Ficd (FIC domain containing) - Rat Genome Database

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Gene: Ficd (FIC domain containing) Mus musculus
Analyze
Symbol: Ficd
Name: FIC domain containing
RGD ID: 1622077
MGI Page MGI
Description: Predicted to enable several functions, including ATP binding activity; Hsp70 protein binding activity; and chaperone binding activity. Predicted to be involved in protein adenylylation; regulation of IRE1-mediated unfolded protein response; and response to endoplasmic reticulum stress. Predicted to act upstream of or within response to unfolded protein. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in central nervous system; genitourinary system; gut gland; and stomach. Orthologous to human FICD (FIC domain protein adenylyltransferase); INTERACTS WITH 3,4-methylenedioxymethamphetamine; bisphenol A; carbon nanotube.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: adenosine monophosphate-protein transferase FICD; AMPylator FICD; D5Ertd40; D5Ertd40e; de-AMPylase FICD; FIC domain-containing protein; huntingtin interacting protein E; huntingtin interactor protein E; Hype; MGC117722
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395113,873,821 - 113,878,670 (+)NCBIGRCm39mm39
GRCm39 Ensembl5113,873,864 - 113,878,661 (+)Ensembl
GRCm385113,735,758 - 113,740,607 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5113,735,803 - 113,740,600 (+)EnsemblGRCm38mm10GRCm38
MGSCv375114,185,791 - 114,190,616 (+)NCBIGRCm37mm9NCBIm37
MGSCv365113,996,802 - 114,001,599 (+)NCBImm8
Celera5110,836,905 - 110,841,730 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15747579   PMID:16141072   PMID:16141073   PMID:24194600  


Genomics

Comparative Map Data
Ficd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395113,873,821 - 113,878,670 (+)NCBIGRCm39mm39
GRCm39 Ensembl5113,873,864 - 113,878,661 (+)Ensembl
GRCm385113,735,758 - 113,740,607 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5113,735,803 - 113,740,600 (+)EnsemblGRCm38mm10GRCm38
MGSCv375114,185,791 - 114,190,616 (+)NCBIGRCm37mm9NCBIm37
MGSCv365113,996,802 - 114,001,599 (+)NCBImm8
Celera5110,836,905 - 110,841,730 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.55NCBI
FICD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12108,515,277 - 108,525,837 (+)EnsemblGRCh38hg38GRCh38
GRCh3812108,515,277 - 108,521,210 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712108,909,054 - 108,914,987 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612107,433,181 - 107,437,510 (+)NCBINCBI36hg18NCBI36
Celera12108,578,435 - 108,582,764 (+)NCBI
Cytogenetic Map12q23.3NCBI
HuRef12105,973,609 - 105,977,938 (+)NCBIHuRef
CHM1_112108,875,263 - 108,879,592 (+)NCBICHM1_1
Ficd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21242,889,195 - 42,894,090 (-)NCBI
Rnor_6.0 Ensembl1248,658,283 - 48,663,143 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01248,658,283 - 48,663,175 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01250,440,239 - 50,445,246 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,924,661 - 43,927,515 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11243,788,050 - 43,790,903 (-)NCBI
Celera1244,492,066 - 44,494,920 (-)NCBICelera
Cytogenetic Map12q16NCBI
Ficd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554559,795,116 - 9,799,006 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554559,794,919 - 9,799,006 (+)NCBIChiLan1.0ChiLan1.0
FICD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112109,482,945 - 109,488,958 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12109,482,945 - 109,488,958 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012106,086,792 - 106,092,765 (+)NCBIMhudiblu_PPA_v0panPan3
FICD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12618,347,393 - 18,353,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2618,348,526 - 18,353,665 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2617,446,758 - 17,452,444 (+)NCBI
ROS_Cfam_1.02618,693,783 - 18,699,469 (-)NCBI
UMICH_Zoey_3.12617,655,763 - 17,661,436 (+)NCBI
UNSW_CanFamBas_1.02618,681,621 - 18,687,306 (-)NCBI
UU_Cfam_GSD_1.02618,703,164 - 18,708,843 (-)NCBI
Ficd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118145,026,455 - 145,031,802 (-)NCBI
SpeTri2.0NW_004936769444,122 - 448,016 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FICD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1442,260,069 - 42,266,858 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11442,261,505 - 42,269,184 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21444,806,796 - 44,812,203 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FICD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111103,709,271 - 103,715,187 (+)NCBI
ChlSab1.1 Ensembl11103,709,173 - 103,715,172 (+)Ensembl
Vero_WHO_p1.0NW_023666037141,379,923 - 141,385,911 (-)NCBI
Ficd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474711,767,059 - 11,773,971 (+)NCBI

Position Markers
RH126887  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385113,736,041 - 113,736,290UniSTSGRCm38
MGSCv375114,186,050 - 114,186,299UniSTSGRCm37
Celera5110,837,164 - 110,837,413UniSTS
Cytogenetic Map5FUniSTS
cM Map561.0UniSTS
D5Ertd40e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385113,740,365 - 113,740,564UniSTSGRCm38
MGSCv375114,190,374 - 114,190,573UniSTSGRCm37
Celera5110,841,488 - 110,841,687UniSTS
Cytogenetic Map5FUniSTS
cM Map561.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526236236138457140Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554342835126924008Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)569900000132500000Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572700000140000000Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574300000132500000Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574300000132500000Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575154687119880564Mouse
10755524Mono1_mmonocyte differential 1 (mouse)580701400114701400Mouse
1301419Cypr3_mcytokine production 3 (mouse)Not determined580871790114871944Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582690609116690738Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582690609116690738Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587239005121239199Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587239005121239199Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587239005121239199Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587239005121239199Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587239005121239199Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589271017118725963Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589271017124100176Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589271017146851125Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590173096124173175Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590413140124413285Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590413140124413285Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592682300126682419Mouse
1301974Chab7_mcholesterol absorption 7 (mouse)Not determined595085348129085464Mouse
1357644Egrd1_mearly growth rate, direct effect 1 (mouse)Not determined595286714129286920Mouse
1558774Lith17_mlithogenic gene 17 (mouse)Not determined595317683129317856Mouse
10402486Dipa1_mdrug induced psychomotor activation 1 (mouse)Not determined595317683129317856Mouse
13464244Ahl19_mage related hearing loss, early onset 19 (mouse)595317683129317856Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596172519130172667Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined596883692130883925Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined596883692130883925Mouse
10045978Tir10_mtrypanosome infection response 10 (mouse)Not determined597871790113883925Mouse
1301042Elmaz1_melevated maze behavior 1 (mouse)Not determined597871790116738565Mouse
4141519Hmtb5_mhemostasis and thrombosis bleeding time 5 (mouse)Not determined99801563126805880Mouse
12904945Tammq2_mtibialis anterior muscle mass QTL 2 (mouse)5100527900134527900Mouse
12904959Smmq1_msoleus muscle mass QTL 1 (mouse)5100527900134527900Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101194514135194514Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101725767135725963Mouse
14746986Manh58_mmandible shape 58 (mouse)5102308218136308218Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102806972136807131Mouse
25314310Syncl4_msynaptonemal complex length 4 (mouse)5102900000115400000Mouse
25314317Sccor3_msynaptonemal complex length to mean MLH1 count ratio 3 (mouse)5104200000114600000Mouse
11528550Sluc33_msusceptibility to lung cancer 33 (mouse)5104239005120573921Mouse
1357886Diht_mdopamine-induced hypothermia (mouse)Not determined5104350872114963481Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104435822138557193Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104567876138567876Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107829235141829348Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107829235141829348Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107829235141829348Mouse
4141139Hmtb4_mhemostasis and thrombosis rebleeding time 4 (mouse)Not determined108614643126805880Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109090176143090317Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109090176143090317Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109090758139133150Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109362284143362395Mouse
4141652Mrdq2_mmodifier of retinal degeneration QTL 2 (mouse)Not determined110105240117955608Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113172519138557193Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:539
Count of miRNA genes:375
Interacting mature miRNAs:429
Transcripts:ENSMUST00000065698
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000065698   ⟹   ENSMUSP00000071719
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5113,735,803 - 113,740,600 (+)Ensembl
RefSeq Acc Id: NM_001010825   ⟹   NP_001010825
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395113,873,843 - 113,878,668 (+)NCBI
GRCm385113,735,782 - 113,740,607 (+)NCBI
MGSCv375114,185,791 - 114,190,616 (+)RGD
Celera5110,836,905 - 110,841,730 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006530285   ⟹   XP_006530348
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395113,873,821 - 113,878,670 (+)NCBI
GRCm385113,735,758 - 113,740,607 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006530286   ⟹   XP_006530349
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395113,873,821 - 113,878,670 (+)NCBI
GRCm385113,735,758 - 113,740,607 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001010825   ⟸   NM_001010825
- UniProtKB: Q8BIX9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006530349   ⟸   XM_006530286
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006530348   ⟸   XM_006530285
- Peptide Label: isoform X2
- UniProtKB: Q8BIX9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000071719   ⟸   ENSMUST00000065698
Protein Domains
Fido

Promoters
RGD ID:6887640
Promoter ID:EPDNEW_M7271
Type:initiation region
Name:Ficd_1
Description:Mus musculus FIC domain containing , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385113,735,828 - 113,735,888EPDNEW
RGD ID:6837518
Promoter ID:MM_KWN:43515
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001010825
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365114,185,491 - 114,186,282 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1098550 AgrOrtholog
Ensembl Genes ENSMUSG00000053334 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000071719 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000065698 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.3290.10 UniProtKB/Swiss-Prot
  1.25.40.10 UniProtKB/Swiss-Prot
InterPro Fido UniProtKB/Swiss-Prot
  Fido-like_dom_sf UniProtKB/Swiss-Prot
  Fido_containing UniProtKB/Swiss-Prot
  TPR-contain_dom UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:231630 UniProtKB/Swiss-Prot
MGD MGI:1098550 ENTREZGENE
NCBI Gene 231630 ENTREZGENE
PANTHER PTHR13504 UniProtKB/Swiss-Prot
Pfam Fic UniProtKB/Swiss-Prot
PhenoGen Ficd PhenoGen
PROSITE FIDO UniProtKB/Swiss-Prot
  TPR_REGION UniProtKB/Swiss-Prot
Superfamily-SCOP SSF140931 UniProtKB/Swiss-Prot
  SSF48452 UniProtKB/Swiss-Prot
UniProt FICD_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A4QPF9 UniProtKB/Swiss-Prot
  Q8BIC9 UniProtKB/Swiss-Prot
  Q8BJ12 UniProtKB/Swiss-Prot