Ddx49 (DEAD box helicase 49) - Rat Genome Database
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Gene: Ddx49 (DEAD box helicase 49) Mus musculus
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Symbol: Ddx49
Name: DEAD box helicase 49
RGD ID: 1621314
MGI Page MGI
Description: Predicted to have ATP binding activity; RNA binding activity; and helicase activity. Predicted to be involved in positive regulation of cell growth; rRNA processing; and regulation of rRNA stability. Predicted to localize to nucleus. Orthologous to human DDX49 (DEAD-box helicase 49); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; choline.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DEAD (Asp-Glu-Ala-Asp) box polypeptide 49; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 27; DEAD box protein 49; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 49; probable ATP-dependent RNA helicase DDX49; R27090_; R27090_2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,745,516 - 70,755,121 (-)NCBIGRCm39mm39
GRCm38870,292,866 - 70,302,471 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,292,866 - 70,302,489 (-)EnsemblGRCm38mm10GRCm38
MGSCv37872,816,765 - 72,826,351 (-)NCBIGRCm37mm9NCBIm37
MGSCv36873,221,855 - 73,231,441 (-)NCBImm8
Celera872,849,364 - 72,858,949 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA)

Molecular Function

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11353399   PMID:11544199   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15489334   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22922362  


Genomics

Comparative Map Data
Ddx49
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,745,516 - 70,755,121 (-)NCBIGRCm39mm39
GRCm38870,292,866 - 70,302,471 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,292,866 - 70,302,489 (-)EnsemblGRCm38mm10GRCm38
MGSCv37872,816,765 - 72,826,351 (-)NCBIGRCm37mm9NCBIm37
MGSCv36873,221,855 - 73,231,441 (-)NCBImm8
Celera872,849,364 - 72,858,949 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
DDX49
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1918,919,705 - 18,929,189 (+)EnsemblGRCh38hg38GRCh38
GRCh381918,919,703 - 18,928,630 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371919,030,484 - 19,039,442 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,891,494 - 18,900,436 (+)NCBINCBI36hg18NCBI36
Build 341918,891,493 - 18,900,436NCBI
Celera1918,935,308 - 18,944,265 (+)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1918,594,898 - 18,603,856 (+)NCBIHuRef
CHM1_11919,030,151 - 19,039,109 (+)NCBICHM1_1
Ddx49
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01620,873,585 - 20,881,312 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,873,642 - 20,881,439 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,725,435 - 20,733,085 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,609,670 - 19,617,320 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11619,609,685 - 19,617,247 (+)NCBI
Celera1619,315,664 - 19,323,314 (+)NCBICelera
Cytogenetic Map16p14NCBI
Ddx49
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555242,760,860 - 2,767,665 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555242,760,692 - 2,767,709 (-)NCBIChiLan1.0ChiLan1.0
DDX49
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11919,364,949 - 19,373,869 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1919,364,949 - 19,373,869 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01918,357,682 - 18,366,614 (+)NCBIMhudiblu_PPA_v0panPan3
DDX49
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2044,187,264 - 44,195,467 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12044,187,407 - 44,195,131 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ddx49
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365962,414,380 - 2,422,730 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DDX49
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl258,920,529 - 58,930,685 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1258,922,985 - 58,930,710 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2258,721,788 - 58,729,508 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DDX49
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl617,376,273 - 17,384,663 (+)Ensembl
ChlSab1.1617,376,050 - 17,384,625 (+)NCBI
Ddx49
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249081,963,701 - 1,970,634 (+)NCBI

