Spink6 (serine peptidase inhibitor, Kazal type 6) - Rat Genome Database

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Gene: Spink6 (serine peptidase inhibitor, Kazal type 6) Mus musculus
Analyze
Symbol: Spink6
Name: serine peptidase inhibitor, Kazal type 6
RGD ID: 1621891
MGI Page MGI
Description: Enables serine-type endopeptidase inhibitor activity. Located in extracellular region. Orthologous to human SPINK6 (serine peptidase inhibitor Kazal type 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EG433180; serine protease inhibitor Kazal-type 6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391844,204,460 - 44,216,678 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1844,204,460 - 44,216,678 (+)EnsemblGRCm39 Ensembl
GRCm381844,071,393 - 44,083,611 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1844,071,393 - 44,083,611 (+)EnsemblGRCm38mm10GRCm38
MGSCv371844,231,047 - 44,243,264 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361844,196,724 - 44,208,941 (+)NCBIMGSCv36mm8
Celera1845,455,030 - 45,467,239 (+)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1823.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:20562862   PMID:21677750   PMID:21873635   PMID:24352040  


Genomics

Comparative Map Data
Spink6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391844,204,460 - 44,216,678 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1844,204,460 - 44,216,678 (+)EnsemblGRCm39 Ensembl
GRCm381844,071,393 - 44,083,611 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1844,071,393 - 44,083,611 (+)EnsemblGRCm38mm10GRCm38
MGSCv371844,231,047 - 44,243,264 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361844,196,724 - 44,208,941 (+)NCBIMGSCv36mm8
Celera1845,455,030 - 45,467,239 (+)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1823.74NCBI
SPINK6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385148,202,778 - 148,215,137 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5148,202,794 - 148,215,137 (+)EnsemblGRCh38hg38GRCh38
GRCh375147,582,341 - 147,594,700 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365147,562,597 - 147,574,893 (+)NCBINCBI36Build 36hg18NCBI36
Build 345147,562,596 - 147,574,892NCBI
Celera5143,661,768 - 143,674,063 (+)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5142,729,472 - 142,741,827 (+)NCBIHuRef
CHM1_15147,014,752 - 147,027,482 (+)NCBICHM1_1
T2T-CHM13v2.05148,737,170 - 148,749,644 (+)NCBIT2T-CHM13v2.0
Spink6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81836,648,725 - 36,660,902 (+)NCBIGRCr8
mRatBN7.21836,397,833 - 36,410,010 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1836,397,910 - 36,409,819 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1836,501,854 - 36,514,034 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01837,220,196 - 37,232,376 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01836,597,099 - 36,609,279 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X43,033,066 - 43,044,975 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl236,064,130 - 36,076,039 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX43,033,066 - 43,044,975 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01835,117,696 - 35,126,927 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41837,696,497 - 37,708,406 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11837,731,762 - 37,743,672 (+)NCBI
Cytogenetic Map18q11NCBI
Spink6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554156,041,712 - 6,053,963 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554156,041,712 - 6,053,963 (-)NCBIChiLan1.0ChiLan1.0
LOC100985521
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24143,435,775 - 143,448,482 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15141,575,325 - 141,588,032 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05143,631,560 - 143,644,177 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15149,639,882 - 149,652,448 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5149,639,882 - 149,652,448 (+)Ensemblpanpan1.1panPan2
SPINK6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1242,409,038 - 42,425,540 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl242,415,406 - 42,425,535 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha239,461,347 - 39,471,396 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0242,875,166 - 42,885,078 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl242,875,095 - 42,885,076 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1239,945,112 - 39,955,177 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0240,755,354 - 40,765,374 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0241,578,385 - 41,588,241 (+)NCBIUU_Cfam_GSD_1.0
SPINK6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12350,735,387 - 50,747,343 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603427,017,893 - 27,029,345 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spink6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247747,630,403 - 7,642,271 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247747,630,554 - 7,642,191 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Spink6
481 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:53
Interacting mature miRNAs:54
Transcripts:ENSMUST00000068473
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060933072Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
13504732Cath6_mcarotid atherosclerosis 6 (mouse)181363712647637126Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
1300994Pvcan3_mprotection against vaginal candidiasis 3 (mouse)Not determined181619964050199776Mouse
1301307Phospq1_mphospholipid QTL 1 (mouse)Not determined181813970452139859Mouse
1300638Im7_mimmunoregulatory 7 (mouse)Not determined181901887453018992Mouse
1558743Kcal1_mkilocalorie 1 (mouse)Not determined181901887453018992Mouse
11532709Sluc41_msusceptibility to lung cancer 41 (mouse)182095369457590708Mouse
13463476Hctq8_mhematocrit QTL 8 (mouse)182121758055217727Mouse
1300877Adip8_madiposity 8 (mouse)Not determined182261991456620127Mouse
11532710Sluc41a_msusceptibility to lung cancer 41a (mouse)182261991456620127Mouse
11532715Sluc41b_msusceptibility to lung cancer 41b (mouse)182261991456620127Mouse
11532716Sluc41c_msusceptibility to lung cancer 41c (mouse)182261991456620127Mouse
1301570Sluc14_msusceptibility to lung cancer 14 (mouse)Not determined182261991456620127Mouse
4142031Moen1_mmodifier of engrailed QTL 1 (mouse)Not determined182411556058115730Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
12904950Smmq3_msoleus muscle mass QTL 3 (mouse)182605687560056875Mouse
25823167Hrsq5_mhost response to SARS QTL 5, D3% weight (mouse)182724111558827077Mouse
25823171Hrsq10_mhost response to SARS QTL 10, D4% weight (mouse)182724111558827077Mouse
25823174Hrsq11_mhost response to SARS QTL 11, log titer (mouse)182724111558827077Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182810938062109518Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2813060462130739Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182966791463668060Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183023306764233067Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183198848065988629Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183309104367091221Mouse
1301771Pcyts6_mplasmacytoma susceptibility 6 (mouse)Not determined183565863269658851Mouse
11041903Lmr27_mleishmaniasis resistance 27 (mouse)183618756745109518Mouse
4142366Chlq10_mcirculating hormone level QTL 10 (mouse)Not determined183629102270291180Mouse
15039381Ltgq8_mliver triglyceride QTL 8 (mouse)183820656972206569Mouse
15039383Mvlq5_mmicrovesicular liver lesion QTL 5 (mouse)183820656972206569Mouse
15039384Liviq1_mliver inflammation QTL 1 (mouse)183820656972206569Mouse
15039386Mvlq4_mmacrovesicular liver lesion QTL 4 (mouse)183820656972206569Mouse
12050070Nabq2_mnasal bone morphology QTL 2 (mouse)183910367773103793Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183961991484638778Mouse
1301902Hrtfm4_mheart failure modifier 4 (mouse)Not determined184331112077311343Mouse
10412262Gre1_mGlucocorticoid receptor expression 1 (mouse)Not determined184354107846536999Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000068473   ⟹   ENSMUSP00000069247
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1844,204,460 - 44,216,678 (+)Ensembl
GRCm38.p6 Ensembl1844,071,393 - 44,083,611 (+)Ensembl
RefSeq Acc Id: ENSMUST00000235436   ⟹   ENSMUSP00000158333
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1844,206,835 - 44,216,493 (+)Ensembl
GRCm38.p6 Ensembl1844,073,768 - 44,083,426 (+)Ensembl
RefSeq Acc Id: ENSMUST00000236634   ⟹   ENSMUSP00000157648
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1844,204,489 - 44,216,512 (+)Ensembl
GRCm38.p6 Ensembl1844,071,422 - 44,083,445 (+)Ensembl
RefSeq Acc Id: ENSMUST00000237636
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1844,207,346 - 44,216,607 (+)Ensembl
GRCm38.p6 Ensembl1844,074,279 - 44,083,540 (+)Ensembl
RefSeq Acc Id: NM_001013797   ⟹   NP_001013819
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391844,204,460 - 44,216,678 (+)NCBI
GRCm381844,071,393 - 44,083,611 (+)NCBI
MGSCv371844,231,047 - 44,243,264 (+)RGD
Celera1845,455,030 - 45,467,239 (+)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001357563   ⟹   NP_001344492
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391844,204,460 - 44,216,678 (+)NCBI
GRCm381844,071,393 - 44,083,611 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001357564   ⟹   NP_001344493
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391844,206,835 - 44,216,678 (+)NCBI
GRCm381844,073,768 - 44,083,611 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001013819   ⟸   NM_001013797
- Peptide Label: isoform 1 precursor
- UniProtKB: Q8BT20 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001344492   ⟸   NM_001357563
- Peptide Label: isoform 2 precursor
- UniProtKB: B9EJQ7 (UniProtKB/TrEMBL),   B7ZWD4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001344493   ⟸   NM_001357564
- Peptide Label: isoform 3
- UniProtKB: A0A494BB62 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000157648   ⟸   ENSMUST00000236634
RefSeq Acc Id: ENSMUSP00000069247   ⟸   ENSMUST00000068473
RefSeq Acc Id: ENSMUSP00000158333   ⟸   ENSMUST00000235436
Protein Domains
Kazal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BT20-F1-model_v2 AlphaFold Q8BT20 1-105 view protein structure

