Advanced Search (OLGA)

Gene: Scn4b (sodium channel, type IV, beta) Mus musculus

Analyze

Symbol:

Scn4b

Name:

sodium channel, type IV, beta

RGD ID:

1620406

MGI Page

MGI

Description:

Enables voltage-gated sodium channel activity. Acts upstream of or within establishment of localization in cell and sodium ion transmembrane transport. Located in intercalated disc. Is expressed in brain; dorsal striatum; and ventral striatum. Human ortholog(s) of this gene implicated in long QT syndrome 10. Orthologous to human SCN4B (sodium voltage-gated channel beta subunit 4).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Gm1471; sodium channel accessory subunit; sodium channel beta 4 subunit; sodium channel regulatory subunit beta-4; sodium channel subunit beta-4; sodium channel, type IV, beta polypeptide; voltage gated sodium channel beta 4 subunit

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	45,049,922 - 45,065,453 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	45,049,693 - 45,065,450 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	45,138,624 - 45,154,155 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	45,138,395 - 45,154,152 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	44,947,125 - 44,962,144 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	44,890,037 - 44,905,056 (+)	NCBI		MGSCv36	mm8
Celera	9	42,414,621 - 42,429,658 (+)	NCBI		Celera
Cytogenetic Map	9	A5.2	NCBI
cM Map	9	24.84	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

CD3epsilon deficiency (ISO)

chromosome 11 partial duplication syndrome (ISO)

dilated cardiomyopathy (ISO)

Dwarfism (ISO)

Familial Atrial Fibrillation 14 (ISO)

Familial Atrial Fibrillation 17 (ISO)

glycogen storage disease Ib (ISO)

immunodeficiency 17 (ISO)

immunodeficiency 18 (ISO)

immunodeficiency 19 (ISO)

inflammatory bowel disease 28 (ISO)

intellectual disability (ISO)

isolated microphthalmia 5 (ISO)

long QT syndrome (ISO)

long QT syndrome 1 (ISO)

long QT syndrome 10 (ISO)

RASopathy (ISO)

Romano-Ward Syndrome (ISO)

sudden infant death syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (EXP)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (EXP)

2,2',5,5'-tetrachlorobiphenyl (EXP)

2,3,4,7,8-Pentachlorodibenzofuran (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

6-propyl-2-thiouracil (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

allethrin (ISO)

alpha-Zearalanol (ISO)

antirheumatic drug (ISO)

arsenous acid (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

beta-naphthoflavone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bromobenzene (ISO)

butanal (ISO)

CGP 52608 (ISO)

chlordecone (EXP)

chlorpyrifos (EXP)

copper atom (ISO)

copper(0) (ISO)

Cuprizon (ISO)

cyhalothrin (ISO)

cypermethrin (ISO)

decabromodiphenyl ether (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

etoposide (ISO)

fenvalerate (ISO)

gentamycin (ISO)

indole-3-methanol (ISO)

isoprenaline (EXP)

ketamine (ISO)

methapyrilene (ISO)

N-nitrosodiethylamine (ISO)

nickel atom (ISO)

panobinostat (ISO)

paracetamol (ISO)

PCB138 (EXP)

pentanal (ISO)

perfluorooctanoic acid (ISO)

phenylmercury acetate (ISO)

pioglitazone (EXP)

pirinixic acid (EXP)

propanal (ISO)

pyrethrins (ISO)

resveratrol (ISO)

rotenone (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (EXP)

sodium fluoride (EXP)

sunitinib (ISO)

tebuconazole (ISO)

tetraphene (EXP)

titanium dioxide (EXP)

trichostatin A (ISO)

tungsten (EXP)

valproic acid (ISO)

vancomycin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

AV node cell action potential (IEA,ISO)

cardiac conduction (IBA)

cardiac muscle cell action potential involved in contraction (IBA,IEA,ISO)

cardiac muscle contraction (ISO)

establishment of localization in cell (IDA,IMP)

membrane depolarization during cardiac muscle cell action potential (IBA,IEA,ISO)

neuronal action potential (ISO,ISS)

positive regulation of sodium ion transport (IEA,ISO)

regulation of heart rate by cardiac conduction (IEA,ISO)

regulation of sodium ion transmembrane transporter activity (ISO)

regulation of ventricular cardiac muscle cell membrane repolarization (IBA,IEA,ISO)

sodium ion transmembrane transport (IDA,IMP,ISO)

sodium ion transport (ISO)

