Ppp1r3e (protein phosphatase 1, regulatory subunit 3E) - Rat Genome Database

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Gene: Ppp1r3e (protein phosphatase 1, regulatory subunit 3E) Mus musculus
Analyze
Symbol: Ppp1r3e
Name: protein phosphatase 1, regulatory subunit 3E
RGD ID: 1621403
MGI Page MGI
Description: Predicted to enable [phosphorylase] phosphatase activity; glycogen binding activity; and protein phosphatase 1 binding activity. Predicted to contribute to phosphoprotein phosphatase activity. Predicted to be involved in positive regulation of glycogen biosynthetic process and regulation of glycogen catabolic process. Predicted to be located in glycogen granule. Predicted to be part of protein phosphatase type 1 complex. Orthologous to human PPP1R3E (protein phosphatase 1 regulatory subunit 3E).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A630071A11Rik; AW049239; Gm1211; protein phosphatase 1 regulatory subunit 3E
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,113,054 - 55,114,995 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,110,126 - 55,115,007 (-)EnsemblGRCm39 Ensembl
GRCm381454,875,597 - 54,877,538 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,872,669 - 54,877,550 (-)EnsemblGRCm38mm10GRCm38
MGSCv371455,494,434 - 55,496,375 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361453,829,802 - 53,833,887 (-)NCBIMGSCv36mm8
Celera1452,681,503 - 52,683,444 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1427.97NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A novel glycogen-targeting subunit of protein phosphatase 1 that is regulated by insulin and shows differential tissue distribution in humans and rodents. Munro S, etal., FEBS J. 2005 Mar;272(6):1478-89.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:14610273   PMID:16141072   PMID:16141073   PMID:21873635  


Genomics

Comparative Map Data
Ppp1r3e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,113,054 - 55,114,995 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,110,126 - 55,115,007 (-)EnsemblGRCm39 Ensembl
GRCm381454,875,597 - 54,877,538 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,872,669 - 54,877,550 (-)EnsemblGRCm38mm10GRCm38
MGSCv371455,494,434 - 55,496,375 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361453,829,802 - 53,833,887 (-)NCBIMGSCv36mm8
Celera1452,681,503 - 52,683,444 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1427.97NCBI
PPP1R3E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381423,295,652 - 23,302,859 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1423,295,652 - 23,302,859 (-)EnsemblGRCh38hg38GRCh38
GRCh371423,764,861 - 23,772,068 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,832,901 - 22,841,835 (-)NCBINCBI36Build 36hg18NCBI36
Celera143,627,819 - 3,634,764 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,881,804 - 3,888,734 (-)NCBIHuRef
CHM1_11423,763,798 - 23,770,725 (-)NCBICHM1_1
T2T-CHM13v2.01417,496,654 - 17,503,863 (-)NCBIT2T-CHM13v2.0
Ppp1r3e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,318,435 - 32,319,595 (-)NCBIGRCr8
mRatBN7.21528,348,443 - 28,349,603 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,347,854 - 28,349,603 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,194,105 - 30,195,265 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,341,307 - 31,342,467 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,584,033 - 29,585,193 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,535,986 - 33,537,146 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,535,986 - 33,537,146 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,422,932 - 37,424,092 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41532,974,172 - 32,975,332 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1527,926,360 - 27,927,520 (-)NCBICelera
Cytogenetic Map15p13NCBI
Ppp1r3e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540937,022,140 - 37,023,312 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540937,016,851 - 37,025,125 (+)NCBIChiLan1.0ChiLan1.0
PPP1R3E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21524,731,153 - 24,734,892 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11423,947,911 - 23,951,382 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,118,827 - 4,122,294 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11422,210,106 - 22,217,167 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,215,635 - 22,216,794 (-)Ensemblpanpan1.1panPan2
PPP1R3E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.183,559,296 - 3,564,849 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl83,563,457 - 3,564,524 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha83,507,425 - 3,513,188 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.083,666,878 - 3,672,635 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,671,247 - 3,672,314 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,358,489 - 3,364,245 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,419,802 - 3,425,549 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,681,735 - 3,687,492 (-)NCBIUU_Cfam_GSD_1.0
Ppp1r3e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864035,322,381 - 35,325,751 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367221,063,576 - 1,066,617 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367221,062,669 - 1,066,611 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R3E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,776,720 - 75,780,649 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,770,813 - 75,782,717 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,960,919 - 80,970,099 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R3E
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,671,906 - 23,675,340 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2923,673,995 - 23,675,136 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605922,743,548 - 22,750,342 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r3e
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248209,248,989 - 9,252,604 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248209,246,477 - 9,255,803 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp1r3e
23 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:828
Count of miRNA genes:406
Interacting mature miRNAs:466
Transcripts:ENSMUST00000168622, ENSMUST00000177403, ENSMUST00000182700
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
27226737Metcl12_mmetatarsal-calcaneal length 12, 10 week (mouse)143322195759437449Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141484Hcbip1_mhexachlorobenzene induced porphyria 1 (mouse)Not determined4733525059962593Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
14746973Manh76_mmandible shape 76 (mouse)142228721756287217Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse

Markers in Region
AW049239  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381454,872,902 - 54,872,990UniSTSGRCm38
MGSCv371455,491,739 - 55,491,827UniSTSGRCm37
Celera1452,678,291 - 52,678,379UniSTS
Cytogenetic Map14C1UniSTS
Whitehead/MRC_RH14598.36UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000168622   ⟹   ENSMUSP00000134915
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,113,054 - 55,114,995 (-)Ensembl
GRCm38.p6 Ensembl1454,875,597 - 54,877,538 (-)Ensembl
Ensembl Acc Id: ENSMUST00000177403   ⟹   ENSMUSP00000134894
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,110,138 - 55,115,007 (-)Ensembl
GRCm38.p6 Ensembl1454,872,681 - 54,877,550 (-)Ensembl
Ensembl Acc Id: ENSMUST00000182700
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,110,126 - 55,110,769 (-)Ensembl
GRCm38.p6 Ensembl1454,872,669 - 54,873,312 (-)Ensembl
Ensembl Acc Id: ENSMUST00000194094
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,113,054 - 55,114,078 (-)Ensembl
GRCm38.p6 Ensembl1454,875,597 - 54,876,621 (-)Ensembl
RefSeq Acc Id: NM_001167908   ⟹   NP_001161380
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391455,113,054 - 55,114,995 (-)NCBI
GRCm381454,875,597 - 54,877,538 (-)ENTREZGENE
MGSCv371455,494,434 - 55,496,375 (-)RGD
Celera1452,681,503 - 52,683,444 (-)RGD
cM Map14 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001161380 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC31772 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000134894.2
  ENSMUSP00000134915
  ENSMUSP00000134915.2
GenBank Protein Q8BRJ4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001161380   ⟸   NM_001167908
- UniProtKB: Q8BRJ4 (UniProtKB/Swiss-Prot),   H3BJB2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000134894   ⟸   ENSMUST00000177403
Ensembl Acc Id: ENSMUSP00000134915   ⟸   ENSMUST00000168622
Protein Domains
CBM21

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BRJ4-F1-model_v2 AlphaFold Q8BRJ4 1-279 view protein structure

Promoters
RGD ID:8682372
Promoter ID:EPDNEW_M19217
Type:multiple initiation site
Name:Ppp1r3e_1
Description:Mus musculus protein phosphatase 1, regulatory subunit 3E , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381454,877,553 - 54,877,613EPDNEW
RGD ID:6825299
Promoter ID:MM_KWN:16909
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000100563,   NM_001167908
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361455,495,356 - 55,496,272 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2145790 AgrOrtholog
Ensembl Genes ENSMUSG00000072494 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000168622 ENTREZGENE
  ENSMUST00000168622.2 UniProtKB/TrEMBL
  ENSMUST00000177403.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.2440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CBM21_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CBM21_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP1_regulatory_subunit_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:105651 UniProtKB/TrEMBL
MGD MGI:2145790 ENTREZGENE
NCBI Gene 105651 ENTREZGENE
PANTHER PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CBM_21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppp1r3e PhenoGen
PROSITE CBM21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt H3BJB2 ENTREZGENE, UniProtKB/TrEMBL
  PPR3E_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-29 Ppp1r3e  protein phosphatase 1, regulatory subunit 3E    protein phosphatase 1, regulatory (inhibitor) subunit 3E  Symbol and/or name change 5135510 APPROVED