Spink11 (serine peptidase inhibitor, Kazal type 11) - Rat Genome Database

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Gene: Spink11 (serine peptidase inhibitor, Kazal type 11) Mus musculus
Analyze
No known orthologs.
Symbol: Spink11
Name: serine peptidase inhibitor, Kazal type 11
RGD ID: 1621890
MGI Page MGI
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9230112K01Rik; serine protease inhibitor Kazal type 11; serine protease inhibitor Kazal-type 11
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391844,323,116 - 44,329,244 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1844,323,112 - 44,329,244 (-)EnsemblGRCm39 Ensembl
GRCm381844,190,049 - 44,196,177 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1844,190,045 - 44,196,177 (-)EnsemblGRCm38mm10GRCm38
MGSCv371844,349,699 - 44,355,831 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361844,315,382 - 44,321,508 (-)NCBIMGSCv36mm8
Celera1845,570,731 - 45,576,863 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1823.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16930550  


Genomics

Variants

.
Variants in Spink11
177 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:69
Interacting mature miRNAs:70
Transcripts:ENSMUST00000097587
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060933072Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
13504732Cath6_mcarotid atherosclerosis 6 (mouse)181363712647637126Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
1300994Pvcan3_mprotection against vaginal candidiasis 3 (mouse)Not determined181619964050199776Mouse
1301307Phospq1_mphospholipid QTL 1 (mouse)Not determined181813970452139859Mouse
1300638Im7_mimmunoregulatory 7 (mouse)Not determined181901887453018992Mouse
1558743Kcal1_mkilocalorie 1 (mouse)Not determined181901887453018992Mouse
11532709Sluc41_msusceptibility to lung cancer 41 (mouse)182095369457590708Mouse
13463476Hctq8_mhematocrit QTL 8 (mouse)182121758055217727Mouse
1300877Adip8_madiposity 8 (mouse)Not determined182261991456620127Mouse
11532710Sluc41a_msusceptibility to lung cancer 41a (mouse)182261991456620127Mouse
11532715Sluc41b_msusceptibility to lung cancer 41b (mouse)182261991456620127Mouse
11532716Sluc41c_msusceptibility to lung cancer 41c (mouse)182261991456620127Mouse
1301570Sluc14_msusceptibility to lung cancer 14 (mouse)Not determined182261991456620127Mouse
4142031Moen1_mmodifier of engrailed QTL 1 (mouse)Not determined182411556058115730Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
12904950Smmq3_msoleus muscle mass QTL 3 (mouse)182605687560056875Mouse
25823167Hrsq5_mhost response to SARS QTL 5, D3% weight (mouse)182724111558827077Mouse
25823171Hrsq10_mhost response to SARS QTL 10, D4% weight (mouse)182724111558827077Mouse
25823174Hrsq11_mhost response to SARS QTL 11, log titer (mouse)182724111558827077Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182810938062109518Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2813060462130739Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182966791463668060Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183023306764233067Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183198848065988629Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183309104367091221Mouse
1301771Pcyts6_mplasmacytoma susceptibility 6 (mouse)Not determined183565863269658851Mouse
11041903Lmr27_mleishmaniasis resistance 27 (mouse)183618756745109518Mouse
4142366Chlq10_mcirculating hormone level QTL 10 (mouse)Not determined183629102270291180Mouse
15039381Ltgq8_mliver triglyceride QTL 8 (mouse)183820656972206569Mouse
15039383Mvlq5_mmicrovesicular liver lesion QTL 5 (mouse)183820656972206569Mouse
15039384Liviq1_mliver inflammation QTL 1 (mouse)183820656972206569Mouse
15039386Mvlq4_mmacrovesicular liver lesion QTL 4 (mouse)183820656972206569Mouse
12050070Nabq2_mnasal bone morphology QTL 2 (mouse)183910367773103793Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183961991484638778Mouse
1301902Hrtfm4_mheart failure modifier 4 (mouse)Not determined184331112077311343Mouse
10412262Gre1_mGlucocorticoid receptor expression 1 (mouse)Not determined184354107846536999Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000097587   ⟹   ENSMUSP00000095194
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1844,323,112 - 44,329,244 (-)Ensembl
GRCm38.p6 Ensembl1844,190,045 - 44,196,177 (-)Ensembl
RefSeq Acc Id: ENSMUST00000185266
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1844,323,522 - 44,325,412 (-)Ensembl
GRCm38.p6 Ensembl1844,190,455 - 44,192,345 (-)Ensembl
RefSeq Acc Id: ENSMUST00000239421   ⟹   ENSMUSP00000159307
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1844,323,112 - 44,329,244 (-)Ensembl
GRCm38.p6 Ensembl1844,190,045 - 44,196,177 (-)Ensembl
RefSeq Acc Id: NM_001048217   ⟹   NP_001041682
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391844,323,116 - 44,329,244 (-)NCBI
GRCm381844,190,049 - 44,196,177 (-)NCBI
MGSCv371844,349,699 - 44,355,831 (-)RGD
Celera1845,570,731 - 45,576,863 (-)RGD
cM Map18 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001041682 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI47525 (Get FASTA)   NCBI Sequence Viewer  
  AAI47542 (Get FASTA)   NCBI Sequence Viewer  
  ABD93326 (Get FASTA)   NCBI Sequence Viewer  
  BAE23116 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000095194.5
  ENSMUSP00000159307
  ENSMUSP00000159307.2
GenBank Protein Q09TK7 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001041682   ⟸   NM_001048217
- Peptide Label: precursor
- UniProtKB: Q09TK7 (UniProtKB/Swiss-Prot),   B9EJS7 (UniProtKB/Swiss-Prot),   Q3UW03 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000159307   ⟸   ENSMUST00000239421
RefSeq Acc Id: ENSMUSP00000095194   ⟸   ENSMUST00000097587
Protein Domains
Kazal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q09TK7-F1-model_v2 AlphaFold Q09TK7 1-88 view protein structure

Promoters
RGD ID:13677712
Promoter ID:EPDNEW_M23005
Type:multiple initiation site
Name:Spink11_1
Description:Mus musculus serine peptidase inhibitor, Kazal type 11 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381844,196,177 - 44,196,237EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSMUSG00000073573 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000097587.5 UniProtKB/TrEMBL
  ENSMUST00000239421 ENTREZGENE
  ENSMUST00000239421.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.60.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kazal_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:433181 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:3588289 ENTREZGENE
NCBI Gene 433181 ENTREZGENE
PANTHER SERINE PROTEASE INHIBITOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE PROTEASE INHIBITOR KAZAL-TYPE 11-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Kazal_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Spink11 PhenoGen
PROSITE KAZAL_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KAZAL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J158_MOUSE UniProtKB/TrEMBL
  B9EJS7 ENTREZGENE
  ISK11_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UW03 ENTREZGENE
UniProt Secondary B9EJS7 UniProtKB/Swiss-Prot
  Q3UW03 UniProtKB/Swiss-Prot