Skor2 (SKI family transcriptional corepressor 2) - Rat Genome Database

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Gene: Skor2 (SKI family transcriptional corepressor 2) Mus musculus
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Symbol: Skor2
Name: SKI family transcriptional corepressor 2
RGD ID: 1619466
MGI Page MGI
Description: Enables SMAD binding activity; chromatin binding activity; and histone deacetylase binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cerebellar Purkinje cell differentiation; regulation of dendrite morphogenesis; and regulation of signal transduction. Located in nucleus. Is expressed in brain; dorsal root ganglion; and spinal cord. Orthologous to human SKOR2 (SKI family transcriptional corepressor 2); INTERACTS WITH 2,3',4,4',5-Pentachlorobiphenyl; bisphenol A (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Co; Corl2; EG664805; functional Smad suppressor element on chromosome 18; Fusse; fussel-18 homolog; Fussel18; Gm7348; ladybird homeobox corepressor 1-like protein; LBX1 corepressor 1-like protein; transcriptional corepressor Corl2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391876,934,428 - 76,988,759 (+)NCBIGRCm39mm39
GRCm39 Ensembl1876,944,100 - 76,988,037 (+)Ensembl
GRCm381876,846,733 - 76,901,064 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1876,856,405 - 76,900,342 (+)EnsemblGRCm38mm10GRCm38
MGSCv371877,095,144 - 77,139,081 (+)NCBIGRCm37mm9NCBIm37
MGSCv361877,060,652 - 77,098,605 (+)NCBImm8
Celera1878,040,716 - 78,084,655 (+)NCBICelera
Cytogenetic Map18E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
1. RGD automated import pipeline
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16200078   PMID:17622165   PMID:18522874   PMID:20004188   PMID:20809939   PMID:21844226   PMID:21873635   PMID:21937600   PMID:22513377   PMID:24491816   PMID:24594479   PMID:27449513  
PMID:28542916   PMID:28893945   PMID:31291246   PMID:31530634   PMID:32187534   PMID:33055198  


Genomics

Comparative Map Data
Skor2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391876,934,428 - 76,988,759 (+)NCBIGRCm39mm39
GRCm39 Ensembl1876,944,100 - 76,988,037 (+)Ensembl
GRCm381876,846,733 - 76,901,064 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1876,856,405 - 76,900,342 (+)EnsemblGRCm38mm10GRCm38
MGSCv371877,095,144 - 77,139,081 (+)NCBIGRCm37mm9NCBIm37
MGSCv361877,060,652 - 77,098,605 (+)NCBImm8
Celera1878,040,716 - 78,084,655 (+)NCBICelera
Cytogenetic Map18E3NCBI
SKOR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1847,206,169 - 47,251,660 (-)EnsemblGRCh38hg38GRCh38
GRCh381847,206,169 - 47,251,660 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371844,732,540 - 44,778,031 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361843,000,291 - 43,029,552 (-)NCBINCBI36hg18NCBI36
Celera1841,579,319 - 41,626,006 (-)NCBI
Cytogenetic Map18q21.1NCBI
HuRef1841,586,480 - 41,623,743 (-)NCBIHuRef
CHM1_11844,733,580 - 44,770,699 (-)NCBICHM1_1
Skor2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21870,404,431 - 70,446,330 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1873,157,973 - 73,193,377 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01873,145,596 - 73,199,395 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01872,836,465 - 72,877,011 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41873,821,250 - 73,864,209 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1868,920,342 - 68,974,524 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
Skor2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540232,582,575 - 32,618,436 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540232,577,189 - 32,618,611 (-)NCBIChiLan1.0ChiLan1.0
SKOR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11843,979,245 - 43,997,434 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01840,594,124 - 40,639,720 (-)NCBIMhudiblu_PPA_v0panPan3
SKOR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1744,250,822 - 44,289,737 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha743,735,496 - 43,774,017 (+)NCBI
ROS_Cfam_1.0744,204,550 - 44,243,076 (+)NCBI
UMICH_Zoey_3.1743,904,624 - 43,943,147 (+)NCBI
UNSW_CanFamBas_1.0743,959,109 - 43,997,423 (+)NCBI
UU_Cfam_GSD_1.0744,242,454 - 44,280,984 (+)NCBI
Skor2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494440,472,580 - 40,516,135 (+)NCBI
SpeTri2.0NW_004936983156,466 - 197,281 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SKOR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl196,795,507 - 96,842,064 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1196,795,362 - 96,842,360 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21309,491,307 - 309,538,198 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SKOR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11833,687,044 - 33,731,464 (+)NCBI
ChlSab1.1 Ensembl1833,687,057 - 33,716,606 (+)Ensembl
Vero_WHO_p1.0NW_0236660507,988,355 - 8,035,852 (+)NCBI
Skor2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477810,757,829 - 10,807,277 (-)NCBI

