Cyb5d2 (cytochrome b5 domain containing 2) - Rat Genome Database
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Gene: Cyb5d2 (cytochrome b5 domain containing 2) Mus musculus
Analyze
Symbol: Cyb5d2
Name: cytochrome b5 domain containing 2
RGD ID: 1619895
MGI Page MGI
Description: Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and skeletal muscle tissue. Orthologous to human CYB5D2 (cytochrome b5 domain containing 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; carbon nanotube; leflunomide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9330151E16Rik; cytochrome b5 domain-containing protein 2; Gm2; neufe; neuferricin; RP23-327G1.2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,668,058 - 72,686,665 (-)NCBIGRCm39mm39
GRCm39 Ensembl1172,668,058 - 72,686,968 (-)Ensembl
GRCm381172,777,232 - 72,795,839 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,777,232 - 72,796,142 (-)EnsemblGRCm38mm10GRCm38
MGSCv371172,590,734 - 72,609,341 (-)NCBIGRCm37mm9NCBIm37
MGSCv361172,593,444 - 72,612,235 (-)NCBImm8
Celera1180,306,068 - 80,324,702 (-)NCBICelera
Cytogenetic Map11B4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. RGD automated import pipeline
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16751776  
PMID:18799693   PMID:19968755   PMID:21267068   PMID:21677750   PMID:21873635   PMID:24194600   PMID:27626380   PMID:28700664   PMID:31340161  


Genomics

Comparative Map Data
Cyb5d2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,668,058 - 72,686,665 (-)NCBIGRCm39mm39
GRCm39 Ensembl1172,668,058 - 72,686,968 (-)Ensembl
GRCm381172,777,232 - 72,795,839 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,777,232 - 72,796,142 (-)EnsemblGRCm38mm10GRCm38
MGSCv371172,590,734 - 72,609,341 (-)NCBIGRCm37mm9NCBIm37
MGSCv361172,593,444 - 72,612,235 (-)NCBImm8
Celera1180,306,068 - 80,324,702 (-)NCBICelera
Cytogenetic Map11B4NCBI
CYB5D2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl174,143,168 - 4,187,310 (+)EnsemblGRCh38hg38GRCh38
GRCh38174,143,117 - 4,157,701 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37174,046,462 - 4,060,995 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36173,993,299 - 4,007,740 (+)NCBINCBI36hg18NCBI36
Celera174,058,042 - 4,072,567 (+)NCBI
Cytogenetic Map17p13.2NCBI
HuRef173,936,031 - 3,950,555 (+)NCBIHuRef
CHM1_1174,055,261 - 4,069,782 (+)NCBICHM1_1
Cyb5d2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21057,394,268 - 57,413,336 (-)NCBI
Rnor_6.0 Ensembl1059,344,470 - 59,360,661 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01059,343,347 - 59,360,979 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01059,082,191 - 59,099,095 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41059,667,011 - 59,683,247 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11059,680,634 - 59,696,870 (-)NCBI
Celera1056,522,097 - 56,538,333 (-)NCBICelera
Cytogenetic Map10q24NCBI
LOC102015496
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495546712,738,072 - 12,760,212 (-)NCBIChiLan1.0ChiLan1.0
LOC100993876
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1174,188,716 - 4,203,396 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl174,189,395 - 4,233,093 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0174,197,524 - 4,212,030 (+)NCBIMhudiblu_PPA_v0panPan3
CYB5D2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl530,236,397 - 30,244,532 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1530,235,996 - 30,246,532 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
LOC101955529
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936677730,112 - 743,911 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYB5D2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1250,155,515 - 50,168,027 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11250,155,216 - 50,171,525 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21252,112,665 - 52,120,899 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103242180
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1163,622,052 - 3,634,636 (+)NCBI
ChlSab1.1 Ensembl163,622,036 - 3,634,386 (+)Ensembl
LOC101697672
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247866,729,755 - 6,756,147 (+)NCBI

