Pradc1 (protease-associated domain containing 1) - Rat Genome Database
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Gene: Pradc1 (protease-associated domain containing 1) Mus musculus
Analyze
Symbol: Pradc1
Name: protease-associated domain containing 1
RGD ID: 1619972
MGI Page MGI
Description: Is expressed in submandibular gland primordium and thymus primordium. Orthologous to human PRADC1 (protease associated domain containing 1); INTERACTS WITH tetrachloromethane; (+)-schisandrin B (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1700040I03Rik; Pap21; protease-associated domain-containing protein 1; protease-associated domain-containing protein of 21 kDa
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39685,423,767 - 85,428,969 (-)NCBIGRCm39mm39
GRCm39 Ensembl685,423,792 - 85,428,952 (-)Ensembl
GRCm38685,446,785 - 85,451,987 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl685,446,810 - 85,451,970 (-)EnsemblGRCm38mm10GRCm38
MGSCv37685,396,779 - 85,401,964 (-)NCBIGRCm37mm9NCBIm37
MGSCv36685,412,443 - 85,416,941 (-)NCBImm8
Celera687,418,724 - 87,423,912 (-)NCBICelera
Cytogenetic Map6C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. RGD automated import pipeline
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:16602821   PMID:18799693   PMID:21267068   PMID:21677750   PMID:31689374  


Genomics

Comparative Map Data
Pradc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39685,423,767 - 85,428,969 (-)NCBIGRCm39mm39
GRCm39 Ensembl685,423,792 - 85,428,952 (-)Ensembl
GRCm38685,446,785 - 85,451,987 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl685,446,810 - 85,451,970 (-)EnsemblGRCm38mm10GRCm38
MGSCv37685,396,779 - 85,401,964 (-)NCBIGRCm37mm9NCBIm37
MGSCv36685,412,443 - 85,416,941 (-)NCBImm8
Celera687,418,724 - 87,423,912 (-)NCBICelera
Cytogenetic Map6C3NCBI
PRADC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl273,228,010 - 73,233,239 (-)EnsemblGRCh38hg38GRCh38
GRCh38273,228,006 - 73,233,284 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37273,455,134 - 73,460,412 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36273,308,642 - 73,313,864 (-)NCBINCBI36hg18NCBI36
Build 34273,366,790 - 73,372,011NCBI
Celera273,305,961 - 73,311,182 (-)NCBI
Cytogenetic Map2p13.2NCBI
HuRef273,190,796 - 73,196,012 (-)NCBIHuRef
CHM1_1273,385,941 - 73,391,163 (-)NCBICHM1_1
Pradc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24117,984,732 - 117,989,710 (-)NCBI
Rnor_6.0 Ensembl4117,230,528 - 117,234,928 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04117,230,523 - 117,235,496 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04181,808,138 - 181,812,927 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera4106,966,767 - 106,971,740 (-)NCBICelera
Cytogenetic Map4q34NCBI
Pradc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542412,402,923 - 12,410,735 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542412,403,090 - 12,408,055 (+)NCBIChiLan1.0ChiLan1.0
PRADC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A74,769,555 - 74,775,787 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A74,769,555 - 74,775,787 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A73,280,791 - 73,286,879 (-)NCBIMhudiblu_PPA_v0panPan3
PRADC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1749,633,769 - 49,637,708 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11749,633,772 - 49,649,450 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Pradc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493649117,011,999 - 17,016,773 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRADC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl369,547,510 - 69,555,085 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1369,546,838 - 69,552,014 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2372,750,448 - 72,755,320 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRADC1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11433,940,270 - 33,945,380 (+)NCBI
Pradc1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624762410,201 - 415,820 (+)NCBI

