Sapcd2 (suppressor APC domain containing 2) - Rat Genome Database

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Gene: Sapcd2 (suppressor APC domain containing 2) Mus musculus
Analyze
Symbol: Sapcd2
Name: suppressor APC domain containing 2
RGD ID: 1619980
MGI Page MGI
Description: Involved in establishment of mitotic spindle orientation; regulation of establishment of planar polarity; and symmetric cell division. Located in apical cortex. Is expressed in several structures, including genitourinary system; liver; lung; nervous system; and neural ectoderm. Orthologous to human SAPCD2 (suppressor APC domain containing 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2010317E24Rik; 6030458L21Rik; a; AL033337; Ang; protein C9orf140 homolog; RP23-47P18.4; suppressor APC domain-containing protein 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,261,974 - 25,268,225 (+)NCBIGRCm39mm39
GRCm39 Ensembl225,262,333 - 25,268,225 (+)Ensembl
GRCm38225,372,035 - 25,378,213 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,372,321 - 25,378,213 (+)EnsemblGRCm38mm10GRCm38
MGSCv37225,227,841 - 25,233,733 (+)NCBIGRCm37mm9NCBIm37
MGSCv36225,194,330 - 25,217,374 (+)NCBImm8
Celera225,099,316 - 25,105,204 (+)NCBICelera
Cytogenetic Map2A3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7671812   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466305   PMID:12466851   PMID:12477932   PMID:15567712   PMID:16141072   PMID:16141073  
PMID:17531978   PMID:26766442  


Genomics

Comparative Map Data
Sapcd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,261,974 - 25,268,225 (+)NCBIGRCm39mm39
GRCm39 Ensembl225,262,333 - 25,268,225 (+)Ensembl
GRCm38225,372,035 - 25,378,213 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,372,321 - 25,378,213 (+)EnsemblGRCm38mm10GRCm38
MGSCv37225,227,841 - 25,233,733 (+)NCBIGRCm37mm9NCBIm37
MGSCv36225,194,330 - 25,217,374 (+)NCBImm8
Celera225,099,316 - 25,105,204 (+)NCBICelera
Cytogenetic Map2A3NCBI
SAPCD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,062,127 - 137,070,557 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9137,062,127 - 137,070,557 (-)EnsemblGRCh38hg38GRCh38
GRCh379139,956,579 - 139,965,009 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,076,585 - 139,084,849 (-)NCBINCBI36hg18NCBI36
Build 349137,232,612 - 137,240,865NCBI
Celera9110,469,998 - 110,478,498 (-)NCBI
Cytogenetic Map9q34.3NCBI
HuRef9109,416,325 - 109,424,724 (-)NCBIHuRef
CHM1_19140,105,341 - 140,113,747 (-)NCBICHM1_1
T2T-CHM13v2.09149,298,084 - 149,306,470 (-)NCBI
Sapcd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.238,186,089 - 8,195,119 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl38,187,266 - 8,192,546 (+)Ensembl
Rnor_6.032,590,355 - 2,597,283 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,591,331 - 2,596,583 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,572,744 - 2,577,997 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,538,477 - 3,543,730 (+)NCBIRGSC3.4rn4RGSC3.4
Celera33,013,398 - 3,018,651 (+)NCBICelera
Cytogenetic Map3p13NCBI
Sapcd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555135,086,379 - 5,090,876 (-)NCBIChiLan1.0ChiLan1.0
SAPCD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19137,091,559 - 137,099,275 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v09108,122,658 - 108,132,397 (-)NCBIMhudiblu_PPA_v0panPan3
SAPCD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,571,045 - 48,578,517 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,570,891 - 48,594,452 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,784,755 - 47,792,772 (+)NCBI
ROS_Cfam_1.0949,449,167 - 49,456,459 (+)NCBI
ROS_Cfam_1.0 Ensembl949,449,028 - 49,453,759 (+)Ensembl
UMICH_Zoey_3.1948,225,429 - 48,233,433 (+)NCBI
UNSW_CanFamBas_1.0948,524,187 - 48,531,479 (+)NCBI
UU_Cfam_GSD_1.0948,571,456 - 48,579,474 (+)NCBI
Sapcd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,481,287 - 202,486,112 (-)NCBI
SpeTri2.0NW_004936669888,911 - 893,981 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SAPCD2
(Sus scrofa - pig)
No map positions available.
SAPCD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,119,873 - 1,127,966 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl121,121,302 - 1,127,533 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660584,174,059 - 4,182,871 (-)NCBIVero_WHO_p1.0
Sapcd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760843,760 - 847,327 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624760843,746 - 848,104 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
2010317E24Rik  
Mouse AssemblyChrPosition (strand)SourceJBrowse
cM Map217.2UniSTS
cM Map2 UniSTS
RH124229  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38225,377,271 - 25,377,394UniSTSGRCm38
MGSCv37225,232,791 - 25,232,914UniSTSGRCm37
Celera225,104,262 - 25,104,385UniSTS
Cytogenetic Map2A3UniSTS
2010317E24Rik  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2A3UniSTS
cM Map217.2UniSTS
2010317E24Rik  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2A3UniSTS
cM Map2 UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141836Tgq11_mtriglyceride QTL 11 (mouse)Not determined125324559Mouse
4142333Tgq10_mtriglyceride QTL 10 (mouse)Not determined125324559Mouse
1301838Sluc16_msusceptibility to lung cancer 16 (mouse)Not determined2126529589Mouse
12904743Carcdq3_mcardiac collagen deposition QTL 3 (mouse)2323494028179150Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
12903993Opfaq1_mopen field activity QTL 1 (mouse)2967669127022642Mouse
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21421456748214713Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22368914557689269Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
26884438Sklq12_mskull length QTL 12, 16 week (mouse)22459001254890012Mouse
8552705Cia25_mcollagen induced arthritis 25 (mouse)Not determined22467911533523172Mouse
8552706Cia24_mcollagen induced arthritis QTL 24 (mouse)Not determined22467911533523172Mouse
12792980Fbmd1_mfemoral bone mineral density 1, females only (mouse)22503449245034492Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir409mmu-miR-409-3pOncomiRDBexternal_infoNANA22531314
Mir29ammu-miR-29a-3pOncomiRDBexternal_infoNANA21998710

Predicted Target Of
Summary Value
Count of predictions:1723
Count of miRNA genes:597
Interacting mature miRNAs:739
Transcripts:ENSMUST00000028329, ENSMUST00000100323, ENSMUST00000114293, ENSMUST00000129214, ENSMUST00000132539, ENSMUST00000137171, ENSMUST00000155310
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001081085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001290407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006498360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004940736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004940737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB197927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL732557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK331200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000028329   ⟹   ENSMUSP00000028329
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl225,262,333 - 25,268,225 (+)Ensembl
GRCm38.p6 Ensembl225,372,321 - 25,378,213 (+)Ensembl
RefSeq Acc Id: ENSMUST00000100323   ⟹   ENSMUSP00000097898
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl225,262,346 - 25,266,815 (+)Ensembl
GRCm38.p6 Ensembl225,372,334 - 25,376,803 (+)Ensembl
RefSeq Acc Id: ENSMUST00000114293   ⟹   ENSMUSP00000109932
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl225,262,342 - 25,266,815 (+)Ensembl
GRCm38.p6 Ensembl225,372,330 - 25,376,803 (+)Ensembl
RefSeq Acc Id: ENSMUST00000129214
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl225,265,972 - 25,266,812 (+)Ensembl
GRCm38.p6 Ensembl225,375,960 - 25,376,800 (+)Ensembl
RefSeq Acc Id: ENSMUST00000132539
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl225,265,786 - 25,266,789 (+)Ensembl
GRCm38.p6 Ensembl225,375,774 - 25,376,777 (+)Ensembl
RefSeq Acc Id: ENSMUST00000137171
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl225,265,033 - 25,266,284 (+)Ensembl
GRCm38.p6 Ensembl225,375,021 - 25,376,272 (+)Ensembl
RefSeq Acc Id: ENSMUST00000155310
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl225,262,372 - 25,265,154 (+)Ensembl
GRCm38.p6 Ensembl225,372,360 - 25,375,142 (+)Ensembl
RefSeq Acc Id: NM_001081085   ⟹   NP_001074554
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39225,262,047 - 25,268,225 (+)NCBI
GRCm38225,372,035 - 25,378,213 (+)NCBI
MGSCv37225,227,841 - 25,233,733 (+)RGD
Celera225,099,030 - 25,105,204 (+)NCBI
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001290407   ⟹   NP_001277336
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39225,262,047 - 25,268,225 (+)NCBI
GRCm38225,372,035 - 25,378,213 (+)NCBI
Celera225,099,030 - 25,105,204 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006498360   ⟹   XP_006498423
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39225,261,974 - 25,266,818 (+)NCBI
GRCm38225,372,099 - 25,376,806 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004940736
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39225,261,974 - 25,266,818 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004940737
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39225,261,974 - 25,266,818 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001074554   ⟸   NM_001081085
- Peptide Label: isoform a
- UniProtKB: Q9D818 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006498423   ⟸   XM_006498360
- Peptide Label: isoform X1
- UniProtKB: Q9D818 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001277336   ⟸   NM_001290407
- Peptide Label: isoform b
- UniProtKB: Q6NS42 (UniProtKB/Swiss-Prot),   Q9D818 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000028329   ⟸   ENSMUST00000028329
RefSeq Acc Id: ENSMUSP00000097898   ⟸   ENSMUST00000100323
RefSeq Acc Id: ENSMUSP00000109932   ⟸   ENSMUST00000114293

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D818-F1-model_v2 AlphaFold Q9D818 1-391 view protein structure

Promoters
RGD ID:6832568
Promoter ID:MM_KWN:28138
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000114293,   NM_001081085,   OTTMUST00000028577,   UC008IRT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36225,227,556 - 25,228,217 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919330 AgrOrtholog
Ensembl Genes ENSMUSG00000026955 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000028329 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000097898 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000109932 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000028329 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000100323 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000114293 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Suppressor_APCD_1/2 UniProtKB/Swiss-Prot
KEGG Report mmu:72080 UniProtKB/Swiss-Prot
MGD MGI:1919330 ENTREZGENE
NCBI Gene 72080 ENTREZGENE
PANTHER PTHR14907 UniProtKB/Swiss-Prot
PhenoGen Sapcd2 PhenoGen
UniProt Q6NS42 ENTREZGENE
  Q9D818 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A2AJ17 UniProtKB/Swiss-Prot
  Q3TL89 UniProtKB/Swiss-Prot
  Q3TP90 UniProtKB/Swiss-Prot
  Q3TQ24 UniProtKB/Swiss-Prot
  Q6NS42 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-11-27 Sapcd2  suppressor APC domain containing 2  2010317E24Rik  RIKEN cDNA 2010317E24 gene  Symbol and/or name change 5135510 APPROVED