Enpp7 (ectonucleotide pyrophosphatase/phosphodiesterase 7) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Enpp7 (ectonucleotide pyrophosphatase/phosphodiesterase 7) Mus musculus
Analyze
Symbol: Enpp7
Name: ectonucleotide pyrophosphatase/phosphodiesterase 7
RGD ID: 1622931
MGI Page MGI
Description: Exhibits sphingomyelin phosphodiesterase activity. Involved in several processes, including fatty acid homeostasis; positive regulation of intestinal cholesterol absorption; and regulation of membrane lipid metabolic process. Predicted to localize to Golgi apparatus; integral component of plasma membrane; and microvillus. Orthologous to human ENPP7 (ectonucleotide pyrophosphatase/phosphodiesterase 7); PARTICIPATES IN Fabry disease pathway; Gaucher's disease pathway; Krabbe disease pathway; INTERACTS WITH bisphenol A; chromium(6+); valproic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Alk-; Alk-SMase; alkaline sphingomyelin phosphodiesterase; E-NPP 7; ectonucleotide pyrophosphatase/phosphodiesterase family member 7; Gm254; intestinal alkaline sphingomyelinase; NPP-7
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911118,879,007 - 118,884,047 (+)NCBIGRCm39mm39
GRCm39 Ensembl11118,879,014 - 118,884,047 (+)Ensembl
GRCm3811118,988,181 - 118,993,221 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11118,988,188 - 118,993,221 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711118,849,502 - 118,854,155 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611118,804,278 - 118,808,931 (+)NCBImm8
Celera11130,732,697 - 130,737,351 (+)NCBICelera
Cytogenetic Map11E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12885774   PMID:16141072   PMID:16141073   PMID:16631405   PMID:20562862   PMID:21177474  
PMID:21873635   PMID:24650549   PMID:25381265   PMID:30087205  


Genomics

Comparative Map Data
Enpp7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911118,879,007 - 118,884,047 (+)NCBIGRCm39mm39
GRCm39 Ensembl11118,879,014 - 118,884,047 (+)Ensembl
GRCm3811118,988,181 - 118,993,221 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11118,988,188 - 118,993,221 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711118,849,502 - 118,854,155 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611118,804,278 - 118,808,931 (+)NCBImm8
Celera11130,732,697 - 130,737,351 (+)NCBICelera
Cytogenetic Map11E2NCBI
ENPP7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1779,730,943 - 79,742,219 (+)EnsemblGRCh38hg38GRCh38
GRCh381779,730,919 - 79,742,926 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371777,704,705 - 77,716,018 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361775,319,477 - 75,330,616 (+)NCBINCBI36hg18NCBI36
Build 341775,319,476 - 75,330,615NCBI
Celera1774,329,818 - 74,341,104 (+)NCBI
Cytogenetic Map17q25.3NCBI
HuRef1773,145,753 - 73,156,851 (+)NCBIHuRef
CHM1_11777,791,135 - 77,802,246 (+)NCBICHM1_1
Enpp7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210104,242,223 - 104,246,589 (+)NCBI
Rnor_6.0 Ensembl10108,095,131 - 108,099,483 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.010108,095,131 - 108,099,483 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.010107,709,166 - 107,713,518 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10102,790,410 - 102,794,661 (+)NCBICelera
Cytogenetic Map10q32.3NCBI
Enpp7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555063,151,133 - 3,154,613 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555063,151,133 - 3,154,613 (-)NCBIChiLan1.0ChiLan1.0
ENPP7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11779,347,505 - 79,359,349 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1779,347,505 - 79,359,349 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01773,811,249 - 73,822,719 (+)NCBIMhudiblu_PPA_v0panPan3
ENPP7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.191,887,093 - 1,894,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl91,887,201 - 1,897,473 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha92,530,265 - 2,537,749 (-)NCBI
ROS_Cfam_1.092,522,957 - 2,530,442 (-)NCBI
UMICH_Zoey_3.192,546,349 - 2,553,429 (-)NCBI
UNSW_CanFamBas_1.092,671,411 - 2,678,888 (-)NCBI
UU_Cfam_GSD_1.092,752,722 - 2,760,208 (-)NCBI
Enpp7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056022,553,048 - 2,557,497 (-)NCBI
SpeTri2.0NW_0049365943,855,071 - 3,864,034 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENPP7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl122,612,574 - 2,619,519 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1122,612,543 - 2,619,541 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2122,680,088 - 2,687,063 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ENPP7
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11671,693,148 - 71,701,517 (+)NCBI
ChlSab1.1 Ensembl1671,693,851 - 71,699,926 (+)Ensembl
Enpp7
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248018,895,138 - 8,901,848 (+)NCBI

