Gab3 (growth factor receptor bound protein 2-associated protein 3) - Rat Genome Database

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Gene: Gab3 (growth factor receptor bound protein 2-associated protein 3) Mus musculus
Analyze
Symbol: Gab3
Name: growth factor receptor bound protein 2-associated protein 3
RGD ID: 1623012
MGI Page MGI
Description: Predicted to enable signaling adaptor activity. Acts upstream of or within macrophage differentiation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human GAB3 (GRB2 associated binding protein 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5930433H21Rik; GRB2-associated binder 3; GRB2-associated-binding protein 3
RGD Orthologs
Human
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X74,032,151 - 74,128,511 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX74,010,449 - 74,129,064 (-)EnsemblGRCm39 Ensembl
GRCm38X74,988,545 - 75,084,905 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX74,966,843 - 75,085,458 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X72,233,884 - 72,330,244 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X71,241,241 - 71,337,625 (-)NCBIMGSCv36mm8
CeleraX66,394,016 - 66,489,831 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX38.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11739737   PMID:11997510   PMID:12466851   PMID:12477932   PMID:12640125   PMID:16141072   PMID:16141073   PMID:21267068  
PMID:21677750   PMID:21873635   PMID:30936879   PMID:31375526  


Genomics

Comparative Map Data
Gab3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X74,032,151 - 74,128,511 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX74,010,449 - 74,129,064 (-)EnsemblGRCm39 Ensembl
GRCm38X74,988,545 - 75,084,905 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX74,966,843 - 75,085,458 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X72,233,884 - 72,330,244 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X71,241,241 - 71,337,625 (-)NCBIMGSCv36mm8
CeleraX66,394,016 - 66,489,831 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX38.12NCBI
GAB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X154,675,249 - 154,751,566 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX154,675,249 - 154,751,583 (-)EnsemblGRCh38hg38GRCh38
GRCh37X153,903,526 - 153,979,841 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,556,720 - 153,632,542 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X153,467,233 - 153,543,036NCBI
CeleraX154,061,594 - 154,137,916 (-)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX142,447,630 - 142,523,043 (-)NCBIHuRef
CHM1_1X153,815,233 - 153,891,023 (-)NCBICHM1_1
T2T-CHM13v2.0X152,911,675 - 152,987,994 (-)NCBIT2T-CHM13v2.0
Gab3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955594912,108 - 956,037 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955594882,921 - 955,079 (+)NCBIChiLan1.0ChiLan1.0
GAB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X154,649,019 - 154,731,187 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X154,652,626 - 154,734,795 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X144,150,062 - 144,232,216 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X153,993,736 - 154,073,529 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,993,736 - 154,038,529 (-)Ensemblpanpan1.1panPan2
GAB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X122,741,199 - 122,822,446 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX122,741,197 - 122,779,143 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX107,734,458 - 107,815,671 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X125,869,755 - 125,948,703 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X121,615,438 - 121,696,660 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X124,138,699 - 124,223,143 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X123,869,043 - 123,912,968 (-)NCBIUU_Cfam_GSD_1.0
Gab3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,709,450 - 119,765,746 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493692770,923 - 124,164 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493692768,506 - 93,899 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GAB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX125,158,154 - 125,209,035 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X125,158,148 - 125,209,080 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X143,274,129 - 143,302,751 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GAB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,904,743 - 129,004,596 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,902,420 - 128,973,550 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606566,899,836 - 66,982,752 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gab3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624963492,292 - 573,878 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624963492,210 - 573,887 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gab3
2045 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:691
Count of miRNA genes:406
Interacting mature miRNAs:476
Transcripts:ENSMUST00000037374, ENSMUST00000114104, ENSMUST00000114109, ENSMUST00000127024, ENSMUST00000129495
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
13208567Bmiq12_mbody mass index QTL 12 (mouse)X3526365377043606Mouse
1300794Spha2_msperm head anomaly 2 (mouse)Not determinedX3992149886260137Mouse
4142200Rtwq1_mreduced testis weight QTL 1 (mouse)Not determined4147706075477203Mouse
1301278Bdln1_mbody length 1 (mouse)Not determinedX4170210675702218Mouse
1300702Fcsa4_mfemoral cross-sectional area 4 (mouse)Not determinedX4602744480027567Mouse
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
25314311Syncl3_msynaptonemal complex length 3 (mouse)X5198887789743606Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
10412108Desp5_mdespair 5 (mouse)Not determinedX5472235188722351Mouse
13464140Hdlq108_mHDL QTL 108 (mouse)X5777196091771960Mouse
25314316Mlh1fc3_mMLH1 foci count 3 (mouse)X6134360689843606Mouse
25314318Sccor2_msynaptonemal complex length to mean MLH1 count ratio 2 (mouse)X7054360696543606Mouse
1357730Hstx1_mhybrid sterility, X chromosome 1 (mouse)Not determinedX7145385277600812Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined71453852139203212Mouse
12879918Shm4_msperm head morphology 4 (mouse)X72072050102062720Mouse

Markers in Region
UniSTS:234876  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X75,011,484 - 75,012,103UniSTSGRCm38
GRCm38415,486,651 - 15,486,956UniSTSGRCm38
MGSCv37415,413,798 - 15,414,103UniSTSGRCm37
MGSCv37X72,256,823 - 72,257,442UniSTSGRCm37
Celera415,285,191 - 15,285,496UniSTS
CeleraX66,416,884 - 66,417,503UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic MapXA7.3UniSTS
px-27a6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X74,987,052 - 74,987,166UniSTSGRCm38
MGSCv37X72,232,391 - 72,232,505UniSTSGRCm37
CeleraX66,392,582 - 66,392,696UniSTS
Cytogenetic MapXA7.3UniSTS
px-51c12  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X75,062,166 - 75,062,321UniSTSGRCm38
MGSCv37X72,307,505 - 72,307,660UniSTSGRCm37
CeleraX66,467,314 - 66,467,469UniSTS
Cytogenetic MapXA7.3UniSTS
px-6g6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X75,069,315 - 75,069,415UniSTSGRCm38
MGSCv37X72,314,654 - 72,314,754UniSTSGRCm37
CeleraX66,474,340 - 66,474,440UniSTS
Cytogenetic MapXA7.3UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000037374   ⟹   ENSMUSP00000041951
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX74,032,127 - 74,128,511 (-)Ensembl
GRCm38.p6 EnsemblX74,988,521 - 75,084,905 (-)Ensembl
RefSeq Acc Id: ENSMUST00000114104   ⟹   ENSMUSP00000109739
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX74,032,310 - 74,128,363 (-)Ensembl
GRCm38.p6 EnsemblX74,988,704 - 75,084,757 (-)Ensembl
RefSeq Acc Id: ENSMUST00000114109   ⟹   ENSMUSP00000109744
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX74,010,449 - 74,128,511 (-)Ensembl
GRCm38.p6 EnsemblX74,966,843 - 75,084,905 (-)Ensembl
RefSeq Acc Id: ENSMUST00000127024
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX74,011,388 - 74,012,731 (-)Ensembl
GRCm38.p6 EnsemblX74,967,782 - 74,969,125 (-)Ensembl
RefSeq Acc Id: ENSMUST00000129495
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX74,032,312 - 74,129,064 (-)Ensembl
GRCm38.p6 EnsemblX74,988,706 - 75,085,458 (-)Ensembl
RefSeq Acc Id: NM_181584   ⟹   NP_853615
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X74,032,151 - 74,128,511 (-)NCBI
GRCm38X74,988,545 - 75,084,905 (-)ENTREZGENE
MGSCv37X72,233,884 - 72,330,244 (-)RGD
CeleraX66,394,016 - 66,489,831 (-)RGD
cM MapX ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_853615   ⟸   NM_181584
- UniProtKB: Q684I9 (UniProtKB/Swiss-Prot),   Q8VH53 (UniProtKB/Swiss-Prot),   Q8BSM5 (UniProtKB/Swiss-Prot),   B9EIZ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000041951   ⟸   ENSMUST00000037374
RefSeq Acc Id: ENSMUSP00000109739   ⟸   ENSMUST00000114104
RefSeq Acc Id: ENSMUSP00000109744   ⟸   ENSMUST00000114109
Protein Domains
PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BSM5-F1-model_v2 AlphaFold Q8BSM5 1-595 view protein structure

Promoters
RGD ID:6845730
Promoter ID:MM_KWN:60871
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:ENSMUST00000114104,   ENSMUST00000114109,   ENSMUST00000114110,   OTTMUST00000044177
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X72,329,661 - 72,330,161 (-)MPROMDB
RGD ID:13680810
Promoter ID:EPDNEW_M24555
Type:initiation region
Name:Gab3_1
Description:Mus musculus growth factor receptor bound protein 2-associatedprotein 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X75,084,905 - 75,084,965EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2387324 AgrOrtholog
Ensembl Genes ENSMUSG00000032750 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000037374 ENTREZGENE
  ENSMUST00000037374.11 UniProtKB/Swiss-Prot
  ENSMUST00000114104.2 UniProtKB/TrEMBL
  ENSMUST00000114109.8 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alpha-D-phosphohexomutase, C-terminal domain UniProtKB/TrEMBL
InterPro CTAG/Pcc1 UniProtKB/TrEMBL
  Gab1-4-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:210710 UniProtKB/Swiss-Prot
MGD MGI:2387324 ENTREZGENE
NCBI Gene 210710 ENTREZGENE
PANTHER GRB2-ASSOCIATED-BINDING PROTEIN 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45960 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pcc1 UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gab3 PhenoGen
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B1AYB9_MOUSE UniProtKB/TrEMBL
  B9EIZ0 ENTREZGENE, UniProtKB/TrEMBL
  GAB3_MOUSE UniProtKB/Swiss-Prot
  Q3V3J9_MOUSE UniProtKB/TrEMBL
  Q684I9 ENTREZGENE
  Q8BSM5 ENTREZGENE
  Q8VH53 ENTREZGENE
UniProt Secondary Q684I9 UniProtKB/Swiss-Prot
  Q8VH53 UniProtKB/Swiss-Prot