Klhl31 (kelch-like 31) - Rat Genome Database

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Gene: Klhl31 (kelch-like 31) Mus musculus
Analyze
Symbol: Klhl31
Name: kelch-like 31
RGD ID: 1619800
MGI Page MGI
Description: Predicted to be involved in negative regulation of JNK cascade and negative regulation of protein phosphorylation. Located in cytoplasm and nucleus. Is expressed in axial skeleton; diaphragm; forearm rest of mesenchyme; and skeletal musculature. Used to study centronuclear myopathy. Orthologous to human KLHL31 (kelch like family member 31).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9830147P19Rik; D930047P17Rik; Kbtbd1; kelch repeat and BTB (POZ) domain containing 1; kelch repeat and BTB domain-containing protein 1; kelch-like protein 31; kelch-like protein KLHL
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39977,544,014 - 77,567,407 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl977,543,782 - 77,567,409 (+)EnsemblGRCm39 Ensembl
GRCm38977,636,732 - 77,660,125 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl977,636,500 - 77,660,127 (+)EnsemblGRCm38mm10GRCm38
MGSCv37977,484,539 - 77,507,932 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36977,422,425 - 77,442,040 (+)NCBIMGSCv36mm8
Celera974,815,043 - 74,838,220 (+)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IDA,ISO)
nucleus  (IBA,IDA,ISO)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15302408   PMID:15489334   PMID:16141072   PMID:16141073   PMID:18719355   PMID:21267068  
PMID:21677750   PMID:21873635   PMID:28872460  


Genomics

Comparative Map Data
Klhl31
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39977,544,014 - 77,567,407 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl977,543,782 - 77,567,409 (+)EnsemblGRCm39 Ensembl
GRCm38977,636,732 - 77,660,125 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl977,636,500 - 77,660,127 (+)EnsemblGRCm38mm10GRCm38
MGSCv37977,484,539 - 77,507,932 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36977,422,425 - 77,442,040 (+)NCBIMGSCv36mm8
Celera974,815,043 - 74,838,220 (+)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.36NCBI
KLHL31
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38653,647,916 - 53,665,756 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl653,647,916 - 53,665,756 (-)EnsemblGRCh38hg38GRCh38
GRCh37653,512,714 - 53,530,554 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36653,620,658 - 53,638,465 (-)NCBINCBI36Build 36hg18NCBI36
Celera655,174,866 - 55,192,685 (-)NCBICelera
Cytogenetic Map6p12.1NCBI
HuRef653,344,091 - 53,361,913 (-)NCBIHuRef
CHM1_1653,514,485 - 53,532,311 (-)NCBICHM1_1
T2T-CHM13v2.0653,487,843 - 53,505,696 (-)NCBIT2T-CHM13v2.0
Klhl31
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8887,395,878 - 87,419,236 (+)NCBIGRCr8
mRatBN7.2878,515,514 - 78,538,873 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl878,515,514 - 78,538,873 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx884,002,767 - 84,026,169 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0882,279,413 - 82,302,810 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0880,102,105 - 80,125,507 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0884,945,444 - 84,968,811 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl884,945,444 - 84,968,811 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0884,514,686 - 84,537,779 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4882,609,180 - 82,633,422 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera878,265,590 - 78,288,826 (+)NCBICelera
Cytogenetic Map8q24NCBI
Klhl31
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554112,457,750 - 2,461,680 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554112,449,241 - 2,461,779 (+)NCBIChiLan1.0ChiLan1.0
KLHL31
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2568,117,144 - 68,138,172 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1663,993,921 - 64,014,712 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0653,201,483 - 53,351,320 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1654,839,066 - 54,893,501 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl654,839,066 - 54,893,640 (-)Ensemblpanpan1.1panPan2
KLHL31
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11221,153,843 - 21,201,345 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1221,156,440 - 21,160,527 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1221,044,587 - 21,158,581 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01221,649,405 - 21,764,165 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1221,653,442 - 21,792,714 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11221,143,028 - 21,256,809 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01221,251,622 - 21,366,537 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01221,390,177 - 21,504,417 (-)NCBIUU_Cfam_GSD_1.0
Klhl31
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494656,672,580 - 56,690,764 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364767,269,396 - 7,287,792 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364767,269,396 - 7,287,617 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL31
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl727,062,044 - 27,106,111 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1727,088,393 - 27,106,104 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2731,581,623 - 31,599,294 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL31
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11718,843,757 - 18,910,041 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1718,892,065 - 18,906,360 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604453,517,052 - 53,537,175 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl31
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624850918,258 - 936,335 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624850920,086 - 936,260 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Klhl31
973 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1193
Count of miRNA genes:575
Interacting mature miRNAs:780
Transcripts:ENSMUST00000057781
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94883105682831177Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94883105682831177Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49452421101406120Mouse
14746993Manh66_mmandible shape 66 (mouse)94981404883814048Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95015132084151448Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95203447899792481Mouse
12790990Tgl7_mtriglyceride 7 (mouse)95455996088559960Mouse
10043877Adip21_madiposity 21 (mouse)Not determined95643910890439255Mouse
4141676Neogq1_mneonatal growth QTL 1 (mouse)Not determined95780504786121973Mouse
1301803Stheal9_msoft tissue heal 9 (mouse)Not determined95902438793024534Mouse
1301172Fembrs6_mfemur breaking strength 6 (mouse)Not determined95902438793024534Mouse
1301456Adip5_madiposity 5 (mouse)Not determined95936994693370128Mouse
1300848Skull13_mskull morphology 13 (mouse)Not determined95936994693370128Mouse
5491195Mobq8_mmultigenic obesity QTL 8 (mouse)Not determined95936994693370128Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959897283109089068Mouse
1301611Lrnx3_mlearning contextual 3 (mouse)Not determined96214976796149881Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
11081165Psl6_mpromotion susceptibility QTL 6 (mouse)96504119195522808Mouse
1301290Smgd1_msubmucosal gland distribution 1 (mouse)Not determined96583105686577967Mouse
1301636Lith5_mlithogenic gene 5 (mouse)Not determined966089077100089175Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967006220101006220Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968779563102779705Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968779563102779705Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969121898103121973Mouse
10412174Habiir4_mhyperoxic acute lung injury imprinted region 4 (mouse)Not determined96926774798701707Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969428566103428698Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972859058106859205Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972859058106859205Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974250230108250378Mouse
1301914Ksc1_mkeratinocyte stem cell locus 1 (mouse)Not determined97540903779998332Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975682646114303447Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975682646114303447Mouse
1301869Tbbmd4_mtotal body bone mineral density 4 (mouse)Not determined976024387101406120Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976417989110418183Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000057781   ⟹   ENSMUSP00000059643
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl977,543,782 - 77,567,409 (+)Ensembl
GRCm38.p6 Ensembl977,636,500 - 77,660,127 (+)Ensembl
RefSeq Acc Id: NM_172925   ⟹   NP_766513
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39977,544,014 - 77,567,407 (+)NCBI
GRCm38977,636,732 - 77,660,125 (+)ENTREZGENE
MGSCv37977,484,539 - 77,507,932 (+)RGD
Celera974,815,043 - 74,838,220 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_766513 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC35261 (Get FASTA)   NCBI Sequence Viewer  
  BAC39566 (Get FASTA)   NCBI Sequence Viewer  
  EDL26352 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000059643
  ENSMUSP00000059643.7
GenBank Protein Q8BWA5 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_766513   ⟸   NM_172925
- UniProtKB: Q148Q5 (UniProtKB/Swiss-Prot),   Q8BWA5 (UniProtKB/Swiss-Prot),   G3X9D8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000059643   ⟸   ENSMUST00000057781
Protein Domains
BACK   BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BWA5-F1-model_v2 AlphaFold Q8BWA5 1-634 view protein structure

Promoters
RGD ID:8670234
Promoter ID:EPDNEW_M13148
Type:initiation region
Name:Klhl31_1
Description:Mus musculus kelch-like 31 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38977,636,722 - 77,636,782EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3045305 AgrOrtholog
Ensembl Genes ENSMUSG00000044938 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000057781 ENTREZGENE
  ENSMUST00000057781.8 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.420 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB-kelch_protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KLHL31 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:244923 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:3045305 ENTREZGENE
NCBI Gene 244923 ENTREZGENE
PANTHER LD33804P UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45632:SF17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Klhl31 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF117281 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3X9D8 ENTREZGENE, UniProtKB/TrEMBL
  KLH31_MOUSE UniProtKB/Swiss-Prot
  Q148Q5 ENTREZGENE
  Q8BWA5 ENTREZGENE
  Q8C3H1_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q148Q5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-22 Klhl31  kelch-like 31    kelch-like 31 (Drosophila)  Symbol and/or name change 5135510 APPROVED