Amt (aminomethyltransferase) - Rat Genome Database
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Gene: Amt (aminomethyltransferase) Mus musculus
Analyze
Symbol: Amt
Name: aminomethyltransferase
RGD ID: 1621879
MGI Page MGI
Description: Predicted to have aminomethyltransferase activity. Predicted to be involved in glycine decarboxylation via glycine cleavage system. Localizes to mitochondrion. Human ortholog(s) of this gene implicated in glycine encephalopathy. Orthologous to human AMT (aminomethyltransferase); PARTICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; folate cycle metabolic pathway; INTERACTS WITH carbon nanotube; ethanol; pregnenolone 16alpha-carbonitrile.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: aminomethyltransferase, mitochondrial; EG434437; GCVT; glycine cleavage system T protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,174,104 - 108,179,501 (+)NCBIGRCm39mm39
GRCm389108,296,905 - 108,302,302 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,296,853 - 108,302,302 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,199,253 - 108,203,928 (+)NCBIGRCm37mm9NCBIm37
MGSCv369108,155,015 - 108,159,690 (+)NCBImm8
Celera9107,905,964 - 107,910,640 (+)NCBICelera
Cytogenetic Map9F2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (HDA,IBA,ISO)
nucleoplasm  (ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:12392556   PMID:12477932   PMID:12487019   PMID:12520002   PMID:12904583   PMID:14610273   PMID:14681479   PMID:18614015   PMID:18799693   PMID:21677750   PMID:21873635   PMID:22171071  
PMID:27965054   PMID:30718289   PMID:32325033  


Genomics

Comparative Map Data
Amt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,174,104 - 108,179,501 (+)NCBIGRCm39mm39
GRCm389108,296,905 - 108,302,302 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,296,853 - 108,302,302 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,199,253 - 108,203,928 (+)NCBIGRCm37mm9NCBIm37
MGSCv369108,155,015 - 108,159,690 (+)NCBImm8
Celera9107,905,964 - 107,910,640 (+)NCBICelera
Cytogenetic Map9F2NCBI
AMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl349,416,778 - 49,422,685 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl349,416,775 - 49,422,753 (-)EnsemblGRCh38hg38GRCh38
GRCh38349,416,778 - 49,422,473 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37349,454,211 - 49,460,111 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,429,215 - 49,435,016 (-)NCBINCBI36hg18NCBI36
Build 34349,429,215 - 49,435,016NCBI
Celera349,418,998 - 49,424,898 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef349,513,933 - 49,519,839 (-)NCBIHuRef
CHM1_1349,406,978 - 49,412,879 (-)NCBICHM1_1
Amt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08117,068,388 - 117,078,633 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,068,582 - 117,077,913 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,421,237 - 116,427,437 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,284,894 - 108,291,149 (+)NCBICelera
Cytogenetic Map8q32NCBI
Amt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,351,743 - 1,358,220 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,351,743 - 1,358,220 (-)NCBIChiLan1.0ChiLan1.0
AMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1350,589,193 - 50,594,968 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,589,193 - 50,594,968 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0349,344,590 - 49,350,383 (-)NCBIMhudiblu_PPA_v0panPan3
AMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2039,815,814 - 39,820,506 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12039,815,449 - 39,820,907 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Amt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365291,049,364 - 1,054,458 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,995,595 - 32,002,470 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,995,600 - 32,002,514 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
AMT
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,813,601 - 10,820,628 (-)NCBI
ChlSab1.1 Ensembl2210,814,358 - 10,819,632 (-)Ensembl
Amt
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247303,366,023 - 3,372,266 (-)NCBI

Position Markers
Amt  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9F2UniSTS
cM Map959.19UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:586
Count of miRNA genes:382
Interacting mature miRNAs:428
Transcripts:ENSMUST00000035230, ENSMUST00000160025, ENSMUST00000160675, ENSMUST00000162568
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000035230   ⟹   ENSMUSP00000035230
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,296,870 - 108,302,302 (+)Ensembl
RefSeq Acc Id: ENSMUST00000160025
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,296,853 - 108,301,571 (+)Ensembl
RefSeq Acc Id: ENSMUST00000160675
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,296,922 - 108,299,443 (+)Ensembl
RefSeq Acc Id: ENSMUST00000162568
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,296,910 - 108,297,531 (+)Ensembl
RefSeq Acc Id: NM_001013814   ⟹   NP_001013836
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,174,104 - 108,179,501 (+)NCBI
GRCm389108,296,905 - 108,302,302 (+)NCBI
MGSCv379108,199,253 - 108,203,928 (+)RGD
Celera9107,905,964 - 107,910,640 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011242894   ⟹   XP_011241196
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,176,010 - 108,179,501 (+)NCBI
GRCm389108,298,811 - 108,302,302 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001013836   ⟸   NM_001013814
- Peptide Label: precursor
- UniProtKB: Q8CFA2 (UniProtKB/Swiss-Prot),   A2RSW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011241196   ⟸   XM_011242894
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000035230   ⟸   ENSMUST00000035230
Protein Domains
GCV_T   GCV_T_C

Promoters
RGD ID:6844152
Promoter ID:MM_KWN:58784
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000082195,   OTTMUST00000082196,   OTTMUST00000082197,   OTTMUST00000082198
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369108,198,831 - 108,199,472 (+)MPROMDB
RGD ID:8670872
Promoter ID:EPDNEW_M13467
Type:initiation region
Name:Amt_1
Description:Mus musculus aminomethyltransferase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389108,296,922 - 108,296,982EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3646700 AgrOrtholog
Ensembl Genes ENSMUSG00000032607 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000035230 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000035230 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1360.120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GCS_T UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GCST/YgfZ/DmdA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GCV_T_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GCV_T_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GcvT/YgfZ_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TrmE/GcvT_dom1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:434437 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:3646700 ENTREZGENE
NCBI Gene 434437 ENTREZGENE
Pfam GCV_T UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GCV_T_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB AMT RGD
PhenoGen Amt PhenoGen
PIRSF GcvT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF101790 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs gcvT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2RSW6 ENTREZGENE, UniProtKB/TrEMBL
  GCST_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE