Lsmem2 (leucine-rich single-pass membrane protein 2) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Lsmem2 (leucine-rich single-pass membrane protein 2) Mus musculus
Analyze
Symbol: Lsmem2
Name: leucine-rich single-pass membrane protein 2
RGD ID: 1621880
MGI Page MGI
Description: Orthologous to human LSMEM2 (leucine rich single-pass membrane protein 2); INTERACTS WITH acrylamide (ortholog); doxorubicin (ortholog); glyphosate (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cDNA sequence BY080835; hypothetical LOC434436; uncharacterized LOC434436; uncharacterized protein C3orf45
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,469,825 - 107,475,189 (-)NCBIGRCm39mm39
GRCm389107,592,626 - 107,597,990 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,592,630 - 107,597,075 (-)EnsemblGRCm38mm10GRCm38
MGSCv379107,495,398 - 107,499,406 (-)NCBIGRCm37mm9NCBIm37
MGSCv369107,451,168 - 107,455,176 (-)NCBImm8
Celera9107,201,848 - 107,205,857 (-)NCBICelera
Cytogenetic Map9F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:12466851   PMID:21677750  


Genomics

Comparative Map Data
Lsmem2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,469,825 - 107,475,189 (-)NCBIGRCm39mm39
GRCm389107,592,626 - 107,597,990 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,592,630 - 107,597,075 (-)EnsemblGRCm38mm10GRCm38
MGSCv379107,495,398 - 107,499,406 (-)NCBIGRCm37mm9NCBIm37
MGSCv369107,451,168 - 107,455,176 (-)NCBImm8
Celera9107,201,848 - 107,205,857 (-)NCBICelera
Cytogenetic Map9F1NCBI
LSMEM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl350,279,087 - 50,288,114 (+)EnsemblGRCh38hg38GRCh38
GRCh38350,277,907 - 50,288,116 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37350,316,458 - 50,325,545 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,291,522 - 50,300,549 (+)NCBINCBI36hg18NCBI36
Celera350,289,343 - 50,298,377 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef350,372,254 - 50,381,288 (+)NCBIHuRef
CHM1_1350,268,741 - 50,277,851 (+)NCBICHM1_1
Lsmem2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08116,348,406 - 116,353,092 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,348,751 - 116,349,896 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08115,704,246 - 115,709,043 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,840,587 - 112,844,108 (-)NCBIRGSC3.4rn4RGSC3.4
Celera8107,572,857 - 107,577,547 (-)NCBICelera
Cytogenetic Map8q32NCBI
Lsmem2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,096,770 - 2,100,876 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555322,096,231 - 2,101,541 (+)NCBIChiLan1.0ChiLan1.0
LSMEM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1351,440,642 - 51,451,467 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,441,739 - 51,451,467 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0350,206,431 - 50,216,716 (+)NCBIMhudiblu_PPA_v0panPan3
LSMEM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2039,053,950 - 39,054,717 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12039,053,152 - 39,058,467 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Lsmem2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365291,819,848 - 1,825,472 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LSMEM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,753,199 - 32,757,036 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11332,752,515 - 32,757,042 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,928,407 - 35,935,562 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LSMEM2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,666,171 - 11,675,465 (+)NCBI
Lsmem2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247304,144,588 - 4,148,953 (+)NCBI

Position Markers
RH126869  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389107,592,812 - 107,593,021UniSTSGRCm38
MGSCv379107,495,143 - 107,495,352UniSTSGRCm37
Celera9107,201,593 - 107,201,802UniSTS
Cytogenetic Map9F1UniSTS
cM Map960.21UniSTS
X85990  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389107,598,444 - 107,598,598UniSTSGRCm38
MGSCv379107,500,775 - 107,500,929UniSTSGRCm37
Celera9107,207,226 - 107,207,380UniSTS
Cytogenetic Map9F1UniSTS
cM Map960.3UniSTS
Whitehead_YAC9 UniSTS
AI838527  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389107,592,690 - 107,592,772UniSTSGRCm38
MGSCv379107,495,021 - 107,495,103UniSTSGRCm37
Celera9107,201,471 - 107,201,553UniSTS
Cytogenetic Map9F1UniSTS
cM Map960.21UniSTS
Whitehead/MRC_RH91107.45UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000191791
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9107,592,630 - 107,594,425 (-)Ensembl
RefSeq Acc Id: ENSMUST00000238519   ⟹   ENSMUSP00000158647
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9107,592,630 - 107,597,075 (-)Ensembl
RefSeq Acc Id: NM_001370877   ⟹   NP_001357806
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399107,470,272 - 107,474,274 (-)NCBI
GRCm389107,593,073 - 107,597,075 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244442   ⟹   XP_030100302
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399107,469,825 - 107,475,105 (-)NCBI
GRCm389107,592,626 - 107,597,906 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244443   ⟹   XP_030100303
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399107,469,825 - 107,475,189 (-)NCBI
GRCm389107,592,626 - 107,597,990 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001357806 (Get FASTA)   NCBI Sequence Viewer  
  XP_030100302 (Get FASTA)   NCBI Sequence Viewer  
  XP_030100303 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_030100303   ⟸   XM_030244443
- Peptide Label: isoform X2
RefSeq Acc Id: XP_030100302   ⟸   XM_030244442
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001357806   ⟸   NM_001370877
RefSeq Acc Id: ENSMUSP00000158647   ⟸   ENSMUST00000238519

Promoters
RGD ID:6844260
Promoter ID:MM_KWN:58729
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Kidney,   Lung
Transcripts:NM_001081244
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369107,499,004 - 107,499,504 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3612240 AgrOrtholog
Ensembl Genes ENSMUSG00000103409 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000158647 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000191791 ENTREZGENE
  ENSMUST00000238519 ENTREZGENE, UniProtKB/TrEMBL
InterPro DUF4714 UniProtKB/TrEMBL
MGD MGI:3612240 ENTREZGENE
NCBI Gene 434436 ENTREZGENE
PANTHER PTHR37333 UniProtKB/TrEMBL
Pfam DUF4714 UniProtKB/TrEMBL
PhenoGen Lsmem2 PhenoGen
UniGene Mm.475142 ENTREZGENE
UniProt A0A571BE98_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-26 Lsmem2  leucine-rich single-pass membrane protein 2  BY080835  cDNA sequence BY080835  Symbol and/or name change 5135510 APPROVED