Position Markers
RH127111  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38685,446,857 - 85,447,100UniSTSGRCm38
MGSCv37685,396,851 - 85,397,094UniSTSGRCm37
Celera687,418,796 - 87,419,039UniSTS
Cytogenetic Map6D1UniSTS
Whitehead/MRC_RH6880.25UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1007
Count of miRNA genes:468
Interacting mature miRNAs:550
Transcripts:ENSMUST00000032080, ENSMUST00000113770, ENSMUST00000122907, ENSMUST00000126805, ENSMUST00000139875, ENSMUST00000146086, ENSMUST00000154918
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000032080   ⟹   ENSMUSP00000032080
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl685,446,810 - 85,451,283 (-)Ensembl
RefSeq Acc Id: ENSMUST00000113770   ⟹   ENSMUSP00000109400
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl685,447,035 - 85,451,248 (-)Ensembl
RefSeq Acc Id: ENSMUST00000122907
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl685,447,680 - 85,451,213 (-)Ensembl
RefSeq Acc Id: ENSMUST00000126805   ⟹   ENSMUSP00000145290
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl685,446,938 - 85,451,970 (-)Ensembl
RefSeq Acc Id: ENSMUST00000139875
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl685,447,208 - 85,451,945 (-)Ensembl
RefSeq Acc Id: ENSMUST00000146086
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl685,447,034 - 85,451,201 (-)Ensembl
RefSeq Acc Id: ENSMUST00000154918
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl685,447,533 - 85,451,224 (-)Ensembl
RefSeq Acc Id: ENSMUST00000203934
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl685,447,548 - 85,451,256 (-)Ensembl
RefSeq Acc Id: NM_001163427   ⟹   NP_001156899
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39685,423,767 - 85,428,284 (-)NCBI
GRCm38685,446,785 - 85,451,302 (-)NCBI
MGSCv37685,396,779 - 85,401,964 (-)RGD
Celera687,418,724 - 87,423,912 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_028505   ⟹   NP_082781
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39685,423,767 - 85,428,284 (-)NCBI
GRCm38685,446,785 - 85,451,302 (-)NCBI
MGSCv37685,396,779 - 85,401,964 (-)RGD
Celera687,418,724 - 87,423,912 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_028081
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39685,423,767 - 85,428,952 (-)NCBI
GRCm38685,446,785 - 85,451,970 (-)ENTREZGENE
MGSCv37685,396,779 - 85,401,964 (-)RGD
Celera687,418,724 - 87,423,912 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011241486   ⟹   XP_011239788
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39685,423,792 - 85,428,969 (-)NCBI
GRCm38685,446,810 - 85,451,987 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003956256
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39685,423,792 - 85,428,831 (-)NCBI
GRCm38685,446,810 - 85,451,849 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_082781   ⟸   NM_028505
- Peptide Label: isoform a precursor
- UniProtKB: Q9D9N8 (UniProtKB/Swiss-Prot),   Q14C45 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001156899   ⟸   NM_001163427
- Peptide Label: isoform b precursor
- UniProtKB: Q9D9N8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011239788   ⟸   XM_011241486
- Peptide Label: isoform X1
- UniProtKB: Q9D9N8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000032080   ⟸   ENSMUST00000032080
RefSeq Acc Id: ENSMUSP00000109400   ⟸   ENSMUST00000113770
RefSeq Acc Id: ENSMUSP00000145290   ⟸   ENSMUST00000126805
Protein Domains
PA

Promoters
RGD ID:6838699
Promoter ID:MM_KWN:46683
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   BoneMarrow_0Hour
Transcripts:UC009CPT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36685,397,611 - 85,398,242 (-)MPROMDB
RGD ID:6839932
Promoter ID:MM_KWN:46684
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day4,   Brain,   MEF_B4,   MEF_B6
Transcripts:NM_001163427,   NM_028505,   NR_028081,   OTTMUST00000059053,   OTTMUST00000059054,   OTTMUST00000059055,   OTTMUST00000059056
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36685,401,421 - 85,402,137 (-)MPROMDB
RGD ID:6890226
Promoter ID:EPDNEW_M8564
Type:initiation region
Name:Pradc1_2
Description:Mus musculus protease-associated domain containing 1 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8566  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38685,451,267 - 85,451,327EPDNEW
RGD ID:6890230
Promoter ID:EPDNEW_M8566
Type:multiple initiation site
Name:Pradc1_1
Description:Mus musculus protease-associated domain containing 1 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8564  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38685,451,972 - 85,452,032EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1920577 AgrOrtholog
Ensembl Genes ENSMUSG00000030008 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000032080 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000109400 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000145290 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000032080 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000113770 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000126805 ENTREZGENE, UniProtKB/TrEMBL
InterPro PA_domain UniProtKB/Swiss-Prot
  PADC1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRADC1-like_PA UniProtKB/Swiss-Prot
KEGG Report mmu:73327 UniProtKB/Swiss-Prot
MGD MGI:1920577 ENTREZGENE
NCBI Gene 73327 ENTREZGENE
PANTHER PTHR22702 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF02225 UniProtKB/Swiss-Prot
PhenoGen Pradc1 PhenoGen
UniProt A0A0N4SVX7_MOUSE UniProtKB/TrEMBL
  PADC1_MOUSE UniProtKB/Swiss-Prot
  Q14C45 ENTREZGENE, UniProtKB/TrEMBL
  Q9D9N8 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-09-25 Pradc1  protease-associated domain containing 1  1700040I03Rik  RIKEN cDNA 1700040I03 gene  Symbol and/or name change 5135510 APPROVED