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Gene: Foxc1 (forkhead box C1) Mus musculus
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Symbol: Foxc1
Name: forkhead box C1
Description: Exhibits several functions, including DNA binding activity; promoter-specific chromatin binding activity; and transcription coactivator activity. Involved in several processes, including animal organ development; cell surface receptor signaling pathway; and negative regulation of vasculature development. Localizes to the nucleus. Used to study buphthalmos. Human ortholog(s) of this gene implicated in Axenfeld-Rieger syndrome; Axenfeld-Rieger syndrome type 3; and glaucoma. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; heart; and sensory organ. Orthologous to human FOXC1 (forkhead box C1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; benzalkonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ch; congenital hydrocephalus; fkh-1; Fkh1; forkhead box protein C1; forkhead-related protein FKHL7; forkhead-related transcription factor 3; FREAC-3; FREAC3; frkhda; mesoderm/mesenchyme forkhead 1; MF-1; Mf1; Mf4; transcription factor FKH-1
Orthologs:
Homo sapiens (human) : FOXC1 (forkhead box C1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Foxc1 (forkhead box C1)  Alliance
Sus scrofa (pig) : FOXC1 (forkhead box C1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1331,806,633 - 31,812,476 (+)Ensembl
GRCm381331,806,646 - 31,810,635 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371331,898,515 - 31,902,504 (+)NCBIGRCm37mm9NCBIm37
MGSCv361331,814,111 - 31,818,100 (+)NCBImm8
Celera1332,016,470 - 32,020,494 (+)NCBICelera
Cytogenetic Map13 A3.2NCBI
cM Map1313.52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Foxc1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1620902
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.