Position Markers
AW146114  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38870,293,221 - 70,293,370UniSTSGRCm38
MGSCv37872,817,120 - 72,817,269UniSTSGRCm37
Celera872,849,719 - 72,849,868UniSTS
Cytogenetic Map8C1UniSTS
Cytogenetic Map8B3.3UniSTS
Whitehead/MRC_RH8741.13UniSTS
RH118314  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38870,303,360 - 70,303,538UniSTSGRCm38
MGSCv37872,827,259 - 72,827,437UniSTSGRCm37
Celera872,859,857 - 72,860,035UniSTS
Cytogenetic Map8B3.3UniSTS
Whitehead/MRC_RH8740.57UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1113
Count of miRNA genes:561
Interacting mature miRNAs:658
Transcripts:ENSMUST00000008004, ENSMUST00000127076, ENSMUST00000127094, ENSMUST00000138688, ENSMUST00000144890
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000008004   ⟹   ENSMUSP00000008004
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,292,866 - 70,302,489 (-)Ensembl
RefSeq Acc Id: ENSMUST00000127076
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,300,911 - 70,302,434 (-)Ensembl
RefSeq Acc Id: ENSMUST00000127094
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,293,586 - 70,295,737 (-)Ensembl
RefSeq Acc Id: ENSMUST00000138688
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,295,820 - 70,302,463 (-)Ensembl
RefSeq Acc Id: ENSMUST00000144890
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,292,877 - 70,302,452 (-)Ensembl
RefSeq Acc Id: NM_001024922   ⟹   NP_001020093
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,745,516 - 70,755,102 (-)NCBI
GRCm38870,292,866 - 70,302,452 (-)NCBI
MGSCv37872,816,765 - 72,826,351 (-)RGD
Celera872,849,364 - 72,858,949 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_157058
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,745,516 - 70,755,121 (-)NCBI
GRCm38870,292,866 - 70,302,471 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001020093 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH99554 (Get FASTA)   NCBI Sequence Viewer  
  BAE23880 (Get FASTA)   NCBI Sequence Viewer  
  EDL28805 (Get FASTA)   NCBI Sequence Viewer  
  Q4FZF3 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001020093   ⟸   NM_001024922
- UniProtKB: Q4FZF3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000008004   ⟸   ENSMUST00000008004
Promoters
RGD ID:8667295
Promoter ID:EPDNEW_M11679
Type:multiple initiation site
Name:Ddx49_1
Description:Mus musculus DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38870,302,471 - 70,302,531EPDNEW
RGD ID:6848278
Promoter ID:MM_ACW:47818
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_2Hour,   Kidney,   Lung,   MEF_B4
Transcripts:DDX49.FSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36872,818,056 - 72,819,107 (-)MPROMDB
RGD ID:6843020
Promoter ID:MM_KWN:54692
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   Lung,   MEF_B6
Transcripts:OTTMUST00000067569
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36872,819,166 - 72,820,197 (-)MPROMDB
RGD ID:6843053
Promoter ID:MM_KWN:54693
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000067558,   OTTMUST00000067559,   OTTMUST00000067561,   OTTMUST00000067562,   OTTMUST00000067565,   OTTMUST00000067566,   OTTMUST00000067567,   OTTMUST00000067568,   UC009LZW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36872,826,274 - 72,826,774 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2136689 AgrOrtholog
Ensembl Genes ENSMUSG00000057788 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000008004 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000008004 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000144890 ENTREZGENE
InterPro DEAD/DEAH_box_helicase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_C UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA-helicase_DEAD-box_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA_helicase_DEAD_Q_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:234374 UniProtKB/Swiss-Prot
MGD MGI:2136689 ENTREZGENE
NCBI Gene 234374 ENTREZGENE
Pfam DEAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_C UniProtKB/Swiss-Prot
PhenoGen Ddx49 PhenoGen
PROSITE DEAD_ATP_HELICASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICASE_ATP_BIND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/Swiss-Prot
  Q_MOTIF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DEXDc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.388127 ENTREZGENE
  Mm.440659 ENTREZGENE
UniProt DDX49_MOUSE UniProtKB/Swiss-Prot
  Q3UTV0_MOUSE UniProtKB/TrEMBL
  Q4FZF3 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-04-07 Ddx49  DEAD box helicase 49  Ddx49  DEAD (Asp-Glu-Ala-Asp) box polypeptide 49  Symbol and/or name change 5135510 APPROVED