Gm5741 (predicted gene 5741) - Rat Genome Database

Name: Gm5741
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Gm5741 (predicted gene 5741) Mus musculus

Analyze

Symbol:

Gm5741

Name:

predicted gene 5741

RGD ID:

1619615

MGI Page

MGI

Description:

Predicted to have G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to localize to G-protein beta/gamma-subunit complex and heterotrimeric G-protein complex. Orthologous to human GNG14 (G protein subunit gamma 14); PARTICIPATES IN glutamate signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil (ortholog); methylisothiazolinone (ortholog); valproic acid (ortholog).

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

EG436049; guanine nucleotide binding protein (G protein), gamma 12-like; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like; MGC182247; MGC182257; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14; uncharacterized LOC105372280 homolog

RGD Orthologs

Human

Rat

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GNG14 (G protein subunit gamma 14)	HGNC	Ensembl, NCBI
Rattus norvegicus (Norway rat):	Gng14 (G protein subunit gamma 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GNG14 (G protein subunit gamma 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GNG14 (G protein subunit gamma 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gng14 (G protein subunit gamma 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GNG14 (G protein subunit gamma 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	GNG14 (G protein subunit gamma 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gng14 (G protein subunit gamma 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Gng14 (G protein subunit gamma 14)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)
Danio rerio (zebrafish):	si:dkey-117i10.1	Alliance	DIOPT (OrthoFinder\|TreeFam)
Homo sapiens (human):	GNG14 (G protein subunit gamma 14)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	gpc-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	Ggamma1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PANTHER)

Latest Assembly:

GRCm38 - Mouse Genome Assembly GRCm38

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	85,794,197 - 85,794,611 (-)	NCBI	GRCm39		mm39
GRCm38	8	85,067,568 - 85,067,982 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	85,067,568 - 85,067,982 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	87,591,467 - 87,591,875 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	87,591,488 - 87,591,793 (-)	NCBI			mm8
Celera	8	89,362,186 - 89,362,594 (-)	NCBI		Celera
Cytogenetic Map	8	C3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

6-propyl-2-thiouracil (ISO)

methylisothiazolinone (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

G protein-coupled receptor signaling pathway (IBA)

Cellular Component

G-protein beta/gamma-subunit complex (IBA)

heterotrimeric G-protein complex (IBA)

Molecular Function

G-protein beta-subunit binding (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

glutamate signaling pathway (IEA)

mitogen activated protein kinase signaling pathway (IEA)

References

References - curated


1.	Pipeline to import KEGG annotations from KEGG into RGD

Additional References at PubMed

PMID:12477932	PMID:14610273	PMID:21873635

Genomics

Comparative Map Data

Gm5741
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	85,794,197 - 85,794,611 (-)	NCBI	GRCm39		mm39
GRCm38	8	85,067,568 - 85,067,982 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	85,067,568 - 85,067,982 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	87,591,467 - 87,591,875 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	87,591,488 - 87,591,793 (-)	NCBI			mm8
Celera	8	89,362,186 - 89,362,594 (-)	NCBI		Celera
Cytogenetic Map	8	C3	NCBI

GNG14
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	19	12,687,998 - 12,688,422 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	19	12,687,998 - 12,688,422 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
Cytogenetic Map	19	p13.13	NCBI
CHM1_1	19	12,799,335 - 12,799,757 (+)	NCBI		CHM1_1

Gng14
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	19	26,180,749 - 26,182,197 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	26,181,143 - 26,181,449 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	37,156,676 - 37,157,577 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	24,746,046 - 24,746,352 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	19	22,646,979 - 22,648,427 (+)	NCBI		Celera
Cytogenetic Map	19	q11	NCBI

GNG14
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	19	12,991,047 - 12,995,513 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	19	12,245,624 - 12,250,695 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

GNG14
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	49,431,212 - 49,435,947 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Gng14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936659	1,816,417 - 1,817,111 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GNG14
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	2	66,297,770 - 66,303,125 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	66,674,393 - 66,682,456 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GNG14
(Chlorocebus sabaeus - African green monkey)

No map positions available.

Gng14
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624901	325,007 - 326,469 (+)	NCBI

QTLs in Region (GRCm38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4140967	Bmd39_m	bone mineral density 39 (mouse)			Not determined		8	32016544	117238700	Mouse
1558875	Eae31_m	experimental allergic encephalomyelitis susceptibility 31 (mouse)			Not determined		8	34642776	114837007	Mouse
1301013	Capsq4_m	capsaicin sensitivity related QTL 4 (mouse)			Not determined		8	36163000	92728652	Mouse
27226754	Femd6_m	femur midshaft diameter 6, 10 week (mouse)					8	37400000	109600000	Mouse
12904744	Carcdq1_m	cardiac collagen deposition QTL 1 (mouse)					8	39709256	94689598	Mouse
14700686	Civq3_m	cerebral infarct volume QTL 3 (mouse)					8	51882191	85882191	Mouse
1301506	Aevm1_m	autoimmune extremity vasculitis in MRL mice 1 (mouse)			Not determined		8	54287817	88287993	Mouse
1301952	Im3_m	immunoregulatory 3 (mouse)			Not determined		8	54706614	88706763	Mouse
10412287	Carg3_m	Candida albicans resistance gene 3 (mouse)			Not determined		8	55545028	89545028	Mouse
11353828	Gf7_m	gonadal fat pad weight 7 (mouse)					8	58201479	92201479	Mouse
10043975	Obq31_m	obesity QTL 31 (mouse)			Not determined		8	58409776	92409776	Mouse
1301688	Orch6_m	autoimmune orchitis resistance 6 (mouse)			Not determined		8	60786850	94786976	Mouse
4141285	Tgq18_m	triglyceride QTL 18 (mouse)			Not determined			63460107	97460107	Mouse
4141797	Skmw16_m	skeletal muscle weight 16 (mouse)			Not determined		8	63939547	97939696	Mouse
1357787	Vtbt5_m	vertebral trabecular bone trait 5 (mouse)			Not determined		8	65357768	99357920	Mouse
10043992	Hbnr11_m	Heligmosomoides bakeri nematode resistance 11 (mouse)			Not determined		8	65600207	99600347	Mouse
1301767	Fcsa2_m	femoral cross-sectional area 2 (mouse)			Not determined		8	70305375	104305495	Mouse
4142283	Imraq2_m	immune response to AAV2 QTL 2 (mouse)			Not determined		8	70305375	104305495	Mouse
1558780	Idd22_m	insulin dependent diabetes susceptibility 22 (mouse)			Not determined		8	71102903	105103009	Mouse
4141395	Char2a_m	P. chabaudi malaria resistance QTL 2a (mouse)			Not determined			71136783	90202598	Mouse
4142023	W3q5_m	weight 3 weeks QTL 5 (mouse)			Not determined			71287817	123895615	Mouse
1357708	Orq1_m	ovulation rate QTL 1 (mouse)			Not determined		8	71287817	123895615	Mouse
1301872	Cd4ts3_m	CD4 T cell subset 3 (mouse)			Not determined		8	71396181	105396393	Mouse
1300920	Pitm3_m	prion incubation time 3 (mouse)			Not determined		8	73202495	107202598	Mouse
27095912	Pglq14_m	pelvic girdle length QTL 14, 16 week (mouse)					8	73400000	126100000	Mouse
1558890	Lith18_m	lithogenic gene 18 (mouse)			Not determined		8	75675517	109675623	Mouse
1357470	Obq16_m	obesity QTL 16 (mouse)			Not determined		8	75685348	109685497	Mouse
1301808	Nhdlq1_m	non-HDL QTL 1 (mouse)			Not determined		8	75685348	109685497	Mouse
1301874	Hdlq16_m	HDL QTL 16 (mouse)			Not determined		8	75685348	109685497	Mouse
10412234	Nhdlq14_m	non-HDL QTL 14 (mouse)			Not determined		8	75685348	109685497	Mouse
1301099	Cbm2_m	cerebellum weight 2 (mouse)			Not determined		8	78518613	112518703	Mouse
1301581	Char2_m	P. chabaudi malaria resistance QTL 2 (mouse)			Not determined		8	79082178	113082403	Mouse
12904012	Cfq10_m	conditioned fear QTL 10 (mouse)					8	80066775	89014359	Mouse
10755530	Wbc2_m	white blood cell count 2 (mouse)					8	81092664	115092664	Mouse
10755519	Wbc1_m	white blood cell count 1 (mouse)					8	81619151	115619151	Mouse
1301766	Desp1_m	despair 1 (mouse)			Not determined		8	84759576	118759741	Mouse

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	144
Count of miRNA genes:	135
Interacting mature miRNAs:	142
Transcripts:	ENSMUST00000177563
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001195531	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC163703	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC147108	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC147109	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000177563 ⟹ ENSMUSP00000136655

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	85,067,568 - 85,067,982 (-)	Ensembl

RefSeq Acc Id:

NM_001195531 ⟹ NP_001182460

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	8	85,794,197 - 85,794,611 (-)	NCBI
GRCm38	8	85,067,568 - 85,067,982 (-)	ENTREZGENE
Celera	8	89,362,186 - 89,362,600 (-)	ENTREZGENE
cM Map	8		ENTREZGENE

Sequence:

show sequence

CAAGCGTGTTCAGGCGTCTTCAGGACCTAAAAGGAGCTGCAAAAGCTTGGAGTCTCAGGCTTGC
ACGGCCCTGCGCACCTTCTCCCAGATGTCTAGCAAGGTGGCCACTGGCAGTGACATCGGACAGG
CCCGTCGGGCAGTGGAGCAACTGCGGATGGAAGCAGGCATCAACCGCATAAAGGTATCCAAGGC
AGCTACAGATCTGCTGCAGTTCTGCACTGAACAGGCCAAGAGCGACCCCTTCCTTGTGGGCATC
CCAGCTGCCACCAACCCTTTCAAGGAAAAGAAACCCTGTGCTATCCTATGAACCCATGATAATG
CTGCTGCC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001182460	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI47109	(Get FASTA)	NCBI Sequence Viewer
	AAI47110	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001182460 ⟸ NM_001195531
- UniProtKB:	B2RVA4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSSKVATGSDIGQARRAVEQLRMEAGINRIKVSKAATDLLQFCTEQAKSDPFLVGIPAATNPFK EKKPCAIL hide sequence

RefSeq Acc Id:

ENSMUSP00000136655 ⟸ ENSMUST00000177563

Protein Domains

G protein gamma

Promoters

RGD ID:

8667741

Promoter ID:

EPDNEW_M11902

Type:

single initiation site

Name:

Gm5741_1

Description:

Mus musculus predicted gene 5741 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	8	85,068,018 - 85,068,078	EPDNEW

RGD ID:

6843223

Promoter ID:

MM_KWN:55135

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, MEF_B6

Transcripts:

BC147108_GM5741

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	8	87,591,386 - 87,592,802 (-)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:3645690	AgrOrtholog
Ensembl Genes	ENSMUSG00000095845	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000136655	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000177563	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	4.10.260.10	UniProtKB/TrEMBL
InterPro	G-protein_gamma-like_dom	UniProtKB/TrEMBL
	GGL_sf	UniProtKB/TrEMBL
	Gprotein-gamma	UniProtKB/TrEMBL
KEGG Report	mmu:100503710	UniProtKB/TrEMBL
MGD	MGI:3645690	ENTREZGENE
NCBI Gene	Gm5741	ENTREZGENE
PANTHER	Gprotein-gamma	UniProtKB/TrEMBL
Pfam	G-gamma	UniProtKB/TrEMBL
PhenoGen	Gm5741	PhenoGen
PRINTS	GPROTEING	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_GAMMA	UniProtKB/TrEMBL
SMART	GGL	UniProtKB/TrEMBL
Superfamily-SCOP	G-protein_gamma-like	UniProtKB/TrEMBL
UniGene	Mm.440240	ENTREZGENE
UniProt	B2RVA4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Annotations - KEGG (archival)