Wasf3 (WASP family, member 3) - Rat Genome Database

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Gene: Wasf3 (WASP family, member 3) Mus musculus
Analyze
Symbol: Wasf3
Name: WASP family, member 3
RGD ID: 1622906
MGI Page MGI
Description: Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Involved in modification of postsynaptic actin cytoskeleton. Acts upstream of or within lamellipodium assembly; oligodendrocyte development; and positive regulation of myelination. Located in lamellipodium. Is active in glutamatergic synapse and postsynapse. Is expressed in adrenal gland; cap mesenchyme; nervous system; and neural retina. Orthologous to human WASF3 (WASP family member 3); INTERACTS WITH 1,2-dichloroethane; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: protein WAVE-3; Scar3; WAS protein family, member 3; WASP family protein member 3; Wav; Wave3; wiskott-Aldrich syndrome protein family member 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395146,321,816 - 146,410,425 (+)NCBIGRCm39mm39
GRCm39 Ensembl5146,321,795 - 146,410,425 (+)Ensembl
GRCm385146,385,006 - 146,473,615 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5146,384,985 - 146,473,615 (+)EnsemblGRCm38mm10GRCm38
MGSCv375147,196,582 - 147,282,701 (+)NCBIGRCm37mm9NCBIm37
MGSCv365146,689,240 - 146,774,650 (+)NCBImm8
Celera5144,372,570 - 144,458,483 (+)NCBICelera
Cytogenetic Map5G3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytoskeleton  (IEA)
glutamatergic synapse  (IDA,IMP)
lamellipodium  (IBA,IDA)
postsynapse  (IDA,IMP)
SCAR complex  (IBA)

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12185600   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12716942   PMID:12856283   PMID:12879075  
PMID:14610273   PMID:14697212   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16190876   PMID:16602821   PMID:16723544   PMID:17664349   PMID:18799693   PMID:19200726   PMID:21267068  
PMID:21873635   PMID:28794159   PMID:29449449   PMID:31542393   PMID:32312818   PMID:32325033  


Genomics

Comparative Map Data
Wasf3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395146,321,816 - 146,410,425 (+)NCBIGRCm39mm39
GRCm39 Ensembl5146,321,795 - 146,410,425 (+)Ensembl
GRCm385146,385,006 - 146,473,615 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5146,384,985 - 146,473,615 (+)EnsemblGRCm38mm10GRCm38
MGSCv375147,196,582 - 147,282,701 (+)NCBIGRCm37mm9NCBIm37
MGSCv365146,689,240 - 146,774,650 (+)NCBImm8
Celera5144,372,570 - 144,458,483 (+)NCBICelera
Cytogenetic Map5G3NCBI
WASF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1326,557,683 - 26,688,948 (+)EnsemblGRCh38hg38GRCh38
GRCh381326,539,139 - 26,688,948 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371327,131,820 - 27,263,085 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361326,029,840 - 26,161,082 (+)NCBINCBI36hg18NCBI36
Build 341326,029,886 - 26,161,063NCBI
Celera138,256,077 - 8,332,052 (+)NCBI
Cytogenetic Map13q12.13NCBI
HuRef137,955,351 - 8,086,464 (+)NCBIHuRef
CHM1_11327,099,816 - 27,231,081 (+)NCBICHM1_1
Wasf3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2128,563,805 - 8,660,799 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl128,562,062 - 8,660,751 (-)Ensembl
Rnor_6.01210,297,896 - 10,391,014 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1210,298,555 - 10,391,270 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01212,401,989 - 12,493,810 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1210,379,274 - 10,474,931 (-)NCBICelera
Cytogenetic Map12p11NCBI
Wasf3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554976,102,909 - 6,190,770 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554976,100,633 - 6,190,639 (+)NCBIChiLan1.0ChiLan1.0
WASF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11326,250,171 - 26,328,553 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1326,250,171 - 26,328,553 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0137,849,687 - 7,980,979 (+)NCBIMhudiblu_PPA_v0panPan3
WASF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12512,804,485 - 12,881,988 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2512,805,431 - 12,877,770 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2512,875,143 - 13,008,318 (-)NCBI
ROS_Cfam_1.02512,944,371 - 13,077,673 (-)NCBI
UMICH_Zoey_3.12512,830,485 - 12,963,635 (-)NCBI
UNSW_CanFamBas_1.02512,822,254 - 12,955,911 (-)NCBI
UU_Cfam_GSD_1.02512,873,760 - 13,006,959 (-)NCBI
Wasf3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945115,180,691 - 115,300,651 (+)NCBI
SpeTri2.0NW_004936948345,942 - 465,323 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WASF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl114,261,177 - 4,366,254 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1114,261,121 - 4,366,258 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2113,736,220 - 3,791,727 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WASF3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.135,805,115 - 5,934,764 (+)NCBI
ChlSab1.1 Ensembl35,889,263 - 5,931,662 (+)Ensembl
Vero_WHO_p1.0NW_02366605738,489,195 - 38,621,738 (-)NCBI
Wasf3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477611,863,880 - 11,985,087 (-)NCBI

Position Markers
Wasf3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G3UniSTS
cM MapUN UniSTS
cM Map5 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301362Prnr1_mprion resistance 1 (mouse)Not determined589271017146851125Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115128044149128176Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115128044149128176Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118920110151834684Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119806972149423861Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121457140151834684Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121556974151834684Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124714580151834684Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125147702151834684Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129583274151834684Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129851021151834684Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5134002093151834684Mouse
13504734Ifvrq4_minfluenza virus resistance QTL 4 (mouse)5140000000153000000Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir200bmmu-miR-200b-3pOncomiRDBexternal_infoNANA19801681
Mir200ammu-miR-200a-3pOncomiRDBexternal_infoNANA19801681
Mir200cmmu-miR-200c-3pOncomiRDBexternal_infoNANA19801681
Mir31mmu-miR-31-5pOncomiRDBexternal_infoNANA21105030

Predicted Target Of
Summary Value
Count of predictions:1214
Count of miRNA genes:624
Interacting mature miRNAs:751
Transcripts:ENSMUST00000016143, ENSMUST00000110600
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000016143   ⟹   ENSMUSP00000016143
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5146,321,795 - 146,410,425 (+)Ensembl
GRCm38.p6 Ensembl5146,384,985 - 146,473,615 (+)Ensembl
RefSeq Acc Id: ENSMUST00000238592   ⟹   ENSMUSP00000158806
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5146,392,419 - 146,405,066 (+)Ensembl
GRCm38.p6 Ensembl5146,455,609 - 146,468,256 (+)Ensembl
RefSeq Acc Id: NM_145155   ⟹   NP_660137
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395146,321,816 - 146,407,935 (+)NCBI
GRCm385146,385,006 - 146,471,125 (+)NCBI
MGSCv375147,196,582 - 147,282,701 (+)RGD
Celera5144,372,570 - 144,458,483 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006504833   ⟹   XP_006504896
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395146,322,146 - 146,410,354 (+)NCBI
GRCm385146,385,336 - 146,473,615 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006504834   ⟹   XP_006504897
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395146,322,053 - 146,410,425 (+)NCBI
GRCm385146,385,243 - 146,473,615 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030254506   ⟹   XP_030110366
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395146,397,970 - 146,410,425 (+)NCBI
GRCm385146,461,169 - 146,473,615 (+)NCBI
Sequence:
RefSeq Acc Id: XR_003955640
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395146,322,051 - 146,410,425 (+)NCBI
GRCm385146,385,241 - 146,473,615 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_660137   ⟸   NM_145155
- UniProtKB: Q8VHI6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006504897   ⟸   XM_006504834
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006504896   ⟸   XM_006504833
- Peptide Label: isoform X1
- UniProtKB: Q8VHI6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030110366   ⟸   XM_030254506
- Peptide Label: isoform X3
RefSeq Acc Id: ENSMUSP00000158806   ⟸   ENSMUST00000238592
RefSeq Acc Id: ENSMUSP00000016143   ⟸   ENSMUST00000016143
Protein Domains
WH2

Promoters
RGD ID:6888776
Promoter ID:EPDNEW_M7839
Type:multiple initiation site
Name:Wasf3_2
Description:Mus musculus WAS protein family, member 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M7840  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385146,384,966 - 146,385,026EPDNEW
RGD ID:6888778
Promoter ID:EPDNEW_M7840
Type:initiation region
Name:Wasf3_1
Description:Mus musculus WAS protein family, member 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M7839  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385146,385,287 - 146,385,347EPDNEW
RGD ID:6838621
Promoter ID:MM_KWN:44864
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell
Transcripts:ENSMUST00000016143,   ENSMUST00000110600
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365147,196,546 - 147,197,046 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2658986 AgrOrtholog
Ensembl Genes ENSMUSG00000029636 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000016143 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000158806 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000016143 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000238592 UniProtKB/TrEMBL
InterPro SCAR/WAVE_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:245880 UniProtKB/Swiss-Prot
MGD MGI:2658986 ENTREZGENE
NCBI Gene 245880 ENTREZGENE
PANTHER PTHR12902 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam WH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Wasf3 PhenoGen
PROSITE WH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART WH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A571BF78_MOUSE UniProtKB/TrEMBL
  Q3V386_MOUSE UniProtKB/TrEMBL
  Q8VHI6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-09-01 Wasf3  WASP family, member 3  Wasf3  WAS protein family, member 3  Symbol and/or name change 5135510 APPROVED