Cellular Component

intercalated disc (IDA)

plasma membrane (IBA,ISO,ISS)

voltage-gated sodium channel complex (IBA,IC,ISO,ISS)

Molecular Function

protein binding (ISO)

sodium channel regulator activity (IBA,ISO,ISS)

transmembrane transporter binding (IBA,IEA,ISO)

voltage-gated sodium channel activity (IDA,IMP,ISO)

voltage-gated sodium channel activity involved in cardiac muscle cell action potential (IEA,ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal action potential (IAGP)

abnormal gait (IEA)

decreased single cell response threshold (IAGP)

impaired behavioral response to amphetamine (IAGP)

reduced long-term depression (IAGP)

tremors (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
2.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:12477932	PMID:12930796	PMID:15664175	PMID:16141072	PMID:16618939	PMID:16805843	PMID:17884088	PMID:18563486	PMID:19228957	PMID:20566860	PMID:21267068
PMID:21832183	PMID:21873635	PMID:24952961	PMID:25413837	PMID:27405468	PMID:27997827	PMID:28243192	PMID:28423317	PMID:28655765	PMID:30175250	PMID:30817077	PMID:31558566
PMID:34100064	PMID:35076394	PMID:36109497	PMID:36166296	PMID:36265442	PMID:38187761	PMID:38355793

Genomics

Comparative Map Data

Scn4b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	45,049,922 - 45,065,453 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	45,049,693 - 45,065,450 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	45,138,624 - 45,154,155 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	45,138,395 - 45,154,152 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	44,947,125 - 44,962,144 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	44,890,037 - 44,905,056 (+)	NCBI		MGSCv36	mm8
Celera	9	42,414,621 - 42,429,658 (+)	NCBI		Celera
Cytogenetic Map	9	A5.2	NCBI
cM Map	9	24.84	NCBI

SCN4B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	118,133,377 - 118,152,823 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	118,133,377 - 118,152,888 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	118,004,092 - 118,023,538 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	117,509,302 - 117,528,747 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	117,509,301 - 117,528,745	NCBI
Celera	11	115,161,938 - 115,181,485 (-)	NCBI		Celera
Cytogenetic Map	11	q23.3	NCBI
HuRef	11	113,937,739 - 113,957,294 (-)	NCBI		HuRef
CHM1_1	11	117,889,900 - 117,909,461 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	118,149,764 - 118,169,227 (-)	NCBI		T2T-CHM13v2.0

Scn4b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	54,343,873 - 54,359,046 (+)	NCBI		GRCr8
mRatBN7.2	8	45,446,580 - 45,462,294 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	45,446,215 - 45,462,292 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	50,942,557 - 50,957,713 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	49,221,301 - 49,236,457 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	47,091,873 - 47,107,048 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	49,441,106 - 49,456,279 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	49,441,106 - 49,456,279 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	48,067,555 - 48,082,728 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	48,091,561 - 48,106,735 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	48,109,134 - 48,115,501 (+)	NCBI
Celera	8	45,031,630 - 45,046,803 (+)	NCBI		Celera
Cytogenetic Map	8	q22	NCBI

Scn4b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	19,311,797 - 19,331,201 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955412	19,312,697 - 19,330,913 (-)	NCBI	ChiLan1.0	ChiLan1.0

SCN4B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	118,833,696 - 118,853,389 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	119,938,643 - 119,958,340 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	112,967,190 - 112,986,727 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	116,899,268 - 116,918,893 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	116,899,268 - 116,918,892 (-)	Ensembl	panpan1.1		panPan2

SCN4B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	15,552,347 - 15,564,085 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	15,543,632 - 15,563,486 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	15,594,377 - 15,614,867 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	15,486,041 - 15,506,544 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	15,486,160 - 15,505,945 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	15,623,816 - 15,644,324 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	15,527,612 - 15,548,083 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	15,569,051 - 15,589,560 (+)	NCBI		UU_Cfam_GSD_1.0

Scn4b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	100,314,832 - 100,331,455 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936542	3,236,231 - 3,252,692 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936542	3,236,238 - 3,252,550 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SCN4B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	9	45,451,473 - 45,475,606 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	50,492,495 - 50,516,631 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SCN4B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	109,507,121 - 109,528,512 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	109,509,979 - 109,528,721 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	16,500,685 - 16,521,279 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Scn4b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624784	13,549,815 - 13,570,026 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624784	13,550,950 - 13,569,937 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Scn4b
453 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1645
Count of miRNA genes:	683
Interacting mature miRNAs:	878
Transcripts:	ENSMUST00000060125
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1301782	Chol11_m	cholesterol 11 (mouse)			Not determined		9	29292929	63293072	Mouse
11532712	Sluc39d_m	susceptibility to lung cancer 39d (mouse)					9	25587485	59587581	Mouse
12790986	Pcho9_m	plasma cholesterol 9 (mouse)					9	38099575	72099575	Mouse
13504834	Hdlq109_m	HDL QTL 109 (mouse)					9	16709641	50709641	Mouse
1357465	Vtbt6_m	vertebral trabecular bone trait 6 (mouse)			Not determined		9	16978840	50978943	Mouse
12790993	Adq1_m	aortic diameter QTL 1 (mouse)					9	15749627	49749627	Mouse
12790992	Arlsq1_m	aortic root lesion size QTL 1 (mouse)					9	38099575	72099575	Mouse
10043917	Obq37_m	obesity QTL 37 (mouse)			Not determined		9	13391175	47391175	Mouse
12790997	Adq2_m	aortic diameter QTL 2 (mouse)					9	15749627	49749627	Mouse
1301252	Etohc3_m	ethanol consumption 3 (mouse)			Not determined		9	35034478	69034599	Mouse
1357709	Si5lq3_m	serum IGFBP-5 level QTL 3 (mouse)			Not determined		9	33111025	67111140	Mouse
12791002	Arlsq2_m	aortic root lesion size QTL 2 (mouse)					9	38099575	72099575	Mouse
1301558	Stheal8_m	soft tissue heal 8 (mouse)			Not determined		9	43480714	77480860	Mouse
1301045	Sluc10_m	susceptibility to lung cancer 10 (mouse)			Not determined		9	20306197	54306370	Mouse
1357746	Vtbt7_m	vertebral trabecular bone trait 7 (mouse)			Not determined		9	30739915	64740021	Mouse
1300532	Tbs2_m	tuberculosis severity 2 (mouse)			Not determined		9	12369970	46370114	Mouse
4141591	Cq4_m	cholesterol QTL 4 (mouse)			Not determined		9	15411751	49411890	Mouse