Position Markers
D11Mit337  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811118,997,798 - 118,997,911UniSTSGRCm38
MGSCv3711118,859,112 - 118,859,225UniSTSGRCm37
Celera11130,742,401 - 130,742,514UniSTS
Cytogenetic Map11E2UniSTS
cM Map1175.0UniSTS
Whitehead Genetic1178.7UniSTS
D11Mit337.2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811118,997,645 - 118,997,768UniSTSGRCm38
MGSCv3711118,858,959 - 118,859,082UniSTSGRCm37
Celera11130,742,248 - 130,742,371UniSTS
Cytogenetic Map11E2UniSTS
cM Map1175.0UniSTS
cM Map11 UniSTS
Whitehead_YAC11 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
14747003Mancz9_mmandible centroid size 9 (mouse)1185954085119954085Mouse
15039374Adip29_madiposity 29 (mouse)1186717494120717494Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186717494120717494Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186717494120717494Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187600000126900000Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187611774121611872Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189978425122082543Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191713782122082543Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191713782122082543Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193338357122082543Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194300000119000000Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195513139122082543Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195513139122082543Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196246848122082543Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196919310122082543Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198461783122082543Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198609643122082543Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199363361122082543Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100167277122082543Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100363360120996339Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101131764122082543Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:361
Count of miRNA genes:275
Interacting mature miRNAs:300
Transcripts:ENSMUST00000092373, ENSMUST00000106273
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000092373   ⟹   ENSMUSP00000090027
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11118,988,188 - 118,992,841 (+)Ensembl
RefSeq Acc Id: ENSMUST00000106273   ⟹   ENSMUSP00000101880
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11118,988,216 - 118,993,221 (+)Ensembl
RefSeq Acc Id: NM_001359574   ⟹   NP_001346503
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911118,879,007 - 118,884,047 (+)NCBI
GRCm3811118,988,181 - 118,993,221 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001346503   ⟸   NM_001359574
- Peptide Label: precursor
RefSeq Acc Id: ENSMUSP00000101880   ⟸   ENSMUST00000106273
RefSeq Acc Id: ENSMUSP00000090027   ⟸   ENSMUST00000092373

Promoters
RGD ID:8677580
Promoter ID:EPDNEW_M16821
Type:initiation region
Name:Enpp7_1
Description:Mus musculus ectonucleotide pyrophosphatase/phosphodiesterase7 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811118,988,186 - 118,988,246EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3027917 AgrOrtholog
Ensembl Genes ENSMUSG00000046697 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000090027 UniProtKB/TrEMBL
  ENSMUSP00000101880 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000092373 UniProtKB/TrEMBL
  ENSMUST00000106273 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.720.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Alkaline_phosphatase_core_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENPP7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phosphodiest/P_Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:3027917 ENTREZGENE
NCBI Gene 238011 ENTREZGENE
PANTHER PTHR10151:SF63 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Phosphodiest UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Enpp7 PhenoGen
Superfamily-SCOP SSF53649 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A6I8MWV7_MOUSE UniProtKB/TrEMBL
  B7ZWB9_MOUSE UniProtKB/TrEMBL
  ENPP7_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2A5N7 UniProtKB/Swiss-Prot
  D3Z6V6 UniProtKB/Swiss-Prot