Promoters
RGD ID:13677708
Promoter ID:EPDNEW_M23003
Type:multiple initiation site
Name:Spink6_1
Description:Mus musculus serine peptidase inhibitor, Kazal type 6 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381844,071,392 - 44,071,452EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3648654 AgrOrtholog
Ensembl Genes ENSMUSG00000055095 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000068473 ENTREZGENE
  ENSMUST00000068473.4 UniProtKB/Swiss-Prot
  ENSMUST00000235436 ENTREZGENE
  ENSMUST00000235436.2 UniProtKB/TrEMBL
  ENSMUST00000236634 ENTREZGENE
  ENSMUST00000236634.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.60.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kazal_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_inh_Kazal-m UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:433180 UniProtKB/Swiss-Prot
MGD MGI:3648654 ENTREZGENE
NCBI Gene 433180 ENTREZGENE
PANTHER SERINE PROTEASE INHIBITOR KAZAL-TYPE 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE PROTEASE INHIBITOR KAZAL-TYPE 7 SPINK7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Kazal_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Spink6 PhenoGen
PRINTS KAZALINHBTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE KAZAL_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KAZAL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART KAZAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494BB62 ENTREZGENE, UniProtKB/TrEMBL
  B7ZWD4 ENTREZGENE, UniProtKB/TrEMBL
  B9EJQ7 ENTREZGENE, UniProtKB/TrEMBL
  ISK6_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE