Gstm3 (glutathione S-transferase, mu 3) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Gstm3 (glutathione S-transferase, mu 3) Mus musculus
Analyze
Symbol: Gstm3
Name: glutathione S-transferase, mu 3
RGD ID: 1620117
MGI Page MGI
Description: Predicted to enable several functions, including glutathione binding activity; glutathione transferase activity; and protein homodimerization activity. Acts upstream of or within cellular response to drug; cellular response to organic cyclic compound; and response to bacterium. Predicted to be located in cytosol and intercellular bridge. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human GSTM1 (glutathione S-transferase mu 1); PARTICIPATES IN glutathione metabolic pathway; .
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI042769; Fsc; Fsc2; glutathione S-transferase GT9.3; glutathione S-transferase Mu 3; glutathione-S-transferase, mu 3; GST class-mu 3; mGSTM; mGSTM5
RGD Orthologs
Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm8834  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393107,871,012 - 107,876,490 (-)NCBIGRCm39mm39
GRCm39 Ensembl3107,871,012 - 107,876,599 (-)Ensembl
GRCm383107,963,696 - 107,969,174 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,963,696 - 107,969,283 (-)EnsemblGRCm38mm10GRCm38
MGSCv373107,766,614 - 107,772,076 (-)NCBIGRCm37mm9NCBIm37
MGSCv363108,091,752 - 108,097,214 (-)NCBImm8
Celera3110,296,772 - 110,302,234 (-)NCBICelera
Cytogenetic Map3F2.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:3417659   PMID:3864155   PMID:6822548   PMID:8471052   PMID:8512323   PMID:8607970   PMID:9545290   PMID:12477932   PMID:15489334   PMID:16549767   PMID:21483640   PMID:21873635  
PMID:23012479   PMID:24859727   PMID:32325033  


Genomics

Comparative Map Data
Gstm3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393107,871,012 - 107,876,490 (-)NCBIGRCm39mm39
GRCm39 Ensembl3107,871,012 - 107,876,599 (-)Ensembl
GRCm383107,963,696 - 107,969,174 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,963,696 - 107,969,283 (-)EnsemblGRCm38mm10GRCm38
MGSCv373107,766,614 - 107,772,076 (-)NCBIGRCm37mm9NCBIm37
MGSCv363108,091,752 - 108,097,214 (-)NCBImm8
Celera3110,296,772 - 110,302,234 (-)NCBICelera
Cytogenetic Map3F2.3NCBI
Gstm3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0 Ensembl2210,685,197 - 210,688,272 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02210,685,204 - 210,688,273 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Celera2188,177,950 - 188,181,024 (+)NCBICelera
Cytogenetic Map2q34NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33200000142700000Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316000000109800000Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316450000130370000Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328900000119100000Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330013439147599053Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337120713143647422Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)341000000116000000Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352300000137500000Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)368000000128600000Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375555995109556242Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379641414113641521Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381177336115177481Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382239727116239868Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383556675117556821Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383556675117556821Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383556675117556821Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383556675117556821Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383556675117556821Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383556675117556821Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383556675117556821Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383975596117975728Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384981602118981751Mouse
14746984Manh54_mmandible shape 54 (mouse)385381836119381836Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387301597125522587Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387320699121320699Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389232660137747247Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390469620124469756Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390470701124470701Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391092789125101432Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392344217126344334Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396700000148100000Mouse
10043955Wt10q4_mbody weight, 10 weeks, QTL 4 (mouse)Not determined398830392132830548Mouse
11533920Mvb3_mmodifier of vibrator 3 (mouse)398841635132841734Mouse
12792984Modn1_mmodifier of Dstn neovascularization 1 (mouse)398841635132841734Mouse
1302114Tbs1_mtuberculosis severity 1 (mouse)Not determined399130456133130601Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100465596147339967Mouse
26884419Bzwq6_mbi-zygomatic width QTL 6, 10 week (mouse)3100700000137500000Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101400000150100000Mouse
1301805Mors2_mmodifier of obesity related sterility 2 (mouse)Not determined3103689010137689134Mouse
1357599msrvh1_mmodifier of susceptibility to renal vascular hypertrophy/hyperplasia 1 (mouse)Not determined3107469620115830548Mouse
4141220Cia22_mcollagen induced arthritis 22 (mouse)Not determined3107469620125522588Mouse
8655599Cia5c_mcollagen induced arthritis QTL 5c (mouse)Not determined3107469620125522588Mouse
1302093Orgwq5_morgan weight QTL 5 (mouse)Not determined3107469620147599053Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:572
Count of miRNA genes:233
Interacting mature miRNAs:256
Transcripts:ENSMUST00000004136, ENSMUST00000106678
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000004136   ⟹   ENSMUSP00000004136
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3107,963,696 - 107,969,283 (-)Ensembl
RefSeq Acc Id: NM_010359   ⟹   NP_034489
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393107,871,012 - 107,876,490 (-)NCBI
GRCm383107,963,696 - 107,969,174 (-)ENTREZGENE
MGSCv373107,766,614 - 107,772,076 (-)RGD
Celera3110,296,772 - 110,302,250 (-)ENTREZGENE
cM Map3 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_034489 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA37748 (Get FASTA)   NCBI Sequence Viewer  
  AAH44927 (Get FASTA)   NCBI Sequence Viewer  
  P19639 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_034489   ⟸   NM_010359
- UniProtKB: P19639 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000004136   ⟸   ENSMUST00000004136
Protein Domains
GST C-terminal   GST N-terminal

Promoters
RGD ID:6833921
Promoter ID:MM_KWN:35738
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000106678,   NM_010359
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363107,771,866 - 107,772,366 (-)MPROMDB
RGD ID:6882038
Promoter ID:EPDNEW_M4470
Type:multiple initiation site
Name:Gstm3_1
Description:Mus musculus glutathione S-transferase, mu 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383107,969,168 - 107,969,228EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:106026 AgrOrtholog
Ensembl Genes ENSMUSG00000004038 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000004136 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000004136 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.30.10 UniProtKB/Swiss-Prot
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot
  GST_C UniProtKB/Swiss-Prot
  GST_mu UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report mmu:14864 UniProtKB/Swiss-Prot
MGD MGI:106026 ENTREZGENE
NCBI Gene 14864 ENTREZGENE
Pfam GST_C UniProtKB/Swiss-Prot
  GST_N UniProtKB/Swiss-Prot
PhenoGen Gstm3 PhenoGen
PRINTS GSTRNSFRASEM UniProtKB/Swiss-Prot
PROSITE GST_CTER UniProtKB/Swiss-Prot
  GST_NTER UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/Swiss-Prot
UniProt GSTM3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE