Amt (aminomethyltransferase) - Rat Genome Database

Name: Amt
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Amt (aminomethyltransferase) Mus musculus

Analyze

Symbol:

Amt

Name:

aminomethyltransferase

RGD ID:

1621879

MGI Page

MGI

Description:

Predicted to have aminomethyltransferase activity. Predicted to be involved in glycine decarboxylation via glycine cleavage system. Localizes to mitochondrion. Human ortholog(s) of this gene implicated in glycine encephalopathy. Orthologous to human AMT (aminomethyltransferase); PARTICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; folate cycle metabolic pathway; INTERACTS WITH carbon nanotube; ethanol; pregnenolone 16alpha-carbonitrile.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

aminomethyltransferase, mitochondrial; EG434437; GCVT; glycine cleavage system T protein

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AMT (aminomethyltransferase)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Amt (aminomethyltransferase)	HGNC	NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Amt (aminomethyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AMT (aminomethyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AMT (aminomethyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Amt (aminomethyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AMT (aminomethyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	AMT (aminomethyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Amt (aminomethyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	AMT (aminomethyltransferase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Danio rerio (zebrafish):	amt (aminomethyltransferase)	Alliance	DIOPT (PhylomeDB\|TreeFam\|ZFIN)
Drosophila melanogaster (fruit fly):	CG6415	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|Roundup\|TreeFam)
Saccharomyces cerevisiae (baker's yeast):	GCV1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Caenorhabditis elegans (roundworm):	gcst-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup)

Latest Assembly:

GRCm38 - Mouse Genome Assembly GRCm38

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	108,174,104 - 108,179,501 (+)	NCBI	GRCm39		mm39
GRCm38	9	108,296,905 - 108,302,302 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	108,296,853 - 108,302,302 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	108,199,253 - 108,203,928 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	9	108,155,015 - 108,159,690 (+)	NCBI			mm8
Celera	9	107,905,964 - 107,910,640 (+)	NCBI		Celera
Cytogenetic Map	9	F2	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acidoses (ISO)

autosomal recessive limb-girdle muscular dystrophy type 2P (ISO)

epilepsy (ISO)

genetic disease (ISO)

glycine encephalopathy (ISO)

visual epilepsy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (ISO)

3-chloropropane-1,2-diol (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

5-fluorouracil (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

bisphenol A (ISO)

bisphenol F (ISO)

butanal (ISO)

carbon nanotube (EXP)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

diuron (ISO)

ethanol (EXP)

finasteride (ISO)

flutamide (ISO)

indometacin (ISO)

leflunomide (ISO)

methylseleninic acid (ISO)

nefazodone (ISO)

nickel atom (ISO)

paracetamol (ISO)

perfluorooctanoic acid (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

quercetin (ISO)

sulindac (ISO)

sunitinib (ISO)

tetrachloromethane (ISO)

thapsigargin (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

glycine catabolic process (IEA)

glycine decarboxylation via glycine cleavage system (IBA,ISO)

Cellular Component

mitochondrion (HDA,IBA,ISO)

nucleoplasm (ISO)

Molecular Function

aminomethyltransferase activity (IBA,ISO)

protein binding (ISO)

transaminase activity (IEA)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

dihydropyrimidine dehydrogenase deficiency pathway (ISO)

dimethylglycine dehydrogenase deficiency pathway (ISO)

folate cycle metabolic pathway (ISO)

folate mediated one-carbon metabolic pathway (IEA)

glycine, serine and threonine metabolic pathway (IEA)

nonketotic hyperglycinemia pathway (ISO)

sarcosinemia pathway (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal neural tube morphology (IAGP)

craniorachischisis (IAGP)

exencephaly (IAGP)

incomplete rostral neuropore closure (IAGP)

prenatal lethality (IAGP)

References

References - curated


1.	Kure S, etal., Hum Genet. 1998 Apr;102(4):430-4.
2.	Kure S, etal., J Hum Genet. 1998;43(2):135-7.
3.	OMIM Disease Annotation Pipeline
4.	Pipeline to import KEGG annotations from KEGG into RGD
5.	Pipeline to import SMPDB annotations from SMPDB into RGD
6.	RGD automated import pipeline
7.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	RGD automated import pipeline for gene-chemical interactions
9.	Tibbetts AS and Appling DR, Annu Rev Nutr. 2010 Aug 21;30:57-81. doi: 10.1146/annurev.nutr.012809.104810.

Additional References at PubMed

PMID:12392556	PMID:12477932	PMID:12487019	PMID:12520002	PMID:12904583	PMID:14610273	PMID:14681479	PMID:18614015	PMID:18799693	PMID:21677750	PMID:21873635	PMID:22171071
PMID:27965054	PMID:30718289	PMID:32325033

Genomics

Comparative Map Data

Amt
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	108,174,104 - 108,179,501 (+)	NCBI	GRCm39		mm39
GRCm38	9	108,296,905 - 108,302,302 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	108,296,853 - 108,302,302 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	108,199,253 - 108,203,928 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	9	108,155,015 - 108,159,690 (+)	NCBI			mm8
Celera	9	107,905,964 - 107,910,640 (+)	NCBI		Celera
Cytogenetic Map	9	F2	NCBI

AMT
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	3	49,416,778 - 49,422,685 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p13 Ensembl	3	49,416,775 - 49,422,753 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	3	49,416,778 - 49,422,473 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	3	49,454,211 - 49,460,111 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	49,429,215 - 49,435,016 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	3	49,429,215 - 49,435,016	NCBI
Celera	3	49,418,998 - 49,424,898 (-)	NCBI
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	49,513,933 - 49,519,839 (-)	NCBI		HuRef
CHM1_1	3	49,406,978 - 49,412,879 (-)	NCBI		CHM1_1

Amt
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	8	117,068,388 - 117,078,633 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	117,068,582 - 117,077,913 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	116,421,237 - 116,427,437 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	8	108,284,894 - 108,291,149 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

Amt
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955532	1,351,743 - 1,358,220 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955532	1,351,743 - 1,358,220 (-)	NCBI	ChiLan1.0	ChiLan1.0

AMT
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	3	50,589,193 - 50,594,968 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	50,589,193 - 50,594,968 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	3	49,344,590 - 49,350,383 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

AMT
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	20	39,815,814 - 39,820,506 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	20	39,815,449 - 39,820,907 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Amt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936529	1,049,364 - 1,054,458 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AMT
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	31,995,595 - 32,002,470 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	31,995,600 - 32,002,514 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

AMT
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	10,813,601 - 10,820,628 (-)	NCBI
ChlSab1.1 Ensembl	22	10,814,358 - 10,819,632 (-)	Ensembl

Amt
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624730	3,366,023 - 3,372,266 (-)	NCBI

Position Markers

Amt

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	9	F2	UniSTS
cM Map	9	59.19	UniSTS

QTLs in Region (GRCm38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
13207569	Tcq13_m	total cholesterol QTL 13 (mouse)					9	59990000	109260000	Mouse
4141833	W10q13_m	weight 10 weeks QTL 13 (mouse)			Not determined			63332429	120362868	Mouse
4141545	Tailaq2_m	tail length adjusted QTL 2 (mouse)			Not determined			63332429	120362868	Mouse
1357635	Splq4_m	spleen weight QTL 4 (mouse)			Not determined		9	63332429	120362868	Mouse
1301725	Lifespan1_m	life span 1 (mouse)			Not determined		9	74368177	108368325	Mouse
1302065	El1_m	epilepsy 1 (mouse)			Not determined		9	75775364	114474379	Mouse
10054492	El7_m	epilepsy 7 (mouse)			Not determined		9	75775364	114474379	Mouse
1301407	Rapop2_m	radiation-induced apoptosis 2 (mouse)			Not determined		9	76535936	110536130	Mouse
1301192	Skts6_m	skin tumor susceptibility 6 (mouse)			Not determined		9	78640645	112640755	Mouse
10401247	Bglu14_m	blood glucose level 14 (mouse)			Not determined		9	79397810	113397888	Mouse
1301732	Char1_m	P. chabaudi malaria resistance QTL 1 (mouse)			Not determined		9	81798268	115798392	Mouse
1300884	Sluc11_m	susceptibility to lung cancer 11 (mouse)			Not determined		9	82910333	116910428	Mouse
1357461	Idd2_m	insulin dependent diabetes susceptibility 2 (mouse)			Not determined		9	82910333	116910428	Mouse
10766454	Char10_m	P. chabaudi malaria resistance QTL 10 (mouse)					9	82910333	116910428	Mouse
1301487	Nociq1_m	nociceptive sensitivity inflammatory QTL 1 (mouse)			Not determined		9	84528818	118528921	Mouse
10412180	Msam3_m	muscle, skeletal, activity measure 3 (mouse)			Not determined		9	85897510	108641186	Mouse
1300549	Bbaa17_m	B. burgdorferi-associated arthritis 17 (mouse)			Not determined		9	86230401	120230530	Mouse
1302103	Dob2_m	dietary obesity 2 (mouse)			Not determined		9	86239845	120289624	Mouse
11251716	Siim2_m	stress induced immobility 2 (mouse)					9	86748483	120748483	Mouse
12880422	V25Dq6_m	vitamin D inactive form serum level QTL 6 (mouse)					9	87800000	121800000	Mouse
10412242	Alpq8_m	alcohol preference QTL 8 (mouse)			Not determined		9	89284925	123284925	Mouse
1301649	Psl1_m	promotion susceptibility QTL 1 (mouse)			Not determined		9	89412277	123412396	Mouse
18182932	Metl3_m	metabolite locus 3, N-acetylglutamate (mouse)					9	89563342	123563342	Mouse
1357657	Pymr_m	Plasmodium yoelli malaria resistance (mouse)			Not determined		9	89977005	118938021	Mouse
12910770	Splic1_m	spleen iron content 1 (mouse)					9	91413879	124595110	Mouse
12910772	Lvic6_m	liver iron content 6 (mouse)					9	91413879	124595110	Mouse
12910773	Splic3_m	spleen iron content 3 (mouse)					9	91413879	124595110	Mouse
1558767	Skmw11_m	skeletal muscle weight 11 (mouse)			Not determined		9	91641084	124595110	Mouse
13463474	Hbbcq5_m	hemoglobin concentration QTL 5 (mouse)					9	91641084	124595110	Mouse
13463475	Hctq7_m	hematocrit QTL 7 (mouse)					9	91641084	124595110	Mouse
13463477	Rbc9_m	red blood cell count 9 (mouse)					9	91641084	124595110	Mouse
13463478	Mchq18_m	mean corpuscular hemoglobin QTL 18 (mouse)					9	91641084	124595110	Mouse
13463480	Mchcq2_m	mean corpuscular hemoglobin concentration QTL 2 (mouse)					9	91641084	124595110	Mouse
12904937	Edlmmq9_m	extensor digitorum longus muscle mass QTL 9 (mouse)					9	91683173	124595110	Mouse
12904947	Tammq7_m	tibialis anterior muscle mass QTL 7 (mouse)					9	91683173	124595110	Mouse
12904961	Gmmq7_m	gastrocnemius muscle mass QTL 7 (mouse)					9	91683173	124595110	Mouse
1302001	Bdln5_m	body length 5 (mouse)			Not determined		9	93762590	124595110	Mouse
1301484	Bwq6_m	body weight (mouse)			Not determined		9	93762590	124595110	Mouse
14746992	Manh67_m	mandible shape 67 (mouse)					9	94036768	124595110	Mouse
11081166	Psl5_m	promotion susceptibility QTL 5 (mouse)					9	94981301	112872929	Mouse
11537364	Cnes5_m	C. neoformans susceptibility locus 5 (mouse)					9	96917590	124595110	Mouse
1301297	Lcho1_m	liver cholesterol 1 (mouse)			Not determined		9	101060861	124595110	Mouse
1357627	Tgq2_m	triglyceride QTL 2 (mouse)			Not determined		9	102000187	124595110	Mouse
1357648	Obq18_m	obesity QTL 18 (mouse)			Not determined		9	102000187	124595110	Mouse
1301789	Pbwg4_m	postnatal body weight growth 4 (mouse)			Not determined		9	103289445	124595110	Mouse
10412290	Pvacm1l_m	plasma vascular cell adhesion molecule 1 levels (mouse)			Not determined		9	103289445	124595110	Mouse
12879896	Berr3_m	berghei resistance locus 3 (mouse)					9	103289445	124595110	Mouse

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	586
Count of miRNA genes:	382
Interacting mature miRNAs:	428
Transcripts:	ENSMUST00000035230, ENSMUST00000160025, ENSMUST00000160675, ENSMUST00000162568
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001013814	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_011242894	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC161260	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ437692	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC132277	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC132279	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466560	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000035230 ⟹ ENSMUSP00000035230

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	9	108,296,870 - 108,302,302 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000160025

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	9	108,296,853 - 108,301,571 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000160675

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	9	108,296,922 - 108,299,443 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000162568

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	9	108,296,910 - 108,297,531 (+)	Ensembl

RefSeq Acc Id:

NM_001013814 ⟹ NP_001013836

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	9	108,174,104 - 108,179,501 (+)	NCBI
GRCm38	9	108,296,905 - 108,302,302 (+)	NCBI
MGSCv37	9	108,199,253 - 108,203,928 (+)	RGD
Celera	9	107,905,964 - 107,910,640 (+)	RGD
cM Map	9		ENTREZGENE

Sequence:

show sequence

AGTGTGCCGGCCGCACCAGTTGCGGGTGACAATGCATCGGATAGTCAGTGTGGTAGCCCCTCTG
GGTTTTCGCCTGCAGGCACAACCCTTGGTCCAGAGTCGCCCACTCAGTTCTGTACAGGATGTGC
TCCGCAGGACTCCACTCTATGACTTCCACCTAGCTCATGGAGGAAAAATGGTGGCGTTTGCAGG
GTGGAGTCTGCCTGTACAATACCGTGACAGTCATGTTGATTCACACCTGCACACACGCCGGCAT
TGCTCTCTCTTTGATGTGTCCCACATGCTACAGACCAAGATATTTGGCTGTGACCGAGTGAAGC
TGCTGGAGAGTGTAGTGGTTGGAGACATTGCGGAACTAAGGCCTAACCAGGGAACACTCTCTTT
GTTTACCAACGAAGCTGGAGGCATCTTAGACGACTTGATTGTAAGCAATACTTCTGAGGGGCAC
CTGTATGTAGTATCCAATGCTGGCTGCCGGGACAAGGACTTGGCTCTCATGCAGGACAAGGTCA
AGGAGTTCCAGAACAGGGGCCTGGATGTAGGCCTGGAGGTGGTAGAGAATGCCCTGTTAGCTCT
GCAAGGACCCACGGCAACACAGGTGTTACAGGCTGGGGTGACAGATGATATGAAGAAACTACCC
TTCATGACAAGTGCTGTGATGGAGGTGTTCGGTGTGTCTGGCTGTCGTGTGACCCGCTGTGGCT
ACACAGGAGAAGATGGTGTTGAGATATCAGTCCCAGCAACAGGGGCAGTCCACTTGGCAACTAC
TCTGTTGAAAAATCCAGAGGTAAAGCTGGCAGGACTAGCAGCCCGAGATAGCCTGCGCCTGGAG
GCAGGCCTCTGTCTGTATGGGAATGACATCGATGAACATACTACACCTGTGGAGGGCAGCCTCA
GCTGGACACTGGGGAAGCGCCGCCGCATTGCTATGGACTTCCCAGGAGCCAAAATCATTGTTCC
CCAACTGAAGGGTGAGGTACAGCGGAGACGTGTGGGGCTGATATGTGAAGGGGCTCCAGTGAGA
GCACACAGTCCTATTTTGAACACAGAAGGCACTGTGATAGGTACTGTGACCAGTGGCTGCCCTT
CACCCAGCCTGAAGAAAAATGTGGCGATGGGTTATGTGCCATTTAAGTACAGTCGACCAGGGAC
ACAGCTGCTGGTGGAAGTCCGGCGGAAGCAGCAAATGACAGTGGTTAGCAAAATGCCCTTTGTG
CCCACCAACTATTATACTCTCAAGTGAAGATGGCCCATGGGGAAGCCCTTCCCTCCAGGAGTGT
TTCTCTAGAGGGCATGGCATAGTGCTTAGTCAGAACAGTGGAGTACAACTCCCACGGGTGGAAG
CTGAATGAGGTTTGCTGGGTCTGCTTAGGGTTGGGGAGAGAATCCTATCTAGAATCTTTCCCTT
ACAAGCCATTCCAATTTTAGGGCCCAATTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGTTTTT
CGAGACAGGGTTTCTCTGTATATCCCTGGCTGTCCTGAAACTCACTTTGTAGACCAGGCTGGCC
TCCAACTCAGAAATCTGCCTGCCTCTGCCTCTGAGTGCTGGGATTAAAGGCGTAGGGCCCAATT
TTTAAATGACAAATCACCTTACTTAATGTCCTGTTTTAGCCCACAGTCCCACTAACCTTAATCT
GCCTGGTGCTGACTTTGGAACAAAGGTCATCCTGCCTTTGTGTGGAGGGTAACACCTCCGCCCA
CCTCACTATGGCTTCTCTAATTTCAAAGAACTATTACTGTGGGCAGTATGGACTTAGGTACCTT
CTCCACTTTGCATACTGCTGCCTTTCCTTAGATAGAAATGACTCCTGACGTGGTGTTGGCTGAG
TTGTTCCTGTGTGCAAACATAGAGATGGCTAAGCAAACATGGGACTCACCCTTCCACATTCTCT
AGTCAACCCAGCCTGCTGTGCAGCAAGACATGGCTGGTTTAATACTTGGGCTGACCTCGGTCAG
TTGTTGTGAATAATTATACTTTACTAACTCTTGAAAAATAAAATTAATTTCTTTCTTACTTGC

hide sequence

RefSeq Acc Id:

XM_011242894 ⟹ XP_011241196

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	9	108,176,010 - 108,179,501 (+)	NCBI
GRCm38	9	108,298,811 - 108,302,302 (+)	NCBI

Sequence:

show sequence

ACGACTTGATTGTAAGCAATACTTCTGAGGGGCACCTGTATGTAGTATCCAATGCTGGCTGCCG
GGACAAGGACTTGGCTCTCATGCAGGACCCACGGCAACACAGGTGTTACAGGCTGGGGTGACAG
ATGATATGAAGAAACTACCCTTCATGACAAGTGCTGTGATGGAGGTGTTCGGTGTGTCTGGCTG
TCGTGTGACCCGCTGTGGCTACACAGGAGAAGATGGTGTTGAGATATCAGTCCCAGCAACAGGG
GCAGTCCACTTGGCAACTACTCTGTTGAAAAATCCAGAGGTAAAGCTGGCAGGACTAGCAGCCC
GAGATAGCCTGCGCCTGGAGGCAGGCCTCTGTCTGTATGGGAATGACATCGATGAACATACTAC
ACCTGTGGAGGGCAGCCTCAGCTGGACACTGGGGAAGCGCCGCCGCATTGCTATGGACTTCCCA
GGAGCCAAAATCATTGTTCCCCAACTGAAGGGTGAGGTACAGCGGAGACGTGTGGGGCTGATAT
GTGAAGGGGCTCCAGTGAGAGCACACAGTCCTATTTTGAACACAGAAGGCACTGTGATAGGTAC
TGTGACCAGTGGCTGCCCTTCACCCAGCCTGAAGAAAAATGTGGCGATGGGTTATGTGCCATTT
AAGTACAGTCGACCAGGGACACAGCTGCTGGTGGAAGTCCGGCGGAAGCAGCAAATGACAGTGG
TTAGCAAAATGCCCTTTGTGCCCACCAACTATTATACTCTCAAGTGAAGATGGCCCATGGGGAA
GCCCTTCCCTCCAGGAGTGTTTCTCTAGAGGGCATGGCATAGTGCTTAGTCAGAACAGTGGAGT
ACAACTCCCACGGGTGGAAGCTGAATGAGGTTTGCTGGGTCTGCTTAGGGTTGGGGAGAGAATC
CTATCTAGAATCTTTCCCTTACAAGCCATTCCAATTTTAGGGCCCAATTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTGGTTTTTCGAGACAGGGTTTCTCTGTATATCCCTGGCTGTCCTGAAACTCA
CTTTGTAGACCAGGCTGGCCTCCAACTCAGAAATCTGCCTGCCTCTGCCTCTGAGTGCTGGGAT
TAAAGGCGTAGGGCCCAATTTTTAAATGACAAATCACCTTACTTAATGTCCTGTTTTAGCCCAC
AGTCCCACTAACCTTAATCTGCCTGGTGCTGACTTTGGAACAAAGGTCATCCTGCCTTTGTGTG
GAGGGTAACACCTCCGCCCACCTCACTATGGCTTCTCTAATTTCAAAGAACTATTACTGTGGGC
AGTATGGACTTAGGTACCTTCTCCACTTTGCATACTGCTGCCTTTCCTTAGATAGAAATGACTC
CTGACGTGGTGTTGGCTGAGTTGTTCCTGTGTGCAAACATAGAGATGGCTAAGCAAACATGGGA
CTCACCCTTCCACATTCTCTAGTCAACCCAGCCTGCTGTGCAGCAAGACATGGCTGGTTTAATA
CTTGGGCTGACCTCGGTCAGTTGTTGTGAATAATTATACTTTACTAACTCTTGAAAAATAAAAT
TAATTTCTTTCTTACTTGC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001013836	(Get FASTA)	NCBI Sequence Viewer
	XP_011241196	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI32278	(Get FASTA)	NCBI Sequence Viewer
	AAI32280	(Get FASTA)	NCBI Sequence Viewer
	CAD26917	(Get FASTA)	NCBI Sequence Viewer
	EDL21275	(Get FASTA)	NCBI Sequence Viewer
	Q8CFA2	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001013836 ⟸ NM_001013814
- Peptide Label:	precursor
- UniProtKB:	Q8CFA2 (UniProtKB/Swiss-Prot), A2RSW6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MHRIVSVVAPLGFRLQAQPLVQSRPLSSVQDVLRRTPLYDFHLAHGGKMVAFAGWSLPVQYRDS HVDSHLHTRRHCSLFDVSHMLQTKIFGCDRVKLLESVVVGDIAELRPNQGTLSLFTNEAGGILD DLIVSNTSEGHLYVVSNAGCRDKDLALMQDKVKEFQNRGLDVGLEVVENALLALQGPTATQVLQ AGVTDDMKKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGVEISVPATGAVHLATTLLKNPEVKLA GLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGKRRRIAMDFPGAKIIVPQLKGEVQRRR VGLICEGAPVRAHSPILNTEGTVIGTVTSGCPSPSLKKNVAMGYVPFKYSRPGTQLLVEVRRKQ QMTVVSKMPFVPTNYYTLK hide sequence

RefSeq Acc Id:

XP_011241196 ⟸ XM_011242894

- Peptide Label:

isoform X1

- Sequence:

show sequence

MKKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGVEISVPATGAVHLATTLLKNPEVKLAGLAARD
SLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGKRRRIAMDFPGAKIIVPQLKGEVQRRRVGLICE
GAPVRAHSPILNTEGTVIGTVTSGCPSPSLKKNVAMGYVPFKYSRPGTQLLVEVRRKQQMTVVS
KMPFVPTNYYTLK

hide sequence

RefSeq Acc Id:

ENSMUSP00000035230 ⟸ ENSMUST00000035230

Protein Domains

GCV_T GCV_T_C

Promoters

RGD ID:

6844152

Promoter ID:

MM_KWN:58784

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Brain, ES_Cell, Kidney, Liver, Lung

Transcripts:

OTTMUST00000082195, OTTMUST00000082196, OTTMUST00000082197, OTTMUST00000082198

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	9	108,198,831 - 108,199,472 (+)	MPROMDB

RGD ID:

8670872

Promoter ID:

EPDNEW_M13467

Type:

initiation region

Name:

Amt_1

Description:

Mus musculus aminomethyltransferase , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	9	108,296,922 - 108,296,982	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:3646700	AgrOrtholog
Ensembl Genes	ENSMUSG00000032607	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSMUSP00000035230	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000035230	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	3.30.1360.120	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	GCS_T	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GCST/YgfZ/DmdA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GCV_T_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GCV_T_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GcvT/YgfZ_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TrmE/GcvT_dom1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:434437	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD	MGI:3646700	ENTREZGENE
NCBI Gene	434437	ENTREZGENE
Pfam	GCV_T	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GCV_T_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	AMT	RGD
PhenoGen	Amt	PhenoGen
PIRSF	GcvT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF101790	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs	gcvT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A2RSW6	ENTREZGENE, UniProtKB/TrEMBL
	GCST_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)