Tmem74 (transmembrane protein 74) - Rat Genome Database

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Gene: Tmem74 (transmembrane protein 74) Mus musculus
Analyze
Symbol: Tmem74
Name: transmembrane protein 74
RGD ID: 1622046
MGI Page MGI
Description: Enables transmembrane transporter binding activity. Acts upstream of or within general adaptation syndrome, behavioral process. Located in plasma membrane. Is expressed in cerebral cortex subventricular zone and cortical plate. Orthologous to human TMEM74 (transmembrane protein 74).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AA549547; B230382K22Rik
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391543,726,741 - 43,733,462 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1543,728,042 - 43,733,432 (-)EnsemblGRCm39 Ensembl
GRCm381543,863,345 - 43,870,059 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1543,864,646 - 43,870,036 (-)EnsemblGRCm38mm10GRCm38
MGSCv371543,698,241 - 43,701,575 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361543,696,769 - 43,700,103 (-)NCBIMGSCv36mm8
Celera1544,326,949 - 44,330,313 (-)NCBICelera
Cytogenetic Map15B3.2NCBI
cM Map1516.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15489334   PMID:16107646   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21677750  
PMID:24357321   PMID:30886335   PMID:34321999  


Genomics

Comparative Map Data
Tmem74
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391543,726,741 - 43,733,462 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1543,728,042 - 43,733,432 (-)EnsemblGRCm39 Ensembl
GRCm381543,863,345 - 43,870,059 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1543,864,646 - 43,870,036 (-)EnsemblGRCm38mm10GRCm38
MGSCv371543,698,241 - 43,701,575 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361543,696,769 - 43,700,103 (-)NCBIMGSCv36mm8
Celera1544,326,949 - 44,330,313 (-)NCBICelera
Cytogenetic Map15B3.2NCBI
cM Map1516.82NCBI
TMEM74
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388108,606,850 - 108,787,594 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8108,606,850 - 108,787,594 (-)EnsemblGRCh38hg38GRCh38
GRCh378109,619,079 - 109,799,823 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368109,864,522 - 109,868,946 (-)NCBINCBI36Build 36hg18NCBI36
Celera8105,982,575 - 105,986,999 (-)NCBICelera
Cytogenetic Map8q23.1NCBI
HuRef8105,116,317 - 105,120,741 (-)NCBIHuRef
CHM1_18109,835,258 - 109,839,682 (-)NCBICHM1_1
T2T-CHM13v2.08109,735,330 - 109,916,112 (-)NCBIT2T-CHM13v2.0
Tmem74
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8776,814,000 - 76,822,633 (-)NCBIGRCr8
mRatBN7.2774,929,290 - 74,937,929 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl774,931,694 - 74,937,934 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx776,780,654 - 76,789,275 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0778,983,152 - 78,991,777 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0778,858,660 - 78,867,300 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0782,684,666 - 82,689,753 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl782,686,213 - 82,687,130 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0782,694,142 - 82,699,197 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4779,611,445 - 79,612,413 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera771,927,405 - 71,932,481 (-)NCBICelera
Cytogenetic Map7q31NCBI
Tmem74
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541731,328,352 - 31,334,228 (-)NCBIChiLan1.0ChiLan1.0
TMEM74
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27126,156,559 - 126,165,236 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18101,679,893 - 101,688,568 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08105,432,869 - 105,441,542 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18107,583,909 - 107,587,990 (-)NCBIpanpan1.1PanPan1.1panPan2
TMEM74
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1139,407,005 - 9,415,906 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl139,412,368 - 9,413,285 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha139,383,998 - 9,391,724 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0139,680,515 - 9,688,244 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl139,680,528 - 9,689,421 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1139,423,244 - 9,430,971 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0139,548,243 - 9,555,974 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0139,628,842 - 9,636,571 (-)NCBIUU_Cfam_GSD_1.0
Tmem74
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530328,658,650 - 28,667,449 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647036,087,350 - 36,088,267 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647036,084,902 - 36,091,517 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM74
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl428,722,273 - 28,731,093 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1428,722,243 - 28,727,007 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2431,062,896 - 31,067,648 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM74
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18103,604,060 - 103,637,945 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8103,509,309 - 103,510,226 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
