Gene: Amt (aminomethyltransferase) Mus musculus
Analyze
Symbol:
Amt
Name:
aminomethyltransferase
Description:
ENCODES a protein that exhibits aminomethyltransferase activity (ortholog); INVOLVED IN glycine decarboxylation via glycine cleavage system (ortholog); PARTICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; folate cycle metabolic pathway; ASSOCIATED WITH abnormal neural tube morphology; craniorachischisis; exencephaly; ASSOCIATED WITH genetic disease (ortholog); glycine encephalopathy (ortholog); FOUND IN mitochondrion (ortholog); nucleoplasm (ortholog); INTERACTS WITH carbon nanotube; ethanol; pregnenolone 16alpha-carbonitrile
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
aminomethyltransferase, mitochondrial; EG434437; GCVT; glycine cleavage system T protein
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
AMT (aminomethyltransferase) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Amt (aminomethyltransferase) HGNC
NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Amt (aminomethyltransferase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
AMT (aminomethyltransferase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
AMT (aminomethyltransferase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Amt (aminomethyltransferase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
AMT (aminomethyltransferase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
AMT (aminomethyltransferase)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Rattus norvegicus (Norway rat):
Amt (aminomethyltransferase)
Alliance
DIOPT (Hieranoid, OrthoFinder, PANTHER, PhylomeDB)
Danio rerio (zebrafish):
amt (aminomethyltransferase)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam, ZFIN)
Drosophila melanogaster (fruit fly):
CG6415
Alliance
DIOPT (InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, Roundup, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
GCV1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
gcst-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 108,296,905 - 108,302,302 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 108,199,253 - 108,203,928 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 108,155,015 - 108,159,690 (+) NCBI mm8 Celera 9 107,905,964 - 107,910,640 (+) NCBI Celera Cytogenetic Map 9 F1 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
genetic disease ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:16450403 more ... genetic disease ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:16450403 more ... glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:28492532 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:27362913 , PMID:28492532 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:16450403 more ... glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:25231368 more ... glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:25741868 , PMID:31319225 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:16450403 more ... glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:11139253 more ... glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:26467025 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:12948742 more ... glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:10873393 more ... glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:27620832 , PMID:28492532 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:20949620 more ... glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:26371980 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:25231368 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:15272469 more ... glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:27620832 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:15272469 more ... glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:16450403 more ... glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:26179960 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:10873393 more ... glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:27362913 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:12948742 , PMID:28492532 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by OMIM:605899 ClinVar PMID:25741868 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by OMIM:605899 ClinVar glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:25741868 , PMID:28492532 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:25741868 , PMID:27362913 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by OMIM:605899 ClinVar PMID:10873393 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by OMIM:605899 ClinVar PMID:9600239 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by OMIM:605899 ClinVar PMID:8005589 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by OMIM:605899 ClinVar PMID:9621520 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by OMIM:605899 ClinVar PMID:19299230 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by OMIM:605899 ClinVar PMID:24033266 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by OMIM:605899 ClinVar PMID:12948742 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by OMIM:605899 ClinVar PMID:16450403 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by OMIM:605899 ClinVar PMID:16450403 , PMID:9621520 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by OMIM:605899 ClinVar PMID:11286506 glycine encephalopathy ISO RGD:1343884 8554872 ClinVar Annotator: match by term: Non-ketotic hyperglycinemia ClinVar PMID:16450403 , PMID:28492532
Imported Annotations - CTD
glycine encephalopathy ISO RGD:1343884 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16450403 Imported Annotations - OMIM
glycine encephalopathy ISO RGD:1343884 7240710 OMIM
Gene-Chemical Interaction Annotations
(+)-schisandrin B multiple interactions ISO RGD:1359408 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of AMT mRNA] CTD PMID:31150632 3-chloropropane-1,2-diol increases expression ISO RGD:1359408 6480464 alpha-Chlorohydrin results in increased expression of AMT mRNA CTD PMID:28522335 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1343884 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AMT mRNA CTD PMID:28628672 5-fluorouracil increases expression ISO RGD:1343884 6480464 Fluorouracil results in increased expression of AMT protein CTD PMID:15585135 , PMID:16803524 acrylamide increases expression ISO RGD:1359408 6480464 Acrylamide results in increased expression of AMT mRNA CTD PMID:28959563 aflatoxin B1 decreases expression ISO RGD:1343884 6480464 Aflatoxin B1 results in decreased expression of AMT mRNA CTD PMID:27153756 bisphenol A decreases expression ISO RGD:1359408 6480464 bisphenol A results in decreased expression of AMT mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:1343884 6480464 bisphenol A results in increased expression of AMT mRNA CTD PMID:29275510 bisphenol F multiple interactions ISO RGD:1343884 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AMT mRNA CTD PMID:28628672 butanal decreases expression ISO RGD:1343884 6480464 butyraldehyde results in decreased expression of AMT mRNA CTD PMID:26079696 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon analog results in decreased expression of AMT mRNA, Nanotubes, Carbon results in decreased expression of AMT mRNA CTD PMID:25620056 cisplatin increases expression ISO RGD:1343884 6480464 Cisplatin results in increased expression of AMT mRNA CTD PMID:27392435 cisplatin multiple interactions ISO RGD:1343884 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of AMT mRNA CTD PMID:27392435 copper atom increases expression ISO RGD:1359408 6480464 Copper results in increased expression of AMT mRNA CTD PMID:30556269 copper(0) increases expression ISO RGD:1359408 6480464 Copper results in increased expression of AMT mRNA CTD PMID:30556269 copper(2+) increases expression ISO RGD:1359408 6480464 Copper results in increased expression of AMT mRNA CTD PMID:30556269 copper(II) sulfate decreases expression ISO RGD:1343884 6480464 Copper Sulfate results in decreased expression of AMT mRNA CTD PMID:19549813 cyclosporin A decreases expression ISO RGD:1343884 6480464 Cyclosporine results in decreased expression of AMT mRNA CTD PMID:25562108 dexamethasone multiple interactions ISO RGD:1343884 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AMT mRNA CTD PMID:28628672 diuron increases expression ISO RGD:1359408 6480464 Diuron results in increased expression of AMT mRNA CTD PMID:21551480 ethanol increases expression EXP 6480464 Ethanol results in increased expression of AMT mRNA CTD PMID:30319688 finasteride increases expression ISO RGD:1359408 6480464 Finasteride results in increased expression of AMT mRNA CTD PMID:24136188 flutamide increases expression ISO RGD:1359408 6480464 Flutamide results in increased expression of AMT mRNA CTD PMID:24136188 indometacin multiple interactions ISO RGD:1343884 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AMT mRNA CTD PMID:28628672 leflunomide increases expression ISO RGD:1359408 6480464 leflunomide results in increased expression of AMT mRNA CTD PMID:24136188 leflunomide decreases expression ISO RGD:1343884 6480464 leflunomide results in decreased expression of AMT mRNA CTD PMID:28988120 methylseleninic acid increases expression ISO RGD:1343884 6480464 methylselenic acid results in increased expression of AMT mRNA CTD PMID:18548127 nefazodone increases expression ISO RGD:1359408 6480464 nefazodone results in increased expression of AMT mRNA CTD PMID:24136188 nickel atom decreases expression ISO RGD:1343884 6480464 Nickel results in decreased expression of AMT mRNA CTD PMID:24768652 , PMID:25583101 paracetamol decreases expression ISO RGD:1343884 6480464 Acetaminophen results in decreased expression of AMT mRNA CTD PMID:25704631 perfluorooctanoic acid increases expression ISO RGD:1343884 6480464 perfluorooctanoic acid results in increased expression of AMT protein CTD PMID:26879310 pregnenolone 16alpha-carbonitrile decreases expression EXP 6480464 Pregnenolone Carbonitrile results in decreased expression of AMT mRNA CTD PMID:28903501 quercetin decreases expression ISO RGD:1343884 6480464 Quercetin results in decreased expression of AMT mRNA CTD PMID:21632981 sulindac increases expression ISO RGD:1359408 6480464 Sulindac results in increased expression of AMT mRNA CTD PMID:24136188 tetrachloromethane multiple interactions ISO RGD:1359408 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of AMT mRNA] CTD PMID:31150632 tetrachloromethane decreases expression ISO RGD:1359408 6480464 Carbon Tetrachloride results in decreased expression of AMT mRNA CTD PMID:31150632 thapsigargin increases expression ISO RGD:1343884 6480464 Thapsigargin results in increased expression of AMT mRNA CTD PMID:22378314 tunicamycin increases expression ISO RGD:1343884 6480464 Tunicamycin results in increased expression of AMT mRNA CTD PMID:22378314 urethane decreases expression ISO RGD:1343884 6480464 Urethane results in decreased expression of AMT mRNA CTD PMID:28818685 valproic acid increases expression ISO RGD:1343884 6480464 Valproic Acid results in increased expression of AMT mRNA CTD PMID:29154799 valproic acid affects expression ISO RGD:1343884 6480464 Valproic Acid affects the expression of AMT mRNA CTD PMID:25979313
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
13207569 Tcq13_m total cholesterol QTL 13 (mouse) 9 59990000 109260000 Mouse 4141833 W10q13_m weight 10 weeks QTL 13 (mouse) Not determined 63332429 120362868 Mouse 4141545 Tailaq2_m tail length adjusted QTL 2 (mouse) Not determined 63332429 120362868 Mouse 1357635 Splq4_m spleen weight QTL 4 (mouse) Not determined 9 63332429 120362868 Mouse 1301725 Lifespan1_m life span 1 (mouse) Not determined 9 74368177 108368325 Mouse 1302065 El1_m epilepsy 1 (mouse) Not determined 9 75775364 114474379 Mouse 10054492 El7_m epilepsy 7 (mouse) Not determined 9 75775364 114474379 Mouse 1301407 Rapop2_m radiation-induced apoptosis 2 (mouse) Not determined 9 76535936 110536130 Mouse 1301192 Skts6_m skin tumor susceptibility 6 (mouse) Not determined 9 78640645 112640755 Mouse 10401247 Bglu14_m blood glucose level 14 (mouse) Not determined 9 79397810 113397888 Mouse 1301732 Char1_m P. chabaudi malaria resistance QTL 1 (mouse) Not determined 9 81798268 115798392 Mouse 1300884 Sluc11_m susceptibility to lung cancer 11 (mouse) Not determined 9 82910333 116910428 Mouse 1357461 Idd2_m insulin dependent diabetes susceptibility 2 (mouse) Not determined 9 82910333 116910428 Mouse 10766454 Char10_m P. chabaudi malaria resistance QTL 10 (mouse) 9 82910333 116910428 Mouse 1301487 Nociq1_m nociceptive sensitivity inflammatory QTL 1 (mouse) Not determined 9 84528818 118528921 Mouse 10412180 Msam3_m muscle, skeletal, activity measure 3 (mouse) Not determined 9 85897510 108641186 Mouse 1300549 Bbaa17_m B. burgdorferi-associated arthritis 17 (mouse) Not determined 9 86230401 120230530 Mouse 1302103 Dob2_m dietary obesity 2 (mouse) Not determined 9 86239845 120289624 Mouse 11251716 Siim2_m stress induced immobility 2 (mouse) 9 86748483 120748483 Mouse 12880422 V25Dq6_m vitamin D inactive form serum level QTL 6 (mouse) 9 87800000 121800000 Mouse 10412242 Alpq8_m alcohol preference QTL 8 (mouse) Not determined 9 89284925 123284925 Mouse 1301649 Psl1_m promotion susceptibility QTL 1 (mouse) Not determined 9 89412277 123412396 Mouse 1357657 Pymr_m Plasmodium yoelli malaria resistance (mouse) Not determined 9 89977005 118938021 Mouse 12910770 Splic1_m spleen iron content 1 (mouse) 9 91413879 124595110 Mouse 12910772 Lvic6_m liver iron content 6 (mouse) 9 91413879 124595110 Mouse 12910773 Splic3_m spleen iron content 3 (mouse) 9 91413879 124595110 Mouse 1558767 Skmw11_m skeletal muscle weight 11 (mouse) Not determined 9 91641084 124595110 Mouse 13463474 Hbbcq5_m hemoglobin concentration QTL 5 (mouse) 9 91641084 124595110 Mouse 13463475 Hctq7_m hematocrit QTL 7 (mouse) 9 91641084 124595110 Mouse 13463477 Rbc9_m red blood cell count 9 (mouse) 9 91641084 124595110 Mouse 13463478 Mchq18_m mean corpuscular hemoglobin QTL 18 (mouse) 9 91641084 124595110 Mouse 13463480 Mchcq2_m mean corpuscular hemoglobin concentration QTL 2 (mouse) 9 91641084 124595110 Mouse 12904937 Edlmmq9_m extensor digitorum longus muscle mass QTL 9 (mouse) 9 91683173 124595110 Mouse 12904947 Tammq7_m tibialis anterior muscle mass QTL 7 (mouse) 9 91683173 124595110 Mouse 12904961 Gmmq7_m gastrocnemius muscle mass QTL 7 (mouse) 9 91683173 124595110 Mouse 1302001 Bdln5_m body length 5 (mouse) Not determined 9 93762590 124595110 Mouse 1301484 Bwq6_m body weight (mouse) Not determined 9 93762590 124595110 Mouse 14746992 Manh67_m mandible shape 67 (mouse) 9 94036768 124595110 Mouse 11081166 Psl5_m promotion susceptibility QTL 5 (mouse) 9 94981301 112872929 Mouse 11537364 Cnes5_m C. neoformans susceptibility locus 5 (mouse) 9 96917590 124595110 Mouse 1301297 Lcho1_m liver cholesterol 1 (mouse) Not determined 9 101060861 124595110 Mouse 1357627 Tgq2_m triglyceride QTL 2 (mouse) Not determined 9 102000187 124595110 Mouse 1357648 Obq18_m obesity QTL 18 (mouse) Not determined 9 102000187 124595110 Mouse 1301789 Pbwg4_m postnatal body weight growth 4 (mouse) Not determined 9 103289445 124595110 Mouse 10412290 Pvacm1l_m plasma vascular cell adhesion molecule 1 levels (mouse) Not determined 9 103289445 124595110 Mouse 12879896 Berr3_m berghei resistance locus 3 (mouse) 9 103289445 124595110 Mouse
Predicted Target Of
Count of predictions: 586 Count of miRNA genes: 382 Interacting mature miRNAs: 428 Transcripts: ENSMUST00000035230, ENSMUST00000160025, ENSMUST00000160675, ENSMUST00000162568 Prediction methods: Miranda, Rnahybrid Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
