Car5b (carbonic anhydrase 5b, mitochondrial) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Car5b (carbonic anhydrase 5b, mitochondrial) Mus musculus
Analyze
Symbol: Car5b
Name: carbonic anhydrase 5b, mitochondrial
RGD ID: 1623247
MGI Page MGI
Description: Exhibits carbonate dehydratase activity. Involved in response to bacterium. Localizes to mitochondrion. Is expressed in medulla oblongata and medulla oblongata floor plate. Orthologous to human CA5B (carbonic anhydrase 5B); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 7330410H16Rik; CA; CA-VB; Ca5b; carbonate dehydratase VB; carbonic anhydrase VB; CarVb; CAVB; D730005F19Rik
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X162,759,818 - 162,811,006 (-)NCBIGRCm39mm39
GRCm39 EnsemblX162,759,818 - 162,810,993 (-)Ensembl
GRCm38X163,976,822 - 164,028,010 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX163,976,822 - 164,027,997 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X160,414,754 - 160,465,942 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X159,323,196 - 159,372,102 (-)NCBImm8
CeleraX147,196,469 - 147,247,766 (-)NCBICelera
Cytogenetic MapXF5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
mitochondrion  (HDA,IBA,IDA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. RGD automated import pipeline
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10677517   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:14681479   PMID:15489334   PMID:16141072  
PMID:16141073   PMID:17362527   PMID:17626619   PMID:18614015   PMID:20820888   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22109883   PMID:22967998   PMID:23012479   PMID:23233153  
PMID:23589845   PMID:32325033   PMID:32371981  


Genomics

Comparative Map Data
Car5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X162,759,818 - 162,811,006 (-)NCBIGRCm39mm39
GRCm39 EnsemblX162,759,818 - 162,810,993 (-)Ensembl
GRCm38X163,976,822 - 164,028,010 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX163,976,822 - 164,027,997 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X160,414,754 - 160,465,942 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X159,323,196 - 159,372,102 (-)NCBImm8
CeleraX147,196,469 - 147,247,766 (-)NCBICelera
Cytogenetic MapXF5NCBI
CA5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX15,688,830 - 15,788,411 (+)EnsemblGRCh38hg38GRCh38
GRCh38X15,738,270 - 15,788,411 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X15,756,393 - 15,806,534 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,666,333 - 15,715,669 (+)NCBINCBI36hg18NCBI36
Build 34X15,516,081 - 15,562,315NCBI
CeleraX19,872,853 - 19,923,232 (+)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX13,510,606 - 13,559,489 (+)NCBIHuRef
CHM1_1X15,787,366 - 15,836,721 (+)NCBICHM1_1
Ca5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X30,474,697 - 30,534,797 (+)NCBI
Rnor_6.0 EnsemblX32,232,142 - 32,292,072 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X32,232,106 - 32,291,124 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X32,597,409 - 32,652,981 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X51,241,437 - 51,290,433 (+)NCBIRGSC3.4rn4RGSC3.4
CeleraX30,830,281 - 30,876,988 (+)NCBICelera
Cytogenetic MapXq14NCBI
Ca5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555192,412,289 - 2,455,280 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555192,415,722 - 2,455,052 (-)NCBIChiLan1.0ChiLan1.0
CA5B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X15,629,967 - 15,678,112 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX15,658,816 - 15,764,323 (+)NCBIpanpan1.1panPan2
Mhudiblu_PPA_v0X8,325,881 - 8,410,506 (+)NCBIMhudiblu_PPA_v0panPan3
CA5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X11,908,426 - 12,042,327 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX11,930,884 - 12,040,221 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX11,809,477 - 11,892,620 (+)NCBI
ROS_Cfam_1.0X11,869,327 - 12,003,333 (+)NCBI
UMICH_Zoey_3.1X11,932,374 - 12,072,571 (+)NCBI
UNSW_CanFamBas_1.0X11,926,678 - 12,059,951 (+)NCBI
UU_Cfam_GSD_1.0X11,951,875 - 12,085,347 (+)NCBI
Ca5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X5,184,444 - 5,230,212 (+)NCBI
SpeTri2.0NW_0049364705,184,489 - 5,227,855 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX12,224,159 - 12,365,025 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X12,295,393 - 12,332,283 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X13,188,075 - 13,222,663 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CA5B
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X14,197,561 - 14,240,294 (+)NCBI
ChlSab1.1 EnsemblX14,197,651 - 14,243,626 (+)Ensembl
Ca5b
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624829455,731 - 572,603 (+)NCBI

