Lsmem2 (leucine-rich single-pass membrane protein 2) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Lsmem2 (leucine-rich single-pass membrane protein 2) Mus musculus
Analyze
Symbol: Lsmem2
Name: leucine-rich single-pass membrane protein 2
RGD ID: 1621880
MGI Page MGI
Description: Orthologous to human LSMEM2 (leucine rich single-pass membrane protein 2); INTERACTS WITH acrylamide (ortholog); doxorubicin (ortholog); glyphosate (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cDNA sequence BY080835; hypothetical LOC434436; uncharacterized LOC434436; uncharacterized protein C3orf45
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,469,825 - 107,475,189 (-)NCBIGRCm39mm39
GRCm389107,592,626 - 107,597,990 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,592,630 - 107,597,075 (-)EnsemblGRCm38mm10GRCm38
MGSCv379107,495,398 - 107,499,406 (-)NCBIGRCm37mm9NCBIm37
MGSCv369107,451,168 - 107,455,176 (-)NCBImm8
Celera9107,201,848 - 107,205,857 (-)NCBICelera
Cytogenetic Map9F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:12466851   PMID:21677750  


Genomics

Comparative Map Data
Lsmem2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,469,825 - 107,475,189 (-)NCBIGRCm39mm39
GRCm389107,592,626 - 107,597,990 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,592,630 - 107,597,075 (-)EnsemblGRCm38mm10GRCm38
MGSCv379107,495,398 - 107,499,406 (-)NCBIGRCm37mm9NCBIm37
MGSCv369107,451,168 - 107,455,176 (-)NCBImm8
Celera9107,201,848 - 107,205,857 (-)NCBICelera
Cytogenetic Map9F1NCBI
LSMEM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl350,279,087 - 50,288,114 (+)EnsemblGRCh38hg38GRCh38
GRCh38350,277,907 - 50,288,116 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37350,316,458 - 50,325,545 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,291,522 - 50,300,549 (+)NCBINCBI36hg18NCBI36
Celera350,289,343 - 50,298,377 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef350,372,254 - 50,381,288 (+)NCBIHuRef
CHM1_1350,268,741 - 50,277,851 (+)NCBICHM1_1
Lsmem2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08116,348,406 - 116,353,092 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,348,751 - 116,349,896 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08115,704,246 - 115,709,043 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,840,587 - 112,844,108 (-)NCBIRGSC3.4rn4RGSC3.4
Celera8107,572,857 - 107,577,547 (-)NCBICelera
Cytogenetic Map8q32NCBI
Lsmem2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,096,770 - 2,100,876 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555322,096,231 - 2,101,541 (+)NCBIChiLan1.0ChiLan1.0
LSMEM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1351,440,642 - 51,451,467 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,441,739 - 51,451,467 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0350,206,431 - 50,216,716 (+)NCBIMhudiblu_PPA_v0panPan3
LSMEM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2039,053,950 - 39,054,717 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12039,053,152 - 39,058,467 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Lsmem2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365291,819,848 - 1,825,472 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LSMEM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,753,199 - 32,757,036 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11332,752,515 - 32,757,042 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,928,407 - 35,935,562 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LSMEM2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,666,171 - 11,675,465 (+)NCBI
Lsmem2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247304,144,588 - 4,148,953 (+)NCBI

Position Markers
RH126869  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389107,592,812 - 107,593,021UniSTSGRCm38
MGSCv379107,495,143 - 107,495,352UniSTSGRCm37
Celera9107,201,593 - 107,201,802UniSTS
Cytogenetic Map9F1UniSTS
cM Map960.21UniSTS
X85990  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389107,598,444 - 107,598,598UniSTSGRCm38
MGSCv379107,500,775 - 107,500,929UniSTSGRCm37
Celera9107,207,226 - 107,207,380UniSTS
Cytogenetic Map9F1UniSTS
cM Map960.3UniSTS
Whitehead_YAC9 UniSTS
AI838527  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389107,592,690 - 107,592,772UniSTSGRCm38
MGSCv379107,495,021 - 107,495,103UniSTSGRCm37
Celera9107,201,471 - 107,201,553UniSTS
Cytogenetic Map9F1UniSTS
cM Map960.21UniSTS
Whitehead/MRC_RH91107.45UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000191791
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9107,592,630 - 107,594,425 (-)Ensembl
RefSeq Acc Id: ENSMUST00000238519   ⟹   ENSMUSP00000158647
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9107,592,630 - 107,597,075 (-)Ensembl
RefSeq Acc Id: NM_001370877   ⟹   NP_001357806
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399107,470,272 - 107,474,274 (-)NCBI
GRCm389107,593,073 - 107,597,075 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244442   ⟹   XP_030100302
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399107,469,825 - 107,475,105 (-)NCBI
GRCm389107,592,626 - 107,597,906 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244443   ⟹   XP_030100303
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399107,469,825 - 107,475,189 (-)NCBI
GRCm389107,592,626 - 107,597,990 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001357806 (Get FASTA)   NCBI Sequence Viewer  
  XP_030100302 (Get FASTA)   NCBI Sequence Viewer  
  XP_030100303 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_030100303   ⟸   XM_030244443
- Peptide Label: isoform X2
RefSeq Acc Id: XP_030100302   ⟸   XM_030244442
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001357806   ⟸   NM_001370877
RefSeq Acc Id: ENSMUSP00000158647   ⟸   ENSMUST00000238519

Promoters
RGD ID:6844260
Promoter ID:MM_KWN:58729
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Kidney,   Lung
Transcripts:NM_001081244
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369107,499,004 - 107,499,504 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3612240 AgrOrtholog
Ensembl Genes ENSMUSG00000103409 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000158647 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000191791 ENTREZGENE
  ENSMUST00000238519 ENTREZGENE, UniProtKB/TrEMBL
InterPro DUF4714 UniProtKB/TrEMBL
MGD MGI:3612240 ENTREZGENE
NCBI Gene 434436 ENTREZGENE
PANTHER PTHR37333 UniProtKB/TrEMBL
Pfam DUF4714 UniProtKB/TrEMBL
PhenoGen Lsmem2 PhenoGen
UniGene Mm.475142 ENTREZGENE
UniProt A0A571BE98_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-26 Lsmem2  leucine-rich single-pass membrane protein 2  BY080835  cDNA sequence BY080835  Symbol and/or name change 5135510 APPROVED