Mreg (melanoregulin) - Rat Genome Database

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Gene: Mreg (melanoregulin) Mus musculus
Analyze
Symbol: Mreg
Name: melanoregulin
RGD ID: 1621189
MGI Page MGI
Description: Enables phosphatidylinositol binding activity. Involved in melanosome localization; minus-end-directed organelle transport along microtubule; and phagosome maturation. Acts upstream of or within melanocyte differentiation and melanosome transport. Located in late endosome membrane and melanosome membrane. Is intrinsic component of organelle membrane. Part of protein-containing complex. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system; liver; and lung. Orthologous to human MREG (melanoregulin); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dilute suppressor protein; ds; dsu; Gm974; MGC92980; Wdt2; whn-dependent transcript 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39172,198,392 - 72,251,473 (-)NCBIGRCm39mm39
GRCm39 Ensembl172,198,601 - 72,251,466 (-)Ensembl
GRCm38172,159,233 - 72,212,314 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl172,159,442 - 72,212,307 (-)EnsemblGRCm38mm10GRCm38
MGSCv37172,205,807 - 72,258,881 (-)NCBIGRCm37mm9NCBIm37
MGSCv36172,092,653 - 72,145,515 (-)NCBImm8
Celera172,720,630 - 72,778,147 (-)NCBICelera
Cytogenetic Map1C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
1. RGD automated import pipeline
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2379821   PMID:3141922   PMID:3410303   PMID:6886377   PMID:7828830   PMID:10512203   PMID:11256068   PMID:11500834   PMID:11698278   PMID:12477932   PMID:12520002   PMID:12904583  
PMID:14610273   PMID:15550542   PMID:15840001   PMID:17260955   PMID:17967808   PMID:18799693   PMID:19240024   PMID:21267068   PMID:21873635   PMID:22275436   PMID:22753477   PMID:22940130  
PMID:22984402   PMID:23523350   PMID:23604909   PMID:23611523   PMID:25301234   PMID:28302729   PMID:28729444   PMID:29212956   PMID:30174147  


Genomics

Comparative Map Data
Mreg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39172,198,392 - 72,251,473 (-)NCBIGRCm39mm39
GRCm39 Ensembl172,198,601 - 72,251,466 (-)Ensembl
GRCm38172,159,233 - 72,212,314 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl172,159,442 - 72,212,307 (-)EnsemblGRCm38mm10GRCm38
MGSCv37172,205,807 - 72,258,881 (-)NCBIGRCm37mm9NCBIm37
MGSCv36172,092,653 - 72,145,515 (-)NCBImm8
Celera172,720,630 - 72,778,147 (-)NCBICelera
Cytogenetic Map1C3NCBI
MREG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2215,942,584 - 216,034,096 (-)EnsemblGRCh38hg38GRCh38
GRCh382215,939,097 - 216,034,096 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372216,807,307 - 216,898,819 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362216,515,559 - 216,586,591 (-)NCBINCBI36hg18NCBI36
Celera2210,576,874 - 210,647,909 (-)NCBI
Cytogenetic Map2q35NCBI
HuRef2208,664,389 - 208,735,443 (-)NCBIHuRef
CHM1_12216,813,382 - 216,884,375 (-)NCBICHM1_1
Mreg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2973,786,727 - 73,842,081 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl973,787,267 - 73,842,087 (-)Ensembl
Rnor_6.0979,490,058 - 79,559,768 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl979,490,050 - 79,545,024 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0979,263,284 - 79,318,250 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4971,303,627 - 71,357,985 (-)NCBIRGSC3.4rn4RGSC3.4
Celera971,188,816 - 71,242,342 (-)NCBICelera
Cytogenetic Map9q33NCBI
Mreg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554579,493 - 78,617 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554579,534 - 78,617 (+)NCBIChiLan1.0ChiLan1.0
MREG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B221,807,379 - 221,877,814 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B221,809,123 - 221,877,814 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B103,204,959 - 103,296,122 (-)NCBIMhudiblu_PPA_v0panPan3
MREG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13722,958,890 - 22,999,955 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3722,960,321 - 23,018,600 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3723,785,172 - 23,846,910 (-)NCBI
ROS_Cfam_1.03722,982,127 - 23,044,110 (-)NCBI
UMICH_Zoey_3.13722,868,646 - 22,930,347 (-)NCBI
UNSW_CanFamBas_1.03722,821,634 - 22,883,527 (-)NCBI
UU_Cfam_GSD_1.03722,838,683 - 22,901,209 (-)NCBI
Mreg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303171,364,467 - 171,422,322 (-)NCBI
SpeTri2.0NW_0049365861,203,520 - 1,261,341 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MREG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15118,208,684 - 118,273,680 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115118,208,681 - 118,273,725 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215131,092,443 - 131,156,411 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MREG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110101,791,816 - 101,864,958 (-)NCBI
ChlSab1.1 Ensembl10101,789,059 - 101,864,172 (-)Ensembl
Vero_WHO_p1.0NW_02366604097,533,360 - 97,605,578 (+)NCBI
Mreg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247654,139 - 38,006 (+)NCBI

