Lrrc75a (leucine rich repeat containing 75A) - Rat Genome Database
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Gene: Lrrc75a (leucine rich repeat containing 75A) Mus musculus
Analyze
Symbol: Lrrc75a
Name: leucine rich repeat containing 75A
RGD ID: 1619896
MGI Page MGI
Description: Orthologous to human LRRC75A (leucine rich repeat containing 75A); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; carbon nanotube.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Fam21; Fam211a; family with sequence similarity 211, member A; leucine-rich repeat-containing protein 75A; leucine-rich repeat-containing protein C17orf76 homolog; leucine-rich repeat-containing protein FAM211A; MGC59632
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,495,708 - 62,539,411 (-)NCBIGRCm39mm39
GRCm39 Ensembl1162,495,710 - 62,539,349 (-)Ensembl
GRCm381162,604,884 - 62,648,523 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,604,884 - 62,648,523 (-)EnsemblGRCm38mm10GRCm38
MGSCv371162,418,386 - 62,462,025 (-)NCBIGRCm37mm9NCBIm37
MGSCv361162,421,079 - 62,464,718 (-)NCBImm8
Celera1169,524,513 - 69,568,024 (-)NCBICelera
Cytogenetic Map11B2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

Molecular Function

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15782199   PMID:16141072   PMID:16141073   PMID:18799693  
PMID:21267068   PMID:21873635  


Genomics

Comparative Map Data
Lrrc75a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,495,708 - 62,539,411 (-)NCBIGRCm39mm39
GRCm39 Ensembl1162,495,710 - 62,539,349 (-)Ensembl
GRCm381162,604,884 - 62,648,523 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,604,884 - 62,648,523 (-)EnsemblGRCm38mm10GRCm38
MGSCv371162,418,386 - 62,462,025 (-)NCBIGRCm37mm9NCBIm37
MGSCv361162,421,079 - 62,464,718 (-)NCBImm8
Celera1169,524,513 - 69,568,024 (-)NCBICelera
Cytogenetic Map11B2NCBI
LRRC75A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1716,441,577 - 16,492,193 (-)EnsemblGRCh38hg38GRCh38
GRCh381716,441,577 - 16,492,193 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371716,344,891 - 16,395,507 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361716,286,053 - 16,335,889 (-)NCBINCBI36hg18NCBI36
Celera1716,248,226 - 16,298,391 (-)NCBI
Cytogenetic Map17p11.2NCBI
HuRef1716,211,784 - 16,261,540 (-)NCBIHuRef
CHM1_11716,354,928 - 16,405,094 (-)NCBICHM1_1
Lrrc75a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21047,298,222 - 47,343,244 (-)NCBI
Rnor_6.0 Ensembl1048,930,416 - 48,944,304 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01048,929,519 - 48,947,606 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01048,712,479 - 48,732,740 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41048,790,628 - 48,809,048 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1046,545,763 - 46,590,012 (-)NCBICelera
Cytogenetic Map10q23NCBI
Lrrc75a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554671,771,857 - 1,820,707 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554671,771,857 - 1,820,707 (-)NCBIChiLan1.0ChiLan1.0
LRRC75A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A110,647,908 - 110,668,484 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A110,649,476 - 110,670,243 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01735,355,438 - 35,405,743 (-)NCBIMhudiblu_PPA_v0panPan3
LRRC75A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl539,483,435 - 39,487,880 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1539,447,113 - 39,488,156 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Lrrc75a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936821151,361 - 194,180 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRC75A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1259,094,833 - 59,132,505 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11259,094,713 - 59,132,516 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21262,221,568 - 62,259,228 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LRRC75A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11615,172,546 - 15,221,460 (+)NCBI
ChlSab1.1 Ensembl1615,172,876 - 15,219,870 (+)Ensembl
Lrrc75a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248773,953,905 - 3,982,947 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11330000063000000Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11330000072800000Mouse
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111160000068600000Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111180000066100000Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1231863768609504Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111231863768609504Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111231863768609504Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1231863768609504Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1231863768609504Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111231863768609504Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1231863768609504Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1231863768609504Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1231863768609504Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111231863768609504Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111231863768609504Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111231863769794121Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111710617567187585Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111783196668609504Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112867832062678320Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112881775462817873Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113111738265117382Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113220975066209867Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113568778969794161Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113661246070618665Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113672273870723028Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113719011571190238Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113812528972125383Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114236579176365904Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114236579176365904Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114473921176963931Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4141000Nidd3_mnon-insulin-dependent diabetes mellitus 3 (mouse)Not determined4515120179151308Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114527504680087498Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114581775489927907Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114629434180294436Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114642858180428696Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115018736584187585Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115260355986603559Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115349976287499911Mouse
4141084Spqq1_msperm quality QTL 1 (mouse)Not determined5417484463428696Mouse
1302186Blmpf2_mbleomycin-induced pulmonary fibrosis 2 (mouse)Not determined115417484467187585Mouse
4142148Ckdbp2_mchronic kidney disease blood pressure locus 2 (mouse)Not determined115419011565213015Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115423592683842826Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5539415972319101Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115786383491863932Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115859972974863932Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15861720487804412Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5882844085175703Mouse
11532697Sluc36_msusceptibility to lung cancer 36 (mouse)115936579169591873Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116179599488808902Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116226517996265327Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:563
Count of miRNA genes:417
Interacting mature miRNAs:468
Transcripts:ENSMUST00000057194, ENSMUST00000128705, ENSMUST00000143262
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000057194   ⟹   ENSMUSP00000062489
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1162,604,884 - 62,648,523 (-)Ensembl
RefSeq Acc Id: ENSMUST00000128705
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1162,605,823 - 62,648,040 (-)Ensembl
RefSeq Acc Id: ENSMUST00000143262
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1162,606,027 - 62,648,049 (-)Ensembl
RefSeq Acc Id: NM_001357955   ⟹   NP_001344884
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391162,495,710 - 62,538,875 (-)NCBI
GRCm381162,604,884 - 62,648,049 (-)NCBI
Sequence:
RefSeq Acc Id: NM_198861   ⟹   NP_942561
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391162,495,710 - 62,539,349 (-)NCBI
GRCm381162,604,884 - 62,648,523 (-)NCBI
MGSCv371162,418,386 - 62,462,025 (-)RGD
Celera1169,524,513 - 69,568,024 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036156449   ⟹   XP_036012342
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391162,504,863 - 62,539,398 (-)NCBI
RefSeq Acc Id: XM_036156450   ⟹   XP_036012343
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391162,495,708 - 62,539,411 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_942561   ⟸   NM_198861
- Peptide Label: isoform 1
- UniProtKB: Q7TSF4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001344884   ⟸   NM_001357955
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000062489   ⟸   ENSMUST00000057194
RefSeq Acc Id: XP_036012343   ⟸   XM_036156450
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036012342   ⟸   XM_036156449
- Peptide Label: isoform X1

