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Gene: Afdn (afadin, adherens junction formation factor) Mus musculus
Symbol: Afdn
Name: afadin, adherens junction formation factor
Description: Exhibits cell adhesion molecule binding activity. Involved in several processes, including adherens junction maintenance; cell-cell adhesion mediated by cadherin; and nervous system development. Localizes to several cellular components, including adherens junction; apical junction complex; and pore complex. Predicted to colocalize with excitatory synapse. Is expressed in eye; genitourinary system; and nervous system. Orthologous to human AFDN (afadin, adherens junction formation factor); PARTICIPATES IN platelet-derived growth factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5033403D15Rik; Af-6; AF6; afadin; Gm314; I-afadin; Mllt4; myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog; myeloid/lymphoid or mixed-lineage leukemia; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); S-afadin; translocated to, 4
Homo sapiens (human) : AFDN (afadin, adherens junction formation factor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Afdn (afadin, adherens junction formation factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Afdn (afadin, adherens junction formation factor)
Pan paniscus (bonobo/pygmy chimpanzee) : AFDN (afadin, adherens junction formation factor)
Canis lupus familiaris (dog) : AFDN (afadin, adherens junction formation factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Afdn (afadin, adherens junction formation factor)
Sus scrofa (pig) : AFDN (afadin, adherens junction formation factor)
Chlorocebus sabaeus (African green monkey) : AFDN (afadin, adherens junction formation factor)
Heterocephalus glaber (naked mole-rat) : Afdn (afadin, adherens junction formation factor)
more info ...
Related Pseudogenes: Gm6809  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1713,760,539 - 13,906,150 (+)EnsemblGRCm38mm10GRCm38
GRCm381713,760,391 - 13,905,798 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371713,897,548 - 14,042,801 (+)NCBIGRCm37mm9NCBIm37
MGSCv361713,497,079 - 13,642,343 (+)NCBImm8
Celera1714,603,626 - 14,705,325 (+)NCBICelera
Cytogenetic Map17A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Afdn
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1620895
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.