Ddx60 (DExD/H box helicase 60) - Rat Genome Database
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Gene: Ddx60 (DExD/H box helicase 60) Mus musculus
Analyze
Symbol: Ddx60
Name: DExD/H box helicase 60
RGD ID: 1621319
MGI Page MGI
Description: Exhibits RNA binding activity. Involved in defense response to virus. Localizes to cytoplasm. Is expressed in lens. Orthologous to human DDX60 (DExD/H-box helicase 60); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9830118M07; DEAD (Asp-Glu-Ala-Asp) box polypeptide 60; MGC19297; probable ATP-dependent RNA helicase DDX60
RGD Orthologs
Human
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39862,381,121 - 62,490,735 (+)NCBIGRCm39mm39
GRCm38861,928,073 - 62,037,704 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl861,928,087 - 62,038,244 (+)EnsemblGRCm38mm10GRCm38
MGSCv37864,406,886 - 64,516,492 (+)NCBIGRCm37mm9NCBIm37
MGSCv36864,820,231 - 64,929,843 (+)NCBImm8
Celera864,500,606 - 64,610,201 (+)NCBICelera
Cytogenetic Map8B3.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:16141072   PMID:16141073   PMID:18755693   PMID:21267068   PMID:21282332  
PMID:21677750   PMID:21791617   PMID:25981042   PMID:26457795  


Genomics

Comparative Map Data
Ddx60
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39862,381,121 - 62,490,735 (+)NCBIGRCm39mm39
GRCm38861,928,073 - 62,037,704 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl861,928,087 - 62,038,244 (+)EnsemblGRCm38mm10GRCm38
MGSCv37864,406,886 - 64,516,492 (+)NCBIGRCm37mm9NCBIm37
MGSCv36864,820,231 - 64,929,843 (+)NCBImm8
Celera864,500,606 - 64,610,201 (+)NCBICelera
Cytogenetic Map8B3.1NCBI
DDX60
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4168,216,294 - 168,318,804 (-)EnsemblGRCh38hg38GRCh38
GRCh384168,216,293 - 168,325,981 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374169,137,442 - 169,239,958 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364169,374,020 - 169,476,478 (-)NCBINCBI36hg18NCBI36
Celera4166,467,307 - 166,569,805 (-)NCBI
Cytogenetic Map4q32.3NCBI
HuRef4164,890,816 - 164,992,748 (-)NCBIHuRef
CHM1_14169,114,069 - 169,216,585 (-)NCBICHM1_1
Ddx60
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540337,679,730 - 37,765,886 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540337,679,939 - 37,765,074 (+)NCBIChiLan1.0ChiLan1.0
DDX60
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14172,501,059 - 172,603,180 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v04160,376,930 - 160,532,561 (-)NCBIMhudiblu_PPA_v0panPan3
DDX60
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1563,649,875 - 63,734,920 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11563,649,441 - 63,741,357 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ddx60
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936516649,217 - 735,499 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DDX60
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1421,083,350 - 21,163,563 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11421,077,491 - 21,163,563 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21422,291,771 - 22,365,670 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DDX60
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17114,474,678 - 114,578,749 (-)NCBI
ChlSab1.1 Ensembl7114,474,680 - 114,578,563 (-)Ensembl

Position Markers
Ddx60  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8B3.1UniSTS
cM Map8 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83383736267837502Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:514
Count of miRNA genes:306
Interacting mature miRNAs:332
Transcripts:ENSMUST00000070631, ENSMUST00000093485, ENSMUST00000136121, ENSMUST00000153806, ENSMUST00000154398, ENSMUST00000155209, ENSMUST00000156980
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001293783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011242214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036153913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036153914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001778429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC139846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC144858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC043663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000070631   ⟹   ENSMUSP00000070741
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl861,928,089 - 62,038,244 (+)Ensembl
RefSeq Acc Id: ENSMUST00000093485   ⟹   ENSMUSP00000091197
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl861,928,089 - 62,037,695 (+)Ensembl
RefSeq Acc Id: ENSMUST00000136121
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl862,021,060 - 62,037,695 (+)Ensembl
RefSeq Acc Id: ENSMUST00000153806
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl861,984,138 - 61,988,309 (+)Ensembl
RefSeq Acc Id: ENSMUST00000154398   ⟹   ENSMUSP00000122841
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl861,928,087 - 61,963,742 (+)Ensembl
RefSeq Acc Id: ENSMUST00000156980   ⟹   ENSMUSP00000120424
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl861,928,089 - 61,940,740 (+)Ensembl
RefSeq Acc Id: NM_001293783   ⟹   NP_001280712
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39862,381,121 - 62,490,735 (+)NCBI
GRCm38861,928,087 - 62,037,701 (+)NCBI
Celera864,500,604 - 64,610,207 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006509393   ⟹   XP_006509456
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39862,381,155 - 62,490,735 (+)NCBI
GRCm38861,928,087 - 62,037,704 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006509396   ⟹   XP_006509459
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39862,381,155 - 62,440,474 (+)NCBI
GRCm38861,928,087 - 61,987,434 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011242214   ⟹   XP_011240516
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39862,381,155 - 62,439,123 (+)NCBI
GRCm38861,928,087 - 61,986,089 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017312697   ⟹   XP_017168186
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39862,381,155 - 62,441,190 (+)NCBI
GRCm38861,928,087 - 61,988,156 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017312698   ⟹   XP_017168187
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39862,381,155 - 62,432,283 (+)NCBI
GRCm38861,928,087 - 61,979,249 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036153913   ⟹   XP_036009806
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39862,403,540 - 62,490,735 (+)NCBI
RefSeq Acc Id: XM_036153914   ⟹   XP_036009807
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39862,381,155 - 62,439,123 (+)NCBI
RefSeq Acc Id: XR_001778429
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39862,381,155 - 62,453,626 (+)NCBI
GRCm38861,928,087 - 62,000,592 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_006509459   ⟸   XM_006509396
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_006509456   ⟸   XM_006509393
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001280712   ⟸   NM_001293783
- UniProtKB: G3X9F7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011240516   ⟸   XM_011242214
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017168187   ⟸   XM_017312698
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_017168186   ⟸   XM_017312697
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSMUSP00000070741   ⟸   ENSMUST00000070631
RefSeq Acc Id: ENSMUSP00000091197   ⟸   ENSMUST00000093485
RefSeq Acc Id: ENSMUSP00000122841   ⟸   ENSMUST00000154398
RefSeq Acc Id: ENSMUSP00000120424   ⟸   ENSMUST00000156980
RefSeq Acc Id: XP_036009807   ⟸   XM_036153914
- Peptide Label: isoform X4
RefSeq Acc Id: XP_036009806   ⟸   XM_036153913
- Peptide Label: isoform X2
Promoters
RGD ID:8667159
Promoter ID:EPDNEW_M11611
Type:initiation region
Name:Ddx60_1
Description:Mus musculus DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38861,928,121 - 61,928,181EPDNEW
RGD ID:6842832
Promoter ID:MM_KWN:54516
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung
Transcripts:NM_001081215,   OTTMUST00000078066,   OTTMUST00000078070,   OTTMUST00000078071,   UC009LUL.1,   UC009LUM.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36864,406,011 - 64,407,097 (+)MPROMDB
RGD ID:6843021
Promoter ID:MM_KWN:54518
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000078068
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36864,499,121 - 64,499,621 (+)MPROMDB
RGD ID:6843022
Promoter ID:MM_KWN:54519
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:OTTMUST00000078069
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36864,502,726 - 64,503,226 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2384570 AgrOrtholog
Ensembl Genes ENSMUSG00000037921 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000070741 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000091197 UniProtKB/TrEMBL
  ENSMUSP00000120424 UniProtKB/TrEMBL
  ENSMUSP00000122841 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000070631 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000093485 UniProtKB/TrEMBL
  ENSMUST00000154398 UniProtKB/TrEMBL
  ENSMUST00000156980 UniProtKB/TrEMBL
InterPro DNA/RNA_helicase_DEAD/DEAH_N UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report mmu:234311 UniProtKB/TrEMBL
MGD MGI:2384570 ENTREZGENE
NCBI Gene 234311 ENTREZGENE
Pfam DEAD UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
PhenoGen Ddx60 PhenoGen
PROSITE HELICASE_ATP_BIND_1 UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/TrEMBL
SMART DEXDc UniProtKB/TrEMBL
  HELICc UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniGene Mm.275233 ENTREZGENE
UniProt D3YZ76_MOUSE UniProtKB/TrEMBL
  D3Z3B3_MOUSE UniProtKB/TrEMBL
  E9PZQ1_MOUSE UniProtKB/TrEMBL
  G3X9F7 ENTREZGENE, UniProtKB/TrEMBL
  Q811K8_MOUSE UniProtKB/TrEMBL
  Q8CB98_MOUSE UniProtKB/TrEMBL
  Q91VI2_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-04-07 Ddx60  DExD/H box helicase 60  Ddx60  DEAD (Asp-Glu-Ala-Asp) box polypeptide 60  Symbol and/or name change 5135510 APPROVED