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Gene: Afdn (afadin, adherens junction formation factor) Mus musculus
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Symbol: Afdn
Name: afadin, adherens junction formation factor
Description: Exhibits cell adhesion molecule binding activity. Involved in several processes, including adherens junction maintenance; cell-cell adhesion mediated by cadherin; and nervous system development. Localizes to several cellular components, including adherens junction; apical junction complex; and pore complex. Predicted to colocalize with excitatory synapse. Is expressed in eye; genitourinary system; and nervous system. Orthologous to human AFDN (afadin, adherens junction formation factor); PARTICIPATES IN platelet-derived growth factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5033403D15Rik; Af-6; AF6; afadin; Gm314; I-afadin; Mllt4; myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog; myeloid/lymphoid or mixed-lineage leukemia; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); S-afadin; translocated to, 4
Orthologs:
Homo sapiens (human) : AFDN (afadin, adherens junction formation factor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Afdn (afadin, adherens junction formation factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Afdn (afadin, adherens junction formation factor)
Pan paniscus (bonobo/pygmy chimpanzee) : AFDN (afadin, adherens junction formation factor)
Canis lupus familiaris (dog) : AFDN (afadin, adherens junction formation factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Afdn (afadin, adherens junction formation factor)
Sus scrofa (pig) : AFDN (afadin, adherens junction formation factor)
Chlorocebus sabaeus (African green monkey) : AFDN (afadin, adherens junction formation factor)
Heterocephalus glaber (naked mole-rat) : Afdn (afadin, adherens junction formation factor)
more info ...
Related Pseudogenes: Gm6809  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1713,760,539 - 13,906,150 (+)EnsemblGRCm38mm10GRCm38
GRCm381713,760,391 - 13,905,798 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371713,897,548 - 14,042,801 (+)NCBIGRCm37mm9NCBIm37
MGSCv361713,497,079 - 13,642,343 (+)NCBImm8
Celera1714,603,626 - 14,705,325 (+)NCBICelera
Cytogenetic Map17A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on Afdn
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1620895
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.