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Gene: Dna2 (DNA replication helicase/nuclease 2) Mus musculus
Symbol: Dna2
Name: DNA replication helicase/nuclease 2
Description: ENCODES a protein that exhibits 5'-flap endonuclease activity; 5'-3' DNA helicase activity (ortholog); DNA binding (ortholog); INVOLVED IN mitotic telomere maintenance via semi-conservative replication; nucleic acid phosphodiester bond hydrolysis; telomere maintenance; PARTICIPATES IN homologous recombination pathway of double-strand break repair; DNA replication pathway; ASSOCIATED WITH isolated growth hormone deficiency type IA (ortholog); long QT syndrome (ortholog); mitochondrial myopathy (ortholog); FOUND IN nuclear chromosome, telomeric region; gamma DNA polymerase complex (ortholog); mitochondrial nucleoid (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; chromium(6+); dibutyl phthalate
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA replication ATP-dependent helicase-like homolog; DNA replication ATP-dependent helicase/nuclease DNA2; DNA replication helicase 2 homolog; DNA2-like helicase; Dna2l; E130315B21Rik; KIAA0083
Homo sapiens (human) : DNA2 (DNA replication helicase/nuclease 2)  HGNC  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dna2 (DNA replication helicase/nuclease 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DNA2 (DNA replication helicase/nuclease 2)
Canis lupus familiaris (dog) : DNA2 (DNA replication helicase/nuclease 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dna2 (DNA replication helicase/nuclease 2)
Sus scrofa (pig) : DNA2 (DNA replication helicase/nuclease 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381062,946,983 - 62,974,188 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371062,409,777 - 62,436,936 (+)NCBIGRCm37mm9NCBIm37
MGSCv361062,342,410 - 62,369,534 (+)NCBImm8
Celera1064,048,162 - 64,075,318 (+)NCBICelera
Cytogenetic Map10 B4NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Dna2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1622846
Created: 2007-05-02
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.