Tmem221 (transmembrane protein 221) - Rat Genome Database
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Gene: Tmem221 (transmembrane protein 221) Mus musculus
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Symbol: Tmem221
Name: transmembrane protein 221
RGD ID: 1622659
MGI Page MGI
Description: Predicted to localize to integral component of membrane. Orthologous to human TMEM221 (transmembrane protein 221); INTERACTS WITH benzo[a]pyrene; benzo[b]fluoranthene; Benzo[k]fluoranthene.
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,006,947 - 72,011,659 (-)NCBIGRCm39mm39
GRCm38871,554,303 - 71,559,015 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,554,238 - 71,558,871 (-)EnsemblGRCm38mm10GRCm38
MGSCv37874,078,202 - 74,082,770 (-)NCBIGRCm37mm9NCBIm37
MGSCv36874,483,220 - 74,487,965 (-)NCBImm8
Celera874,065,000 - 74,069,568 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:21267068  


Genomics

Comparative Map Data
Tmem221
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,006,947 - 72,011,659 (-)NCBIGRCm39mm39
GRCm38871,554,303 - 71,559,015 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,554,238 - 71,558,871 (-)EnsemblGRCm38mm10GRCm38
MGSCv37874,078,202 - 74,082,770 (-)NCBIGRCm37mm9NCBIm37
MGSCv36874,483,220 - 74,487,965 (-)NCBImm8
Celera874,065,000 - 74,069,568 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
TMEM221
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1917,435,509 - 17,448,668 (-)EnsemblGRCh38hg38GRCh38
GRCh381917,435,509 - 17,448,839 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371917,546,318 - 17,559,376 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,408,267 - 17,420,493 (-)NCBINCBI36hg18NCBI36
Celera1917,448,072 - 17,461,124 (-)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1917,112,238 - 17,125,017 (-)NCBIHuRef
CHM1_11917,545,819 - 17,558,888 (-)NCBICHM1_1
Tmem221
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01619,984,368 - 19,992,507 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,984,301 - 19,988,004 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,843,726 - 19,850,930 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,737,596 - 18,741,584 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1618,467,034 - 18,475,546 (-)NCBICelera
Cytogenetic Map16p14NCBI
Tmem221
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955524830,555 - 839,089 (+)NCBIChiLan1.0ChiLan1.0
TMEM221
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11917,895,562 - 17,909,597 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01916,922,770 - 16,936,459 (-)NCBIMhudiblu_PPA_v0panPan3
TMEM221
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12045,353,366 - 45,361,175 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Tmem221
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365963,452,433 - 3,467,389 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM221
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1260,256,477 - 60,264,026 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,719,285 - 59,726,739 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM221
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1615,930,946 - 15,938,414 (-)NCBI
Tmem221
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624908555,619 - 562,318 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:332
Count of miRNA genes:252
Interacting mature miRNAs:284
Transcripts:ENSMUST00000052072
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000052072   ⟹   ENSMUSP00000058317
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,554,238 - 71,558,871 (-)Ensembl
RefSeq Acc Id: NM_001100462   ⟹   NP_001093932
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39872,006,947 - 72,011,515 (-)NCBI
GRCm38871,554,303 - 71,558,871 (-)NCBI
MGSCv37874,078,202 - 74,082,770 (-)RGD
Celera874,065,000 - 74,069,568 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006509705   ⟹   XP_006509768
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39872,007,800 - 72,011,659 (-)NCBI
GRCm38871,555,156 - 71,559,015 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001093932   ⟸   NM_001100462
- UniProtKB: Q8K071 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006509768   ⟸   XM_006509705
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000058317   ⟸   ENSMUST00000052072

Promoters
RGD ID:8667409
Promoter ID:EPDNEW_M11736
Type:multiple initiation site
Name:Tmem221_1
Description:Mus musculus transmembrane protein 221 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38871,558,917 - 71,558,977EPDNEW
RGD ID:6842835
Promoter ID:MM_KWN:54795
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Lung
Transcripts:UC009MDU.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36874,082,639 - 74,083,139 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3525074 AgrOrtholog
Ensembl Genes ENSMUSG00000043664 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000058317 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000052072 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Jiraiya UniProtKB/Swiss-Prot
KEGG Report mmu:434325 UniProtKB/Swiss-Prot
MGD MGI:3525074 ENTREZGENE
NCBI Gene 434325 ENTREZGENE
Pfam Jiraiya UniProtKB/Swiss-Prot
PhenoGen Tmem221 PhenoGen
UniGene Mm.33613 ENTREZGENE
UniProt Q8K071 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B2RWI9 UniProtKB/Swiss-Prot