Position Markers
UniSTS:237494  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381632,722,905 - 32,723,130UniSTSGRCm38
GRCm38172,159,875 - 72,160,100UniSTSGRCm38
MGSCv371632,722,991 - 32,723,216UniSTSGRCm37
MGSCv37172,206,449 - 72,206,674UniSTSGRCm37
Celera1633,202,991 - 33,203,216UniSTS
Celera172,721,272 - 72,721,497UniSTS
Cytogenetic Map1C3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13000000185000000Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12307051073937756Mouse
1357822Lvrq3_mliver weight QTL 3 (mouse)Not determined13472105773937756Mouse
1357759W3q12_mweight 3 weeks QTL 12 (mouse)Not determined13472105773937756Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13472105773937756Mouse
1357506W10q6_mweight 10 weeks QTL 6 (mouse)Not determined13472105773937756Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13472105773937756Mouse
1357824Estoq4_membryo survival total QTL 4 (mouse)Not determined13472105773937756Mouse
39128207Lwq16_mliver weight QTL 16 (mouse)13472105773937756Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134721057150318120Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134721057150318120Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134721057150318120Mouse
1301954Lrnx11_mlearning-contextual 11 (mouse)Not determined13909372774477206Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139093727126517573Mouse
1301166Thypr2_mthymocyte proliferative response 2 (mouse)Not determined14123396575234112Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14123624075236240Mouse
4141032Wbcc1_mwhite blood cell count 1 (mouse)Not determined4222050876220508Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14289887276899008Mouse
1558855Eae30_mexperimental allergic encephalomyelitis susceptibility 30 (mouse)Not determined14537861372935898Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145744740189571420Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14590759679907723Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14681553180815680Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14681553180815680Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14731073581310854Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14884984782850051Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14884984782850051Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14885318682853326Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15085105784851057Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5138244685382446Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52418578182423027Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15593578989935898Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15622705590227201Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15622705590227201Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15668776390687918Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15668776390687918Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15790219291902192Mouse
14747009Manh49_mmandible shape 49 (mouse)15790219291902192Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15795281891952921Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15795281891952921Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15795281891952921Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15857254792572799Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15857254792572799Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162907596120601949Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163815531189571420Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163880843153681816Mouse
1302119Cia15_mcollagen induced arthritis 15 (mouse)Not determined16584984788568379Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167300000129800000Mouse
4141625Emo4_memotionality 4 (mouse)Not determined6803218686307305Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170205811104211835Mouse
4141393Mol2_mmodifier of LPS-response 2 (mouse)Not determined7158552078206507Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:403
Count of miRNA genes:326
Interacting mature miRNAs:350
Transcripts:ENSMUST00000048860
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000048860   ⟹   ENSMUSP00000041878
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl172,198,601 - 72,251,466 (-)Ensembl
GRCm38.p6 Ensembl172,159,442 - 72,212,307 (-)Ensembl
RefSeq Acc Id: NM_001005423   ⟹   NP_001005423
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39172,198,392 - 72,251,466 (-)NCBI
GRCm38172,159,233 - 72,212,307 (-)ENTREZGENE
MGSCv37172,205,807 - 72,258,881 (-)RGD
Celera172,720,630 - 72,778,147 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001357488   ⟹   NP_001344417
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39172,198,392 - 72,251,473 (-)NCBI
GRCm38172,159,233 - 72,212,314 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006496111   ⟹   XP_006496174
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39172,198,392 - 72,237,440 (-)NCBI
GRCm38172,159,233 - 72,198,281 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001005423   ⟸   NM_001005423
- Peptide Label: isoform 1
- UniProtKB: Q6NVG5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006496174   ⟸   XM_006496111
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001344417   ⟸   NM_001357488
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000041878   ⟸   ENSMUST00000048860

Promoters
RGD ID:6874064
Promoter ID:EPDNEW_M458
Type:multiple initiation site
Name:Mreg_1
Description:Mus musculus melanoregulin , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38172,212,259 - 72,212,319EPDNEW
RGD ID:6818114
Promoter ID:MM_KWN:1112
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   Brain,   ES_Cell,   Liver
Transcripts:NM_001005423
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36172,258,499 - 72,258,999 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2151839 AgrOrtholog
Ensembl Genes ENSMUSG00000039395 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000041878 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000048860 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Melanoregulin UniProtKB/Swiss-Prot
KEGG Report mmu:381269 UniProtKB/Swiss-Prot
MGD MGI:2151839 ENTREZGENE
NCBI Gene 381269 ENTREZGENE
PANTHER PTHR34340 UniProtKB/Swiss-Prot
Pfam MREG UniProtKB/Swiss-Prot
PhenoGen Mreg PhenoGen
UniProt MREG_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE