Pm20d2 (peptidase M20 domain containing 2) - Rat Genome Database

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Gene: Pm20d2 (peptidase M20 domain containing 2) Mus musculus
Analyze
Symbol: Pm20d2
Name: peptidase M20 domain containing 2
RGD ID: 1619808
MGI Page MGI
Description: Enables dipeptidase activity. Acts upstream of or within proteolysis and regulation of protein metabolic process. Predicted to be located in nucleoplasm. Orthologous to human PM20D2 (peptidase M20 domain containing 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Acy1; Acy1l2; aminoacylase 1-like 2; aminoacylase 1-like protein 2; aminoacylase-1-like protein 2; Gm424; peptidase M20 domain-containing protein 2; xaa-Arg dipeptidase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39433,170,309 - 33,189,732 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl433,174,230 - 33,189,737 (-)EnsemblGRCm39 Ensembl
GRCm38433,170,401 - 33,189,737 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl433,174,230 - 33,189,737 (-)EnsemblGRCm38mm10GRCm38
MGSCv37433,257,376 - 33,276,712 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36433,510,233 - 33,518,350 (-)NCBIMGSCv36mm8
Celera432,921,441 - 32,940,787 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map414.71NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
nucleoplasm  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:14610273   PMID:16141072   PMID:16141073   PMID:16602821   PMID:21677750   PMID:21873635   PMID:24891507  


Genomics

Comparative Map Data
Pm20d2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39433,170,309 - 33,189,732 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl433,174,230 - 33,189,737 (-)EnsemblGRCm39 Ensembl
GRCm38433,170,401 - 33,189,737 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl433,174,230 - 33,189,737 (-)EnsemblGRCm38mm10GRCm38
MGSCv37433,257,376 - 33,276,712 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36433,510,233 - 33,518,350 (-)NCBIMGSCv36mm8
Celera432,921,441 - 32,940,787 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map414.71NCBI
PM20D2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38689,093,940 - 89,165,565 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl689,146,055 - 89,165,565 (+)EnsemblGRCh38hg38GRCh38
GRCh37689,855,774 - 89,875,284 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36689,912,488 - 89,932,003 (+)NCBINCBI36Build 36hg18NCBI36
Celera690,273,652 - 90,293,174 (+)NCBICelera
Cytogenetic Map6q15NCBI
HuRef687,071,380 - 87,091,359 (+)NCBIHuRef
CHM1_1689,953,721 - 89,973,244 (+)NCBICHM1_1
T2T-CHM13v2.0690,329,918 - 90,374,228 (+)NCBIT2T-CHM13v2.0
Pm20d2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8552,362,384 - 52,382,647 (-)NCBIGRCr8
mRatBN7.2547,566,059 - 47,586,334 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl547,566,072 - 47,586,212 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx549,712,103 - 49,732,173 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0551,311,289 - 51,331,359 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0551,254,978 - 51,275,034 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0548,416,005 - 48,437,054 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl548,420,302 - 48,436,531 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0552,998,671 - 53,019,507 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4549,472,136 - 49,481,017 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1549,467,315 - 49,483,485 (-)NCBI
Celera546,322,990 - 46,344,463 (-)NCBICelera
Cytogenetic Map5q21NCBI
Pm20d2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541115,932,365 - 15,945,579 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541115,932,367 - 15,943,946 (+)NCBIChiLan1.0ChiLan1.0
PM20D2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25109,224,811 - 109,245,658 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16107,125,128 - 107,145,832 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0687,021,249 - 87,040,809 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1690,296,747 - 90,316,025 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl690,296,808 - 90,312,728 (+)Ensemblpanpan1.1panPan2
PM20D2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11248,402,912 - 48,416,239 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1248,339,346 - 48,415,732 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1248,209,331 - 48,222,232 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01249,209,225 - 49,222,198 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1249,209,124 - 49,222,655 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11248,527,261 - 48,540,363 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01248,425,713 - 48,438,831 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01248,617,962 - 48,631,084 (+)NCBIUU_Cfam_GSD_1.0
Pm20d2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494683,412,615 - 83,429,270 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365103,041,592 - 3,058,513 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365103,041,598 - 3,058,193 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PM20D2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl157,188,336 - 57,219,233 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1157,188,019 - 57,219,243 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2163,965,900 - 63,996,614 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PM20D2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11313,900,702 - 13,922,217 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1313,902,015 - 13,919,532 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040190,217,625 - 190,239,751 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pm20d2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247995,011,394 - 5,025,734 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247995,010,153 - 5,025,154 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pm20d2
778 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:209
Count of miRNA genes:195
Interacting mature miRNAs:201
Transcripts:ENSMUST00000098181, ENSMUST00000119167
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
1302010Wta1_mweight adult 1 (mouse)Not determined4868324042683429Mouse
1558992Ses8_msalmonella enteritidis susceptibility 8 (mouse)Not determined4868324042683429Mouse
1301473Triglq1_mtriglyceride QTL 1 (mouse)Not determined4868324042683429Mouse
1302125Lxw1_mlupus BXSB x NZW 1 (mouse)Not determined4868324042683429Mouse
4141302Ssrq5_mstress response QTL 5 (mouse)Not determined868324042683430Mouse
10401905Sicd3_mseizure-induced cell death 3 (mouse)Not determined4939552543760862Mouse
10401115Pgia35_mproteoglycan induced arthritis 35 (mouse)Not determined41256237746562509Mouse
12880405Jcdq1_mjoint cartilage degeneration QTL 1 (mouse)41256237746562509Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763283678Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
1301203Alcp8_malcohol preference locus 8 (mouse)Not determined41739516051395290Mouse
1301237Alcp7_malcohol preference locus 7 (mouse)Not determined41739516051395290Mouse
4141555Nbwa2_mNZB and NZW autoimmunity 2 (mouse)Not determined41789251551892635Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261688982216Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261688982216Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261688982216Mouse
25440481Moaq1_mmodifier of alien QTL 1 (mouse)41950000046000000Mouse
1302058Hrtfm3_mheart failure modifier 3 (mouse)Not determined42211194456112145Mouse
1300769Pcyts2_mplasmacytoma susceptibility 2 (mouse)Not determined42211194456112145Mouse
1301437Scon1_msucrose consumption 1 (mouse)Not determined42237344856373612Mouse
1302075Bdln6_mbody length 6 (mouse)Not determined42237344856373612Mouse
1301697Sluc18_msusceptibility to lung cancer 18 (mouse)Not determined42237344856373612Mouse
1302184Aaom1_mautoimmune aoritis in MRL mice 1 (mouse)Not determined42432229946332776Mouse
1300574Im2_mimmunoregulatory 2 (mouse)Not determined42807768262077816Mouse
1301586Stheal3_msoft tissue heal 3 (mouse)Not determined42865844262658566Mouse
1357877Synch1_msynechia 1 (mouse)Not determined42870992562710107Mouse
1301990Arvm1_mautoimmune renal vasculitis 1 (mouse)Not determined42933264663332776Mouse
12903995Opfaq2_mopen field activity QTL 2 (mouse)43034341933824057Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000098181   ⟹   ENSMUSP00000095783
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl433,174,230 - 33,189,433 (-)Ensembl
GRCm38.p6 Ensembl433,174,230 - 33,189,433 (-)Ensembl
RefSeq Acc Id: ENSMUST00000119167   ⟹   ENSMUSP00000113669
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl433,181,620 - 33,189,737 (-)Ensembl
GRCm38.p6 Ensembl433,181,620 - 33,189,737 (-)Ensembl
RefSeq Acc Id: NM_001034867   ⟹   NP_001030039
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39433,170,309 - 33,189,420 (-)NCBI
GRCm38433,170,401 - 33,189,737 (-)ENTREZGENE
MGSCv37433,257,376 - 33,276,712 (-)RGD
Celera432,921,441 - 32,940,787 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001419440   ⟹   NP_001406369
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39433,170,309 - 33,189,420 (-)NCBI
RefSeq Acc Id: NM_001419441   ⟹   NP_001406370
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39433,181,617 - 33,189,420 (-)NCBI
RefSeq Acc Id: NM_001419442   ⟹   NP_001406371
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39433,186,584 - 33,189,420 (-)NCBI
RefSeq Acc Id: NR_185084
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39433,170,309 - 33,189,420 (-)NCBI
RefSeq Acc Id: XR_004941890
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39433,174,744 - 33,189,732 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001030039   ⟸   NM_001034867
- Peptide Label: isoform 2
- UniProtKB: Q3ULU7 (UniProtKB/Swiss-Prot),   A3KG59 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000113669   ⟸   ENSMUST00000119167
RefSeq Acc Id: ENSMUSP00000095783   ⟸   ENSMUST00000098181
RefSeq Acc Id: NP_001406369   ⟸   NM_001419440
- Peptide Label: isoform 1
RefSeq Acc Id: NP_001406370   ⟸   NM_001419441
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001406371   ⟸   NM_001419442
- Peptide Label: isoform 4

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A3KG59-F1-model_v2 AlphaFold A3KG59 1-431 view protein structure

Promoters
RGD ID:6882986
Promoter ID:EPDNEW_M4944
Type:initiation region
Name:Pm20d2_2
Description:Mus musculus peptidase M20 domain containing 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4945  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38433,189,418 - 33,189,478EPDNEW
RGD ID:6882988
Promoter ID:EPDNEW_M4945
Type:multiple initiation site
Name:Pm20d2_1
Description:Mus musculus peptidase M20 domain containing 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4944  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38433,189,700 - 33,189,760EPDNEW
RGD ID:6835881
Promoter ID:MM_KWN:37003
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell,   Kidney,   Liver,   Lung
Transcripts:ENSMUST00000067819,   ENSMUST00000119167
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36433,276,056 - 33,276,556 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2685270 AgrOrtholog
Ensembl Genes ENSMUSG00000054659 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000098181 ENTREZGENE
  ENSMUST00000098181.9 UniProtKB/Swiss-Prot
  ENSMUST00000119167 ENTREZGENE
  ENSMUST00000119167.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.360 UniProtKB/Swiss-Prot
  Zn peptidases UniProtKB/Swiss-Prot
InterPro Amidohydrolase UniProtKB/Swiss-Prot
  Bact_exopeptidase_dim_dom UniProtKB/Swiss-Prot
  Pept_M20A_amidohydro_pred UniProtKB/Swiss-Prot
  Peptidase_M20 UniProtKB/Swiss-Prot
  Peptidase_M20_dimer UniProtKB/Swiss-Prot
KEGG Report mmu:242377 UniProtKB/Swiss-Prot
MGD MGI:2685270 ENTREZGENE
NCBI Gene 242377 ENTREZGENE
PANTHER PEPTIDASE M20 UniProtKB/Swiss-Prot
  PEPTIDASE M20 DOMAIN-CONTAINING PROTEIN 2 UniProtKB/Swiss-Prot
Pfam M20_dimer UniProtKB/Swiss-Prot
  Peptidase_M20 UniProtKB/Swiss-Prot
PhenoGen Pm20d2 PhenoGen
PIRSF Amidohydrolase_ACY1L2_prd UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55031 UniProtKB/Swiss-Prot
  Zn-dependent exopeptidases UniProtKB/Swiss-Prot
UniProt A3KG59 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3ULU7 ENTREZGENE
UniProt Secondary Q3ULU7 UniProtKB/Swiss-Prot