Psme2b (protease (prosome, macropain) activator subunit 2B) - Rat Genome Database

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Gene: Psme2b (protease (prosome, macropain) activator subunit 2B) Mus musculus
Analyze
No known orthologs.
Symbol: Psme2b
Name: protease (prosome, macropain) activator subunit 2B
RGD ID: 1620319
MGI Page MGI
Description: Predicted to enable identical protein binding activity. Orthologous to human PSME2 (proteasome activator subunit 2).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: OTTMUSWSBG00059279; OTTMUSWSBP00075795; PA28; PA28 beta subunit (PA28b) pseudogene; PA28b-p; PA28b2; protease (prosome, macropain) 28 subunit beta B; protease (prosome, macropain) 28 subunit beta B, pseudogene; protease (prosome, macropain) 28 subunit, beta, b; proteasome activator complex like; Psme; Psme2; Psme2-; Psme2-like; Psme2b-ps
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391148,836,172 - 48,837,237 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1148,836,181 - 48,837,017 (-)EnsemblGRCm39 Ensembl
GRCm381148,945,345 - 48,946,410 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1148,945,354 - 48,946,190 (-)EnsemblGRCm38mm10GRCm38
MGSCv371148,758,847 - 48,759,650 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361148,788,495 - 48,789,833 (-)NCBIMGSCv36mm8
Cytogenetic Map11B1.2NCBI
cM Map1128.93NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9162094   PMID:9218537   PMID:9590240   PMID:9914329   PMID:10222192   PMID:11345588   PMID:11689430   PMID:15489334   PMID:15944286   PMID:16141072   PMID:21267068   PMID:23170223  
PMID:30457570  


Genomics


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse
12910801Pwbwq14_mpost-weaning body weight QTL 14 (mouse)112719805750636094Mouse
12910804Pwbwq16_mpost-weaning body weight QTL 16 (mouse)112719805750636094Mouse
12910806Pwbwq15_mpost-weaning body weight QTL 15 (mouse)112719805750636094Mouse
12910817Pwgrq20_mpost-weaning growth rate QTL 20 (mouse)112719805750636094Mouse
12910818Ogrq5_moverall growth rate QTL 5 (mouse)112719805750636094Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
10053675Eae44b_mexperimental allergic encephalomyelitis susceptibility 44b (mouse)Not determined113995072854094448Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
1300713Vmbic10_mventral midbrain iron content 10 (mouse)Not determined114277262654081064Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
13452402Hipmt3_mhippocampal morphometry trait 3 (mouse)114797732550277325Mouse

Markers in Region
RH129915  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381455,587,466 - 55,588,058UniSTSGRCm38
GRCm381148,945,380 - 48,945,585UniSTSGRCm38
MGSCv371456,206,303 - 56,206,895UniSTSGRCm37
MGSCv371148,758,882 - 48,759,087UniSTSGRCm37
Celera1453,392,526 - 53,393,118UniSTS
Cytogenetic Map14C2-D1UniSTS
Cytogenetic Map11B1.2UniSTS
RH124942  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381148,945,524 - 48,945,860UniSTSGRCm38
MGSCv371148,759,026 - 48,759,362UniSTSGRCm37
Cytogenetic Map14C2-D1UniSTS
Cytogenetic Map11B1.2UniSTS
MARC_4677-4678:996679594:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381455,588,475 - 55,589,335UniSTSGRCm38
GRCm381148,945,721 - 48,945,793UniSTSGRCm38
MGSCv371456,207,312 - 56,208,172UniSTSGRCm37
MGSCv371148,759,223 - 48,759,295UniSTSGRCm37
Celera1453,393,535 - 53,394,395UniSTS
Cytogenetic Map14C2-D1UniSTS
Cytogenetic Map11B1.2UniSTS
RH71322  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381148,945,405 - 48,945,575UniSTSGRCm38
MGSCv371148,758,907 - 48,759,077UniSTSGRCm37
Cytogenetic Map14C2-D1UniSTS
Cytogenetic Map11B1.2UniSTS
Psme2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1.2UniSTS
Cytogenetic Map14C2-D1UniSTS
Cytogenetic Map13B3UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000104958   ⟹   ENSMUSP00000100564
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1148,836,181 - 48,837,017 (-)Ensembl
GRCm38.p6 Ensembl1148,945,354 - 48,946,190 (-)Ensembl
RefSeq Acc Id: NM_001281472   ⟹   NP_001268401
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391148,836,172 - 48,837,237 (-)NCBI
GRCm381148,945,345 - 48,946,410 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001268401 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD38121 (Get FASTA)   NCBI Sequence Viewer  
  BAA22040 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000100564
  ENSMUSP00000100564.2
  ENSMUSP00000123798.2
GenBank Protein SDA08594 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001268401   ⟸   NM_001281472
- UniProtKB: O35562 (UniProtKB/Swiss-Prot),   P97372 (UniProtKB/Swiss-Prot),   Q5SVP3 (UniProtKB/TrEMBL),   A0A1G5SJA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000100564   ⟸   ENSMUST00000104958
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97372-F1-model_v2 AlphaFold P97372 1-239 view protein structure

Promoters
RGD ID:8674446
Promoter ID:EPDNEW_M15254
Type:single initiation site
Name:Psme2b_1
Description:Mus musculus protease (prosome, macropain) activator subunit2B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381148,946,451 - 48,946,511EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1341073 AgrOrtholog
Ensembl Genes ENSMUSG00000078153 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSG00000079197 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000104958 ENTREZGENE
  ENSMUST00000104958.2 UniProtKB/Swiss-Prot
  ENSMUST00000161807.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.5.120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PA28_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PA28_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PA28_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Proteasome_activ_PA28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Proteasome_activ_PA28_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Proteasome_activ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19188 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  mmu:621823 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1341073 ENTREZGENE
NCBI Gene 621823 ENTREZGENE
PANTHER PROTEASOME ACTIVATOR COMPLEX SUBUNIT 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10660 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PA28_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PA28_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Psme2b PhenoGen
Superfamily-SCOP SSF47216 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1G5SJA5 ENTREZGENE
  O35562 ENTREZGENE
  P97372 ENTREZGENE, UniProtKB/Swiss-Prot
  Q5SVP3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O35562 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-06 Psme2b  protease (prosome, macropain) activator subunit 2B  Psme2b-ps  protease (prosome, macropain) 28 subunit beta B, pseudogene  Symbol and/or name change 5135510 APPROVED