Adam6a (a disintegrin and metallopeptidase domain 6A) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Adam6a (a disintegrin and metallopeptidase domain 6A) Mus musculus
Analyze
Symbol: Adam6a
Name: a disintegrin and metallopeptidase domain 6A
RGD ID: 1619823
MGI Page MGI
Description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Located in external side of plasma membrane and sperm head plasma membrane. Part of protein-containing complex. Orthologous to human ADAM6 (ADAM metallopeptidase domain 6 (pseudogene)).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a disintegrin and metallopeptidase domain 6; a disintegrin and metalloprotease domain 6; Ada; Adam6; disintegrin and metalloproteinase domain 6; tMDCIV
RGD Orthologs
Human
Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912113,507,528 - 113,510,034 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12113,507,528 - 113,510,085 (+)EnsemblGRCm39 Ensembl
GRCm3812113,543,908 - 113,546,414 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12113,543,908 - 113,546,465 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712114,782,119 - 114,784,625 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612113,991,716 - 113,994,222 (+)NCBIMGSCv36mm8
Celera12114,727,041 - 114,729,547 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1262.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15028286   PMID:19129510   PMID:21267068   PMID:21339297   PMID:21873635   PMID:24079728  


Genomics

Comparative Map Data
Adam6a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912113,507,528 - 113,510,034 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12113,507,528 - 113,510,085 (+)EnsemblGRCm39 Ensembl
GRCm3812113,543,908 - 113,546,414 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12113,543,908 - 113,546,465 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712114,782,119 - 114,784,625 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612113,991,716 - 113,994,222 (+)NCBIMGSCv36mm8
Celera12114,727,041 - 114,729,547 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1262.12NCBI
ADAM6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814105,969,729 - 105,972,269 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14105,969,729 - 105,972,269 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl14105,970,168 - 105,971,166 (-)EnsemblGRCh38hg38GRCh38
GRCh3714106,435,818 - 106,438,358 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614105,506,864 - 105,509,403 (-)NCBINCBI36Build 36hg18NCBI36
Celera1486,366,419 - 86,368,958 (-)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1486,568,723 - 86,571,224 (-)NCBIHuRef
CHM1_114106,306,686 - 106,309,225 (-)NCBICHM1_1
T2T-CHM13v2.014100,240,816 - 100,243,356 (-)NCBIT2T-CHM13v2.0
Adam6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86138,488,008 - 138,490,496 (+)NCBIGRCr8
mRatBN7.26132,666,974 - 132,669,462 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx6132,831,539 - 132,834,027 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06133,230,764 - 133,233,252 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06132,505,448 - 132,507,936 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06138,432,550 - 138,435,038 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6138,432,550 - 138,435,035 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06147,426,645 - 147,429,133 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46138,590,268 - 138,592,756 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16138,596,454 - 138,598,940 (+)NCBI
Celera6130,181,108 - 130,183,596 (+)NCBICelera
Cytogenetic Map6q32NCBI

Variants

.
Variants in Adam6a
2 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:119
Count of miRNA genes:116
Interacting mature miRNAs:119
Transcripts:ENSMUST00000053086
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
4141297Plyid_mPolymeric IgA dominance (mouse)Not determined109183385115885122Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
15092085Igly2_mIgG glycosylation 2, GP14 (mouse)12111737297119992757Mouse
15092083Igly5_mIgG glycosylation 5, GP20 (mouse)12113373605117830647Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289939031120092757Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
10412156Nociq3_mnociceptive sensitivity inflammatory QTL 3 (mouse)Not determined1286396075114831653Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
10402491Dipa4_mdrug induced psychomotor activation 4 (mouse)Not determined1291222515120092757Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
1302138Im6_mimmunoregulatory 6 (mouse)Not determined1296860337120092757Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289664071120092757Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288308354120092757Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290308268120092757Mouse
1302177Dps2_mdelta power in slow-wave sleep 2 (mouse)Not determined1294146064120092757Mouse
10412075Nils1_mneointima lesion size 1 (mouse)Not determined12102024665120092757Mouse
1558957Igan4_mIgA nephropathy 4 (mouse)Not determined12109750025119024949Mouse
1300973Abmm_mantibody mediated myocarditis (mouse)Not determined1293264461120092757Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000053086   ⟹   ENSMUSP00000059315
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12113,507,528 - 113,510,085 (+)Ensembl
GRCm38.p6 Ensembl12113,543,908 - 113,546,465 (+)Ensembl
RefSeq Acc Id: NM_174885   ⟹   NP_777479
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912113,507,528 - 113,510,034 (+)NCBI
GRCm3812113,543,908 - 113,546,414 (+)ENTREZGENE
MGSCv3712114,782,119 - 114,784,625 (+)RGD
Celera12114,727,041 - 114,729,547 (+)RGD
cM Map12 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_777479 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI08388 (Get FASTA)   NCBI Sequence Viewer  
  AAI39060 (Get FASTA)   NCBI Sequence Viewer  
  AAN77878 (Get FASTA)   NCBI Sequence Viewer  
  AGR55486 (Get FASTA)   NCBI Sequence Viewer  
  AGR55487 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000059315
  ENSMUSP00000059315.2
RefSeq Acc Id: NP_777479   ⟸   NM_174885
- UniProtKB: B2RSY5 (UniProtKB/TrEMBL),   Q8CGQ1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000059315   ⟸   ENSMUST00000053086
Protein Domains
Disintegrin   EGF-like   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RSY5-F1-model_v2 AlphaFold B2RSY5 1-754 view protein structure

Promoters
RGD ID:8679442
Promoter ID:EPDNEW_M17752
Type:multiple initiation site
Name:Adam6a_1
Description:Mus musculus a disintegrin and metallopeptidase domain 6A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3812113,543,952 - 113,544,012EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2676316 AgrOrtholog
Ensembl Genes ENSMUSG00000043945 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000053086 ENTREZGENE
  ENSMUST00000053086.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Blood-coag_inhib_Disintegrin UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
KEGG Report mmu:238406 UniProtKB/TrEMBL
MGD MGI:2676316 ENTREZGENE
NCBI Gene 238406 ENTREZGENE
PANTHER A DISINTEGRIN AND METALLOPEPTIDASE DOMAIN 6-RELATED UniProtKB/TrEMBL
  ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PhenoGen Adam6a PhenoGen
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Disintegrin UniProtKB/TrEMBL
  Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt B2RSY5 ENTREZGENE, UniProtKB/TrEMBL
  Q32NZ3_MOUSE UniProtKB/TrEMBL
  Q8CGQ1 ENTREZGENE, UniProtKB/TrEMBL