ChlSab1.1 Ensembl8103,509,309 - 103,510,226 (-)NCBIChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603936,940,773 - 37,071,831 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem74
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476323,762,606 - 23,765,496 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476323,762,204 - 23,765,889 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmem74
297 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:59
Interacting mature miRNAs:60
Transcripts:ENSMUST00000067469
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401902Sicd2_mseizure-induced cell death 2 (mouse)Not determined15347438971197538Mouse
4141952W3q7_mweight 3 weeks QTL 7 (mouse)Not determined348969478601286Mouse
4142252Tailaq4_mtail length adjusted QTL 4 (mouse)Not determined348969478601286Mouse
4142448Tailq6_mtail length QTL 6 (mouse)Not determined348969478601286Mouse
1357559Scfq2_msubcutaneous fat pad weight QTL 2 (mouse)Not determined15348969478601286Mouse
1357659Epfpq4_mepididymal fat percentage QTL 4 (mouse)Not determined15348969478601286Mouse
26884384Skwq12_mskull length QTL 12, 16 week (mouse)15612948150763396Mouse
26884387Skwq8_mskull length QTL 8, 10 week (mouse)15612948168271849Mouse
26884412Bzwq10_mbi-zygomatic width QTL 10, 10 week (mouse)15612948171471849Mouse
26884417Bzwq4_mbi-zygomatic width QTL 4, 5 week (mouse)15612948172471849Mouse
27226786Feml11_mfemur length 11, 5 week (mouse)15612948175871849Mouse
27095932Ulnl11_mulna length 11, 16 week (mouse)15612948176384200Mouse
27226717Tibw4_mtibia width 4, proximal, 10 week (mouse)15612948178684200Mouse
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15612948186684201Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
26884429Zlq6_mzygomatic length QTL 6, 10 week (mouse)15682948144963396Mouse
27226721Tibw8_mtibia width 8, proximal, 16 week (mouse)15692948175871849Mouse
27226773Tibl16_mtibia length 16, 10 week (mouse)15692948175871849Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15692948184584201Mouse
27095940Ulnl8_mulna length 8, 10 week (mouse)15722948155263396Mouse
27226759Feml17_mfemur length 17, 10 week (mouse)15762948155263396Mouse
27226755Feml22_mfemur length 22, 16 week (mouse)15762948159271849Mouse
26884439Sklq11_mskull length QTL 11, 10 week (mouse)15812948447663396Mouse
4141192Ssrq2_mstress response QTL 2 (mouse)Not determined927302256186850Mouse
1301433Rapop5_mradiation-induced apoptosis 5 (mouse)Not determined15927302279474762Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
1301020Pheo_mpheomelanin (mouse)Not determined151384700647847148Mouse
1302165Yv_myellow value (mouse)Not determined151384700647847148Mouse
4141423Nstr2_mnerve sheath tumor resistance QTL 2 (mouse)Not determined1492758748927756Mouse
1301951Eila3_methanol induced locomotor activity 3 (mouse)Not determined151492758748927756Mouse
1302007Bbaa14_mB.burgdorferi-associated arthritis 14 (mouse)Not determined151492758748927756Mouse
1301499Bdln2_mbody length 2 (mouse)Not determined151564534349645470Mouse
12859288Criq1_mCitrobacter rodentium infection QTL 1 (mouse)151603395450033954Mouse
26884423Zlq10_mzygomatic length QTL 10, 16 week (mouse)152060008650763396Mouse
14928313Manh78_mmandible shape 78 (mouse)152148464155484641Mouse
12859289Criq3_mCitrobacter rodentium infection QTL 3 (mouse)152259376556593765Mouse
4142160Femwf10_mfemur work to failure 10 (mouse)Not determined2289301456893160Mouse
1301557Bbaa22_mB.burgdorferi-associated arthritis 22 (mouse)Not determined152446257258462805Mouse
1300967Bdt6_mbone density traits 6 (mouse)Not determined152529580659295928Mouse
4141409Radsvq1_mradiation sensitivity QTL 1 (mouse)Not determined2548497859484978Mouse
1300772Bglq16_mbody growth late QTL 16 (mouse)Not determined152631178060311880Mouse
1301345Bgeq14_mbody growth early QTL 14 (mouse)Not determined152631178060311880Mouse
1357514Mbis3_mMycobacterium bovis-induced systemic lupus erythematosus 3 (mouse)Not determined162631178060311880Mouse
1301406Egrd2_mearly growth rate (mouse)Not determined152631178060311880Mouse
27226800Scvln20_msacral vertebrae length 2, 16 week (mouse)152660008666371849Mouse
1301450Bpq6_mblood pressure QTL 6 (mouse)Not determined152828264662282739Mouse
1357512Bsbob5_mBSB obesity 5 (mouse)Not determined152828264662282739Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
26884392Humsd8_mhumerus midshaft diameter 8, 16 week (mouse)152930014676084200Mouse
26884452Sklq17_mskull length QTL 17, 16 week (mouse)153020014657963396Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
1300578Cd8ts3_mCD8 T cell subset 3 (mouse)Not determined153400469468004804Mouse
1301324Cdif_mcolor difference (mouse)Not determined153597590669976019Mouse
27226729Tibmd2_mtibia midshaft diameter 2, 5 week (mouse)153800024486684201Mouse
12792977Tbmd1_mtibial bone mineral density 1, males only (mouse)153807048952031841Mouse
1301580Hrq2_mheart rate quantitative locus 2 (mouse)Not determined153910039573100593Mouse
1300949Lore5_mloss of righting induced by ethanol 5 (mouse)Not determined154001944158022297Mouse
4142459Lfnq3_mlung function QTL 3 (mouse)Not determined4017702272372580Mouse
26884402Cvht9_mcranial vault height 9, 16 week (mouse)154216339695497881Mouse

