Trim60 (tripartite motif-containing 60) - Rat Genome Database
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Gene: Trim60 (tripartite motif-containing 60) Mus musculus
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Symbol: Trim60
Name: tripartite motif-containing 60
RGD ID: 1621318
MGI Page MGI
Description: Predicted to have ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to localize to cytoplasm. Is expressed in early conceptus; gonad; and urinary system. Orthologous to human TRIM60 (tripartite motif containing 60); INTERACTS WITH N-ethyl-N-nitrosourea; valproic acid; arsane (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2czf45; ring finger protein 33; Rnf; Rnf33; tripartite motif-containing protein 60
RGD Orthologs
Human
Rat
Bonobo
Dog
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39865,451,100 - 65,471,340 (-)NCBIGRCm39mm39
GRCm38864,998,448 - 65,018,688 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl864,999,307 - 65,018,584 (-)EnsemblGRCm38mm10GRCm38
MGSCv37867,522,347 - 67,542,587 (-)NCBIGRCm37mm9NCBIm37
MGSCv36867,929,042 - 67,947,566 (-)NCBImm8
Celera867,559,812 - 67,582,546 (-)NCBICelera
Cytogenetic Map8B3.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:11424210   PMID:12160726   PMID:12433986   PMID:12466851   PMID:12477932  
PMID:15618518   PMID:16141072   PMID:16141073   PMID:18287559   PMID:21267068   PMID:21873635   PMID:21909995  


Genomics

Comparative Map Data
Trim60
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39865,451,100 - 65,471,340 (-)NCBIGRCm39mm39
GRCm38864,998,448 - 65,018,688 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl864,999,307 - 65,018,584 (-)EnsemblGRCm38mm10GRCm38
MGSCv37867,522,347 - 67,542,587 (-)NCBIGRCm37mm9NCBIm37
MGSCv36867,929,042 - 67,947,566 (-)NCBImm8
Celera867,559,812 - 67,582,546 (-)NCBICelera
Cytogenetic Map8B3.1NCBI
TRIM60
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4165,016,458 - 165,041,749 (+)EnsemblGRCh38hg38GRCh38
GRCh384165,031,953 - 165,041,821 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374165,953,151 - 165,962,896 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364166,172,601 - 166,182,346 (+)NCBINCBI36hg18NCBI36
Build 344166,310,755 - 166,320,501NCBI
Celera4163,284,633 - 163,294,264 (+)NCBI
Cytogenetic Map4q32.3NCBI
HuRef4161,706,427 - 161,716,170 (+)NCBIHuRef
CHM1_14165,929,664 - 165,939,409 (+)NCBICHM1_1
Trim60
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01626,602,941 - 26,604,692 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01626,485,843 - 26,487,261 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41626,463,664 - 26,465,082 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1624,807,709 - 24,809,432 (+)NCBICelera
Cytogenetic Map16p13NCBI
TRIM60
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14169,274,623 - 169,285,387 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4169,283,716 - 169,285,131 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04157,222,400 - 157,233,643 (+)NCBIMhudiblu_PPA_v0panPan3
TRIM61
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11561,019,766 - 61,021,170 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
TRIM60
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl7111,396,744 - 111,398,159 (+)Ensembl
ChlSab1.17111,387,027 - 111,398,428 (+)NCBI

Position Markers
RH127152  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38865,012,992 - 65,013,234UniSTSGRCm38
MGSCv37867,536,891 - 67,537,133UniSTSGRCm37
Celera867,574,377 - 67,574,619UniSTS
Cytogenetic Map8B3.1-3.2UniSTS
Whitehead/MRC_RH8708.4UniSTS
RH136249  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38865,013,051 - 65,013,262UniSTSGRCm38
MGSCv37867,536,950 - 67,537,161UniSTSGRCm37
Celera867,574,436 - 67,574,647UniSTS
Cytogenetic Map8B3.1-3.2UniSTS
RH124364  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38865,000,269 - 65,000,412UniSTSGRCm38
MGSCv37867,524,168 - 67,524,311UniSTSGRCm37
Celera867,561,633 - 67,561,776UniSTS
Cytogenetic Map8B3.1-3.2UniSTS
UniSTS:235901  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38865,000,953 - 65,001,283UniSTSGRCm38
MGSCv37867,524,852 - 67,525,182UniSTSGRCm37
Celera867,562,317 - 67,562,647UniSTS
Cytogenetic Map8B3.1-3.2UniSTS
UniSTS:235900  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38864,999,561 - 64,999,762UniSTSGRCm38
MGSCv37867,523,460 - 67,523,661UniSTSGRCm37
Celera867,560,925 - 67,561,126UniSTS
Cytogenetic Map8B3.1-3.2UniSTS
UniSTS:235902  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38865,013,857 - 65,014,069UniSTSGRCm38
MGSCv37867,537,756 - 67,537,968UniSTSGRCm37
Celera867,575,242 - 67,575,454UniSTS
Cytogenetic Map8B3.1-3.2UniSTS
PMC137171P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38865,014,487 - 65,014,878UniSTSGRCm38
MGSCv37867,538,386 - 67,538,777UniSTSGRCm37
Celera867,575,872 - 67,576,263UniSTS
Cytogenetic Map8B3.1-3.2UniSTS
Trim61  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38865,013,256 - 65,014,878UniSTSGRCm38
MGSCv37867,537,155 - 67,538,777UniSTSGRCm37
Celera867,574,641 - 67,576,263UniSTS
Cytogenetic Map8B3.1-3.2UniSTS
Rnf35  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38865,013,256 - 65,013,790UniSTSGRCm38
MGSCv37867,537,155 - 67,537,689UniSTSGRCm37
Celera867,574,641 - 67,575,175UniSTS
Cytogenetic Map8B3.1-3.2UniSTS
cM Map8 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83383736267837502Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:588
Count of miRNA genes:423
Interacting mature miRNAs:473
Transcripts:ENSMUST00000048565
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000048565   ⟹   ENSMUSP00000040299
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl864,999,307 - 65,018,584 (-)Ensembl
RefSeq Acc Id: NM_153097   ⟹   NP_694737
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39865,451,100 - 65,471,340 (-)NCBI
GRCm38864,998,448 - 65,018,688 (-)ENTREZGENE
MGSCv37867,522,347 - 67,542,587 (-)RGD
Celera867,559,812 - 67,582,546 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_694737   ⟸   NM_153097
- UniProtKB: Q8VI40 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000040299   ⟸   ENSMUST00000048565
Protein Domains
B box-type   B30.2/SPRY   RING-type


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2387430 AgrOrtholog
Ensembl Genes ENSMUSG00000053490 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000040299 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000048565 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro B30.2/SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Butyrophylin_SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY/PRY_TRIM60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_B-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:234329 UniProtKB/Swiss-Prot
MGD MGI:2387430 ENTREZGENE
NCBI Gene 234329 ENTREZGENE
Pfam PRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-B_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Trim60 PhenoGen
PRINTS BUTYPHLNCDUF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_BBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.28010 ENTREZGENE
UniProt B2RTP1_MOUSE UniProtKB/TrEMBL
  Q8VI40 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q3UX74 UniProtKB/Swiss-Prot