Position Markers
D5Mit392.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS
Cytogenetic Map18A1UniSTS
Cytogenetic Map1G3UniSTS
Cytogenetic Map9A3UniSTS
Cytogenetic Map7F1UniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map4D2.2UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map16B2UniSTS
Cytogenetic Map6F1UniSTS
Cytogenetic Map4B1UniSTS
Cytogenetic Map17DUniSTS
Cytogenetic Map14C3UniSTS
Cytogenetic Map5C3.3UniSTS
Cytogenetic Map18A2UniSTS
Cytogenetic MapXF5UniSTS
Cytogenetic Map2G3UniSTS
Cytogenetic Map7A2UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map1H6UniSTS
Cytogenetic Map7D3UniSTS
Cytogenetic Map1G2UniSTS
Cytogenetic MapXF3UniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map2F3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map15A1UniSTS
Cytogenetic Map1A2UniSTS
Cytogenetic Map13A3.1UniSTS
Cytogenetic Map11B4UniSTS
Cytogenetic Map1D2.3UniSTS
Cytogenetic Map19C1UniSTS
Cytogenetic Map10D3UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map2E1UniSTS
cM Map528.0UniSTS
Whitehead Genetic518.6UniSTS
RH125010  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381172,779,460 - 72,779,790UniSTSGRCm38
MGSCv371172,592,962 - 72,593,292UniSTSGRCm37
Celera1180,308,347 - 80,308,677UniSTS
Cytogenetic Map11B4UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11330000072800000Mouse
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114236579176365904Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114236579176365904Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114473921176963931Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4141000Nidd3_mnon-insulin-dependent diabetes mellitus 3 (mouse)Not determined4515120179151308Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114527504680087498Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114581775489927907Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114629434180294436Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114642858180428696Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115018736584187585Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115260355986603559Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115349976287499911Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115423592683842826Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115786383491863932Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115859972974863932Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15861720487804412Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5882844085175703Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116179599488808902Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116226517996265327Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116342858181939647Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116342858194173092Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116493951098939647Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116493951098939647Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116493951098939647Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166842594100842826Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166842594100842826Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66842594100842826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166842594100842826Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166842594100842826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166842594100842826Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116718736579923086Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168300000102000000Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170800372104800540Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170800372104800540Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170800372104800540Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170800372104800540Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172128823106128908Mouse
1301078Alcp2_malcohol preference locus 2 (mouse)Not determined117231897084840636Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1445
Count of miRNA genes:540
Interacting mature miRNAs:640
Transcripts:ENSMUST00000079681, ENSMUST00000141141, ENSMUST00000156294, ENSMUST00000169476
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001024926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK034043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL663082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC117721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX632403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD776759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ150252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ151047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ284318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ548405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000079681   ⟹   ENSMUSP00000078623
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1172,777,232 - 72,795,856 (-)Ensembl
RefSeq Acc Id: ENSMUST00000141141
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1172,778,878 - 72,796,094 (-)Ensembl
RefSeq Acc Id: ENSMUST00000156294   ⟹   ENSMUSP00000131961
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1172,777,249 - 72,796,142 (-)Ensembl
RefSeq Acc Id: ENSMUST00000169476
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1172,792,889 - 72,795,841 (-)Ensembl
RefSeq Acc Id: NM_001024926   ⟹   NP_001020097
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391172,668,058 - 72,686,665 (-)NCBI
GRCm381172,777,232 - 72,795,839 (-)ENTREZGENE
MGSCv371172,590,734 - 72,609,341 (-)RGD
Celera1180,306,068 - 80,324,702 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001020097   ⟸   NM_001024926
- Peptide Label: precursor
- UniProtKB: Q5SSH8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000078623   ⟸   ENSMUST00000079681
RefSeq Acc Id: ENSMUSP00000131961   ⟸   ENSMUST00000156294
Protein Domains
Cytochrome b5 heme-binding

Promoters
RGD ID:6820685
Promoter ID:MM_KWN:8339
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001045536,   OTTMUST00000013812,   OTTMUST00000013813,   OTTMUST00000013814,   OTTMUST00000072179
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361172,608,946 - 72,609,727 (-)MPROMDB
RGD ID:8675456
Promoter ID:EPDNEW_M15758
Type:multiple initiation site
Name:Cyb5d2_1
Description:Mus musculus cytochrome b5 domain containing 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15759  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381172,795,818 - 72,795,878EPDNEW
RGD ID:8675458
Promoter ID:EPDNEW_M15759
Type:initiation region
Name:Cyb5d2_2
Description:Mus musculus cytochrome b5 domain containing 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15758  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381172,796,064 - 72,796,124EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2684848 AgrOrtholog
Ensembl Genes ENSMUSG00000057778 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000078623 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000131961 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000079681 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000156294 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.120.10 UniProtKB/Swiss-Prot
InterPro Cyt_B5-like_heme/steroid-bd UniProtKB/Swiss-Prot
  Cyt_B5-like_heme/steroid_sf UniProtKB/Swiss-Prot
KEGG Report mmu:192986 UniProtKB/Swiss-Prot
MGD MGI:2684848 ENTREZGENE
NCBI Gene 192986 ENTREZGENE
Pfam Cyt-b5 UniProtKB/Swiss-Prot
PhenoGen Cyb5d2 PhenoGen
SMART Cyt-b5 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55856 UniProtKB/Swiss-Prot
UniProt NEUFC_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0AUN6 UniProtKB/Swiss-Prot
  Q0VGS6 UniProtKB/Swiss-Prot
  Q8BHV3 UniProtKB/Swiss-Prot