Position Markers
Fussel18  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18E3UniSTS
cM MapUN UniSTS
cM Map18 UniSTS
Skor2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18E3UniSTS
Skor2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18E3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182476282478296340Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183948686184620653Mouse
1301902Hrtfm4_mheart failure modifier 4 (mouse)Not determined184317804877178271Mouse
12904745Carcdq2_mcardiac collagen deposition QTL 2 (mouse)184629021680290216Mouse
11039493Ltpr8d_mLeishmania tropica response 8d (mouse)184674183280741971Mouse
11039494Ltpr8b_mLeishmania tropica response 8b (mouse)184674183280741971Mouse
1357630Tgq1_mtriglyceride QTL 1 (mouse)Not determined185091908584919240Mouse
11252137Modvl5_mmodifier of vacuolated lens 5 (mouse)185091908584919240Mouse
1302099Hdlq30_mHDL QTL 30 (mouse)Not determined185153522985535397Mouse
10412244Par5_mpulmonary adenoma resistance 5 (mouse)Not determined185153522985535397Mouse
1301853Heal9_mwound healing/regeneration 9 (mouse)Not determined185267220586672345Mouse
1301500Szs4_mseizure susceptibility 4 (mouse)Not determined185484280185496018Mouse
12880410V125Dq13_mvitamin D active form serum level QTL 13 (mouse)185630000090300000Mouse
12880430Fgf23lq4_mFGF23 serum level QTL 4 (mouse)185630000090300000Mouse
12880428V125Dq14_mvitamin D active form serum level QTL 14 (mouse)185730000090702639Mouse
1301353Lbw6_mlupus NZB x NZW 6 (mouse)Not determined185742926790702639Mouse
4141132Eae18_mexperimental allergic encephalomyelitis susceptibility 18 (mouse)Not determined5745748782586603Mouse
4140971Mbmq1_mmale body mass QTL 1 (mouse)Not determined5785721090702639Mouse
11039492Ltpr8a_mLeishmania tropica response 8a (mouse)185904702190702639Mouse
11039495Ltpr8c_mLeishmania tropica response 8c (mouse)185904702190702639Mouse
11049564Lmr29_mleishmaniasis resistance 29 (mouse)185904702190702639Mouse
1301103Pgia11_mproteoglycan induced arthritis 11 (mouse)Not determined185982648990702639Mouse
1302109Sluc28_msusceptibility to lung cancer 28 (mouse)Not determined185984762690702639Mouse
38455998Cdtm1_mCD62L+ CD8 TM cells 1 (mouse)186000000080000000Mouse
1558803W3q16_mweight 3 weeks QTL 16 (mouse)Not determined186113937681448616Mouse
1558782Orgwq9_morgan weight QTL 9 (mouse)Not determined186113937682586603Mouse
1301798Hdlq31_mHDL QTL 31 (mouse)Not determined186712626490702639Mouse
10401904Sicd4_mseizure-induced cell death 4 (mouse)Not determined186967220585496018Mouse
15014786Mvlq2_mmacrovesicular liver lesion QTL 2 (mouse)187155126490702639Mouse
1302183Pas7_mpulmonary adenoma susceptibility 7 (mouse)Not determined187261252384126470Mouse
4142153Idd21.1_minsulin dependent diabetes susceptibility 21.1 (mouse)Not determined187442926784126470Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:119
Interacting mature miRNAs:125
Transcripts:ENSMUST00000166956
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000166956   ⟹   ENSMUSP00000132338
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1876,856,405 - 76,900,342 (+)Ensembl
RefSeq Acc Id: NM_001109743   ⟹   NP_001103213
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391876,944,100 - 76,988,037 (+)NCBI
GRCm381876,856,405 - 76,900,342 (+)NCBI
MGSCv371877,095,144 - 77,139,081 (+)RGD
Celera1878,040,716 - 78,084,655 (+)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006526436   ⟹   XP_006526499
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391876,934,428 - 76,988,759 (+)NCBI
GRCm381876,846,733 - 76,901,064 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001103213 (Get FASTA)   NCBI Sequence Viewer  
  XP_006526499 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A7M7C7 (Get FASTA)   NCBI Sequence Viewer  
  BAF76044 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001103213   ⟸   NM_001109743
- UniProtKB: A7M7C7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006526499   ⟸   XM_006526436
- Peptide Label: isoform X1
- UniProtKB: A7M7C7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000132338   ⟸   ENSMUST00000166956


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3645984 AgrOrtholog
Ensembl Genes ENSMUSG00000091519 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000132338 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000166956 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.260.20 UniProtKB/Swiss-Prot
  3.10.390.10 UniProtKB/Swiss-Prot
InterPro c-SKI_SMAD4-bd_dom UniProtKB/Swiss-Prot
  DNA-bd_dom_put_sf UniProtKB/Swiss-Prot
  SAND-like_dom_sf UniProtKB/Swiss-Prot
  SKI/SNO/DAC UniProtKB/Swiss-Prot
  SKI_corepress_2 UniProtKB/Swiss-Prot
  Ski_DNA-bd_sf UniProtKB/Swiss-Prot
  Tscrpt_reg_SKI_SnoN UniProtKB/Swiss-Prot
KEGG Report mmu:664805 UniProtKB/Swiss-Prot
MGD MGI:3645984 ENTREZGENE
NCBI Gene 664805 ENTREZGENE
PANTHER PTHR10005 UniProtKB/Swiss-Prot
  PTHR10005:SF7 UniProtKB/Swiss-Prot
Pfam c-SKI_SMAD_bind UniProtKB/Swiss-Prot
  Ski_Sno UniProtKB/Swiss-Prot
PhenoGen Skor2 PhenoGen
SMART c-SKI_SMAD_bind UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46955 UniProtKB/Swiss-Prot
  SSF63763 UniProtKB/Swiss-Prot
UniProt A7M7C7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Skor2  SKI family transcriptional corepressor 2  Fussel18  functional Smad suppressor element on chromosome 18  Data Merged 737654 PROVISIONAL
2011-07-27 Skor2  SKI family transcriptional corepressor 2  Gm7348  predicted gene 7348  Symbol and/or name change 5135510 APPROVED