Immp1l (IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)) - Rat Genome Database

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Gene: Immp1l (IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)) Mus musculus
Analyze
Symbol: Immp1l
Name: IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
RGD ID: 1622322
MGI Page MGI
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein processing involved in protein targeting to mitochondrion. Located in mitochondrion. Orthologous to human IMMP1L (inner mitochondrial membrane peptidase subunit 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1500034J20Rik; 2610528O17Rik; AU042386; IMP1-like protein; MGC101970; mitochondrial inner membrane protease subunit 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm8121  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392105,735,013 - 105,795,904 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2105,734,983 - 105,795,903 (+)EnsemblGRCm39 Ensembl
GRCm382105,904,638 - 105,965,558 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2105,904,638 - 105,965,558 (+)EnsemblGRCm38mm10GRCm38
MGSCv372105,744,795 - 105,805,715 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362105,705,524 - 105,768,025 (+)NCBIMGSCv36mm8
Celera2107,127,142 - 107,181,499 (+)NCBICelera
Cytogenetic Map2E3NCBI
cM Map255.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Processing of mitochondrial presequences. Mossmann D, etal., Biochim Biophys Acta. 2012 Sep-Oct;1819(9-10):1098-106. doi: 10.1016/j.bbagrm.2011.11.007. Epub 2011 Dec 7.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10725249   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15489334   PMID:15814844  
PMID:16141072   PMID:16141073   PMID:16450175   PMID:16919269   PMID:18799693   PMID:19474196   PMID:21677750   PMID:21873635  


Genomics

Comparative Map Data
Immp1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392105,735,013 - 105,795,904 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2105,734,983 - 105,795,903 (+)EnsemblGRCm39 Ensembl
GRCm382105,904,638 - 105,965,558 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2105,904,638 - 105,965,558 (+)EnsemblGRCm38mm10GRCm38
MGSCv372105,744,795 - 105,805,715 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362105,705,524 - 105,768,025 (+)NCBIMGSCv36mm8
Celera2107,127,142 - 107,181,499 (+)NCBICelera
Cytogenetic Map2E3NCBI
cM Map255.43NCBI
IMMP1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381131,432,401 - 31,509,622 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1131,432,401 - 31,509,645 (-)EnsemblGRCh38hg38GRCh38
GRCh371131,453,948 - 31,531,169 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361131,410,525 - 31,487,745 (-)NCBINCBI36Build 36hg18NCBI36
Celera1131,601,371 - 31,678,615 (-)NCBICelera
Cytogenetic Map11p13NCBI
HuRef1131,148,356 - 31,225,919 (-)NCBIHuRef
CHM1_11131,453,476 - 31,530,721 (-)NCBICHM1_1
T2T-CHM13v2.01131,568,225 - 31,645,460 (-)NCBIT2T-CHM13v2.0
Immp1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83112,840,015 - 112,904,297 (+)NCBIGRCr8
mRatBN7.2392,385,329 - 92,449,559 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl392,385,379 - 92,452,313 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx395,881,218 - 95,945,313 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03104,480,148 - 104,544,243 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03102,308,165 - 102,372,323 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0395,955,126 - 96,024,316 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl395,959,703 - 96,024,836 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03102,575,250 - 102,646,194 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4391,408,864 - 91,436,603 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera391,434,869 - 91,498,889 (+)NCBICelera
Cytogenetic Map3q33NCBI
Immp1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554769,784,838 - 9,850,091 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554769,784,838 - 9,850,076 (-)NCBIChiLan1.0ChiLan1.0
IMMP1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2933,642,647 - 33,719,978 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11133,647,146 - 33,724,483 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01131,396,011 - 31,473,342 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11131,285,619 - 31,362,866 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1131,285,619 - 31,362,843 (-)Ensemblpanpan1.1panPan2
IMMP1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11835,880,278 - 35,963,128 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1835,880,183 - 35,963,494 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1835,529,405 - 35,612,247 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01836,524,425 - 36,607,191 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1836,524,319 - 36,607,242 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11836,097,808 - 36,180,183 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01835,679,026 - 35,761,612 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01836,314,293 - 36,397,070 (+)NCBIUU_Cfam_GSD_1.0
Immp1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494733,091,418 - 33,164,763 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365336,216,225 - 6,289,554 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365336,216,254 - 6,289,554 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IMMP1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl229,230,210 - 29,307,210 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1229,230,172 - 29,305,906 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2231,737,387 - 31,813,219 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IMMP1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1133,679,133 - 33,757,924 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl133,710,582 - 33,756,884 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038130,842,507 - 130,926,241 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Immp1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476620,285,362 - 20,343,659 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476620,279,082 - 20,343,857 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Immp1l
2157 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:41
Interacting mature miRNAs:43
Transcripts:ENSMUST00000037499
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11038697Ltpr2d_mLeishmania tropica response 2d (mouse)286095716120095823Mouse
1301330Tbbmd2_mtotal body bone mineral density 2 (mouse)Not determined2100942930134943090Mouse
11038698Ltpr2c_mLeishmania tropica response 2c (mouse)286095716120095823Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
1301909Smdq2_msegregation of mitochondrial DNA QTL 2 (mouse)Not determined292778465126778607Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
11049568Lmr28c_mleishmaniasis resistance 28c (mouse)297123370131123532Mouse
11049569Lmr28d_mleishmaniasis resistance 28d (mouse)297123370131123532Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274524117129213005Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
11532731Sluc31a_msusceptibility to lung cancer 31a (mouse)288015003122015170Mouse
4141802Ignpq1_mIgA nephropathy QTL 1 (mouse)Not determined2100824060134824269Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
1301834Bits1_mbitterness sensitivity 1 (mouse)Not determined287440643121440778Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
11041906Lmr28a_mleishmaniasis resistance 28a (mouse)2103095716129213005Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260520612119355518Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
1558901Skmw8_mskeletal muscle weight 8 (mouse)Not determined284008488118008593Mouse
12904935Edlmmq2_mextensor digitorum longus muscle mass QTL 2 (mouse)297210364131210364Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1302071Fembrs1_mfemur breaking strength 1 (mouse)Not determined2100942930134943090Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
1300852Lmr14_mleishmaniasis resistance 14 (mouse)Not determined286095716120095823Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
1302203Gvhd3_mgraft-versus host disease 3 (mouse)Not determined2100942930134943090Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1301374Cplaq7_mcircadian period of locomotor activity 7 (mouse)Not determined276421483110421651Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
10043894Bw22_mbody weight QTL 22 (mouse)Not determined280895334114895334Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
15092054Egrme5_mearly growth rate, maternal effect 5 (mouse)282190187118004745Mouse
4142223Femwf4_mfemur work to failure 4 (mouse)Not determined88143423122143570Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
11049565Lmr28g_mleishmaniasis resistance 28g (mouse)286095716120095823Mouse
4142088Parms1_mpatched associated RMS 1 (mouse)Not determined74524117114123532Mouse
4141448Mpaps1_mmicrophthalmia anophthalmia susceptibility 1 (mouse)Not determined97028557112115196Mouse
1301098Cd8mts3_mCD8 memory T cell subset 3 (mouse)Not determined291089974125090104Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
12904954Gmmq2_mgastrocnemius muscle mass QTL 2 (mouse)297210364131210364Mouse

Markers in Region
AU042386  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38557,608,773 - 57,608,901UniSTSGRCm38
MGSCv37558,000,012 - 58,000,140UniSTSGRCm37
Celera554,978,945 - 54,979,073UniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map2E3UniSTS
Whitehead/MRC_RH5812.93UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_028260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK005356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK009570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK012181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK015978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL590380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000037499   ⟹   ENSMUSP00000049044
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2105,734,983 - 105,795,903 (+)Ensembl
GRCm38.p6 Ensembl2105,904,638 - 105,965,558 (+)Ensembl
RefSeq Acc Id: NM_028260   ⟹   NP_082536
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392105,735,013 - 105,795,904 (+)NCBI
GRCm382105,904,638 - 105,965,558 (+)ENTREZGENE
MGSCv372105,744,795 - 105,805,715 (+)RGD
Celera2107,127,142 - 107,181,499 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_082536   ⟸   NM_028260
- UniProtKB: Q3THN4 (UniProtKB/Swiss-Prot),   Q9CQU8 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000049044   ⟸   ENSMUST00000037499

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CQU8-F1-model_v2 AlphaFold Q9CQU8 1-166 view protein structure

Promoters
RGD ID:6831620
Promoter ID:MM_KWN:30893
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000111073,   NM_028260,   OTTMUST00000035858,   OTTMUST00000035859
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362105,744,536 - 105,745,036 (+)MPROMDB
RGD ID:6878142
Promoter ID:EPDNEW_M2522
Type:initiation region
Name:Immp1l_1
Description:Mus musculus IMP1 inner mitochondrial membrane peptidase-like, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M2523  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382105,904,681 - 105,904,741EPDNEW
RGD ID:6878144
Promoter ID:EPDNEW_M2523
Type:single initiation site
Name:Immp1l_2
Description:Mus musculus IMP1 inner mitochondrial membrane peptidase-like, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M2522  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382105,915,488 - 105,915,548EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913791 AgrOrtholog
Ensembl Genes ENSMUSG00000042670 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000037499 ENTREZGENE
  ENSMUST00000037499.6 UniProtKB/Swiss-Prot
Gene3D-CATH Umud Fragment, subunit A UniProtKB/Swiss-Prot
InterPro LexA/Signal_pep-like_sf UniProtKB/Swiss-Prot
  Mito_IMP1_subunit UniProtKB/Swiss-Prot
  Pept_S26A_signal_pept_1 UniProtKB/Swiss-Prot
  Peptidase_S26 UniProtKB/Swiss-Prot
KEGG Report mmu:66541 UniProtKB/Swiss-Prot
MGD MGI:1913791 ENTREZGENE
NCBI Gene 66541 ENTREZGENE
PANTHER MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1 UniProtKB/Swiss-Prot
  PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED UniProtKB/Swiss-Prot
Pfam Peptidase_S26 UniProtKB/Swiss-Prot
PhenoGen Immp1l PhenoGen
PRINTS LEADERPTASE UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51306 UniProtKB/Swiss-Prot
UniProt IMP1L_MOUSE UniProtKB/Swiss-Prot
  Q3THN4 ENTREZGENE
  Q9CQU8 ENTREZGENE
UniProt Secondary Q3THN4 UniProtKB/Swiss-Prot