Urad (ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5) decarboxylase) - Rat Genome Database

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Gene: Urad (ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5) decarboxylase) Mus musculus
Analyze
Symbol: Urad
Name: ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5) decarboxylase
RGD ID: 1619839
MGI Page MGI
Description: Enables 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity. Involved in allantoin metabolic process; purine-containing compound catabolic process; and urate catabolic process. Is active in peroxisome. Orthologous to human URAD (ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase); PARTICIPATES IN purine metabolic pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; EG231903; OHCU decarboxylase; parahox cluster neighbor; parahox neighbor; Prh; Prhoxnb; ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395147,251,794 - 147,259,250 (-)NCBIGRCm39mm39
GRCm39 Ensembl5147,251,794 - 147,259,250 (-)Ensembl
GRCm385147,314,984 - 147,322,440 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5147,314,984 - 147,322,440 (-)EnsemblGRCm38mm10GRCm38
MGSCv375148,126,560 - 148,134,016 (-)NCBIGRCm37mm9NCBIm37
MGSCv365147,625,165 - 147,636,683 (-)NCBImm8
Celera5145,306,316 - 145,313,792 (-)NCBICelera
Cytogenetic Map5G3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:12477932   PMID:14681479   PMID:16462750   PMID:16602821   PMID:21873635  


Genomics

Comparative Map Data
Urad
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395147,251,794 - 147,259,250 (-)NCBIGRCm39mm39
GRCm39 Ensembl5147,251,794 - 147,259,250 (-)Ensembl
GRCm385147,314,984 - 147,322,440 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5147,314,984 - 147,322,440 (-)EnsemblGRCm38mm10GRCm38
MGSCv375148,126,560 - 148,134,016 (-)NCBIGRCm37mm9NCBIm37
MGSCv365147,625,165 - 147,636,683 (-)NCBImm8
Celera5145,306,316 - 145,313,792 (-)NCBICelera
Cytogenetic Map5G3NCBI
URAD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1327,977,717 - 27,988,693 (-)EnsemblGRCh38hg38GRCh38
GRCh381327,977,717 - 27,988,693 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371328,551,854 - 28,562,830 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361327,450,243 - 27,460,774 (-)NCBINCBI36hg18NCBI36
Celera139,627,284 - 9,637,823 (-)NCBI
Cytogenetic Map13q12.2NCBI
HuRef139,372,921 - 9,383,423 (-)NCBIHuRef
CHM1_11328,520,709 - 28,531,241 (-)NCBICHM1_1
Urad
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2127,709,233 - 7,718,925 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl127,709,312 - 7,718,923 (+)Ensembl
Rnor_6.0129,446,808 - 9,456,777 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,446,940 - 9,455,673 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01211,562,153 - 11,571,615 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera129,447,491 - 9,457,737 (+)NCBICelera
Cytogenetic Map12p11NCBI
URAD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v0139,259,104 - 9,270,066 (-)NCBIMhudiblu_PPA_v0panPan3
URAD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12511,682,304 - 11,693,143 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2511,581,206 - 11,692,284 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2511,745,604 - 11,756,396 (+)NCBI
ROS_Cfam_1.02511,811,279 - 11,822,095 (+)NCBI
UMICH_Zoey_3.12511,705,882 - 11,716,673 (+)NCBI
UNSW_CanFamBas_1.02511,698,288 - 11,709,123 (+)NCBI
UU_Cfam_GSD_1.02511,742,263 - 11,753,054 (+)NCBI
Urad
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945172,790,827 - 172,800,858 (+)NCBI
SpeTri2.0NW_00493647223,151,674 - 23,161,292 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
URAD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1115,353,524 - 5,363,481 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2115,096,514 - 5,106,242 (+)NCBISscrofa10.2Sscrofa10.2susScr3
URAD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.137,092,926 - 7,109,949 (-)NCBI
Vero_WHO_p1.0NW_02366605737,281,520 - 37,293,239 (+)NCBI
Urad
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477610,533,806 - 10,543,091 (+)NCBI

Position Markers
Prhoxnb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G3UniSTS
cM Map586.87UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118920110151834684Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121556974151834684Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124714580151834684Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119806972149423861Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129583274151834684Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125147702151834684Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115128044149128176Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115128044149128176Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5134002093151834684Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121457140151834684Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129851021151834684Mouse
13504734Ifvrq4_minfluenza virus resistance QTL 4 (mouse)5140000000153000000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:204
Count of miRNA genes:187
Interacting mature miRNAs:200
Transcripts:ENSMUST00000100433
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000100433   ⟹   ENSMUSP00000098000
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5147,251,794 - 147,259,250 (-)Ensembl
GRCm38.p6 Ensembl5147,314,984 - 147,322,440 (-)Ensembl
RefSeq Acc Id: NM_001039678   ⟹   NP_001034767
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395147,251,794 - 147,259,250 (-)NCBI
GRCm385147,314,984 - 147,322,440 (-)ENTREZGENE
MGSCv375148,126,560 - 148,134,016 (-)RGD
Celera5145,306,316 - 145,313,792 (-)RGD
cM Map5 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001034767 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI47780 (Get FASTA)   NCBI Sequence Viewer  
  AAI47791 (Get FASTA)   NCBI Sequence Viewer  
  ABB46374 (Get FASTA)   NCBI Sequence Viewer  
  EDL05831 (Get FASTA)   NCBI Sequence Viewer  
  Q283N4 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001034767   ⟸   NM_001039678
- UniProtKB: Q283N4 (UniProtKB/Swiss-Prot),   B9EK13 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000098000   ⟸   ENSMUST00000100433
Protein Domains
OHCU_decarbox

Promoters
RGD ID:6888810
Promoter ID:EPDNEW_M7856
Type:initiation region
Name:Urad_1
Description:Mus musculus ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5)decarboxylase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385147,322,393 - 147,322,453EPDNEW
RGD ID:6838096
Promoter ID:MM_KWN:44893
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_001039678_PRHOXNB
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365148,133,736 - 148,134,236 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3647519 AgrOrtholog
Ensembl Genes ENSMUSG00000075543 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000098000 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000100433 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.3330.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro OHCU_decarboxylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OHCU_decarboxylase-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OHCU_decarboxylase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:231903 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:3647519 ENTREZGENE
NCBI Gene 231903 ENTREZGENE
Pfam OHCU_decarbox UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Urad PhenoGen
Superfamily-SCOP SSF158694 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs UHCUDC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B9EK13 ENTREZGENE, UniProtKB/TrEMBL
  Q283N4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-02 Urad  ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5) decarboxylase  Prhoxnb  parahox cluster neighbor  Symbol and/or name change 5135510 APPROVED