Tktl1 (transketolase-like 1) - Rat Genome Database

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Gene: Tktl1 (transketolase-like 1) Mus musculus
Analyze
Symbol: Tktl1
Name: transketolase-like 1
RGD ID: 1621435
MGI Page MGI
Description: Predicted to enable thiamine pyrophosphate binding activity and transketolase activity. Predicted to be located in cytosol. Is expressed in early conceptus and secondary oocyte. Orthologous to human TKTL1 (transketolase like 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C79967; MGC132800; TK 2; transketolase 2; transketolase-like protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X73,220,865 - 73,252,104 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX73,220,865 - 73,252,106 (+)EnsemblGRCm39 Ensembl
GRCm38X74,177,259 - 74,208,498 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX74,177,259 - 74,208,500 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X71,422,598 - 71,453,837 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X70,430,004 - 70,461,211 (+)NCBIMGSCv36mm8
CeleraX65,429,659 - 65,462,614 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (ISO)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11279525   PMID:12466851   PMID:12477932   PMID:14681479   PMID:15489334   PMID:16118233  
PMID:16141072   PMID:16141073   PMID:17660561   PMID:21233279   PMID:21267068   PMID:21677750   PMID:21873635   PMID:24392079   PMID:27357688   PMID:28204537   PMID:28245920   PMID:32325033  
PMID:34174788  


Genomics

Comparative Map Data
Tktl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X73,220,865 - 73,252,104 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX73,220,865 - 73,252,106 (+)EnsemblGRCm39 Ensembl
GRCm38X74,177,259 - 74,208,498 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX74,177,259 - 74,208,500 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X71,422,598 - 71,453,837 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X70,430,004 - 70,461,211 (+)NCBIMGSCv36mm8
CeleraX65,429,659 - 65,462,614 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
TKTL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X154,295,795 - 154,330,350 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX154,295,795 - 154,330,350 (+)EnsemblGRCh38hg38GRCh38
GRCh37X153,524,148 - 153,558,700 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,177,345 - 153,211,894 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X153,044,997 - 153,079,545NCBI
CeleraX153,685,095 - 153,719,771 (+)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX142,101,239 - 142,134,950 (+)NCBIHuRef
CHM1_1X153,435,658 - 153,470,347 (+)NCBICHM1_1
T2T-CHM13v2.0X152,532,310 - 152,566,865 (+)NCBIT2T-CHM13v2.0
Tktl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X151,954,261 - 151,987,208 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,954,175 - 151,987,208 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X156,507,797 - 156,540,733 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,507,797 - 156,540,733 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01151,506,633 - 151,523,468 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01152,248,857 - 152,281,793 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X160,144,916 - 160,177,852 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1135,909,517 - 135,940,852 (-)NCBICelera
Cytogenetic MapXq37NCBI
Tktl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580829,594 - 851,470 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955580829,653 - 851,422 (+)NCBIChiLan1.0ChiLan1.0
TKTL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v0X143,736,589 - 143,772,277 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TKTL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X122,007,270 - 122,034,500 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX122,007,282 - 122,034,255 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX107,336,003 - 107,363,191 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X125,148,940 - 125,176,143 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX125,148,958 - 125,176,646 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X120,918,050 - 120,945,228 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X123,433,366 - 123,460,383 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X123,194,859 - 123,221,957 (+)NCBIUU_Cfam_GSD_1.0
Tktl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,310,855 - 119,346,858 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049368091,048,672 - 1,084,125 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TKTL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,839,995 - 124,867,614 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,840,072 - 124,867,313 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TKTL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,607,766 - 128,642,074 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,607,901 - 128,642,063 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606566,535,359 - 66,559,996 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tktl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624946760,078 - 775,073 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
RH126774  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X74,208,168 - 74,208,400UniSTSGRCm38
MGSCv37X71,453,507 - 71,453,739UniSTSGRCm37
CeleraX65,462,284 - 65,462,516UniSTS
Cytogenetic MapXA7.3UniSTS
Whitehead/MRC_RHX864.62UniSTS
G65223  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X74,208,088 - 74,208,241UniSTSGRCm38
MGSCv37X71,453,427 - 71,453,580UniSTSGRCm37
CeleraX65,462,204 - 65,462,357UniSTS
Cytogenetic MapXA7.3UniSTS
cM MapX UniSTS
G65797  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA7.3UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
13208567Bmiq12_mbody mass index QTL 12 (mouse)X3526365377043606Mouse
1300794Spha2_msperm head anomaly 2 (mouse)Not determinedX3992149886260137Mouse
4142200Rtwq1_mreduced testis weight QTL 1 (mouse)Not determined4147706075477203Mouse
1301278Bdln1_mbody length 1 (mouse)Not determinedX4170210675702218Mouse
1300702Fcsa4_mfemoral cross-sectional area 4 (mouse)Not determinedX4602744480027567Mouse
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
25314311Syncl3_msynaptonemal complex length 3 (mouse)X5198887789743606Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
10412108Desp5_mdespair 5 (mouse)Not determinedX5472235188722351Mouse
13464140Hdlq108_mHDL QTL 108 (mouse)X5777196091771960Mouse
25314316Mlh1fc3_mMLH1 foci count 3 (mouse)X6134360689843606Mouse
25314318Sccor2_msynaptonemal complex length to mean MLH1 count ratio 2 (mouse)X7054360696543606Mouse
1357730Hstx1_mhybrid sterility, X chromosome 1 (mouse)Not determinedX7145385277600812Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined71453852139203212Mouse
12879918Shm4_msperm head morphology 4 (mouse)X72072050102062720Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:333
Count of miRNA genes:254
Interacting mature miRNAs:294
Transcripts:ENSMUST00000010127, ENSMUST00000156959
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000010127   ⟹   ENSMUSP00000010127
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX73,220,865 - 73,252,106 (+)Ensembl
GRCm38.p6 EnsemblX74,177,259 - 74,208,500 (+)Ensembl
RefSeq Acc Id: ENSMUST00000156959   ⟹   ENSMUSP00000117388
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX73,220,896 - 73,240,650 (+)Ensembl
GRCm38.p6 EnsemblX74,177,290 - 74,197,044 (+)Ensembl
RefSeq Acc Id: NM_031379   ⟹   NP_113556
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X73,220,865 - 73,252,104 (+)NCBI
GRCm38X74,177,259 - 74,208,498 (+)ENTREZGENE
MGSCv37X71,422,598 - 71,453,837 (+)RGD
CeleraX65,429,659 - 65,462,614 (+)RGD
cM MapX ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_113556   ⟸   NM_031379
- UniProtKB: Q8CDU7 (UniProtKB/Swiss-Prot),   Q99MX0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000117388   ⟸   ENSMUST00000156959
RefSeq Acc Id: ENSMUSP00000010127   ⟸   ENSMUST00000010127