Markers in Region
UniSTS:237288  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381543,866,309 - 43,866,404UniSTSGRCm38
MGSCv371543,697,855 - 43,697,950UniSTSGRCm37
Celera1544,326,563 - 44,326,658UniSTS
Cytogenetic Map15B3.2UniSTS
BE119323  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381543,866,745 - 43,866,919UniSTSGRCm38
MGSCv371543,698,291 - 43,698,465UniSTSGRCm37
Celera1544,326,999 - 44,327,173UniSTS
Cytogenetic Map15B3.2UniSTS
UniSTS:492325  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381543,866,695 - 43,867,758UniSTSGRCm38
MGSCv371543,698,241 - 43,699,304UniSTSGRCm37
Celera1544,326,949 - 44,328,012UniSTS
Cytogenetic Map15B3.2UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000067469   ⟹   ENSMUSP00000070748
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1543,728,042 - 43,733,432 (-)Ensembl
GRCm38.p6 Ensembl1543,864,646 - 43,870,036 (-)Ensembl
RefSeq Acc Id: NM_175502   ⟹   NP_780711
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391543,730,091 - 43,733,425 (-)NCBI
GRCm381543,866,695 - 43,870,029 (-)NCBI
MGSCv371543,698,241 - 43,701,575 (-)RGD
Celera1544,326,949 - 44,330,313 (-)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006520908   ⟹   XP_006520971
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391543,726,741 - 43,733,462 (-)NCBI
GRCm381543,863,345 - 43,870,059 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_780711 (Get FASTA)   NCBI Sequence Viewer  
  XP_006520971 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI17022 (Get FASTA)   NCBI Sequence Viewer  
  AAI17026 (Get FASTA)   NCBI Sequence Viewer  
  BAC32721 (Get FASTA)   NCBI Sequence Viewer  
  EDL08751 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000070748
  ENSMUSP00000070748.5
GenBank Protein Q8BQU7 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_780711   ⟸   NM_175502
- UniProtKB: Q8BQU7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006520971   ⟸   XM_006520908
- Peptide Label: isoform X1
- UniProtKB: Q8BQU7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000070748   ⟸   ENSMUST00000067469

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BQU7-F1-model_v2 AlphaFold Q8BQU7 1-305 view protein structure

Promoters
RGD ID:8683686
Promoter ID:EPDNEW_M19873
Type:initiation region
Name:Tmem74_1
Description:Mus musculus transmembrane protein 74 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381543,870,029 - 43,870,089EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2443417 AgrOrtholog
Ensembl Genes ENSMUSG00000054409 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000067469 ENTREZGENE
  ENSMUST00000067469.6 UniProtKB/Swiss-Prot
InterPro TMEM74-like UniProtKB/Swiss-Prot
KEGG Report mmu:239408 UniProtKB/Swiss-Prot
MGD MGI:2443417 ENTREZGENE
NCBI Gene 239408 ENTREZGENE
PANTHER PTHR16125 UniProtKB/Swiss-Prot
  PTHR16125:SF3 UniProtKB/Swiss-Prot
Pfam Neurensin UniProtKB/Swiss-Prot
PhenoGen Tmem74 PhenoGen
UniProt Q8BQU7 ENTREZGENE, UniProtKB/Swiss-Prot