Promoters
RGD ID:6820485
Promoter ID:MM_KWN:7839
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung
Transcripts:ENSMUST00000062860,   NM_175002,   NM_198861,   OTTMUST00000013055,   OTTMUST00000013058,   OTTMUST00000013059,   OTTMUST00000013060,   OTTMUST00000013061,   OTTMUST00000013062,   UC007JJN.1,   UC007JJQ.1,   UC007JJS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361162,461,591 - 62,462,402 (+)MPROMDB
RGD ID:8674998
Promoter ID:EPDNEW_M15530
Type:multiple initiation site
Name:Lrrc75a_1
Description:Mus musculus leucine rich repeat containing 75A , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381162,648,479 - 62,648,539EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2682293 AgrOrtholog
Ensembl Genes ENSMUSG00000046417 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000062489 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000057194 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
InterPro LRR_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:192976 UniProtKB/Swiss-Prot
MGD MGI:2682293 ENTREZGENE
NCBI Gene 192976 ENTREZGENE
PhenoGen Lrrc75a PhenoGen
UniProt LR75A_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3UIX7 UniProtKB/Swiss-Prot
  Q811G5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-04-30 Lrrc75a  leucine rich repeat containing 75A  Fam211a  family with sequence similarity 211, member A  Symbol and/or name change 5135510 APPROVED
2012-11-27 Fam211a  family with sequence similarity 211, member A  BC046404  cDNA sequence BC046404  Symbol and/or name change 5135510 APPROVED