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99MX0-F1-model_v2 AlphaFold Q99MX0 1-595 view protein structure

Promoters
RGD ID:13680770
Promoter ID:EPDNEW_M24534
Type:multiple initiation site
Name:Tktl1_1
Description:Mus musculus transketolase-like 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X74,177,255 - 74,177,315EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1933244 AgrOrtholog
Ensembl Genes ENSMUSG00000031397 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000010127 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000117388.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000010127 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000156959.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.920 UniProtKB/Swiss-Prot
InterPro THDP-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketo_C/PFOR_II UniProtKB/Swiss-Prot
  Transketolase-like_Pyr-bd UniProtKB/Swiss-Prot
  Transketolase_C UniProtKB/Swiss-Prot
  Transketolase_N UniProtKB/Swiss-Prot
KEGG Report mmu:83553 UniProtKB/Swiss-Prot
MGD MGI:1933244 ENTREZGENE
NCBI Gene 83553 ENTREZGENE
Pfam Transket_pyr UniProtKB/Swiss-Prot
  Transketolase_C UniProtKB/Swiss-Prot
  Transketolase_N UniProtKB/Swiss-Prot
PhenoGen Tktl1 PhenoGen
SMART Transket_pyr UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52922 UniProtKB/Swiss-Prot
UniProt D6REV0_MOUSE UniProtKB/TrEMBL
  Q8CDU7 ENTREZGENE
  Q99MX0 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B1AYP0 UniProtKB/Swiss-Prot
  Q684Q5 UniProtKB/Swiss-Prot
  Q8CDU7 UniProtKB/Swiss-Prot