1301435	Trigq1_m	triglyceride QTL 1 (mouse)			Not determined		9	44428174	78428262	Mouse
1301439	Morph2_m	morphine antinociception 2 (mouse)			Not determined		9	20153362	54153492	Mouse
12738415	Lfibq8_m	liver fibrosis QTL 8 (mouse)					9	41402162	45343743	Mouse
4142352	Lmr17_m	leishmaniasis resistance 17 (mouse)			Not determined		9	20306197	54306370	Mouse
12904939	Edlmmq8_m	extensor digitorum longus muscle mass QTL 8 (mouse)					9	20852740	54852740	Mouse
1301692	Hts_m	hypothermia sensitivity (mouse)			Not determined		9	32511172	66511421	Mouse
1558968	Tbdr1_m	body temperature response to dietary restriction, QTL 1 (mouse)			Not determined		9	35034478	69034599	Mouse
1300643	Pvcan2_m	protection against vaginal candidiasis 2 (mouse)			Not determined		9	19943406	53943525	Mouse
4141071	Ath29_m	atherosclerosis 29 (mouse)			Not determined		9	40419594	74607925	Mouse
13432191	Actrse4_m	activity response to saline/ethanol 4 (mouse)					9	43703214	48603195	Mouse
4141323	Ptnu3_m	proteinuria 3 (mouse)			Not determined		9	32889702	66889836	Mouse
10045613	Rapop7_m	radiation-induced apoptosis 6 (mouse)			Not determined		9	36736243	49420511	Mouse
10043950	Pbft5_m	percent body fat 5 (mouse)			Not determined		9	20306197	54306370	Mouse
11532696	Sluc39c_m	susceptibility to lung cancer 39c (mouse)					9	25587485	59587581	Mouse
1302180	Actd4_m	activity-distance traveled 4 (mouse)			Not determined		9	32434563	66434857	Mouse
4141447	Cfmq2_m	cystic fibrosis modifier QTL 2 (mouse)			Not determined		9	15411751	49411890	Mouse
11532695	Sluc39b_m	susceptibility to lung cancer 39b (mouse)					9	25587485	59587581	Mouse
11532694	Sluc39a_m	susceptibility to lung cancer 39a (mouse)					9	25587485	59587581	Mouse
13208563	Bmiq8_m	body mass index QTL 8 (mouse)					9	24911296	68907282	Mouse
11532693	Sluc39_m	susceptibility to lung cancer 39 (mouse)					9	40645374	48351476	Mouse
1301421	Lgth4_m	body length 4 (mouse)			Not determined		9	15411751	49411890	Mouse
10043867	Mtbcq9_m	multiple trait body composition QTL 9 (mouse)			Not determined		9	26796421	60796552	Mouse
1558993	Tdmq1_m	type 2 diabetes modifying QTL 1 (mouse)			Not determined		9	40419594	51808670	Mouse
1301972	Cocrb8_m	cocaine related behavior 8 (mouse)			Not determined		9	35034478	69034599	Mouse
10043987	Stheal13_m	soft tissue heal 13 (mouse)			Not determined		9	26796421	60796552	Mouse
1558872	Ibdq1_m	inflammatory bowel disease QTL 1 (mouse)			Not determined		9	33978840	73439255	Mouse
1357637	Si5lq2_m	serum IGFBP-5 level QTL 2 (mouse)			Not determined		9	15411751	49411890	Mouse
12738449	Spcq2_m	sperm count QTL 2 (mouse)					9	39399885	73399885	Mouse
1301702	Brm1_m	brachyury modifier 1 (mouse)			Not determined		9	40805047	74805204	Mouse
1300932	Hdlq17_m	HDL QTL 17 (mouse)			Not determined		9	26796421	60796552	Mouse
10043971	Obq32_m	obesity QTL 32 (mouse)			Not determined		9	37819528	71819528	Mouse
12880415	V125Dq7_m	vitamin D active form serum level QTL 7 (mouse)					9	16011296	50011296	Mouse
10043847	Hdlq89_m	HDL QTL 89 (mouse)			Not determined		9	29292929	63293072	Mouse
10045639	Heal28_m	wound healing/regeneration 28 (mouse)			Not determined		9	43480714	77480860	Mouse
4141148	Cq5_m	cholesterol QTL 5 (mouse)			Not determined		9	32452421	66452546	Mouse
12880416	V125Dq8_m	vitamin D active form serum level QTL 8 (mouse)					9	16011296	50011296	Mouse
4142042	Alpq3_m	alcohol preference QTL 3 (mouse)			Not determined		9	37306197	98701707	Mouse
1301365	Ap5q_m	alcohol preference 5 QTL (mouse)			Not determined		9	30053164	64053277	Mouse
1301883	Skull12_m	skull morphology 12 (mouse)			Not determined		9	20306197	54306370	Mouse
11354951	Pdcc3_m	plasmacytoid dentritic cell compartment 3 (mouse)					9	15749627	49749627	Mouse
1301501	Lmr2_m	leishmaniasis resistance 2 (mouse)			Not determined		9	36943406	50111140	Mouse
10043878	Adip20_m	adiposity 20 (mouse)			Not determined		9	27251194	61251323	Mouse

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001013390	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB118946	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC122305	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AI844796	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY669079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC028468	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC050045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC139399	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC139400	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BK001031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466522	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CJ057833	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CJ146846	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000060125 ⟹ ENSMUSP00000062507

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	9	45,049,693 - 45,065,450 (+)	Ensembl
GRCm38.p6 Ensembl	9	45,138,395 - 45,154,152 (+)	Ensembl

RefSeq Acc Id:

NM_001013390 ⟹ NP_001013408

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	9	45,049,922 - 45,065,453 (+)	NCBI
GRCm38	9	45,138,624 - 45,154,155 (+)	NCBI
MGSCv37	9	44,947,125 - 44,962,144 (+)	RGD
Celera	9	42,414,621 - 42,429,658 (+)	RGD
cM Map	9		ENTREZGENE

Sequence:

show sequence

ATTCCCGTCCCGCTGGAGAGGAAGAGGGCTGCCCAGGCTGGACCCTACGGCCGTGATACACGGC
GCAACGGGCACTGTGCGAAACCGACGGGGACGCCGCCCCTCCTGCGGCTGGAGCGCTTCCAGAG
CAGAGGCGCATCGCAGTGCCGCTCGCCCCGGCGTCCTCCCTTCAGCTCCGGCTCCTCCTCCCCC
TTCCAGCCCCGGCTCCTGCAGCCGGCTCCAAGAGGCGGCGGGCGCGCCTCCCCCTCCTTGGTCT
CCCCCTCGTCTCGCTCTCTCGCGGCTAACTTTCCGGAGCCCCGACCCGCGGCTCGGAGCTCCCC
TGGCAGCTGCGGGGCCCACAGACGACCTCGGGTGGAGAGCCCGGCTGTCCCCACTATTCCATCC
CAAGCCCCCGGAGCGCTCCAGAGAGAACAGGACCATGTCCCGGGCTGGGAACCGAGGCAATACT
CAGGCGAGATGGCTGGGCACTGGGCTTTTGGGTCTCTTCCTGCTTCCCATGTACCTGTCGTTGG
AGGTATCTGTGGGAAAGGCCACCACCATCTACGCTATTAACGGCTCATCGATCCTGCTGCCCTG
CACCTTCTCCAGCTGTTATGGCTTTGAGAACCTCTACTTCAAGTGGTCCTACAATAACAGCGAA
ACATCCAGGATTCTCATCGACGGGATCGTGAAGAACGATAAGTCTGACCCTAAGGTGAGAGTGA
AGGATGATGATCGAATCACCCTAGAGGGCTCCACCAAGGAGAAGACGAATAACATCTCCATCCT
CTTGAGTGACCTGGAGTTCAGTGACACGGGCAGATACACCTGCTTCGTGAGGAACCCCAAGGAG
AAGGACTTGAACAACTCTGCCACCATCTTCCTCCAAGTGGTTGATAAATTGGAAAAAGTGGACA
ACACGGTGACTCTCATCATCCTGGCTGTGGTGGGCGGGGTCATTGGACTTCTTGTTTGCATCCT
TCTGCTGAAGAAGCTCATCACCTTCATCCTGAAGAAGACCCGAGAGAAGAAGAAGGAGTGTCTC
GTGAGTTCCTCTGGGAATGACAACACAGAGAACGGGTTGCCTGGCTCCAAGGCAGAAGAGAAGC
CACCCACAAAAGTGTGAGGCCCTGCTCGGGCCAAGCAGGGCAGGGAGCCTCGCTTTCTGATGGT
GATCCTGATGCCAAGTCCTATCTGAGATGTGTGCTGCTTGGCCCAAACTGTTCTTTCTGAGCAG
GAAGGACCTGGCCCTGCCCAGCTGCCGTTCTCTCCCCAGCCAGGGCTTCCTAGGGACAAGGGTT
GGTTGACTGGGGGAGGAAGCCTACAGGAGATTGAAGACAGGGAAGGGAGGGGCTGGAGTGGTGT
GGAAGGTTGGTTCCCGGATCCTGGGCACGTGGGGTCTCCTTTAGATTTTCCCCTCTGTGAAGCC
TTGTTTTCTCCTCAGTTTTCCTTCTGATCTTTCACCAGGAAATCGGGGTGACCAGTGAGGGCTG
CTTCCAAAGCTGGGGTCTGGAGATGGGTAGAGGGTGACCGCTTCAGAAGCTGGGAATGCACAAG
AAGTCTAGAATGGTGTCTTCTGGGGGGGGGGGGGGCAGTTGTGAGAGGCAAGCTGGGCTCTGAA
GAATATCAGGCTTCTGGAAGTTCCTTTAGAGAGGACTTCTCTTTCCCTTACCCTAGAACACCTG
CCCACACTGTCCTGGCTCCCCGACCAGCCTCCTCCTGCTGCCTGCCTAGTCTGTCTTTGCTCTC
TGGGCTGCAGCTGCTGAGGAGGCTTGTGGGGAGGGGGCAGCCTCCACTCTCCTGGAGCACTGGG
GTGCTATTTGCAGCTATACTGGCTTTGCTCTTTGGGTTTCAGAGGCAGGAGAACAGTGCCCCTG
GTCTCCTAGCCTTTGGAATGTCTACCCCAGCCCTACAAGACTGACAGCCCTTGTCCTTGGCATG
GCAGGACCATGCCACCCTGGCACTTCCGGAGCTCAGTTTTTCACTCTTCTTCCCTTCCCTTGAA
ACAGCTGGCATTGCCACCTTCCCTGAGGGATGCTTTCCTAGGACTTGTCATCCCATACCTTTGC
TCCTTCTGTGTCCATCCAGCATGCCTGGCCTTCCCCTGCTCCTGGCCCCCCAGCTCTGGGTCTG
CCTTTGCCTCAGGGACCCTTGTTTCCAGATGAGAAGGCCCTTGGCTTTTCCAGCTTCTTTTTTG
CCCAGCTGGGCTGACTCCTCACCTAGCCTGAGGCTGAGGAGGAGCTGGGAGAAGGTACTCACAC
CTTCTCTTGACTTCTGGCAGAGCCGGCTTGCACACCCCCTGAGTGTGGGGCTAGATTGTGCCTT
AGTTCCTCGAGTCCTGGTTCTGAGCCCCTTTTCTTTCGGCTCACACTCCCTGAATTAATTGCAC
AGCTTGGTGTGACTTTGGCGGGGCTCCCCAGCTCCTTACCCCAAAGCCATGGAAGAGACCATGA
AGCCGGGGTTGGTGGCAGCCTTGATGACACCTGAGGGCACCCTTTCTTGTCCCTGACATGGAGA
TAGGATGGCATTTGATGTGGGACCTTCAGATGGGTTTGACCGTGTACAAACCGTAGTGCTAGCT
AGGGTTTCTGTGATGTATGAAATGGGATACCCAAAGTCCCTCTTCCTCATCAGATTTCTGATAC
CCTTAATGTCAGAAGATGGAGATTAGTCCTCTTTTCAGGGGGGTGTAAGGACTGCTACAGGCTC
TGCCCAGGAGTAGCTGAAGGTTCCCCCCCCCAAATGGAAGTTGGGGGAGACTAAGGCACAGTAG
GATCTGTAGGTGACTGTGGCTTTGGCTAGTGTCTGTTGCCCAAGCCAAGGGGCTCTTGGGGTTG
CCTCCACTCTTCCCATTCTTCTTTACCCAGAACTCATTGTGAGCTGGGTAAAAATTGCCCGTCT
CCTGCTTTTTAAATATTTATTTGAGCAGAGTCTCATGTGTGGCCCAGGCGGGCCTCCACCTCTC
TATGTAGCCAAGACTGGCCTTGAACTCCCAATCTCCTGCCTCCATTGCCACAGTGCTGGTATGA
CAGGTGTGAGCCCACACCCTGCTTAGAGTAACCTGGCTCTGAGAACCAACATGGCACCCGAGCC
TCCAGCCATTCAGGAAACTTCCAGCTGCCTTCATGTAAAACTGCTTTCTCCCCCAACACTGGAA
GAGGCCAAGTGTTGGGGGTTCTTCTTGCTTTCCTGAGAGGAAGCCAAGGCATAGAGCAGAAGAG
AGGGAGGGACTCTCCCTTCCCAGCTTCCTGCTCACTGTCAGCTTATAGGCAGCCCTTGCAGCTT
CTCCCATCTACCCAAAGGGTGAAATAATACCTACCTCACAGGACTGCAGTGAGGCTTGGTGAGA
