Themis3 (thymocyte selection associated family member 3) - Rat Genome Database

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Gene: Themis3 (thymocyte selection associated family member 3) Mus musculus
Analyze
Symbol: Themis3
Name: thymocyte selection associated family member 3
RGD ID: 1620737
MGI Page MGI
Description: Predicted to be involved in T cell receptor signaling pathway. Predicted to be active in cytoplasm and nucleus. Orthologous to human THEMIS3P (thymocyte selection associated family member 3, pseudogene).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9130404H23Rik; thymocyte-expressed molecule involved in selection protein 3
RGD Orthologs
Human
Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391766,861,519 - 66,901,642 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1766,861,500 - 66,901,616 (-)EnsemblGRCm39 Ensembl
GRCm381766,554,524 - 66,594,647 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1766,554,505 - 66,594,621 (-)EnsemblGRCm38mm10GRCm38
MGSCv371766,904,592 - 66,943,962 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361766,460,197 - 66,499,567 (-)NCBIMGSCv36mm8
Celera1770,851,938 - 70,891,294 (-)NCBICelera
Cytogenetic Map17E1.1NCBI
cM Map1737.88NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
silver atom  (EXP)
silver(0)  (EXP)
triptonide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
nucleus  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:16141072   PMID:16141073   PMID:19597497   PMID:19597499   PMID:21677750   PMID:21873635  


Genomics

Comparative Map Data
Themis3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391766,861,519 - 66,901,642 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1766,861,500 - 66,901,616 (-)EnsemblGRCm39 Ensembl
GRCm381766,554,524 - 66,594,647 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1766,554,505 - 66,594,621 (-)EnsemblGRCm38mm10GRCm38
MGSCv371766,904,592 - 66,943,962 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361766,460,197 - 66,499,567 (-)NCBIMGSCv36mm8
Celera1770,851,938 - 70,891,294 (-)NCBICelera
Cytogenetic Map17E1.1NCBI
cM Map1737.88NCBI
THEMIS3P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38188,512,827 - 8,513,841 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl188,486,997 - 8,513,849 (+)EnsemblGRCh38hg38GRCh38
GRCh37188,512,825 - 8,513,839 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera188,397,164 - 8,398,178 (+)NCBICelera
Cytogenetic Map18p11.22NCBI
HuRef188,477,180 - 8,478,194 (+)NCBIHuRef
CHM1_1188,512,967 - 8,513,981 (+)NCBICHM1_1
T2T-CHM13v2.0188,675,983 - 8,676,997 (+)NCBIT2T-CHM13v2.0
Themis3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89113,989,689 - 114,027,720 (-)NCBIGRCr8
mRatBN7.29106,543,112 - 106,580,780 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9106,543,723 - 106,580,907 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.09114,748,302 - 114,786,017 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9114,748,840 - 114,785,893 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09114,246,877 - 114,284,629 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49105,685,992 - 105,723,832 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera9103,717,398 - 103,755,107 (-)NCBICelera
Cytogenetic Map9q37NCBI

Variants

.
Variants in Themis3
1509 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:131
Interacting mature miRNAs:132
Transcripts:ENSMUST00000024914
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
1300885Mbis4_mMycobacterium bovis-induced systemic lupus erythematosus 4 (mouse)Not determined173517581770165926Mouse
10755514Amzn2_manatomical modifier of Zfp423 2 (mouse)173596629469966424Mouse
12904951Smmq2_msoleus muscle mass QTL 2 (mouse)173678974370789743Mouse
1300592Pcyts5_mplasmacytoma susceptibility 5 (mouse)Not determined173871288772712970Mouse
10755525Lymph2_mlymphocyte differential 2 (mouse)173880562672805626Mouse
10755534Lymph4_mlymphocyte differential 4 (mouse)173880562672805626Mouse
4141319Hmtb8_mhemostasis and thrombosis rebleeding time 8 (mouse)Not determined4053444774534623Mouse
15039324Nmrs48_mNAFLD-associated magnetic resonance shift 48 (mouse)174093918774939187Mouse
26884390Skwq9_mskull length QTL 9, 10 week (mouse)174371089167806995Mouse
26884428Cvht3_mcranial vault height 3, 5 week (mouse)174651092682407429Mouse
14700692Cihvtq1_mcoxsackieviral infection heart viral titre QTL 1 (mouse)175000702870006995Mouse
1357754Ahl3_mage related hearing loss 3 (mouse)Not determined175020395784204103Mouse
4141879Chlq9_mcirculating hormone level QTL 9 (mouse)Not determined175175842585758612Mouse
1357532Bmch7_mbone mechanical trait 7 (mouse)Not determined175175842585758612Mouse
1357447Heal13_mwound healing/regeneration 13 (mouse)Not determined175710765191107803Mouse
4141758Pstc5_mperiosteal circumference 5 (mouse)Not determined175710765191107803Mouse
4141011Bmd26_mbone mineral density 26 (mouse)Not determined175710765191107803Mouse
1300735Pgia20_mproteoglycan induced arthritis 20 (mouse)Not determined175710765191107803Mouse
12910536Nrq8a_mnoise-induced hearing loss resistant QTL 8a (mouse)175710765191107803Mouse
12910537Nrq8_mnoise-induced hearing loss resistant QTL 8 (mouse)175710765191107803Mouse
4142201Obrq15_mobesity resistance QTL 15 (mouse)Not determined5753444780885776Mouse
4142414Pregq4_mpregnancy QTL 4 (mouse)Not determined175753444793507179Mouse
4141040Hmtb9_mhemostasis and thrombosis rebleeding time 9 (mouse)Not determined5758908991589197Mouse
1301107Scc4_mcolon tumor susceptibility 4 (mouse)Not determined176230101095294699Mouse
11528551Sluc32_msusceptibility to lung cancer 32 (mouse)176230101095294699Mouse
1302017Aliq3_macute lung injury QTL 3 (mouse)Not determined176388554895294699Mouse
1301728Ffal1_mfree fatty acid level 1 (mouse)Not determined176521493895294699Mouse
14928308Manh82_mmandible shape 82 (mouse)176631524395294699Mouse
12738435Lfibq28_mliver fibrosis QTL 28 (mouse)176674319567812236Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000024914   ⟹   ENSMUSP00000024914
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1766,861,500 - 66,901,616 (-)Ensembl
GRCm38.p6 Ensembl1766,554,505 - 66,594,621 (-)Ensembl
RefSeq Acc Id: NM_028998   ⟹   NP_083274
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391766,861,519 - 66,901,642 (-)NCBI
GRCm381766,554,524 - 66,594,647 (-)NCBI
MGSCv371766,904,592 - 66,943,962 (-)RGD
Celera1770,851,938 - 70,891,294 (-)RGD
cM Map17 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_083274 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB31332 (Get FASTA)   NCBI Sequence Viewer  
  EDL38333 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000024914
  ENSMUSP00000024914.3
GenBank Protein Q9CU24 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_083274   ⟸   NM_028998
- UniProtKB: Q9CU24 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000024914   ⟸   ENSMUST00000024914

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CU24-F1-model_v2 AlphaFold Q9CU24 1-569 view protein structure

Promoters
RGD ID:13676660
Promoter ID:EPDNEW_M22479
Type:initiation region
Name:Themis3_1
Description:Mus musculus thymocyte selection associated family member 3 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381766,594,606 - 66,594,666EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921806 AgrOrtholog
Ensembl Genes ENSMUSG00000024105 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000024914 ENTREZGENE
  ENSMUST00000024914.4 UniProtKB/Swiss-Prot
InterPro CABIT_dom UniProtKB/Swiss-Prot
  THEMIS UniProtKB/Swiss-Prot
KEGG Report mmu:74556 UniProtKB/Swiss-Prot
MGD MGI:1921806 ENTREZGENE
NCBI Gene 74556 ENTREZGENE
PANTHER PROTEIN THEMIS3 UniProtKB/Swiss-Prot
  PTHR15215 UniProtKB/Swiss-Prot
Pfam CABIT UniProtKB/Swiss-Prot
PhenoGen Themis3 PhenoGen
UniProt Q9CU24 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-09-19 Themis3  thymocyte selection associated family member 3  9130404H23Rik  RIKEN cDNA 9130404H23 gene  Symbol and/or name change 5135510 APPROVED