA Gene. 2012 Feb 10;493(2):176-84. doi: 10.1016/j.gene.2011.08.006. Epub 2011 Aug 26. |
Additional References at PubMed
| PMID:7671812 | PMID:8786137 | PMID:8889548 | PMID:9776760 | PMID:10349636 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:11544199 | PMID:11752298 | PMID:12466851 | PMID:12477932 |
| PMID:14610273 | PMID:15489334 | PMID:16141072 | PMID:16141073 | PMID:16602821 | PMID:18287559 | PMID:18799693 | PMID:20059953 | PMID:20211142 | PMID:21267068 | PMID:21670248 | PMID:21873635 |
| PMID:22341442 | PMID:22570620 | PMID:25760041 | PMID:27626380 | PMID:34321999 |
Genomics
Comparative Map Data
| Supt4a (Mus musculus - house mouse) |
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| SUPT4H1 (Homo sapiens - human) |
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| Supt4h1 (Rattus norvegicus - Norway rat) |
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| Supt4h1 (Chinchilla lanigera - long-tailed chinchilla) |
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| SUPT4H1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| SUPT4H1 (Canis lupus familiaris - dog) |
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| Supt4h1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| SUPT4H1 (Sus scrofa - pig) |
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| SUPT4H1 (Chlorocebus sabaeus - green monkey) |
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| Supt4h1 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Supt4a
1 total Variants 
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