TTTTTGTGTTTTTTGTTTTTTTGGCCTGGCTTGGAAAGGCACTGGGAAACAAGGCTAATAACCA
GCGAGAATGTTCCACATCTATCCTGTCCTCATCTCTGGTTTGCATCCCAATAATATGCATATGC
CTCATTCTTCTTCCTTTAGCAACCTTAGGCATCATGACTCAGATGCTTAAAGCATCTTTGTCCC
CAGTTCTTTTTTTTTTTTGATGGAGGTACCTGGGACTATGGGAGTACTTTTTTATATTGTTGTT
GCCCCAATGCCTGTGATAAATACTAGCGTTTAATGGATAGGGATTAAGAGCACAAATCTCAGTC
CTCTTAACAAAGAATGTCTGGCCTAGTGCTAGCGGCATGCCTGTGCAGGCATTACCACGGATTG
TGTTAGAATGTATATTTGCAAAGCCATTTTCTCTAGCCAGACCCTCTGACAGGCAAGTCTTCAA
ATAGCGATCTCAGGGTTGCTGAGGTTGGTCCCGGTGCCAGTGGGCTACAGCACCTCTCATACGG
TTGACTTTGGGGAAACCTGGACCCATGCAGTTGTGTTGACCTTGATGTCAGTGAGACCAAAGAC
AAAGCACAAGTACCTTACTCTTGACTTCCAAATAAACTTCTGCCCTTGAGGGCTCAGATCCCTT
GGTGTAGAAACTAAGCAGAGGGCAACTGGAATCAACCTGCAGTGTGGAAGGCCCAGGAGAATGA
CAGACAGGAGGGCAGCAGAATGTCACGTATCTGACTGACTCGCTTCTGTGGAGCCAGGGAGGCA
AGAGCATCCTGCTGGTGGGAGGTGAGGGTGCACTTGTGTGGAGTGCTTGTGGTGTGTGGGAGGT
GGAAAGGCGTGCCTAGTCAGTCTGCGGGTGCAGAGGCATGACAGAAGAGGGTGGGCTGTGCACG
CGAGGGGTGATGTGGGATGAAGGGGTTGGGGGTGGGGCTCTGCATCTTCAGTAGCCTGAACTGG
AGACTGAAGAAGGGTTAAGAGACATAAATGAACGGCTATGCTCCTGGATTCTACTGGGTGACTC
CATGTCAGGGTGACAGACGACTGCCACCGGAGGGCTGGGGCAAGGATGCCCAAATGAGGGATTT
GTGGGGAAGTCCTCTAGCTTGCTACATTTTATTTTGTCCCAGGTTGGAGTCCCTGCTCTCCCAT
CTCCCACTGGATGTGCAGTGCTTTTGACTATCTTATGCATGGTTTAGTCCTCTGGCTTGGATAA
CAGTACCCATAGTCAATTTTCCTATCTAACTTTATAGGCAATACAGTGGTGGGCCGTGGGAGCC
TCCAGGAGGCACCGACCTGCACATGCCCAGCGCTTGCGTCTAAGCACAGATCGAATGCCATTAG
GTTGTCTTGCCTCTACAATACATTTTGCATTGCAGACTTGGATTTAGCTTCGCTTTGGATGAAA
TAAAAATTATTTTTTAATAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001013408	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI39400	(Get FASTA)	NCBI Sequence Viewer
	AAI39401	(Get FASTA)	NCBI Sequence Viewer
	AAU05394	(Get FASTA)	NCBI Sequence Viewer
	BAE93689	(Get FASTA)	NCBI Sequence Viewer
	DAA01205	(Get FASTA)	NCBI Sequence Viewer
	EDL25637	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000062507
	ENSMUSP00000062507.6
GenBank Protein	Q7M729	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001013408 ⟸ NM_001013390
- Peptide Label:	precursor
- UniProtKB:	Q7M729 (UniProtKB/Swiss-Prot), Q1MXF9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSRAGNRGNTQARWLGTGLLGLFLLPMYLSLEVSVGKATTIYAINGSSILLPCTFSSCYGFENL YFKWSYNNSETSRILIDGIVKNDKSDPKVRVKDDDRITLEGSTKEKTNNISILLSDLEFSDTGR YTCFVRNPKEKDLNNSATIFLQVVDKLEKVDNTVTLIILAVVGGVIGLLVCILLLKKLITFILK KTREKKKECLVSSSGNDNTENGLPGSKAEEKPPTKV hide sequence

Ensembl Acc Id:

ENSMUSP00000062507 ⟸ ENSMUST00000060125

Protein Domains

Ig-like Ig-like C2-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q7M729-F1-model_v2	AlphaFold	Q7M729	1-228	view protein structure

Promoters

RGD ID:

6849272

Promoter ID:

MM_XEF:7422

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Brain

Transcripts:

NM_001142349

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	9	44,953,581 - 44,954,081 (+)	MPROMDB

RGD ID:

8669436

Promoter ID:

EPDNEW_M12749

Type:

initiation region

Name:

Scn4b_1

Description:

Mus musculus sodium channel, type IV, beta , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	9	45,138,944 - 45,139,004	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:2687406	AgrOrtholog
Ensembl Genes	ENSMUSG00000046480	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000060125	ENTREZGENE
	ENSMUST00000060125.7	UniProtKB/Swiss-Prot
Gene3D-CATH	2.60.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Ig-like_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig_sub	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig_V-set	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Myelin_P0-rel	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:399548	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD	MGI:2687406	ENTREZGENE
NCBI Gene	399548	ENTREZGENE
PANTHER	PTHR13869	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR13869:SF14	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	V-set	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	SCN4B	RGD
PhenoGen	Scn4b	PhenoGen
PROSITE	IG_LIKE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	SM00409	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	Q1MXF9	ENTREZGENE, UniProtKB/TrEMBL
	Q7M729	ENTREZGENE, UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Mammalian Phenotype

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Mammalian Phenotype