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Gene: Dsp (desmoplakin) Mus musculus
Symbol: Dsp
Name: desmoplakin
Description: Predicted to have protein kinase C binding activity; scaffold protein binding activity; and structural molecule activity. Involved in several processes, including desmosome organization; intermediate filament organization; and ventricular compact myocardium morphogenesis. Localizes to basolateral plasma membrane; desmosome; and intercalated disc. Colocalizes with intermediate filament. Used to study Carvajal syndrome and arrhythmogenic right ventricular dysplasia 8. Human ortholog(s) of this gene implicated in Carvajal syndrome; arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 8; and dilated cardiomyopathy. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; heart; and sensory organ. Orthologous to human DSP (desmoplakin); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2300002E22Rik; 5730453H04Rik; AA407887; AA407888; AW109828; desmoplakin I/II; desmosomal cytoskeletal connector molecule; DP; RIKEN cDNA 5730453H04 gene; rul
Homo sapiens (human) : DSP (desmoplakin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dsp (desmoplakin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dsp (desmoplakin)
Pan paniscus (bonobo/pygmy chimpanzee) : DSP (desmoplakin)
Canis lupus familiaris (dog) : DSP (desmoplakin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dsp (desmoplakin)
Sus scrofa (pig) : DSP (desmoplakin)
Chlorocebus sabaeus (African green monkey) : DSP (desmoplakin)
Heterocephalus glaber (naked mole-rat) : Dsp (desmoplakin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1338,151,294 - 38,198,577 (+)EnsemblGRCm38mm10GRCm38
GRCm381338,151,294 - 38,198,577 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371338,243,163 - 38,290,446 (+)NCBIGRCm37mm9NCBIm37
MGSCv361338,158,760 - 38,206,043 (+)NCBImm8
Celera1339,265,897 - 39,313,259 (+)NCBICelera
Cytogenetic Map13A3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Dsp
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1620673
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.