Dbr1 (debranching RNA lariats 1) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Dbr1 (debranching RNA lariats 1) Mus musculus
Analyze
Symbol: Dbr1
Name: debranching RNA lariats 1
RGD ID: 1619922
MGI Page MGI
Description: Exhibits RNA lariat debranching enzyme activity. Involved in mRNA splicing, via spliceosome. Predicted to localize to nucleoplasm. Is expressed in several structures, including alimentary system; cranial ganglion; early conceptus; nose; and skin. Orthologous to human DBR1 (debranching RNA lariats 1); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW018415; debranching enzyme homolog 1; lariat debranching enzyme
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39999,457,839 - 99,467,060 (+)NCBIGRCm39mm39
GRCm38999,575,786 - 99,585,007 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl999,575,799 - 99,584,501 (+)EnsemblGRCm38mm10GRCm38
MGSCv37999,476,218 - 99,484,762 (+)NCBIGRCm37mm9NCBIm37
MGSCv36999,385,151 - 99,393,695 (+)NCBImm8
Celera999,110,559 - 99,119,100 (+)NCBICelera
Cytogenetic Map9E3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleoplasm  (ISO)
nucleus  (IBA,ISO)

Molecular Function

References

References - curated
1. RGD automated import pipeline
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10982890   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11355701   PMID:12466851   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15489334   PMID:16141072  
PMID:16141073   PMID:21267068   PMID:21873635   PMID:25957684   PMID:32325033  


Genomics

Comparative Map Data
Dbr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39999,457,839 - 99,467,060 (+)NCBIGRCm39mm39
GRCm38999,575,786 - 99,585,007 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl999,575,799 - 99,584,501 (+)EnsemblGRCm38mm10GRCm38
MGSCv37999,476,218 - 99,484,762 (+)NCBIGRCm37mm9NCBIm37
MGSCv36999,385,151 - 99,393,695 (+)NCBImm8
Celera999,110,559 - 99,119,100 (+)NCBICelera
Cytogenetic Map9E3.3NCBI
DBR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3138,160,988 - 138,174,921 (-)EnsemblGRCh38hg38GRCh38
GRCh383138,160,988 - 138,174,921 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373137,879,830 - 137,893,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363139,362,542 - 139,376,463 (-)NCBINCBI36hg18NCBI36
Build 343139,362,550 - 139,376,471NCBI
Celera3136,304,598 - 136,318,559 (-)NCBI
Cytogenetic Map3q22.3NCBI
HuRef3135,254,888 - 135,268,849 (-)NCBIHuRef
CHM1_13137,843,634 - 137,857,589 (-)NCBICHM1_1
Dbr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08107,826,690 - 107,838,186 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8107,826,424 - 107,838,339 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08107,251,356 - 107,262,732 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48104,443,418 - 104,455,249 (+)NCBIRGSC3.4rn4RGSC3.4
Celera899,539,355 - 99,551,081 (+)NCBICelera
Cytogenetic Map8q31NCBI
DBR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13142,639,712 - 142,653,016 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3142,639,712 - 142,653,016 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03135,188,636 - 135,202,934 (-)NCBIMhudiblu_PPA_v0panPan3
DBR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2334,376,228 - 34,388,263 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12334,375,691 - 34,388,317 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dbr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936540504,638 - 515,913 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DBR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1378,958,211 - 78,970,137 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11378,958,301 - 78,970,250 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21386,477,860 - 86,480,220 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DBR1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1552,367,357 - 52,380,227 (+)Ensembl
ChlSab1.11552,367,197 - 52,381,076 (+)NCBI
Dbr1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473014,682,951 - 14,693,450 (-)NCBI

Position Markers
AW018415  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38999,584,006 - 99,584,085UniSTSGRCm38
MGSCv37999,484,425 - 99,484,504UniSTSGRCm37
Celera999,118,763 - 99,118,842UniSTS
Cytogenetic Map9F1UniSTS
Whitehead/MRC_RH91011.48UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49541121101528921Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95212317899910428Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1301636Lith5_mlithogenic gene 5 (mouse)Not determined966207024100207122Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967124167101124167Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968897510102897652Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968897510102897652Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969239845103239920Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969546513103546645Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301869Tbbmd4_mtotal body bone mineral density 4 (mouse)Not determined976117105101528921Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:808
Count of miRNA genes:487
Interacting mature miRNAs:599
Transcripts:ENSMUST00000066650, ENSMUST00000136884, ENSMUST00000138002, ENSMUST00000139796, ENSMUST00000148987, ENSMUST00000156035
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000066650   ⟹   ENSMUSP00000070991
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl999,575,799 - 99,584,501 (+)Ensembl
RefSeq Acc Id: ENSMUST00000136884   ⟹   ENSMUSP00000114670
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl999,580,297 - 99,582,689 (+)Ensembl
RefSeq Acc Id: ENSMUST00000138002   ⟹   ENSMUSP00000119924
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl999,576,108 - 99,582,058 (+)Ensembl
RefSeq Acc Id: ENSMUST00000139796   ⟹   ENSMUSP00000115203
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl999,580,202 - 99,583,838 (+)Ensembl
RefSeq Acc Id: ENSMUST00000148987   ⟹   ENSMUSP00000115074
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl999,575,828 - 99,582,441 (+)Ensembl
RefSeq Acc Id: ENSMUST00000156035   ⟹   ENSMUSP00000115978
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl999,576,080 - 99,582,049 (+)Ensembl
RefSeq Acc Id: NM_001368298   ⟹   NP_001355227
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39999,457,839 - 99,467,060 (+)NCBI
GRCm38999,575,786 - 99,585,007 (+)NCBI
Sequence:
RefSeq Acc Id: NM_031403   ⟹   NP_113580
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39999,457,852 - 99,466,396 (+)NCBI
GRCm38999,575,799 - 99,584,343 (+)NCBI
MGSCv37999,476,218 - 99,484,762 (+)RGD
Celera999,110,559 - 99,119,100 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_113580   ⟸   NM_031403
- Peptide Label: isoform 1
- UniProtKB: Q923B1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001355227   ⟸   NM_001368298
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000115203   ⟸   ENSMUST00000139796
RefSeq Acc Id: ENSMUSP00000070991   ⟸   ENSMUST00000066650
RefSeq Acc Id: ENSMUSP00000119924   ⟸   ENSMUST00000138002
RefSeq Acc Id: ENSMUSP00000115074   ⟸   ENSMUST00000148987
RefSeq Acc Id: ENSMUSP00000115978   ⟸   ENSMUST00000156035
RefSeq Acc Id: ENSMUSP00000114670   ⟸   ENSMUST00000136884
Protein Domains
DBR1

Promoters
RGD ID:6844397
Promoter ID:MM_KWN:58496
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000086435,   OTTMUST00000086436,   OTTMUST00000086437,   OTTMUST00000086438
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36999,476,111 - 99,476,611 (+)MPROMDB
RGD ID:8670574
Promoter ID:EPDNEW_M13316
Type:initiation region
Name:Dbr1_1
Description:Mus musculus debranching RNA lariats 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38999,575,817 - 99,575,877EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1931520 AgrOrtholog
Ensembl Genes ENSMUSG00000032469 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000070991 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000114670 UniProtKB/TrEMBL
  ENSMUSP00000115074 UniProtKB/TrEMBL
  ENSMUSP00000115203 UniProtKB/TrEMBL
  ENSMUSP00000115978 UniProtKB/TrEMBL
  ENSMUSP00000119924 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000066650 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000136884 UniProtKB/TrEMBL
  ENSMUST00000138002 UniProtKB/TrEMBL
  ENSMUST00000139796 UniProtKB/TrEMBL
  ENSMUST00000148987 UniProtKB/TrEMBL
  ENSMUST00000156035 UniProtKB/TrEMBL
InterPro Calcineurin-like_PHP_ApaH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DBR1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dbr1_N UniProtKB/Swiss-Prot
KEGG Report mmu:83703 UniProtKB/Swiss-Prot
MGD MGI:1931520 ENTREZGENE
NCBI Gene 83703 ENTREZGENE
Pfam DBR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metallophos UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dbr1 PhenoGen
SMART DBR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.31324 ENTREZGENE
UniProt D3YXA2_MOUSE UniProtKB/TrEMBL
  DBR1_MOUSE UniProtKB/Swiss-Prot
  F6S2R9_MOUSE UniProtKB/TrEMBL
  F6SDN8_MOUSE UniProtKB/TrEMBL
  F6UCV1_MOUSE UniProtKB/TrEMBL
  F6ZYX6_MOUSE UniProtKB/TrEMBL
  Q8BP51_MOUSE UniProtKB/TrEMBL
  Q923B1 ENTREZGENE
UniProt Secondary Q8C1T9 UniProtKB/Swiss-Prot
  Q8C7J7 UniProtKB/Swiss-Prot
  Q99MT1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-22 Dbr1  debranching RNA lariats 1    debranching enzyme homolog 1 (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED