Semp2l2b (SUMO/sentrin specific peptidase 2-like 2B) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Semp2l2b (SUMO/sentrin specific peptidase 2-like 2B) Mus musculus
Analyze
No known orthologs.
Symbol: Semp2l2b
Name: SUMO/sentrin specific peptidase 2-like 2B
RGD ID: 1622146
MGI Page MGI
Description: Predicted to enable deSUMOylase activity. Predicted to be involved in protein desumoylation. Predicted to be active in nucleus.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4930444G20Rik; hypothetical protein LOC114671; SUMO/sentrin specific peptidase-like
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391021,942,208 - 21,943,978 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1021,942,206 - 21,943,978 (-)EnsemblGRCm39 Ensembl
GRCm381022,066,309 - 22,068,079 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1022,066,307 - 22,068,079 (-)EnsemblGRCm38mm10GRCm38
MGSCv371021,786,113 - 21,787,885 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361021,755,723 - 21,757,495 (-)NCBIMGSCv36mm8
MGSCv361021,974,929 - 21,976,704 (-)NCBIMGSCv36mm8
Celera1022,012,326 - 22,013,371 (-)NCBICelera
Cytogenetic Map10A3NCBI
cM Map109.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:16141072   PMID:16141073   PMID:21873635  


Genomics

Variants

.
Variants in Semp2l2b
61 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:98
Interacting mature miRNAs:99
Transcripts:ENSMUST00000092672
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11532725Sluc44b_msusceptibility to lung cancer 44b (mouse)10126289265Mouse
11532724Sluc44c_msusceptibility to lung cancer 44c (mouse)10126289265Mouse
11532723Sluc44d_msusceptibility to lung cancer 44d (mouse)10126289265Mouse
11532722Sluc44e_msusceptibility to lung cancer 44e (mouse)10126289265Mouse
11532721Sluc44_msusceptibility to lung cancer 44 (mouse)10126289265Mouse
11532720Sluc44a_msusceptibility to lung cancer 44a (mouse)10126289265Mouse
11532718Sluc44f_msusceptibility to lung cancer 44f (mouse)10126289265Mouse
11532717Sluc44g_msusceptibility to lung cancer 44g (mouse)10126289265Mouse
11533917Mts2_mmammary tumor susceptibility 2 (mouse)10126289265Mouse
1300759Geot_mgeotaxia (mouse)Not determined10126289265Mouse
1300881Sluc29_msusceptibility to lung cancer 29 (mouse)Not determined10126289265Mouse
12879494Facq1_mfear acquisition QTL 1 (mouse)10131279130Mouse
15039341Nmrs28_mNAFLD-associated magnetic resonance shift 28 (mouse)1035100134351001Mouse
1357813Ath20_matherosclerosis 20 (mouse)Not determined10328318537283334Mouse
1300790Pgia6_mproteoglycan induced arthritis 6 (mouse)Not determined10381017137810295Mouse
1300997Eae15_msusceptibility to experimental allergic encephalomyelitis 15 (mouse)Not determined10440815438408276Mouse
13208561Wght8_mweight 8 (mouse)10495000043875996Mouse
1302092Ath11_matherosclerosis 11 (mouse)Not determined10615194558693521Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
1558865Lith21_mlithogenic gene 21 (mouse)Not determined10852500342525126Mouse
1301796Mop2_mmorphine preference 2 (mouse)Not determined10928911929028424Mouse
1301448Pas11_mpulmonary adenoma susceptibility 11 (mouse)Not determined10989026443890391Mouse
1301129Alcp15_malcohol preference locus 15 (mouse)Not determined10989026443890391Mouse
1302133Alcp16_malcohol preference locus 16 (mouse)Not determined10989026443890391Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
13208570Bmiq9_mbody mass index QTL 9 (mouse)101287574424875898Mouse
1558857Igan1_mIgA nephropathy 1 (mouse)Not determined101771831329704155Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
10755518Chol16_mcholesterol 16 (mouse)101891504352915043Mouse
1301659Arrd2_mage-related retinal degeneration 2 (mouse)Not determined102028318526890391Mouse
1302160Mbis2_mMycobacterium bovis-induced systemic lupus erythematosus 2 (mouse)Not determined102028318556031223Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102159119268091639Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000092672   ⟹   ENSMUSP00000097613
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1021,942,206 - 21,943,978 (-)Ensembl
GRCm38.p6 Ensembl1022,066,307 - 22,068,079 (-)Ensembl
RefSeq Acc Id: NM_053264   ⟹   NP_444494
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391021,942,208 - 21,943,978 (-)NCBI
GRCm381022,066,309 - 22,068,079 (-)ENTREZGENE
MGSCv371021,786,113 - 21,787,885 (-)RGD
Celera1022,012,326 - 22,013,371 (-)NCBI
cM Map10 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_444494 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000097613
  ENSMUSP00000097613.4
Reference Protein Sequences
RefSeq Acc Id: NP_444494   ⟸   NM_053264
- UniProtKB: D3Z741 (UniProtKB/TrEMBL),   Q71RI2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000097613   ⟸   ENSMUST00000092672
Protein Domains
Ubiquitin-like protease family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z741-F1-model_v2 AlphaFold D3Z741 1-495 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2149738 AgrOrtholog
Ensembl Genes ENSMUSG00000069712 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000092672 ENTREZGENE
  ENSMUST00000092672.6 UniProtKB/TrEMBL
InterPro Papain_like_cys_pep_sf UniProtKB/TrEMBL
  Peptidase_C48 UniProtKB/TrEMBL
KEGG Report mmu:114671 UniProtKB/TrEMBL
MGD MGI:2149738 ENTREZGENE
NCBI Gene 114671 ENTREZGENE
PANTHER RIKEN CDNA 4930444G20 GENE-RELATED UniProtKB/TrEMBL
  SENTRIN/SUMO-SPECIFIC PROTEASE UniProtKB/TrEMBL
Pfam Peptidase_C48 UniProtKB/TrEMBL
PhenoGen Semp2l2b PhenoGen
PROSITE ULP_PROTEASE UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt D3Z741 ENTREZGENE, UniProtKB/TrEMBL
  Q71RI2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-07-12 Semp2l2b  SUMO/sentrin specific peptidase 2-like 2B  4930444G20Rik  RIKEN cDNA 4930444G20 gene  Symbol and/or name updated 27372883 PROVISIONAL