Grip2 (glutamate receptor interacting protein 2) - Rat Genome Database

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Gene: Grip2 (glutamate receptor interacting protein 2) Mus musculus
Analyze
Symbol: Grip2
Name: glutamate receptor interacting protein 2
RGD ID: 1620556
MGI Page MGI
Description: Predicted to have glutamate receptor binding activity and protein C-terminus binding activity. Involved in several processes, including Notch signaling pathway; artery smooth muscle contraction; and neurotransmitter receptor transport, endosome to postsynaptic membrane. Localizes to glutamatergic synapse. Is expressed in diencephalon lateral wall mantle layer; olfactory cortex mantle layer; and tongue. Orthologous to human GRIP2 (glutamate receptor interacting protein 2); INTERACTS WITH 1,2-dimethylhydrazine; benzo[a]pyrene; ethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: glutamate receptor-interacting protein 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39691,738,433 - 91,820,935 (-)NCBIGRCm39mm39
GRCm39 Ensembl691,738,490 - 91,804,231 (-)Ensembl
GRCm38691,761,452 - 91,843,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl691,761,509 - 91,827,250 (-)EnsemblGRCm38mm10GRCm38
MGSCv37691,711,503 - 91,757,387 (-)NCBIGRCm37mm9NCBIm37
MGSCv36691,727,013 - 91,754,107 (-)NCBImm8
Celera693,655,323 - 93,701,161 (-)NCBICelera
Cytogenetic Map6D1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14730302   PMID:16141072   PMID:16141073   PMID:16495457   PMID:16602821   PMID:17273929  
PMID:18509036   PMID:20956289   PMID:21267068   PMID:21383172   PMID:21873635   PMID:23117660   PMID:24126453   PMID:26216979   PMID:28063882   PMID:31476380  


Genomics

Comparative Map Data
Grip2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39691,738,433 - 91,820,935 (-)NCBIGRCm39mm39
GRCm39 Ensembl691,738,490 - 91,804,231 (-)Ensembl
GRCm38691,761,452 - 91,843,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl691,761,509 - 91,827,250 (-)EnsemblGRCm38mm10GRCm38
MGSCv37691,711,503 - 91,757,387 (-)NCBIGRCm37mm9NCBIm37
MGSCv36691,727,013 - 91,754,107 (-)NCBImm8
Celera693,655,323 - 93,701,161 (-)NCBICelera
Cytogenetic Map6D1NCBI
GRIP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl314,489,107 - 14,556,075 (-)EnsemblGRCh38hg38GRCh38
GRCh38314,485,105 - 14,602,996 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37314,530,615 - 14,581,849 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36314,510,177 - 14,558,592 (-)NCBINCBI36hg18NCBI36
Celera314,468,851 - 14,521,806 (-)NCBI
Cytogenetic Map3p25.1NCBI
HuRef314,466,560 - 14,519,524 (-)NCBIHuRef
CHM1_1314,481,705 - 14,532,899 (-)NCBICHM1_1
Grip2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24124,271,456 - 124,356,538 (-)NCBI
Rnor_6.0 Ensembl4123,586,231 - 123,636,040 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04123,585,184 - 123,636,040 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04188,120,198 - 188,170,081 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44125,951,936 - 126,001,803 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14126,196,782 - 126,267,614NCBI
Celera4113,190,739 - 113,240,094 (-)NCBICelera
Cytogenetic Map4q34NCBI
Grip2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542917,134,158 - 17,160,036 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542917,132,520 - 17,177,547 (-)NCBIChiLan1.0ChiLan1.0
GRIP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1314,754,145 - 14,803,236 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl314,756,638 - 14,804,952 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0314,411,825 - 14,525,388 (-)NCBIMhudiblu_PPA_v0panPan3
GRIP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1204,618,702 - 4,677,040 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl204,620,179 - 4,677,263 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha204,656,123 - 4,753,287 (-)NCBI
ROS_Cfam_1.0204,640,107 - 4,737,316 (-)NCBI
UMICH_Zoey_3.1204,358,668 - 4,455,875 (-)NCBI
UNSW_CanFamBas_1.0204,681,321 - 4,778,501 (-)NCBI
UU_Cfam_GSD_1.0204,692,533 - 4,789,738 (-)NCBI
Grip2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494218,600,766 - 18,632,699 (+)NCBI
SpeTri2.0NW_004936602276,964 - 334,942 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1369,949,584 - 70,088,719 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11369,949,608 - 70,088,719 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21377,365,567 - 77,515,248 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRIP2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12250,429,351 - 50,546,403 (-)NCBI
ChlSab1.1 Ensembl2250,433,405 - 50,468,769 (-)Ensembl
Grip2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248721,215,698 - 1,264,723 (+)NCBI

Position Markers
RH124443  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38691,803,364 - 91,803,579UniSTSGRCm38
MGSCv37691,753,358 - 91,753,573UniSTSGRCm37
Celera693,697,132 - 93,697,347UniSTS
Cytogenetic Map6D2UniSTS
RH136997  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38691,761,544 - 91,761,731UniSTSGRCm38
MGSCv37691,711,538 - 91,711,725UniSTSGRCm37
Celera693,655,358 - 93,655,545UniSTS
Cytogenetic Map6D2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686806805113544602Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687503360121503555Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined689005405123005603Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690795610124795846Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2785
Count of miRNA genes:696
Interacting mature miRNAs:904
Transcripts:ENSMUST00000159684, ENSMUST00000161545, ENSMUST00000161566, ENSMUST00000162293, ENSMUST00000162300
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000159684   ⟹   ENSMUSP00000125047
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl691,763,448 - 91,807,318 (-)Ensembl
RefSeq Acc Id: ENSMUST00000161545   ⟹   ENSMUSP00000125538
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl691,784,730 - 91,796,244 (-)Ensembl
RefSeq Acc Id: ENSMUST00000161566   ⟹   ENSMUSP00000123941
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl691,783,657 - 91,807,393 (-)Ensembl
RefSeq Acc Id: ENSMUST00000162293   ⟹   ENSMUSP00000124717
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl691,761,509 - 91,827,250 (-)Ensembl
RefSeq Acc Id: ENSMUST00000162300   ⟹   ENSMUSP00000124709
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl691,761,509 - 91,807,456 (-)Ensembl
RefSeq Acc Id: ENSMUST00000205964
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl691,792,706 - 91,796,260 (-)Ensembl
RefSeq Acc Id: NM_001159507   ⟹   NP_001152979
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39691,738,490 - 91,784,374 (-)NCBI
GRCm38691,761,509 - 91,807,393 (-)NCBI
MGSCv37691,711,503 - 91,757,387 (-)RGD
Celera693,655,323 - 93,701,161 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006506102   ⟹   XP_006506165
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39691,738,433 - 91,773,287 (-)NCBI
GRCm38691,761,452 - 91,796,307 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006506103   ⟹   XP_006506166
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39691,738,433 - 91,765,942 (-)NCBI
GRCm38691,761,452 - 91,788,969 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006506104   ⟹   XP_006506167
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39691,738,433 - 91,820,935 (-)NCBI
GRCm38691,761,452 - 91,843,954 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011241351   ⟹   XP_011239653
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39691,738,433 - 91,784,414 (-)NCBI
GRCm38691,761,452 - 91,807,393 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003956197
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39691,738,433 - 91,773,288 (-)NCBI
GRCm38691,761,452 - 91,796,307 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003956198
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39691,738,433 - 91,773,288 (-)NCBI
GRCm38691,761,452 - 91,796,307 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004942951
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39691,738,433 - 91,765,958 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001152979   ⟸   NM_001159507
- UniProtKB: G3XA20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006506167   ⟸   XM_006506104
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006506165   ⟸   XM_006506102
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006506166   ⟸   XM_006506103
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011239653   ⟸   XM_011241351
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSMUSP00000125047   ⟸   ENSMUST00000159684
RefSeq Acc Id: ENSMUSP00000124717   ⟸   ENSMUST00000162293
RefSeq Acc Id: ENSMUSP00000124709   ⟸   ENSMUST00000162300
RefSeq Acc Id: ENSMUSP00000125538   ⟸   ENSMUST00000161545
RefSeq Acc Id: ENSMUSP00000123941   ⟸   ENSMUST00000161566
Protein Domains
PDZ

Promoters
RGD ID:6839424
Promoter ID:MM_KWN:46929
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   MEF_B6
Transcripts:ENSMUST00000105080
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36691,712,271 - 91,713,462 (-)MPROMDB
RGD ID:6847998
Promoter ID:MM_ACW:42007
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:GRIP2.CSEP07,   GRIP2.DSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36691,745,901 - 91,746,401 (-)MPROMDB
RGD ID:6890460
Promoter ID:EPDNEW_M8681
Type:initiation region
Name:Grip2_1
Description:Mus musculus glutamate receptor interacting protein 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38691,807,432 - 91,807,492EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2681173 AgrOrtholog
Ensembl Genes ENSMUSG00000030098 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000123941 UniProtKB/TrEMBL
  ENSMUSP00000124709 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000124717 UniProtKB/TrEMBL
  ENSMUSP00000125047 UniProtKB/TrEMBL
  ENSMUSP00000125538 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000159684 UniProtKB/TrEMBL
  ENSMUST00000161545 UniProtKB/TrEMBL
  ENSMUST00000161566 UniProtKB/TrEMBL
  ENSMUST00000162293 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000162300 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/TrEMBL
InterPro GRIP1/2 UniProtKB/TrEMBL
  GRIP2 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_6 UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
KEGG Report mmu:243547 UniProtKB/TrEMBL
MGD MGI:2681173 ENTREZGENE
NCBI Gene 243547 ENTREZGENE
PANTHER PTHR46227 UniProtKB/TrEMBL
  PTHR46227:SF4 UniProtKB/TrEMBL
Pfam PDZ UniProtKB/TrEMBL
  PDZ_6 UniProtKB/TrEMBL
PhenoGen Grip2 PhenoGen
PROSITE PDZ UniProtKB/TrEMBL
SMART PDZ UniProtKB/TrEMBL
Superfamily-SCOP PDZ UniProtKB/TrEMBL
UniProt E0CXE0_MOUSE UniProtKB/TrEMBL
  E0CXS4_MOUSE UniProtKB/TrEMBL
  E0CYS1_MOUSE UniProtKB/TrEMBL
  F7BQ55_MOUSE UniProtKB/TrEMBL
  G3XA20 ENTREZGENE, UniProtKB/TrEMBL
  Q3UYP0_MOUSE UniProtKB/TrEMBL
  Q499W6_MOUSE UniProtKB/TrEMBL