Reep2 (receptor accessory protein 2) - Rat Genome Database

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Gene: Reep2 (receptor accessory protein 2) Mus musculus
Analyze
Symbol: Reep2
Name: receptor accessory protein 2
RGD ID: 1620614
MGI Page MGI
Description: Enables taste receptor binding activity. Involved in regulation of intracellular transport. Acts upstream of or within protein transport into membrane raft; sensory perception of bitter taste; and sensory perception of sweet taste. Located in endoplasmic reticulum membrane and plasma membrane. Is expressed in central nervous system; eye; ganglia; incisor; and testis. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 72A. Orthologous to human REEP2 (receptor accessory protein 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BC020184; C85440; MGC28827; receptor expression enhancing protein 2; receptor expression-enhancing protein 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391834,973,642 - 34,980,516 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1834,973,642 - 34,980,516 (+)EnsemblGRCm39 Ensembl
GRCm381834,840,589 - 34,847,463 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,840,589 - 34,847,463 (+)EnsemblGRCm38mm10GRCm38
MGSCv371835,000,312 - 35,007,109 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361834,966,632 - 34,973,429 (+)NCBIMGSCv36mm8
Celera1835,294,660 - 35,301,457 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15489334   PMID:15550249  
PMID:16141072   PMID:16141073   PMID:16602821   PMID:20943918   PMID:21267068   PMID:21677750   PMID:21873635   PMID:24098485   PMID:36417873   PMID:36808153   PMID:37228035  


Genomics

Comparative Map Data
Reep2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391834,973,642 - 34,980,516 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1834,973,642 - 34,980,516 (+)EnsemblGRCm39 Ensembl
GRCm381834,840,589 - 34,847,463 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,840,589 - 34,847,463 (+)EnsemblGRCm38mm10GRCm38
MGSCv371835,000,312 - 35,007,109 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361834,966,632 - 34,973,429 (+)NCBIMGSCv36mm8
Celera1835,294,660 - 35,301,457 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.75NCBI
REEP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385138,439,057 - 138,446,965 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5138,439,057 - 138,446,969 (+)EnsemblGRCh38hg38GRCh38
GRCh375137,774,746 - 137,782,654 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,802,675 - 137,810,557 (+)NCBINCBI36Build 36hg18NCBI36
Build 345137,802,674 - 137,810,556NCBI
Celera5133,895,609 - 133,903,492 (+)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5132,965,471 - 132,973,440 (+)NCBIHuRef
CHM1_15137,207,413 - 137,215,380 (+)NCBICHM1_1
T2T-CHM13v2.05138,965,273 - 138,973,181 (+)NCBIT2T-CHM13v2.0
Reep2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81826,712,236 - 26,721,275 (+)NCBIGRCr8
mRatBN7.21826,438,130 - 26,447,165 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1826,438,346 - 26,447,161 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1826,565,715 - 26,574,530 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01827,329,357 - 27,338,172 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01826,664,242 - 26,673,057 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01827,632,562 - 27,641,594 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,632,786 - 27,641,591 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,344,320 - 27,353,125 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1826,176,145 - 26,183,810 (+)NCBICelera
Cytogenetic Map18p12NCBI
Reep2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554182,018,891 - 2,024,456 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554182,018,891 - 2,024,545 (-)NCBIChiLan1.0ChiLan1.0
REEP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24133,714,394 - 133,722,391 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15131,854,023 - 131,861,945 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05133,819,005 - 133,826,930 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15139,949,903 - 139,957,204 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5139,949,903 - 139,959,112 (+)Ensemblpanpan1.1panPan2
REEP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11126,026,715 - 26,032,489 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1126,026,828 - 26,032,505 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,796,108 - 24,801,822 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01126,883,086 - 26,888,808 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1126,883,024 - 26,888,808 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11125,590,050 - 25,595,759 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01125,412,856 - 25,418,549 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01126,077,063 - 26,082,784 (+)NCBIUU_Cfam_GSD_1.0
Reep2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213154,002,847 - 154,009,633 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365317,601,728 - 7,608,696 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365317,601,869 - 7,608,658 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
REEP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2140,420,516 - 140,427,160 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12140,420,422 - 140,427,160 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22146,132,363 - 146,137,774 (-)NCBISscrofa10.2Sscrofa10.2susScr3
REEP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12341,113,517 - 41,121,831 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2341,113,561 - 41,121,826 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603436,765,681 - 36,774,005 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Reep2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474331,226,825 - 31,235,343 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474331,226,744 - 31,233,030 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Reep2
202 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:442
Count of miRNA genes:300
Interacting mature miRNAs:338
Transcripts:ENSMUST00000043484
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060933072Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
1558873Hrtfm7_mheart failure modifier 7 (mouse)Not determined18808696442087106Mouse
13504732Cath6_mcarotid atherosclerosis 6 (mouse)181363712647637126Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
1300994Pvcan3_mprotection against vaginal candidiasis 3 (mouse)Not determined181619964050199776Mouse
1301307Phospq1_mphospholipid QTL 1 (mouse)Not determined181813970452139859Mouse
1300638Im7_mimmunoregulatory 7 (mouse)Not determined181901887453018992Mouse
1558743Kcal1_mkilocalorie 1 (mouse)Not determined181901887453018992Mouse
11532709Sluc41_msusceptibility to lung cancer 41 (mouse)182095369457590708Mouse
13463476Hctq8_mhematocrit QTL 8 (mouse)182121758055217727Mouse
1301950Otx2m1_morthodenticle homolog 2 (Drosophila) modifier 1 (mouse)Not determined182156868236187740Mouse
1300877Adip8_madiposity 8 (mouse)Not determined182261991456620127Mouse
11532710Sluc41a_msusceptibility to lung cancer 41a (mouse)182261991456620127Mouse
11532715Sluc41b_msusceptibility to lung cancer 41b (mouse)182261991456620127Mouse
11532716Sluc41c_msusceptibility to lung cancer 41c (mouse)182261991456620127Mouse
1301570Sluc14_msusceptibility to lung cancer 14 (mouse)Not determined182261991456620127Mouse
4142031Moen1_mmodifier of engrailed QTL 1 (mouse)Not determined182411556058115730Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
12904950Smmq3_msoleus muscle mass QTL 3 (mouse)182605687560056875Mouse
25823167Hrsq5_mhost response to SARS QTL 5, D3% weight (mouse)182724111558827077Mouse
25823171Hrsq10_mhost response to SARS QTL 10, D4% weight (mouse)182724111558827077Mouse
25823174Hrsq11_mhost response to SARS QTL 11, log titer (mouse)182724111558827077Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182810938062109518Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2813060462130739Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182966791463668060Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183023306764233067Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183198848065988629Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183309104367091221Mouse

Markers in Region
C85440  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381834,847,176 - 34,847,311UniSTSGRCm38
MGSCv371835,006,830 - 35,006,965UniSTSGRCm37
Celera1835,301,178 - 35,301,313UniSTS
Cytogenetic Map18B1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000043484   ⟹   ENSMUSP00000036065
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1834,973,642 - 34,980,516 (+)Ensembl
GRCm38.p6 Ensembl1834,840,589 - 34,847,463 (+)Ensembl
RefSeq Acc Id: NM_001204914   ⟹   NP_001191843
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391834,973,642 - 34,980,516 (+)NCBI
GRCm381834,840,589 - 34,847,463 (+)ENTREZGENE
Celera1835,294,591 - 35,301,465 (+)ENTREZGENE
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_144865   ⟹   NP_659114
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391834,973,642 - 34,980,516 (+)NCBI
GRCm381834,840,589 - 34,847,463 (+)ENTREZGENE
MGSCv371835,000,312 - 35,007,109 (+)RGD
Celera1835,294,591 - 35,301,465 (+)ENTREZGENE
cM Map18 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_659114   ⟸   NM_144865
- Peptide Label: isoform 1
- UniProtKB: Q8VCD6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001191843   ⟸   NM_001204914
- Peptide Label: isoform 2
- UniProtKB: C1IE02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000036065   ⟸   ENSMUST00000043484

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VCD6-F1-model_v2 AlphaFold Q8VCD6 1-254 view protein structure

Promoters
RGD ID:13677394
Promoter ID:EPDNEW_M22846
Type:initiation region
Name:Reep2_1
Description:Mus musculus receptor accessory protein 2 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381834,840,640 - 34,840,700EPDNEW
RGD ID:6829499
Promoter ID:MM_KWN:24904
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung,   Spleen
Transcripts:NM_144865
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361834,999,911 - 35,000,411 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2385070 AgrOrtholog
Ensembl Genes ENSMUSG00000038555 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000043484 ENTREZGENE
  ENSMUST00000043484.8 UniProtKB/Swiss-Prot
InterPro TB2_DP1_HVA22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:225362 UniProtKB/Swiss-Prot
MGD MGI:2385070 ENTREZGENE
NCBI Gene 225362 ENTREZGENE
PANTHER PTHR12300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR EXPRESSION-ENHANCING PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TB2_DP1_HVA22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Reep2 PhenoGen
UniProt C1IE02 ENTREZGENE, UniProtKB/TrEMBL
  Q3TYE9_MOUSE UniProtKB/TrEMBL
  Q8VCD6 ENTREZGENE, UniProtKB/Swiss-Prot