Position Markers
D5Mit392.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS
Cytogenetic Map18A1UniSTS
Cytogenetic Map1G3UniSTS
Cytogenetic Map9A3UniSTS
Cytogenetic Map7F1UniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map4D2.2UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map16B2UniSTS
Cytogenetic Map6F1UniSTS
Cytogenetic Map4B1UniSTS
Cytogenetic Map17DUniSTS
Cytogenetic Map14C3UniSTS
Cytogenetic Map5C3.3UniSTS
Cytogenetic Map18A2UniSTS
Cytogenetic MapXF5UniSTS
Cytogenetic Map2G3UniSTS
Cytogenetic Map7A2UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map1H6UniSTS
Cytogenetic Map7D3UniSTS
Cytogenetic Map1G2UniSTS
Cytogenetic MapXF3UniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map2F3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map15A1UniSTS
Cytogenetic Map1A2UniSTS
Cytogenetic Map13A3.1UniSTS
Cytogenetic Map11B4UniSTS
Cytogenetic Map1D2.3UniSTS
Cytogenetic Map19C1UniSTS
Cytogenetic Map10D3UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map2E1UniSTS
cM Map528.0UniSTS
Whitehead Genetic518.6UniSTS
Car5b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXF5UniSTS
cM MapX UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558900Bw3_mbody weight QTL 3 (mouse)Not determinedX134639291166515599Mouse
1302000Pgia25_mproteoglycan induced arthritis 2 (mouse)Not determinedX145691384171031299Mouse
10401118Pgia39_mproteoglycan induced arthritis 39 (mouse)Not determinedX145691384171031299Mouse
1357619Obsty5_mobesity 5 (mouse)Not determinedX161429897165366288Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1320
Count of miRNA genes:687
Interacting mature miRNAs:852
Transcripts:ENSMUST00000033739, ENSMUST00000126650
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000033739   ⟹   ENSMUSP00000033739
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 EnsemblX163,976,822 - 164,027,997 (-)Ensembl
RefSeq Acc Id: ENSMUST00000126650
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 EnsemblX164,011,885 - 164,027,981 (-)Ensembl
RefSeq Acc Id: NM_181315   ⟹   NP_851832
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X162,759,818 - 162,811,006 (-)NCBI
GRCm38X163,976,822 - 164,028,010 (-)ENTREZGENE
MGSCv37X160,414,754 - 160,465,942 (-)RGD
CeleraX147,196,469 - 147,247,766 (-)RGD
cM MapX ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_851832 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF08291 (Get FASTA)   NCBI Sequence Viewer  
  AAH34413 (Get FASTA)   NCBI Sequence Viewer  
  BAC39501 (Get FASTA)   NCBI Sequence Viewer  
  EDL40764 (Get FASTA)   NCBI Sequence Viewer  
  Q9QZA0 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_851832   ⟸   NM_181315
- Peptide Label: precursor
- UniProtKB: Q9QZA0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000033739   ⟸   ENSMUST00000033739
Protein Domains
Alpha-carbonic anhydrase

Promoters
RGD ID:6845428
Promoter ID:MM_KWN:62678
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4
Transcripts:UC009UVB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X160,415,581 - 160,416,177 (-)MPROMDB
RGD ID:6845546
Promoter ID:MM_KWN:62679
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000046594,   OTTMUST00000046595
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X160,465,441 - 160,465,982 (-)MPROMDB
RGD ID:13681800
Promoter ID:EPDNEW_M25049
Type:initiation region
Name:Car5b_1
Description:Mus musculus carbonic anhydrase 5b, mitochondrial , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X164,028,010 - 164,028,070EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1926249 AgrOrtholog
Ensembl Genes ENSMUSG00000031373 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000033739 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000033739 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.200.10 UniProtKB/Swiss-Prot
InterPro CA-VB_mt UniProtKB/Swiss-Prot
  CA_dom UniProtKB/Swiss-Prot
  CA_dom_sf UniProtKB/Swiss-Prot
  Carbonic_anhydrase_a-class UniProtKB/Swiss-Prot
  Carbonic_anhydrase_a-class_CS UniProtKB/Swiss-Prot
KEGG Report mmu:56078 UniProtKB/Swiss-Prot
MGD MGI:1926249 ENTREZGENE
NCBI Gene 56078 ENTREZGENE
PANTHER PTHR18952 UniProtKB/Swiss-Prot
  PTHR18952:SF25 UniProtKB/Swiss-Prot
Pfam Carb_anhydrase UniProtKB/Swiss-Prot
PhenoGen Car5b PhenoGen
PROSITE ALPHA_CA_1 UniProtKB/Swiss-Prot
  ALPHA_CA_2 UniProtKB/Swiss-Prot
SMART Carb_anhydrase UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51069 UniProtKB/Swiss-Prot
UniProt CAH5B_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q8C3J9 UniProtKB/Swiss-Prot
  Q8K014 UniProtKB/Swiss-Prot