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Gene: Foxc1 (forkhead box C1) Mus musculus
Symbol: Foxc1
Name: forkhead box C1
Description: Exhibits several functions, including DNA binding activity; promoter-specific chromatin binding activity; and transcription coactivator activity. Involved in several processes, including animal organ development; cell surface receptor signaling pathway; and negative regulation of vasculature development. Localizes to the nucleus. Used to study buphthalmos. Human ortholog(s) of this gene implicated in Axenfeld-Rieger syndrome; Axenfeld-Rieger syndrome type 3; and glaucoma. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; heart; and sensory organ. Orthologous to human FOXC1 (forkhead box C1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; benzalkonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ch; congenital hydrocephalus; fkh-1; Fkh1; forkhead box protein C1; forkhead-related protein FKHL7; forkhead-related transcription factor 3; FREAC-3; FREAC3; frkhda; mesoderm/mesenchyme forkhead 1; MF-1; Mf1; Mf4; transcription factor FKH-1
Homo sapiens (human) : FOXC1 (forkhead box C1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Foxc1 (forkhead box C1)  Alliance
Sus scrofa (pig) : FOXC1 (forkhead box C1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1331,806,633 - 31,812,476 (+)Ensembl
GRCm381331,806,646 - 31,810,635 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371331,898,515 - 31,902,504 (+)NCBIGRCm37mm9NCBIm37
MGSCv361331,814,111 - 31,818,100 (+)NCBImm8
Celera1332,016,470 - 32,020,494 (+)NCBICelera
Cytogenetic Map13 A3.2NCBI
cM Map1313.52NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Foxc1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1620902
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.