Spryd3 (SPRY domain containing 3) - Rat Genome Database

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Gene: Spryd3 (SPRY domain containing 3) Mus musculus
Analyze
Symbol: Spryd3
Name: SPRY domain containing 3
RGD ID: 1621350
MGI Page MGI
Description: Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human SPRYD3 (SPRY domain containing 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BC008150; SPRY domain-containing protein 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915102,024,961 - 102,044,678 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15102,024,963 - 102,044,669 (-)EnsemblGRCm39 Ensembl
GRCm3815102,116,526 - 102,136,218 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,116,528 - 102,136,234 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715101,946,959 - 101,966,646 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615101,944,379 - 101,964,251 (-)NCBIMGSCv36mm8
Celera15104,272,445 - 104,291,128 (-)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1557.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:15782199   PMID:16141072   PMID:16141073   PMID:18799693  
PMID:21267068   PMID:21873635   PMID:34321999  


Genomics

Comparative Map Data
Spryd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915102,024,961 - 102,044,678 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15102,024,963 - 102,044,669 (-)EnsemblGRCm39 Ensembl
GRCm3815102,116,526 - 102,136,218 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,116,528 - 102,136,234 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715101,946,959 - 101,966,646 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615101,944,379 - 101,964,251 (-)NCBIMGSCv36mm8
Celera15104,272,445 - 104,291,128 (-)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1557.3NCBI
SPRYD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381253,064,316 - 53,079,390 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1253,064,316 - 53,079,404 (-)EnsemblGRCh38hg38GRCh38
GRCh371253,458,100 - 53,473,174 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,744,665 - 51,759,405 (-)NCBINCBI36Build 36hg18NCBI36
Celera1253,105,994 - 53,121,098 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,501,184 - 50,516,289 (-)NCBIHuRef
CHM1_11253,424,507 - 53,439,612 (-)NCBICHM1_1
T2T-CHM13v2.01253,028,683 - 53,043,758 (-)NCBIT2T-CHM13v2.0
Spryd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,126,598 - 135,143,775 (-)NCBIGRCr8
mRatBN7.27133,247,982 - 133,265,161 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,247,981 - 133,265,202 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7135,009,334 - 135,026,503 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,238,700 - 137,255,869 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,217,622 - 137,235,005 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,721,088 - 143,738,237 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,721,088 - 143,738,237 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,517,639 - 141,534,847 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,857,095 - 140,874,240 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7129,683,279 - 129,700,424 (-)NCBICelera
Cytogenetic Map7q36NCBI
Spryd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955458348,752 - 367,264 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955458347,600 - 367,264 (-)NCBIChiLan1.0ChiLan1.0
SPRYD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21041,109,199 - 41,124,520 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11241,105,965 - 41,121,286 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01235,677,077 - 35,691,926 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11236,458,094 - 36,473,169 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,458,094 - 36,473,169 (+)Ensemblpanpan1.1panPan2
SPRYD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,080,644 - 2,096,069 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,080,700 - 2,095,157 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2744,153,172 - 44,168,610 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,084,754 - 2,100,577 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,084,794 - 2,100,577 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1272,101,783 - 2,117,478 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,088,232 - 2,103,818 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,551,899 - 44,567,615 (-)NCBIUU_Cfam_GSD_1.0
Spryd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494562,758,484 - 62,776,723 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651210,390,626 - 10,406,555 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651210,382,651 - 10,406,326 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPRYD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,320,759 - 18,338,648 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1518,321,006 - 18,338,691 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,884,021 - 18,901,703 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPRYD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11149,183,353 - 49,207,741 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1149,184,586 - 49,198,556 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037196,867,196 - 196,882,697 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spryd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249041,129,077 - 1,146,256 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249041,129,077 - 1,145,651 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Spryd3
679 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:871
Count of miRNA genes:503
Interacting mature miRNAs:584
Transcripts:ENSMUST00000128884, ENSMUST00000139279, ENSMUST00000154032, ENSMUST00000156475
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570349271104073951Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570349271104073951Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572382669104073951Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573430144104073951Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577527592104073951Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78601103102901704Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578601103102901704Mouse
14928306Manh79_mmandible shape 79 (mouse)1578847557104073951Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1578897881104073951Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579163411104073951Mouse
4141897Imrfq2_mimmune response to Factor IX QTL 2 (mouse)Not determined79908940104073951Mouse
1301284Cosz3_mcocaine seizure 3 (mouse)Not determined1580313634104073951Mouse
4141902Cia37_mcollagen induced arthritis 37 (mouse)Not determined1580884933104073951Mouse
1300974Pgia9_mproteoglycan induced arthritis 9 (mouse)Not determined1580884933104073951Mouse
4141511Gdcr1_mglycerolphosphate dehydrogenase regulator 1 (mouse)Not determined82615474104073951Mouse
11530037Sluc34a_msusceptibility to lung cancer 34a (mouse)1585896437104073951Mouse
11530038Sluc34b_msusceptibility to lung cancer 34b (mouse)1585896437104073951Mouse
1357614Bmca_mbile mucin accumulation (mouse)Not determined1585896437104073951Mouse
1301918Skull22_mskull morphology 22 (mouse)Not determined1585901546104073951Mouse
4141581Dshv1_mdorsal hippocampal volume 1 (mouse)Not determined92788640103425899Mouse
14700689Carg5_mCandida albicans resistance gene 5 (mouse)1597697881103008427Mouse
11528547Sluc34_msusceptibility to lung cancer 34 (mouse)1597884933102896555Mouse

Markers in Region
UniSTS:237411  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3815102,117,003 - 102,117,168UniSTSGRCm38
MGSCv3715101,947,434 - 101,947,599UniSTSGRCm37
Celera15104,272,920 - 104,273,085UniSTS
Cytogenetic Map15F3UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000128884
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,026,604 - 102,037,319 (-)Ensembl
GRCm38.p6 Ensembl15102,118,169 - 102,128,884 (-)Ensembl
RefSeq Acc Id: ENSMUST00000139279
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,024,963 - 102,044,627 (-)Ensembl
GRCm38.p6 Ensembl15102,116,528 - 102,136,192 (-)Ensembl
RefSeq Acc Id: ENSMUST00000154032   ⟹   ENSMUSP00000121493
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,024,963 - 102,044,669 (-)Ensembl
GRCm38.p6 Ensembl15102,116,528 - 102,136,234 (-)Ensembl
RefSeq Acc Id: ENSMUST00000156475
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,038,647 - 102,039,337 (-)Ensembl
GRCm38.p6 Ensembl15102,130,212 - 102,130,902 (-)Ensembl
RefSeq Acc Id: NM_001033277   ⟹   NP_001028449
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915102,024,963 - 102,044,650 (-)NCBI
GRCm3815102,116,528 - 102,136,215 (-)NCBI
MGSCv3715101,946,959 - 101,966,646 (-)RGD
Celera15104,272,445 - 104,291,128 (-)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006520886   ⟹   XP_006520949
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915102,024,961 - 102,044,678 (-)NCBI
GRCm3815102,116,526 - 102,136,218 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001028449 (Get FASTA)   NCBI Sequence Viewer  
  XP_006520949 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH08150 (Get FASTA)   NCBI Sequence Viewer  
  BAE27362 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000121493
  ENSMUSP00000121493.2
Reference Protein Sequences
RefSeq Acc Id: NP_001028449   ⟸   NM_001033277
- UniProtKB: E9Q9B3 (UniProtKB/TrEMBL),   Q3UIZ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006520949   ⟸   XM_006520886
- Peptide Label: isoform X1
- UniProtKB: Q3UIZ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000121493   ⟸   ENSMUST00000154032
Protein Domains
B30.2/SPRY   SPRY

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9Q9B3-F1-model_v2 AlphaFold E9Q9B3 1-442 view protein structure

Promoters
RGD ID:6848662
Promoter ID:MM_TRO:3709
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day4
Transcripts:MTR067823.15.1853.3
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3615101,948,391 - 101,948,891 (-)MPROMDB
RGD ID:6826512
Promoter ID:MM_KWN:19824
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000085848
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3615101,958,831 - 101,959,331 (-)MPROMDB
RGD ID:6826509
Promoter ID:MM_KWN:19826
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000100176,   OTTMUST00000085843,   OTTMUST00000085846,   UC007XUQ.1,   UC007XUR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3615101,966,481 - 101,967,092 (-)MPROMDB
RGD ID:8685172
Promoter ID:EPDNEW_M20616
Type:multiple initiation site
Name:Spryd3_1
Description:Mus musculus SPRY domain containing 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3815102,136,207 - 102,136,267EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2446175 AgrOrtholog
Ensembl Genes ENSMUSG00000036966 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000154032 ENTREZGENE
  ENSMUST00000154032.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.920 UniProtKB/TrEMBL
InterPro B30.2/SPRY UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/TrEMBL
  ConA-like_dom UniProtKB/TrEMBL
  SPRY_rcpt UniProtKB/TrEMBL
  SPRYD3_SPRY UniProtKB/TrEMBL
KEGG Report mmu:223918 UniProtKB/TrEMBL
MGD MGI:2446175 ENTREZGENE
NCBI Gene 223918 ENTREZGENE
PANTHER RAN BINDING PROTEIN 9-RELATED UniProtKB/TrEMBL
  SPRY DOMAIN-CONTAINING PROTEIN 3 UniProtKB/TrEMBL
Pfam SPRY UniProtKB/TrEMBL
PhenoGen Spryd3 PhenoGen
PROSITE B302_SPRY UniProtKB/TrEMBL
SMART SPRY UniProtKB/TrEMBL
Superfamily-SCOP ConA_like_lec_gl UniProtKB/TrEMBL
UniProt E9Q9B3 ENTREZGENE, UniProtKB/TrEMBL
  Q3UIZ3 ENTREZGENE, UniProtKB/TrEMBL
  Q922G6_MOUSE UniProtKB/TrEMBL