Nlrp2 (NLR family, pyrin domain containing 2) - Rat Genome Database

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Gene: Nlrp2 (NLR family, pyrin domain containing 2) Mus musculus
Analyze
Symbol: Nlrp2
Name: NLR family, pyrin domain containing 2
RGD ID: 1622951
MGI Page MGI
Description: Predicted to enable several functions, including Pyrin domain binding activity; aspartic-type endopeptidase inhibitor activity; and caspase binding activity. Predicted to be involved in regulation of inflammatory response. Predicted to be located in Golgi apparatus and cytosol. Predicted to be active in cytoplasm. Predicted to colocalize with chromosome, telomeric region. Is expressed in early conceptus and gonad. Human ortholog(s) of this gene implicated in gestational trophoblastic neoplasm. Orthologous to human NLRP2 (NLR family pyrin domain containing 2) and NLRP7 (NLR family pyrin domain containing 7).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E330007A02Rik; N; NACHT, leucine rich repeat and PYD containing 2; NACHT, LRR and PYD domains-containing protein 2; Nalp2; Nb; NBS1; P; PAN1; PYP; PYPAF2
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm18774   Gm21926  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3975,301,546 - 5,354,034 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl75,301,546 - 5,354,034 (-)EnsemblGRCm39 Ensembl
GRCm3875,298,547 - 5,351,035 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl75,298,547 - 5,351,035 (-)EnsemblGRCm38mm10GRCm38
MGSCv3775,250,149 - 5,302,637 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3674,901,639 - 4,954,122 (-)NCBIMGSCv36mm8
Celera75,045,338 - 5,098,132 (-)NCBICelera
Cytogenetic Map7A1NCBI
cM Map73.07NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:15302403   PMID:16141072   PMID:16141073   PMID:17015433   PMID:21677750   PMID:21873635   PMID:21976665  
PMID:22295082   PMID:22750073   PMID:23964092   PMID:24194600   PMID:25089626   PMID:27693696   PMID:27881734   PMID:28317850   PMID:28630100   PMID:30172704   PMID:30454891   PMID:31162334  
PMID:33090377   PMID:36976514   PMID:37499769  


Genomics

Comparative Map Data
Nlrp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3975,301,546 - 5,354,034 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl75,301,546 - 5,354,034 (-)EnsemblGRCm39 Ensembl
GRCm3875,298,547 - 5,351,035 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl75,298,547 - 5,351,035 (-)EnsemblGRCm38mm10GRCm38
MGSCv3775,250,149 - 5,302,637 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3674,901,639 - 4,954,122 (-)NCBIMGSCv36mm8
Celera75,045,338 - 5,098,132 (-)NCBICelera
Cytogenetic Map7A1NCBI
cM Map73.07NCBI
NLRP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381954,965,284 - 55,001,138 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1954,953,130 - 55,001,142 (+)EnsemblGRCh38hg38GRCh38
GRCh371955,476,652 - 55,512,506 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361960,169,579 - 60,204,318 (+)NCBINCBI36Build 36hg18NCBI36
Build 341960,169,582 - 60,204,315NCBI
Celera1952,517,226 - 52,552,009 (+)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1951,799,766 - 51,831,255 (+)NCBIHuRef
CHM1_11955,470,282 - 55,506,253 (+)NCBICHM1_1
T2T-CHM13v2.01958,059,583 - 58,095,245 (+)NCBIT2T-CHM13v2.0
Nlrp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,557,956 - 78,597,160 (-)NCBIGRCr8
mRatBN7.2169,515,505 - 69,554,689 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,515,505 - 69,554,454 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0173,082,648 - 73,121,118 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl173,082,977 - 73,121,085 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,425,340 - 75,463,631 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera167,580,163 - 67,618,281 (+)NCBICelera
Cytogenetic Map1q12NCBI
NLRP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22061,098,151 - 61,136,122 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11962,826,650 - 62,865,454 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01952,006,026 - 52,038,766 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11960,700,166 - 60,723,730 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1960,700,166 - 60,732,329 (+)Ensemblpanpan1.1panPan2
NLRP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,613,871 - 102,637,379 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1102,671,096 - 102,694,435 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01103,280,457 - 103,303,829 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11102,900,223 - 102,923,628 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01102,615,468 - 102,638,862 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,376,178 - 103,399,708 (-)NCBIUU_Cfam_GSD_1.0
Nlrp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093492,266,752 - 2,280,135 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936886280,872 - 292,452 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NLRP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1659,191,459 - 59,212,026 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2654,065,028 - 54,083,839 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NLRP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1647,572,570 - 47,604,885 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl647,578,397 - 47,604,892 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045132,998 - 159,066 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Nlrp2
1684 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:215
Count of miRNA genes:188
Interacting mature miRNAs:197
Transcripts:ENSMUST00000045022
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301177Vent3_mventricular size 3 (mouse)Not determined7120511925Mouse
10054067Sle20_msystematic lupus erythematosus susceptibility 20 (mouse)Not determined7120511925Mouse
1302188Lxw6_mlupus BXSB x NZW 6 (mouse)Not determined7121698146Mouse
12904941Edlmmq6_mextensor digitorum longus muscle mass QTL 6 (mouse)7121821047Mouse
12904948Tammq5_mtibialis anterior muscle mass QTL 5 (mouse)7121821047Mouse
12904953Gmmq5_mgastrocnemius muscle mass QTL 5 (mouse)7121821047Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1302115Abhr3_mallergen-induced bronchial hyperresponsiveness 3 (mouse)Not determined7331599616637423Mouse
1301115Lrdm1_mlymphoproliferation (Fas) renal disease modifier 1 (mouse)Not determined7335204824879418Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
25394570Skmw58_mskeletal muscle weight 58, TA (mouse)735524286281481Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25394569Skmw57_mskeletal muscle weight 57, gastroc (mouse)7458046916687861Mouse

Markers in Region
Nlrp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A1UniSTS
cM Map7 UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000045022   ⟹   ENSMUSP00000045077
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl75,301,546 - 5,354,034 (-)Ensembl
GRCm38.p6 Ensembl75,298,547 - 5,351,035 (-)Ensembl
RefSeq Acc Id: ENSMUST00000207520   ⟹   ENSMUSP00000147102
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl75,301,745 - 5,325,456 (-)Ensembl
GRCm38.p6 Ensembl75,298,746 - 5,322,457 (-)Ensembl
RefSeq Acc Id: ENSMUST00000207685   ⟹   ENSMUSP00000146451
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl75,301,634 - 5,320,540 (-)Ensembl
GRCm38.p6 Ensembl75,298,635 - 5,317,541 (-)Ensembl
RefSeq Acc Id: NM_177690   ⟹   NP_808358
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3975,301,546 - 5,354,034 (-)NCBI
GRCm3875,298,547 - 5,351,035 (-)ENTREZGENE
MGSCv3775,250,149 - 5,302,637 (-)RGD
Celera75,045,338 - 5,098,132 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_808358   ⟸   NM_177690
- UniProtKB: Q4PLS0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000045077   ⟸   ENSMUST00000045022
RefSeq Acc Id: ENSMUSP00000146451   ⟸   ENSMUST00000207685
RefSeq Acc Id: ENSMUSP00000147102   ⟸   ENSMUST00000207520
Protein Domains
NACHT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4PLS0-F1-model_v2 AlphaFold Q4PLS0 1-1046 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3041206 AgrOrtholog
Ensembl Genes ENSMUSG00000035177 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000045022 ENTREZGENE
  ENSMUST00000045022.9 UniProtKB/TrEMBL
  ENSMUST00000207520.2 UniProtKB/TrEMBL
  ENSMUST00000207685.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro DEATH-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  NACHT_NTPase UniProtKB/TrEMBL
  NLRC_HD2 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Pyrin UniProtKB/TrEMBL
KEGG Report mmu:232827 UniProtKB/TrEMBL
MGD MGI:3041206 ENTREZGENE
NCBI Gene 232827 ENTREZGENE
PANTHER NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 UniProtKB/TrEMBL
  NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
Pfam LRR_6 UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
  NLRC4_HD2 UniProtKB/TrEMBL
  PAAD_DAPIN UniProtKB/TrEMBL
PhenoGen Nlrp2 PhenoGen
PROSITE NACHT UniProtKB/TrEMBL
SMART LRR_RI UniProtKB/TrEMBL
  PYRIN UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
  RNI-like UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A140LHK4_MOUSE UniProtKB/TrEMBL
  A0A140LJ71_MOUSE UniProtKB/TrEMBL
  Q4PLS0 ENTREZGENE, UniProtKB/TrEMBL
  Q8C6M5_MOUSE UniProtKB/TrEMBL